Quitting Drugs:  With the Aid of Cannabis


Research is showing using cannabis to taper off other hard drugs that you are physically addicted to is definitely a good idea and can be effective. Cannabis can take your mind off your desire to use the dangerous and often lethal drug, and can even take the edge off the withdrawals.

During the temperance movement of the 1890's, marijuana was commonly recommended as a substitute for alcohol.
"If cannabis is to be suggested as a gateway drug, is it not reasonable to suggest that the gate can swing in either direction?"

 Grant Cluff Quote
Cannabis Science, Inc, with CEO Robert Melamede, PhD
Can medical marijuana help addicts transition off heroin and oxycontin?

Cannabis Medical Journals

2019 - Substance Use & Misuse ~ Marijuana as a Substitute for Prescription Medications: A Qualitative Study.

2019 - NeuroToxicology ~ Cannabidiol (CBD) use in psychiatric disorders: A systematic review.

2019 - Addiction Biology ~ Endocannabinoid contributions to alcohol habits and motivation: Relevance to treatment.

2019 - Alcoholism: Clinical and Experimental Research ~ Endocannabinoid Signaling in the Central Amygdala and Bed Nucleus of the Stria Terminalis: Implications for the Pathophysiology and Treatment of Alcohol Use Disorder.

2016 - Oxford Academic: Health Education Research ~ The association between cannabis use and motivation and intentions to quit tobacco within a sample of Australian socioeconomically disadvantaged smokers.

Addiction Biology ~ Cannabidiol disrupts the reconsolidation of contextual drug-associated memories in Wistar rats.

2016 - Therapie ~ Co-occurrent cannabis and tobacco uses: Clinical knowledge and therapeutic prospects.

2016 - Drug and Alcohol Dependence ~ Opioid withdrawal suppression efficacy of oral dronabinol in opioid dependent humans.

2016 - Interdepartmental Program in Neuroscience ~ Comorbid Cannabis and Tobacco Use in Adolescents and Adults.

2016 - Pharmacokinetics ~ Pharmacokinetic Drug Interactions with Tobacco, Cannabinoids and Smoking Cessation Products.

2016 - Neuropsychopharmacology ~ Blockade of Nicotine and Cannabinoid Reinforcement and Relapse by a Cannabinoid CB1-Receptor Neutral Antagonist AM4113 and Inverse Agonist Rimonabant in Squirrel Monkeys.

2016 - Psychopharmacology ~ Attenuation of cue-induced reinstatement of nicotine seeking by URB597 through cannabinoid CB1 receptor in rats.

2016 -
Progress in Brain Research ~ Neuroscience of nicotine for addiction medicine: novel targets for smoking cessation medications.

2016 -
Frontiers in Pharmacology ~ Splendor in the Grass? A Pilot Study Assessing the Impact of Medical Marijuana on Executive Function.

2016 -
Frontiers in Psychiatry ~ No Smoke without Tobacco: A Global Overview of Cannabis and Tobacco Routes of Administration and Their Association with Intention to Quit.

2016 - Frontiers in Pharmacology ~ Effect of Pharmacological Modulation of the Endocannabinoid System on Opiate Withdrawal: A Review of the Preclinical Animal Literature.

2016 - Pharmacological Reports ~ The effect of O-1602, an atypical cannabinoid, on morphine-induced conditioned place preference and physical dependence.

2016 -
Alcoholism: Clinical and Experimental Research ~ Impacts of Changing Marijuana Policies on Alcohol Use in the United States.

2016 - Neurotoxicity Research ~ Cannabinoid Ligands and Alcohol Addiction: A Promising Therapeutic Tool or a Humbug?

2015 - Drug and Alcohol Dependence ~ Is cannabis use associated with less opioid use among people who inject drugs?

2015 - The American Journal of Addiction ~ A cannabinoid receptor 1 polymorphism is protective against major depressive disorder in methadone-maintained outpatients.

2015 - Journal of Substance Abuse Treatment ~ Variations in Cannabis Use Level and Correlates in Opiate-Users on Methadone Maintenance Treatment: A French Prospective Study.

2015 -
Drug and Alcohol Review ~ A safer alternative: Cannabis substitution as harm reduction.

2015 -
The American Journal of Addictions ~ A review of co-morbid tobacco and cannabis use disorders: Possible mechanisms to explain high rates of co-use.

2015 - European Journal of Public Health ~ Trends in the co-occurrence of tobacco and cannabis use in 15-year-olds from 2002 to 2010 in 28 countries of Europe and North America.

2014 - Public Health & Epidemiology: Oxford University ~ Can Cannabis be Considered a Substitute Medication for Alcohol?

2014 - Hawaii Journal of Medicine & Public Health ~ Therapeutic benefits of cannabis: a patient survey.

2013 - Neuropsychopharmacology, Brain Behavior and Therapeutics ~ Dual Inhibition of Endocannabinoid Catabolic Enzymes Produces Enhanced Anti-Withdrawal Effects in Morphine-Dependent Mice.

2013 - Journal of Psycopharmacology ~ AM404 attenuates reinstatement of nicotine seeking induced by nicotine-associated cues and nicotine priming but does not affect nicotine- and food-taking.

2013 - Current Opinion in Neurobiology ~ Endocannabinoid system and drug addiction: new insights from mutant mice approaches.

2013 - The New York Academy of Sciences ~ Lipids and addiction: how sex steroids, prostaglandins, and cannabinoids interact with drugs of abuse.

2013 - Neuroscience ~ Cannabinoid and opioid interactions: implications for opiate dependence and withdrawal.

2013 - Addictive BehaviorCannabidiol reduces cigarette consumption in tobacco smokers: Preliminary findings.

2013 - American Journal on Addiction ~ Impact of Cannabis Use during Stabilization on Methadone Maintenance Treatment.

2013 - Philosophical Transactions of the Royal Society: Biological Sciences ~ Targeting the endocannabinoid system with cannabinoid receptor agonists: pharmacological strategies and therapeutic possibilities.

2013 - Transitional Psychiatry ~ THC reduces the anticipatory nucleus accumbens response to reward in subjects with a nicotine addiction.

2012 - Addiction Biology ~ Cannabidiol inhibits the reward-facilitating effect of morphine: involvement of 5-HT1A receptors in the dorsal raphe nucleus.

2012 - Addiction Research & Theory ~ Cannabis as a substitute for alcohol and other drugs: A dispensary-based survey of substitution effect in Canadian medical cannabis patients.

2011 - PLOS: A Peer Reviewed, Open Access Journal ~ Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition.

2011 - Nature: Neuroscience ~ Brain cannabinoid CB2 receptors modulate cocaine's actions in mice.

2011 - British Journal of Pharmacology ~ The anandamide transport inhibitor AM404 reduces the rewarding effects of nicotine and nicotine-induced dopamine elevations in the nucleus accumbens shell in rats.

2011 - PLOS: A Peer Reviewed, Open Access Journal ~ Pharmacological activation/inhibition of the cannabinoid system affects alcohol withdrawal-induced neuronal hypersensitivity to excitotoxic insults.

2011 - Nature: Neuroscience ~ Brain cannabinoid CB2 receptors modulate cocaine's actions in mice.

2010 - Swartz Harm Reduction Journal ~ Medical marijuana users in substance abuse treatment.

2010 - Neuropharmacology ~ Attenuation of morphine antinociceptive tolerance by a CB(1) receptor agonist and an NMDA receptor antagonist: Interactive effects.

2010 - Psychopharmacology (Berl) ~ Randomized, controlled, double-blind trial of taranabant for smoking cessation.

2009 - Journal of Neuroscience ~ Cannabidiol, a Nonpsychotropic Component of Cannabis, Inhibits Cue-Induced Heroin Seeking and Normalizes Discrete Mesolimbic Neuronal Disturbances.

2009 - American Journal of Addiction ~ Intermittent marijuana use is associated with improved retention in naltrexone treatment for opiate-dependence.

2009 - Harm Reduction Journal ~ Cannabis as a substitute for alcohol and other drugs.

2009 - Pharmacological Reports ~ Effects of the cannabinoid CB1 receptor antagonist AM 251 on the reinstatement of nicotine-conditioned place preference by drug priming in rats.

2009 - International Review of Psychiatry ~ Interaction of the cannabinoid and opioid systems in the modulation of nociception.

2008 - Journal of Pharmacology and Experimental Therapeutics ~ Inhibition of anandamide hydrolysis by URB597 reverses abuse-related behavioral and neurochemical effects of nicotine in rats.

2007 - Neuropsychopharmacology ~ Subchronic cannabinoid agonist (WIN 55,212-2) treatment during cocaine abstinence alters subsequent cocaine seeking behavior.

2007 - Medicine: Department of Legal Medicine, Kyoto University, Japan ~ Chronologically overlapping occurrences of nicotine-induced anxiety- and depression-related behavioral symptoms: effects of anxiolytic and cannabinoid drugs.

2007 - National Institutes of Health ~ Modulation of the endocannabinoid system: therapeutic potential against cocaine dependence.

2005 - Journal of Pharmacology and Experimental Therapeutics ~ Comparison of Cannabidiol, Antioxidants, and Diuretics in Reversing Binge Ethanol-Induced Neurotoxicity.

2004 - Australian & New Zealand Journal of Psychiatry ~ Cannabis Abuse is Not a Risk Factor for Treatment Outcome in Methadone Maintenance Treatment: a 1-year Prospective Study in an Israeli Clinic.

2004 - European Journal of Neuroscience ~ Delta9-tetrahydrocannabinol decreases somatic and motivational manifestations of nicotine withdrawal in mice.

2003 - National Institutes of Health: Addiction ~ Does Cannabis Use Predict Poor Outcome for Heroin-Dependent Patients on Maintenance Treatment? A Review of Past Findings, and More Evidence Against.

2003 - Journal of Pharmacology and Experimental Therapeutics ~ Modulation of oral morphine antinociceptive tolerance and naloxone-precipitated withdrawal signs by oral Delta 9-tetrahydrocannabinol.

2003 - Alexander DeLuca, M.D. ~ Cannabis as a Substitute for Alcohol.

2002 - Journal of Cannabis Therapies ~ Crack heads and roots daughters: The therapeutic use of cannabis in Jamaica (Cocaine Addiction).

1999 - Journal of Psychoactive Drugs ~ Therapeutic use of cannabis by crack addicts in Brazil.

1998 - Society For The Study On Addiction ~ Marijuana use and treatment outcome among opioid-dependent patients.

1985 - Pharmacology, Biochemistry, and Behavior ~ The quasi-morphine withdrawal syndrome: effect of cannabinol, cannabidiol and tetrahydrocannabinol.

1978 - Pharmacology, Biochemistry, and Behavior ~ Time course of the effects of naturally occurring cannabinoids on morphine abstinence syndrome.

1976 - Psychopharmacology (Berl) ~ Effect of some cannabinoids on naloxone-precipitated abstinence in morphine-dependent mice.

1976 - European Journal of Pharmacology ~ Inhibition of naloxone-induced withdrawal in morphine dependent mice by 1-trans-delta9-tetrahydrocannabinol.

1975 - Science Vol. 187 ~ Morphine-dependent rats: blockade of precipitated abstinence by tetrahydrocannabinol.

1975 - Research Communications in Chemical Pathology and Pharmacology ~ Differential effect of cannabinol and cannabidiol on THC-induced responses during abstinence in morphine-dependent rats.

1970 - Medical Times. California Cannabis Research Medical Group, Berkley University, California, USA ~ Cannabis substitution. An adjunctive therapeutic tool in the treatment of alcoholism.

1889 - E.A. BIRCH, M.D. - The Use of Indian Hemp in the Treatment of Chronic Chloral and Chronic Opium Poisoning.

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