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PAIN RELIEF USING CANNABIS THERAPY

Overview
Recommended Cannabis Strains for Various Types of Pain
Pain is an unpleasant feeling often caused by intense or damaging stimuli, such as stubbing a toe, burning a finger, putting alcohol on a cut, and bumping the "funny bone". Pain comes in many forms including mental pain.
Cannabis Science and Medical Journals

2018 - Abstract ~ Cannabis Use is Associated with Lower Odds of Prescription Opioid Analgesic Use Among HIV-Infected Individuals with Chronic Pain.

Substance Use & Misuse.


2018 - Abstract ~ The role of cannabinoids in pain control: the good, the bad, and the ugly.

Edizioni Minerva Medica.


2018 - Abstract ~ The therapeutic effects of Cannabis and cannabinoids: An update from the National Academies of Sciences, Engineering and Medicine report.

European Journal of Internal Medicine.


2018 - Full ~ CB1 cannabinoid receptor agonist mouse VD-hemopressin(α) produced supraspinal analgesic activity in the preclinical models of pain.

Brain Research.

2018 - Full ~ Molecular Understanding of the Activation of CB1 and Blockade of TRPV1 Receptors: Implications for Novel Treatment Strategies in Osteoarthritis.

Institute of Pharmacology Polish Academy of Sciences.


2018 - Abstract ~ Mechanisms and treatment of painful neuromas.

Reviews in the Neurosciences.

The Journal of Pharmacology and Experimental Therapeutics.

Leslie Dan Faculty of Pharmacy, University of Toronto.

US Department of Veterans Affairs.


European Journal of Rheumatology.

Annals of Palliative Medicine.

2017 - Full ~ Use of ketamine for acute suicidal ideation in a patient with chronic pain on prescribed cannabinoids.
Journal of Clinical Pathology: BMJ Case Reports.
Cannabis and Cannabinoid Research.

Journal of Pain Research.

2017 - Full ~ Cannabinoids in Pain Management and Palliative Medicine.
Department of Internal Medicine, Germany.

2017 - Abstract ~ Substitution of medical cannabis for pharmaceutical agents for pain, anxiety, and sleep.

Journal of Psychopharmacology.


2017 - Full ~ The effect of medical marijuana laws on the health and labor supply of older adults: Evidence from the Health and Retirement Study.

National Bureau of Economic Research.


2017 - Abstract ~ Cannabinoids for the treatment of neuropsychiatric symptoms, pain and weight loss in dementia.

Current Opinion in Psychiatry.


2017 - Abstract ~ Differential neuromodulatory role of endocannabinoids in the rodent trigeminal sensory ganglion and cerebral cortex relevant to pain processing.

Neuropharmacology.

2017 - Abstract ~ The antinociceptive agent SBFI-26 binds to anandamide transporters FABP5 and FABP7 at two different sites.

Biochemistry.


2017 - Abstract ~ Antinociceptive effects of mixtures of mu opioid receptor agonists and cannabinoid receptor agonists in rats: impact of drug and fixed-dose ratio.

European Journal of Pharmacology.

2017 - Abstract ~ Acetaminophen Relieves Inflammatory Pain Through CB1 Cannabinoid Receptors in the Rostral Ventromedial Medulla.

The Journal of Neuroscience.


2017 - Abstract ~ Current evidence of cannabinoid-based analgesia obtained in preclinical and human experimental settings.

European Journal of Pain.


2017 - Abstract ~ CB1 Receptors Mediated Inhibition of ATP-Induced [Ca2+]i Increase in Cultured Rat Spinal Dorsal Horn Neurons.
Neurochemical Research.


2017 - Abstract ~ Increased expression of type 1 cannabinoid (CB1) receptor among patients with rotator cuff lesions and shoulder stiffness.

Journal of Shoulder and Elbow Surgery.


2017 - Abstract ~ Medical cannabis for the treatment of chronic pain and other disorders: misconceptions and facts.

Polish Archives of Internal Medicine.


2017 - Abstract ~ Efficacy, tolerability and safety of cannabis-based medicines for chronic pain  management – An overview of systematic reviews.

European Journal of Pain.


2017 - Abstract ~ Cannabis and Cannabinoids for Chronic Pain.
Current Rheumatology Reports.


2017 - Abstract ~ The monoacylglycerol lipase inhibitor KML29 with gabapentin synergistically produces analgesia in mice.

British Journal of Pharmacology.


2017 - Abstract ~ Preferences for Medical Marijuana over Prescription Medications Among Persons Living with Chronic Conditions: Alternative, Complementary, and Tapering Uses.

The Journal of Alternative and Complementary Medicine.


2017 - Abstract ~ Comparison of cannabinoids with known analgesics using a novel high throughput zebrafish larval model of nociception.

Behavioural Brain Research.


2017 - Abstract ~ Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as Adjunctive Therapy in Advanced Cancer Patients With Chronic Uncontrolled Pain.

Journal of Pain and Symptom Management.


2017 - Abstract ~ Antinociceptive effects of JWH015 in female and male rats.

Behavioural Pharmacology.


2017 - Abstract ~ Anti-nociceptive interactions between opioids and a cannabinoid receptor 2 agonist in inflammatory pain.

Molecular Pain.


2017 - Abstract ~ The Endogenous Cannabinoid System: A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain.

Neuropsychopharmacology.


2017 - Abstract ~ Bufalin attenuates cancer-induced pain and bone destruction in a model of bone cancer.

Naunyn-Schmiedeberg's Archives of Pharmacology.


2017 - Abstract ~ Cannabinoids and Pain: Sites and Mechanisms of Action.

Advances in Pharmacology.


2017 - Abstract ~ The Role of Nuclear Hormone Receptors in Cannabinoid Function.
Advances in Pharmacology.


2017 - Abstract ~ Positive Allosteric Modulation of Cannabinoid Receptor Type 1 Suppresses Pathological Pain Without Producing Tolerance or Dependence.

Biological Psychiatry.


2017 - Abstract ~ Topical Medical Cannabis (TMC): A new treatment for wound pain-Three cases of Pyoderma Gangrenosum.

Journal of Pain and Symptom Management.


2017 - Abstract ~ Perioperative Patient Beliefs Regarding Potential Effectiveness of Marijuana  (Cannabinoids) for Treatment of Pain: A Prospective Population Survey.
Regional Anesthesia and Pain Medicine.


2017 - Abstract ~ Effects of Centrally Administered Endocannabinoids and Opioids on Orofacial Pain Perception in Rats.

British Journal of Pharmacology.


2017 - Abstract ~ Administrations of thalidomide into the rostral ventromedial medulla produce antinociceptive effects in a rat model of postoperative pain.

Journal of Neuroscience Research.


2017 - Abstract ~ The cannabinoid system and pain.

Neuropharmacology.

Cerebral Cortex Journal.

Journal of Substance Abuse Treatment.

Regional Anesthesia and Pain Medicine.

Alimentary Pharmacology and Therapeutics.

The Journal of Pain.

The Journal of the International Association for the Study of Pain.

2012 - Study ~ Pharmacological characterization of the peripheral FAAH inhibitor URB937 in female rodents: interaction with the Abcg2 transporter in the blood-placenta barrier.

2012 - Study ~ Therapeutic modulation of cannabinoid lipid signaling: Metabolic profiling of a novel antinociceptive cannabinoid-2 receptor agonist.

2012 - Study ~ Sex Differences in Cannabinoid 1 vs. Cannabinoid 2 Receptor-Selective Antagonism of Antinociception Produced by Δ9-Tetrahydrocannabinol and CP55,940 in the Rat

2012 - Study ~ Analgesic effects of cannabinoids on central pain syndrome

2012 - News ~ Cannabinoid therapy helps provide effective analgesia for cancer patients with pain

2012 - News ~ Reefer tokin' seniors in South Florida see pain go up in smoke

2012 - News ~ Cannabinoid Shown Effective as Adjuvant Analgesic for Cancer Pai

2012 - Study ~ Medical Marijuana: Clearing Away the Smoke

2012 - Study ~ Synergistic interaction of pregabalin with the synthetic cannabinoid WIN 55,212-2 mesylate in the hot-plate test in mice: an isobolographic analysis.

2012 - Study ~ Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain

2012 - Study ~ Neonatal DSP-4 Treatment Modifies Antinociceptive Effects of the CB(1) Receptor Agonist Methanandamide in Adult Rats.

2012 - Study ~ Behavioral effects of pulp exposure in mice lacking cannabinoid receptor 2.

2012 - Study ~ Cannabinoids and muscular pain. Effectiveness of the local administration in rat.

2012 - Study ~ Cannabinergic Pain Medicine: A Concise Clinical Primer and Survey of Randomized-controlled Trial Results.

2012 - Study ~ The Role of Cannabinoids In Inflammatory Modulation of Allergic Respiratory Disorders, Inflammatory Pain and Ischemic Stroke.

2012 - Study ~ Intrathecal cannabilactone CB(2)R agonist, AM1710, controls pathological pain and restores basal cytokine levels.

2012 - Study ~ Effects of Peptide and Lipid Endocannabinoids on Arthritic Pain at Spinal Level.

2012 - Study ~ Role of cannabinoid 2 receptor in the development of bone cancer pain

2012 - Study ~ Nabiximols for Opioid-Treated Cancer Patients With Poorly-Controlled Chronic Pain: A Randomized, Placebo-Controlled, Graded-Dose Trial.

2012 - Study ~ Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors.

2012 - Study ~ The interaction between intrathecal administration of low doses of palmitoylethanolamide and AM251 in formalin-induced pain related behavior and spinal cord IL1-β expression in rats.

2012 - Study ~ Acute Reduction of Anandamide-Hydrolase (FAAH) Activity is Coupled With a Reduction of Nociceptive Pathways Facilitation in Medication-Overuse Headache Subjects After Withdrawal Treatment

2011 - Study ~ Activation of Type 5 Metabotropic Glutamate Receptors and Diacylglycerol Lipase-α Initiates 2-Arachidonoylglycerol Formation and Endocannabinoid-Mediated Analgesia.
2011 - Study ~ Cannabinoid type-1 receptor reduces pain and neurotoxicity produced by chemotherapy.

2011 - Study ~ Palmitoylethanolamide reduces granuloma-induced hyperalgesia by modulation of mast cell activation in rats

2011 - Study ~ Cannabinoid CB2 Receptors Contribute to Upregulation of β-endorphin in Inflamed Skin Tissues by Electroacupuncture

2011 - Study ~ The Central Role of Glia in Pathological Pain and the Potential of Targeting the Cannabinoid 2 Receptor for Pain Relief

2011 - Study ~ Pharmacological characterization of AM1710, a putative cannabinoid CB(2) agonist from the cannabilactone class: Antinociception without central nervous system side-effects.

2011 - Study ~ Treating pain in multiple sclerosis.

2011 - Study ~ Sex Differences in Cannabinoid 1 vs. Cannabinoid 2 Receptor-Selective Antagonism of Antinociception Produced by Δ9-Tetrahydrocannabinol and CP55,940 in the Rat

2011 - Study ~ Cannabis in Palliative Medicine: Improving Care and Reducing Opioid-Related Morbidity

2011 - Study ~ Cannabinoid-opioid interaction in chronic pain.

2011 - Study ~ Antinociception and sedation following intracerebroventricular administration of Δ⁹-tetrahydrocannabinol in female vs. male rats.

2011 - Study ~ Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action

2011 - Study ~ Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice.

2011 - Study ~ Cannabinoids for Treatment of Chronic Non-Cancer Pain; a Systematic Review of Randomized Trials.

2011 - Anecdotal ~ Father: Medical marijuana eased pain of my cancer-battling son

2011 - News ~ Marijuana, Narcotics Help Patients Reduce Chronic Pain, Study Finds

2011 - News ~ Part of placebo effect ascribed to cannabinoids

2011 - News ~ The Positive Uses of Marijuana for Cancer Patients

2011 - News ~ Cannabis brings relief to women suffering from PMS and PMDD symptoms

2010 - Study ~ Evidence for a Role of Endocannabinoids, Astrocytes and p38 Phosphorylation in the Resolution of Postoperative Pain

2010 - Study ~ Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism

2010 - Study ~ Adjuvant topical therapy with a cannabinoid receptor agonist in facial postherpetic neuralgia.

2010 - Study ~ A cannabinoid 2 receptor agonist attenuates bone cancer-induced pain and bone loss.

2010 - Study ~ Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain.

2010 - News ~ Pain target enzyme's working made crystal clear

2010 - News ~ Chronic Pain Improved by Cannabis Smoking

2010 - News ~ Study: Smoking pot may ease chronic pain

2010 - News ~ Marijuana better than pharmaceuticals at treating chronic pain, improving mood

2010 - News ~ Painkilling System in Brain: Too Much of a Good Thing?

2010 - News ~ Smoking cannabis relieves chronic pain

2009 - Study ~ The endocannabinoid system and pain.

2009 - Study ~ Cannabinoids: An emerging role in pain management?

2009 - Study ~ Standardized natural product cannabis in pain management and observations at a Canadian compassion society: a case report

2009 - Study ~ Systematic Review and Meta-analysis of Cannabis Treatment for Chronic Pain.

2009 - Study ~ Interaction of the cannabinoid and opioid systems in the modulation of nociception.

2009 - Study ~ The analgesic potential of cannabinoids.

2009 - Study ~ Characteristics of patients with chronic pain accessing treatment with medical cannabis in Washington State.

2009 - News ~ Endocannabinoids, Closely Related To Active Ingredients In Cannabis Plant, Can Promote Pain

2008 - Study ~ Therapeutic potential of cannabis in pain medicine

2008 - Study ~ Cannabinoids in the management of difficult to treat pain

2008 - Study ~ Repeated Cannabinoid Injections into the Rat Periaqueductal Gray Enhances Subsequent Morphine Antinociception

2008 - Study ~ Cannabinoids in chronic pain and palliative care.

2008 - Study ~ NOVEL SYNERGISTIC OPIOID-CANNABINOID CODRUG FOR PAIN MANAGEMENT

2008 - Study ~ Cannabinoid Modulation of Cutaneous A{delta} Nociceptors During Inflammation

2008 - Study ~ A Randomized, Placebo Controlled Cross-Over Trial of Cannabis Cigarettes in Neuropathic Pain

2008 - Study ~ Nabilone for the treatment of pain in fibromyalgia.

2008 - Study ~ Pain relief with cannabinoids-- the importance of endocannabinoids and cannabinoids for pain therapy

2008 - News ~ Marijuana-Based Drug Reduces Fibromyalgia Pain, Study Suggests

2008 - News ~ Scientist Discovers New Molecule to Treat Chronic Pain

2008 - News ~ New Cannabis-Like Drugs Could Block Pain Without Affecting Brain, Says Study

2008 - News ~ Cannabis like Drugs May Hold Key to Treating Pain While Bypassing the Brain

2008 - News ~ Cannabis suggests treatment for chronic pain

2008 - Study ~ Dynamic regulation of the endocannabinoid system: implications for analgesia

2007 - Study ~ Cross-sensitization and cross-tolerance between exogenous cannabinoid antinociception and endocannabinoid-mediated stress-induced analgesia

2007 - Study ~ Low dose combination of morphine and Δ9-tetrahydrocannabinol circumvents antinociceptive tolerance and apparent desensitization of receptors

2007 - Study ~ Antinociceptive Synergy Between the Cannabinoid Receptor Agonist WIN 55,212-2 and Bupivacaine in the Rat Formalin Test

2007 - Study ~ Dose-dependent effects of smoked cannabis on capsaicin-induced pain and hyperalgesia in healthy volunteers.

2007 - Study ~ Endocannabinoid metabolism and uptake: novel targets for neuropathic and inflammatory pain

2007 - Study ~ Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors

2007 - Study ~ Continuous infusion of the cannabinoid WIN 55,212–2 to the site of a peripheral nerve injury reduces mechanical and cold hypersensitivity

2007 - Study ~ A cannabinoid agonist differentially attenuates deep tissue hyperalgesia in animal models of cancer and inflammatory muscle pain.

2007 - Study ~ Cannabis, pain, and sleep: lessons from trials of Sativex, a cannabis-based medicine.

2007 - Letter ~ Cannabinoids for postoperative pain.

2007 - News ~ Pain relief from cannabis depends on how much you smoke

2006 - Study ~ A multicenter dose-escalation study of the analgesic and adverse effects of an oral cannabis extract (Cannador) for postoperative pain management.

2006 - Study ~ Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models

2006 - Study ~ Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the Management of Acute and Chronic Pain Episodes

2006 - Study ~ Cannabinoids In Medicine: A Review Of Their Therapeutic Potential

2006 - Study ~ The synthetic cannabinoid nabilone improves pain and symptom management in cancer patients

2006 - Study ~ Role of cannabinoid receptor agonists in mechanisms of suppression of central pain syndrome.

2006 - Study ~ Cannabinoid analgesia as a potential new therapeutic option in the treatment of chronic pain.

2006 - Study ~ Low dose treatment with the synthetic cannabinoid Nabilone significantly reduces spasticity-related pain : A double-blind placebo-controlled cross-over trial.

2006 - Study ~ Delta-9-THC based monotherapy in fibromyalgia patients on experimentally induced pain, axon reflex flare, and pain relief

2006 - Study ~ Benefits of an add-on treatment with the synthetic cannabinomimetic nabilone on patients with chronic pain - a randomized controlled trial.

2006 - Study ~ Synergistic affective analgesic interaction between delta-9-tetrahydrocannabinol and morphine.

2006 - Study ~ Local interactions between anandamide, an endocannabinoid, and ibuprofen, a nonsteroidal anti-inflammatory drug, in acute and inflammatory pain

2006 - News ~ Cannabinoids Enhance Analgesic Effects Of Anti-Inflammatory Drugs, Study Says

2006 - News ~ In MedPanel Summit, Leading Pain Experts Name Cannabinoids Among Most Promising Approaches to Treating Neuropathic Pain, Assert That Sociopolitical Climate Will Hamper Drug Approvals

2006 - News ~ Cannabis effective at relieving pain after major surgery

2005 - Study ~ CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids

2005 - Study ~ Ajulemic acid (IP-751): Synthesis, proof of principle, toxicity studies, and clinical trials

2005 - Study ~ Analgesia through endogenous cannabinoids

2005 - Study ~ Enhancement of transdermal fentanyl and buprenorphine antinociception by transdermal delta9-tetrahydrocannabinol.

2005 - Study ~ Cannabis: Use in HIV for Pain and Other Medical Symptoms

2005 - News ~ Body's Pot-Like Chemicals May Help Curb Pain

2005 - News ~ Depression: URB597 increases endocannabinoids in brain

2004 - Study ~ Cannabis Use in HIV for Pain and Other Medical Symptoms

2004 - Study ~ 3-[2-cyano-3-(trifluoromethyl)phenoxy]phenyl-4,4,4-trifluoro-1-butanesulfonate (BAY 59-3074): a novel cannabinoid Cb1/Cb2 receptor partial agonist with antihyperalgesic and antiallodynic effects.

2004 - Study ~ Are oral cannabinoids safe and effective in refractory neuropathic pain?

2004 - Study ~ Ajulemic acid: A novel cannabinoid produces analgesia without a “high”

2004 - News ~ Cannabinoids called equivalent to codeine for killing pain

2004 - News ~ High hopes for cannabinoid analgesia

2004 - News ~ Marijuana-like compounds may aid array of debiliating conditions ranging from Parkinson's to pain

2003 - Study ~ A preliminary controlled study to determine whether whole-plant cannabis extracts can improve intractable neurogenic symptoms

2003 - Study ~ Cannabis reduces opioid dose in the treatment of chronic non-cancer pain.

2003 - Study ~ Inhibition of Inflammatory Hyperalgesia by Activation of Peripheral CB2 Cannabinoid Receptors

2003 - Study ~ Topical cannabinoid enhances topical morphine antinociception.

2003 - Study ~ Cannabis use for chronic non-cancer pain: results of a prospective survey.

2003 - Study ~ Safety and efficacy of dronabinol in the treatment of agitation in patients with Alzheimer’s disease with anorexia: A retrospective chart review

2003 - Article ~ Cannabis and Pain Management

2002 - Study ~ The Role of Cannabis and Cannabinoids in Pain Management

2002 - Study ~ A Dramatic Response to Inhaled Cannabis in a Woman with Central Thalamic Pain and Dystonia

2002 - Study ~ CB2 cannabinoid receptor agonists: pain relief without psychoactive effects?

2002 - Study ~ The Pharmacology of Cannabinoid Derivatives: Are There Applications to Treatment of Pain?

2001 - Study ~ Therapeutic aspects of cannabis and cannabinoids.

2001 - Study ~ Are cannabinoids an effective and safe treatment option in the management of pain? A qualitative systematic review

2000 - News ~ Most pain patients gain benefit from cannabis in a British study

1999 - Study ~ Pain modulation by release of the endogenous cannabinoid anandamide

1999 - Study ~ Analgesic effect of the cannabinoid analogue nabilone is not mediated by opioid receptors.

1999 - News ~ Brain Releases Marijuana-Like Substance In Response To Pain, Study Finds

1998 - Study ~ Hypoactivity of the Spinal Cannabinoid System Results in NMDA-Dependent Hyperalgesia

1998 - News ~ Doped skin

1997 - Study ~ The perceived effects of smoked cannabis on patients with multiple sclerosis.

1997 - Study ~ Pain relief with oral cannabinoids in familial Mediterranean fever

1996 - Study ~ The effect of orally and rectally administered delta-9-tetrahydrocannabinol on spasticity: a pilot study with 2 patients.

1980 - Study ~ Marihuana as a therapeutic agent for muscle spasm or spasticity.

1988 - Study ~ ANALGESIC AND ANTIINFLAMMATORY ACTIVITY OF CONSTITUENTS OF CANNABIS SATIVA L.

1975 - Study ~ Analgesic effect of delta-9-tetrahydrocannabinol.

1975 - Study ~ The analgesic properties of delta-9-tetrahydrocannabinol and codeine.

1973 - Study ~ ANTI-EDEMA AND ANALGESIC PROPERTIES OF Δ9-TETRAHYDROCANNABINOL (THC)