Cannabis Research A-Z

Open Access to Science

Obesity: Cannabis Research


Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have a negative effect on health, leading to reduced life expectancy and/or increased health problems.

Science & Research

Undated - News ~ Hemp & GLA: Good Fat Burns Bad Fat

2014 - Study ~ CB1 blockade-induced weight loss over 48 weeks decreases liver fat in proportion to weight loss in humans

2014 - Study ~ Effect of intermittent cold exposure on brown fat activation, obesity, and energy
homeostasis in mice.

2013 - Study ~ Reduced endothelium-dependent relaxation to anandamide in mesenteric arteries from young obese zucker rats.

2013 - Study ~ Alterations to Melanocortinergic, GABAergic and Cannabinoid Neurotransmission Associated with Olanzapine-Induced Weight Gain

2013 - Study ~ Obesity-driven synaptic remodeling affects endocannabinoid control of orexinergic neurons

2013 - Study ~ Moderation of antipsychotic-induced weight gain by energy balance gene variants in the RUPP autism network risperidone studies

2013 - Study ~ Orexin neurons use endocannabinoids to break obesity-induced inhibition

2013 - Study ~ Reduced Food Intake is the Major Contributor to the Protective Effect of Rimonabant on Islet in Established Obesity-Associated Type 2 Diabetes.

2013 - Study ~ Genetic variation in the cannabinoid receptor gene (CNR1) (G1359A polymorphism) and their influence on anthropometric parameters and metabolic parameters under a high monounsaturated vs. high polyunsaturated fat hypocaloric diets.

2013 - Study ~ Insulin induces long-term depression of ventral tegmental area dopamine neurons via endocannabinoids

2013 - Study ~ Endocannabinoids and obesity.

2013 - Study ~ Fat to treat fat: Emerging relationship between dietary PUFA, endocannabinoids, and obesity.

2013 - Study ~ The endocannabinoid system in obesity

2013 - Study ~ Effects of CB1 receptor blockade on monosodium glutamate induced hypometabolic and hypothalamic obesity in rats.

2013 - Study ~ Activation of type 2 cannabinoid receptors (CB2R) promotes fatty acid oxidation through the SIRT1/PGC-1α pathway.

2013 - Study ~ Analysis of the "endocannabinoidome" in peripheral tissues of obese Zucker rats

2013 - Study ~ Novel effects of the cannabinoid inverse agonist AM 251 on parameters related to metabolic syndrome in obese Zucker rats.

2013 - Study ~ Endocannabinoid crosstalk between placenta and maternal fat in a baboon model (Papiospp.) of obesity.

2013 - Study ~ Monounsaturated fatty acids generated via stearoyl CoA desaturase-1 are endogenous inhibitors of fatty acid amide hydrolase.

2013 - Study ~ Role of Genetic Variation in the Cannabinoid Receptor Gene (CNR1) (G1359A Polymorphism) on Weight Loss and Cardiovascular Risk Factors After Liraglutide Treatment in Obese Patients With Diabetes Mellitus Type 2.

2013 - Study ~ Vascular targets for cannabinoids: animal and human studies

2013 - Study ~ Cannabinoids, eating behaviour, and energy homeostasis.

2013 - Study ~ A potential role for GPR55 in the regulation of energy homeostasis.

2013 - Study ~ Effect of high fat-diet and obesity on gastrointestinal motility.

2013 - Study ~ Effects of C358A polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) on weight loss, adipocytokines levels, and insulin resistance after a high polyunsaturated fat diet in obese patients.

2012 - Study ~ To Be or Not To Be—Obese

2012 - Study ~ Resistance to diet-induced adiposity in cannabinoid receptor-1 deficient mice is not due to impaired adipocyte function.

2012 - Study ~ Cannabinoid Receptor 1 (CNR1) 4895 C/T Genetic Polymorphism was Associated with Obesity in Japanese Men.

2012 - Study ~ Relationships between glucose, energy intake and dietary composition in obese adults with type 2 diabetes receiving the cannabinoid 1 (CB1) receptor antagonist, rimonabant

2012 - Study ~ Excess of the endocannabinoid anandamide during lactation induces overweight, fat accumulation and insulin resistance in adult mice

2012 - Study ~ Dietary linoleic acid elevates endogenous 2-AG and anandamide and induces obesity.

2012 - Study ~ Over-Expression of Monoacylglycerol Lipase (MGL) in Small Intestine Alters Endocannabinoid Levels and Whole Body Energy Balance, Resulting in Obesity.

2012 - Study ~ Type 2 Diabetes Associated Changes in the Plasma Non-Esterified Fatty Acids, Oxylipins and Endocannabinoids

2012 - Study ~ Endocannabinoids measurement in human saliva as potential biomarker of obesity.

2012 - Study ~ Metabolic effects of n-3 PUFA as phospholipids are superior to triglycerides in mice fed a high-fat diet: possible role of endocannabinoids.

2012 - Study ~ Gut microbiota and the development of obesity.

2012 - Study ~ CNR1 genotype influences HDL-cholesterol response to change in dietary fat intake.

2012 - Study ~ Hypothalamic CB1 Cannabinoid Receptors Regulate Energy Balance in Mice

2012 - Study ~ Dietary linoleic acid elevates endogenous 2-arachidonoylglycerol and anandamide in Atlantic salmon (Salmo salar L.) and mice, and induces weight gain and inflammation in mice.

2012 - Study ~ Cannabinoid signalling regulates inflammation and energy balance: The importance of the brain-gut axis

2012 - Study ~ Diet-dependent modulation of hippocampal expression of endocannabinoid signaling-related proteins in cannabinoid antagonist-treated obese rats.

2012 - Study ~ Cannabis exposure associated with weight reduction and β-cell protection in an obese rat model.

2012 - Study ~ Cannabinol and cannabidiol exert opposing effects on rat feeding patterns.

2012 - Study ~ The thrifty lipids: endocannabinoids and the neural control of energy conservation.

2012 - Study ~ Stimulation of acumbens shell cannabinoid CB(1) receptors by noladin ether, a putative endocannabinoid, modulates food intake and dietary selection in rats.

2012 - Study ~ Photoperiodic Changes in Endocannabinoid Levels and Energetic Responses to Altered Signalling at CB1 Receptors in Siberian Hamsters

2012 - Study ~ The role of the endocannabinoid system in eating disorders: pharmacological

2012 - Study ~ The potential use of cannabidiol in the therapy of metabolic syndrome

2012 - Study ~ GPR119 as a fat sensor.

2012 - Study ~ Role of G1359A polymorphism of the cannabinoid receptor gene on weight loss and adipocytokines levels after two different hypocaloric diets.

2012 - Study ~ The role of the endocannabinoid system in skeletal muscle and metabolic adaptations to exercise: potential implications for the treatment of obesity.

2012 - Study ~ Cannabinoid Type 1 Receptor Gene Polymorphism and Macronutrient Intake.

2012 - Study ~ New vistas for treatment of obesity and diabetes? Endocannabinoid signalling and metabolism in the modulation of energy balance.

2012 - Study ~ Fatty acid flux and oxidation are increased by rimonabant in obese women

2011 - Study ~ Resistance to diet-induced adiposity in cannabinoid receptor-1 deficient mice is not due to impaired adipocyte function

2011 - Study ~ Krill oil significantly decreases 2-arachidonoylglycerol plasma levels in obese subjects.

2011 - Study ~ Effect of dietary krill oil supplementation on the endocannabinoidome of metabolically relevant tissues from high-fat-fed mice

2011 - Study ~ Lipid transport function is the main target of oral oleoylethanolamide to reduce adiposity in high-fat-fed mice

2011 - Study ~ The activity of the endocannabinoid metabolising enzyme fatty acid amide hydrolase in subcutaneous adipocytes correlates with BMI in metabolically healthy humans

2011 - Study ~ Sympathetic activity controls fat-induced oleoylethanolamide signaling in small intestine.

2011 - Study ~ The association of the rs1049353 polymorphism of the CNR1 gene with hypoadiponectinemia.

2011 - Study ~ Gadolinium-HU-308-incorporated micelles.

2011 - Study ~ Adipose tissue endocannabinoid system gene expression: depot differences and effects of diet and exercise

2011 - Study ~ 385 C/A polymorphism of the fatty acid amide hydrolase gene is associated with metabolic syndrome in the Chinese Han population.

2011 - Study ~ Greasing the wheels of managing overweight and obesity with omega-3 fatty acids

2011 - Study ~ Obesity and Cannabis Use: Results From 2 Representative National Surveys

2011 - Study ~ Psychiatric adverse effects of rimonobant in adults with Prader Willi syndrome.

2011 - Study ~ The neutral cannabinoid CB1 receptor antagonist AM4113 regulates body weight through changes in energy intake in the rat.

2011 - Study ~ Effects of Chronic Oral Rimonabant Administration on Energy Budgets of Diet-Induced Obese C57BL/6 Mice.

2011 - Study ~ The role of central CB2 cannabinoid receptors on food intake in neonatal chicks.

2011 - Study ~ Investigations of the human endocannabinoid system in two subcutaneous adipose tissue depots in lean subjects and in obese subjects before and after weight loss

2011 - Study ~ Cannabinoid type 1 receptor mediates depot-specific effects on differentiation, inflammation and oxidative metabolism in inguinal and epididymal white adipocytes.

2011 - Study ~ The central cannabinoid CB1 receptor is required for diet-induced obesity and rimonabant's antiobesity effects in mice

2010 - Study ~ Alterations in the hippocampal endocannabinoid system in diet-induced obese mice.

2010 - Study ~ Differential alterations of the concentrations of endocannabinoids and related lipids in the subcutaneous adipose tissue of obese diabetic patients

2010 - Study ~ Expression of cannabinoid CB1 receptors by vagal afferent neurons: kinetics and role in influencing neurochemical phenotype

2010 - Study ~ Polymorphisms in the endocannabinoid receptor 1 in relation to fat mass distribution

2010 - Study ~ The endocannabinoid system links gut microbiota to adipogenesis

2010 - Study ~ CD36 gene deletion decreases oleoylethanolamide levels in small intestine of free-feeding mice.

2010 - Study ~ A common CNR1 (cannabinoid receptor 1) haplotype attenuates the decrease in HDL cholesterol that typically accompanies weight gain.

2010 - Study ~ The Effects of Rimonabant on Brown Adipose Tissue in Rat: Implications for Energy Expenditure

2010 - Study ~ Differential alterations of the concentrations of endocannabinoids and related lipids in the subcutaneous adipose tissue of obese diabetic patients.

2010 - Study ~ Cannabinoid receptor stimulation impairs mitochondrial biogenesis in mouse white adipose tissue, muscle, and liver: the role of eNOS, p38 MAPK, and AMPK pathways.

2010 - Study ~ The novel cannabinoid CB1 antagonist AM6545 suppresses food intake and food-reinforced behavior.

2010 - Study ~ Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity.

2010 - Study ~ A common polymorphism in the cannabinoid receptor 1 (CNR1) gene is associated with antipsychotic-induced weight gain in Schizophrenia.

2010 - Study ~ Rehashing endocannabinoid antagonists: can we selectively target the periphery to safely treat obesity and type 2 diabetes?

2010 - Study ~ Modulation of Adipocyte Biology by Δ9-Tetrahydrocannabinol

2010 - Study ~ Cannabidiol Attenuates the Appetitive Effects of Δ9-Tetrahydrocannabinol in Humans Smoking Their Chosen Cannabis

2010 - Study ~ Perspectives of CB1 Antagonist in Treatment of Obesity: Experience of RIO-Asia

2010 - Study ~ A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents

2010 - Study ~ Deficiency of CB2 cannabinoid receptor in mice improves insulin sensitivity but increases food intake and obesity with age.

2010 - Study ~ A clinical trial assessing the safety and efficacy of the CB1R inverse agonist taranabant in obese and overweight patients: low-dose study

2010 - Study ~ A one-year study to assess the safety and efficacy of the CB1R inverse agonist taranabant in overweight and obese patients with type 2 diabetes.

2010 - Study ~ Analysis of gene expression pattern reveals potential targets of dietary oleoylethanolamide in reducing body fat gain in C3H mice.

2010 - Study ~ G1359A polymorphism in the cannabinoid receptor-1 gene is associated with metabolic syndrome in the Chinese Han population

2010 - Study ~ Effect of dietary fat on endocannabinoids and related mediators: consequences on energy homeostasis, inflammation and mood.

2010 - Study ~ Cannabis Use and Obesity and Young Adults

2010 - Study ~ The endocannabinoid system modulates the valence of the emotion associated to food ingestion

2009 - Study ~ Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice

2009 - Study ~ Peripheral endocannabinoid dysregulation in obesity: relation to intestinal motility and energy processing induced by food deprivation and re-feeding.

2009 - Study ~ Cannabinoid CB2 Receptor Potentiates Obesity-Associated Inflammation, Insulin Resistance and Hepatic Steatosis

2009 - Study ~ Biomarkers of Endocannabinoid System Activation in Severe Obesity

2009 - Study ~ The endocanabinnoid system and diabetes - critical analyses of studies conducted with rimonabant

2009 - Study ~ Cannabinoids for clinicians: the rise and fall of the cannabinoid antagonists

2009 - Study ~ Endocannabinoids and Their Receptors as Targets for Obesity Therapy

2009 - Study ~ The endocannabinoid system as a link between homoeostatic and hedonic pathways involved in energy balance regulation

2009 - Study ~ Endocannabinoids and cardiovascular prevention: real progress?

2009 - Study ~ N-acylethanolamines, anandamide and food intake

2009 - Study ~ Effects of cannabinoid drugs on the reinforcing properties of food in gestationally undernourished rats

2009 - Study ~ Anti-inflammatory effect of palmitoylethanolamide on human adipocytes.

2008 - Study ~ Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations

2008 - Study ~ GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity

2008 - Study ~ Activating Parabrachial Cannabinoid CB1 Receptors Selectively Stimulates Feeding of Palatable Foods in Rats

2008 - Study ~ Targeted enhancement of oleoylethanolamide production in proximal small intestine induces across-meal satiety in rats.

2008 - Study ~ Endocannabinoids and the Control of Energy Homeostasis

2008 - Study ~ The lipid messenger OEA links dietary fat intake to satiety.

2008 - Study ~ The Role of Adipocyte Insulin Resistance in the Pathogenesis of Obesity-Related Elevations in Endocannabinoids

2008 - Study ~ The discovery of taranabant, a selective cannabinoid-1 receptor inverse agonist for the treatment of obesity.

2008 - Study ~ Dysregulation of peripheral endocannabinoid levels in hyperglycemia and obesity: Effect of high fat diets.

2008 - Study ~ Emerging role of cannabinoids in gastrointestinal and liver diseases: basic and clinical aspects

2008 - Study ~ Endocannabinoids and the neurochemistry of gluttony

2008 - Study ~ Dysregulation of peripheral endocannabinoid levels in hyperglycemia and obesity: Effect of high fat diets.

2008 - Study ~ Dysregulation of the endocannabinoid system in obesity.

2008 - Study ~ Cholesterol-induced stimulation of platelet aggregation is prevented by a hempseed- enriched diet

2008 - Study ~ Inhibitory effect of the anorexic compound oleoylethanolamide on gastric emptying in control and overweight mice.

2007 - Study ~ Identification of Endocannabinoids and Related Compounds in Human Fat Cells

2007 - Study ~ Genetic variations at the endocannabinoid type 1 receptor gene (CNR1) are associated with obesity phenotypes in men

2007 - Study ~ The endogenous cannabinoid system: a new player in the brain-gut-adipose axis

2007 - Study ~ No evidence for an involvement of variants in the cannabinoid receptor gene (CNR1) in obesity in German children and adolescents.

2007 - Study ~ Immune-mediated Activation of the Endocannabinoid System in Visceral Adipose Tissue in Obesity

2006 - Study ~ Dysregulation of the Peripheral and Adipose Tissue Endocannabinoid System in Human Abdominal Obesity

2006 - Study ~ Regulation, Function, and Dysregulation of Endocannabinoids in Models of Adipose and ß-Pancreatic Cells and in Obesity and Hyperglycemia

2006 - Study ~ AM 251 produces sustained reductions in food intake and body weight that are resistant to tolerance and conditioned taste aversion

2006 - Study ~ Weight Control in Individuals With Diabetes

2006 - Study ~ The emerging role of the endocannabinoid system in endocrine regulation and energy balance.

2006 - Study ~ Does Cannabis Hold the Key to Treating Cardiometabolic Disease

2006 - Study ~ The impact of obesity on reproduction in women with polycystic ovary syndrome.

2006 - Study ~ Human adipose tissue binds and metabolizes the endocannabinoids anandamide and 2-arachidonoylglycerol.

2005 - Study ~ Activation of the Peripheral Endocannabinoid System in Human Obesity

2005 - Study ~ Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity

2005 - Study ~ Food for thought: endocannabinoid modulation of lipogenesis

2005 - Study ~ Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity

2005 - Study ~ Endocannabinoids and food intake: newborn suckling and appetite regulation in adulthood.

2005 - Study ~ Endocannabinoids in the Regulation of Appetite and Body Weight.

2004 - Study ~ CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity

2003 - Study ~ The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis

2003 - Study ~ Short-term fasting and prolonged semistarvation have opposite effects on 2-AG levels in mouse brain.

2001 - Study ~ Dietary intake and nutritional status of US adult marijuana users: results from the Third National Health and Nutrition Examination Survey.

2000 - Study ~ Low dose anandamide affects food intake, cognitive function, neurotransmitter and corticosterone levels in diet-restricted mice.