Fothergill's disease is a neuropathic disorder characterized by episodes of intense pain in the face, originating from the trigeminal nerve.

It has been described as among the most painful conditions known to mankind and therefore has been sometimes labeled the 'suicide disease'

2016 - Study ~ Neuropathic orofacial pain: Cannabinoids as a therapeutic avenue. International Journal of Biochemistry & Cell Biology.

2015 - Study ~ The Efficacy of Eslicarbazepine Acetate in Models of Trigeminal, Neuropathic, and Visceral Pain: The Involvement of 5-HT1B/1D Serotonergic and CB1/CB2 Cannabinoid
Receptors. Anesthesia & Analgesia.

2009 - News - Medical Marijuana and Tic Douloureux. Marijuana Doctors.

2007 - Study ~ The synthetic cannabinoids attenuate allodynia and hyperalgesia in a rat model of trigeminal neuropathic pain. Neuropharmacology.

2004 - Study ~ Anandamide Is Able to Inhibit Trigeminal Neurons Using an in Vivo Model of Trigeminovascular-Mediated Nociception. Journal of Pharmacology and Experimental Therapeutics.

2004 - Study ~Therapeutic potential of cannabinoids in trigeminal neuralgia. Current Drug Targets.