JWH-015 (a synthetic CB2 & GPR-55 agonist) & Cannabis studies completed


JWH-015 is a chemical from the naphthoylindole family, which acts as a subtype-selective cannabinoid agonist. Its affinity for CB2 receptors is 13.8nM, while its affinity for CB1 is 383nM, meaning that it binds almost 28x more strongly to CB2 than CB1. However it still displays some weak CB1 activity. It has been shown to possess immunomodulatory effects and CB2 agonists may be useful in the treatment of pain and inflammation.

Science and Research

2012 - Study ~ Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro.

2012 - Study ~ Cannabinoids and muscular pain. Effectiveness of the local administration in rat.

2012 - Study ~ Cannabinoid receptor 2 agonist ameliorates mesenteric angiogenesis and portosystemic collaterals in cirrhotic rats.

2012 - Study ~ Evidence for the Putative Cannabinoid Receptor (GPR55)-Mediated Inhibitory Effects on Intestinal Con

2011 - Study ~ Crosstalk between Chemokine Receptor CXCR4 and Cannabinoid Receptor CB(2) in Modulating Breast Cancer Growth and Invasion.

2011 - Study ~ Marijuana-based Drugs: Innovative Therapeutics or Designer Drugs of Abuse?

2011 - Study ~ The Antinociceptive Effects of JWH-015 in Chronic Inflammatory Pain Are Produced by Nitric Oxide-cGMP-PKG-KATP Pathway Activation Mediated by Opioids.

2011 - Study ~ Beyond THC: The New Generation of Cannabinoid Designer Drugs.

2011 - Study ~ Crosstalk between chemokine receptor CXCR4 and cannabinoid receptor CB2 in modulating breast cancer growth and invasion.

2011 - Study ~ Intrathecal Administration of the Cannabinoid 2 Receptor Agonist JWH015 Can Attenuate Cancer Pain and Decrease mRNA Expression of the 2B Subunit of N-Methyl-d-Aspartic Acid

2011 - News ~ Latest blood test detects 12 popular synthetic cannabinoids in "fake pot".

2011 - News ~ Chemicals Used in "Spice" and "K2" Type Products Now Under Federal Control and Regulation

tractility in Mice.

2010 - Study ~ Protective effects of the synthetic cannabinoids CP55,940 and JWH-015 on rat brain mitochondria upon paraquat exposure.

2010 - News ~ Now, There's a Test for That -- Norchem's "Fake Marijuana" Test Reveals Significantly Increased Abuse of Spice/K2

2009 - Study - Inhibition of human tumour prostate PC-3 cell growth by cannabinoids R(+)-Methanandamide and JWH-015: Involvement of CB2

2009 - Study - The activation of cannabinoid CB2 receptors stimulates in situ and in vitro beta-amyloid removal by human macrophages

2008 - Study ~ CB2 cannabinoid receptor agonist JWH-015 modulates human monocyte migration through defined intracellular signaling pathways.

2008 - Study ~ Behavioral effects of CB2 cannabinoid receptor activation and its influence on food and alcohol consumption.

2007 - Study ~ Potential role for CB2 selective ligands as immunosuppressive agents

2007 - Study ~ Opposing control of cannabinoid receptor stimulation on amyloid-beta-induced reactive gliosis: in vitro and in vivo evidence.

2007 - Study ~ Spinal cannabinoid receptor type 2 activation reduces hypersensitivity and spinal cord glial activation after paw incision.
2006 - Study ~ CB2 cannabinoid receptor agonist, JWH-015 triggers apoptosis in immune cells: Potential role for CB2 selective ligands as immunosuppressive agents

2005 - Study ~ Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation

2005 - Study ~ CB2 cannabinoid receptors in trabecular meshwork cells mediate JWH015-induced enhancement of aqueous humor outflow facility.

2005 - Study ~ Avoidance of Abeta[(25-35)] / (H(2)O(2)) -induced apoptosis in lymphocytes by the cannabinoid agonists CP55,940 and JWH-015 via receptor-independent and PI3K-dependent mechanisms: role of NF-kappaB and p53.
2002 - Study ~ Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease

2000 - Study ~ Effects of cannabinoid receptor agonists on neuronally-evoked contractions of urinary bladder tissues isolated from rat, mouse, pig, dog, monkey and human