Cannabis Research A-Z

Open Access to Science

Cannabis Medical Journals: Drug Interactions


Some people use marijuana for recreational purposes, to create a sense of well being or to alter the senses. It is either taken by mouth or smoked (inhaled).

A drug interaction is a reaction between two (or more) drugs or between a drug and a food, beverage, or supplement. Taking a drug while having certain medical conditions can also cause a drug interaction. For example, taking a nasal decongestant if you have high blood pressure may cause an unwanted reaction.

Science and Research

2012 - Study ~ Synergistic interaction of pregabalin with the synthetic cannabinoid WIN 55,212-2 mesylate in the hot-plate test in mice: an isobolographic analysis.

2012 - Study ~ Synergistic interaction of pregabalin with the synthetic cannabinoid WIN 55,212-2 mesylate in the hot-plate test in mice: an isobolographic analysis.

2012 - Study ~ Changes of Blood Endocannabinoids during Anaesthesia: a Special Case for Fatty Acid Amide Hydrolase Inhibition by Propofol?

2012 - Study ~ Effects of amphetamine on dopamine release in the rat nucleus accumbens shell region depend on cannabinoid CB1 receptor activation.

2011 - Study ~ Cannabidiol Attenuates Cisplatin-Induced Nephrotoxicity by Decreasing Oxidative/Nitrosative Stress, Inflammation, and Cell Death

2011 - Study ~ Cannabidiol Attenuates Cisplatin-Induced Nephrotoxicity by Decreasing Oxidative/Nitrosative Stress, Inflammation, and Cell Death

2011 - Study ~ Acute effects of MDMA (3,4-methylenedioxymethamphetamine) on EEG oscillations: alone and in combination with ethanol or THC (delta-9-tetrahydrocannabinol)

2011 - Study ~ Combined effects of acute, very-low-dose ethanol and delta(9)-tetrahydrocannabinol in healthy human volunteers

2011 - Study ~ Inhibition of monoacylglycerol lipase (MAGL) attenuates NSAID-induced gastric hemorrhages in mice.

2011 - Study ~ Cannabinoid system and cyclooxygenases inhibitors

2011 - Study ~ Possible involvement of the endocannabinoid system in memory modulation effect of general anesthetics

2011 - Study ~ Role of GLT-1 transporter activation in prevention of cannabinoid tolerance by the beta-lactam antibiotic, ceftriaxone, in mice.

2011 - Study ~ Cannabis in Palliative Medicine: Improving Care and Reducing Opioid-Related Morbidity

2011 - Study ~ Cannabinoid-opioid interaction in chronic pain.

2011 - Study ~ A combined preclinical therapy of cannabinoids and temozolomide against glioma.

2011 - Study ~ The safety of modafinil in combination with oral Δ9-tetrahydrocannabinol in humans.

2011 - Study ~ Cannabidiol potentiates Δ(9)-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats.

2011 - Study ~ The G protein-coupled cannabinoid-1 (CB(1)) receptor of mammalian brain: Inhibition by phthalate esters in vitro.

2011 - Study ~ The interplay of cannabinoid and NMDA glutamate receptor systems in humans: preliminary evidence of interactive effects of cannabidiol and ketamine in healthy human subjects.

2011 - Study ~ Chronic administration of THC prevents the behavioral effects of intermittent adolescent MDMA administration and attenuates MDMA-induced hyperthermia and neurotoxicity in rats

2011 - Study ~ Combined effects of THC and caffeine on working memory in rats.

2011 - Study ~ Pretreatment with Δ9-tetrahydrocannabinol (THC) increases cocaine-stimulated activity in adolescent but not adult male rats

2011 - Study ~ Previous exposure to delta9-tetrahydrocannibinol enhances locomotor responding to but not self-administration of amphetamine.

2011 - Study ~ THC-methadone and THC-naltrexone interactions on discrimination, antinociception, and locomotion in rats.

2011 - Study ~ Pharmacokinetics of a combination of Δ9-tetrahydro-cannabinol and celecoxib in a porcine model of hemorrhagic shock.

2011 - Study ~ Low-volume binary drug therapy for the treatment of hypovolemia.

2011 - Study ~ Efavirenz interference in urine screening immunoassays for tetrahydrocannabinol.

2011 - Study ~ Clozapine and SCH 23390 prevent the spatial working memory disruption induced by Δ9-THC administration into the medial prefrontal cortex.

2010 - Study ~ THC Prevents MDMA Neurotoxicity in Mice.

2010 - Study ~ Attenuation of morphine antinociceptive tolerance by a CB(1) receptor agonist and an NMDA receptor antagonist: Interactive effects.

2010 - Study ~ Influence of ethanol on cannabinoid pharmacokinetic parameters in chronic users

2010 - Study ~ Methamphetamine neurotoxicity increases brain expression and alters behavioral functions of CB₁ cannabinoid receptors.

2010 - Study ~ The safety of modafinil in combination with oral Δ9-tetrahydrocannabinol in humans

2010 - Study ~ Opioid antagonism enhances marijuana's effects in heavy marijuana smokers.

2010 - Study ~ The analgesic potential of cannabinoids.

2010 - Study - Probable Interaction Between Warfarin and Marijuana Smoking

2010 - Study - Adolescent cannabis use increases risk for cocaine-induced paranoia

2009 - Study ~ Effects of Cannabinoids on Caffeine Contractures in Slow and Fast Skeletal Muscle Fibers of the Frog

2009 - Study ~ Cannabinoid receptor-independent cytotoxic effects of cannabinoids in human colorectal carcinoma cells: synergism with 5-fluorouracil.

2009 - Study ~ Pharmacological synergism between cannabinoids and paclitaxel in gastric cancer cell lines.

2009 - Study ~ Delayed onset of seizures and toxicity associated with recreational use of Bromo-dragonFLY.

2009 - Study ~ An unusual cause of syncope

2009 - Study - Cannabis Coadministration Potentiates the Effects of "Ecstasy" on Heart Rate and Temperature in Humans

2009 - Study - Induction dose of propofol in patients using cannabis

2009 - Study - Interaction of the cannabinoid and opioid systems in the modulation of nociception

2009 - Study - Cannabis coadministration potentiates the effects of "ecstasy" on heart rate and temperature in human

2009 - Study - Cannabinoids, Opioids and MDMA: Neuropsychological Interactions Related to Addiction

2008 - Study - Enhancing the in vitro cytotoxic activity of Δ9-tetrahydrocannabinol in leukemic cells through a combinatorial approach

2008 - Study ~ Repeated Cannabinoid Injections into the Rat Periaqueductal Gray Enhances Subsequent Morphine Antinociception

2008 - Study ~ Priapism, ecstasy, and marijuana: is there a connection?

2008 - Study ~ Propofol Sedation Is Reduced by {Delta}9-Tetrahydrocannabinol in Mice

2008 - Study ~ Additive Interaction of the Cannabinoid Receptor I Agonist Arachidonyl-2-chloroethylamide with Etomidate in a Sedation Model in Mice

2008 - Study ~ Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1).

2007 - Study - Efficacy of dronabinol alone and in combination with ondansetron versus ondansetron alone for delayed chemotherapy-induced nausea and vomiting.

2007 - Study - Synergy between Delta(9)-tetrahydrocannabinol and morphine in the arthritic rat

2007 - Study ~ Opioid Antagonism of Cannabinoid Effects: Differences between Marijuana Smokers and Nonmarijuana Smokers

2007 - Study ~ Low dose combination of morphine and Δ9-tetrahydrocannabinol circumvents antinociceptive tolerance and apparent desensitization of receptors

2007 - Study - Medicinal cannabis does not influence the clinical pharmacokinetics of irinotecan and docetaxel

2007 - Study ~ Antinociceptive Synergy Between the Cannabinoid Receptor Agonist WIN 55,212-2 and Bupivacaine in the Rat Formalin Test

2007 - Study - The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids

2007 - Study ~ Activation of cannabinoid CB1 and CB2 receptors suppresses neuropathic nociception evoked by the chemotherapeutic agent vincristine in rats.

2007 - Study ~ Additive Effects of Timolol and Cannabinoids on Intraocular Pressure in a Rat Glaucoma Model

2007 - Study ~ Propranolol effects on acute marihuana intoxication in man

2006 - Study ~ Modulation of paraoxon toxicity by the cannabinoid receptor agonist WIN 55,212-2.

2006 - Study ~ Local interactions between anandamide, an endocannabinoid, and ibuprofen, a nonsteroidal anti-inflammatory drug, in acute and inflammatory pain

2006 - Study ~ Benefits of an add-on treatment with the synthetic cannabinomimetic nabilone on patients with chronic pain - a randomized controlled trial.

2006 - Study ~ Arachidonyl-2'-chloroethylamide, a highly selective cannabinoid CB1 receptor agonist, enhances the anticonvulsant action of valproate in the mouse maximal electroshock-induced seizure model.

2006 - Study - Synergistic affective analgesic interaction between delta-9-tetrahydrocannabinol and morphine

2006 - Study - Add-on treatment with the synthetic cannabinomimetic nabilone on patients with chronic pain

2004 - Study - Cyclic Antidepressants

2004 - Study ~ Cannabinoids prevent the acute hyperthermia and partially protect against the 5-HT depleting effects of MDMA ("Ecstasy") in rats.

2004 - Study ~ Cannabis Abuse is Not a Risk Factor for Treatment Outcome in Methadone Maintenance Treatment: a 1-year Prospective Study in an Israeli Clinic.

2003 - Study - Cannabis reduces opioid dose in the treatment of chronic non-cancer pain

2003 - Study ~ Haloperidol, but not clozapine, produces dramatic catalepsy in delta9-THC-treated rats: possible clinical implications.

2003 - Study ~ Manipulation of the endocannabinoid system by a general anaesthetic.

2003 - Study ~ Modulation of oral morphine antinociceptive tolerance and naloxone-precipitated withdrawal signs by oral Delta 9-tetrahydrocannabinol.

2002 - Study ~ Decrease in efficacy and potency of nonsteroidal anti-inflammatory drugs by chronic delta(9)-tetrahydrocannabinol administration.

2001 - Study ~ Protective effects of cannabinoid receptor ligands analogous to anandamide against cocaine toxicity.

2000 - Study ~ Involvement of central and peripheral cannabinoid receptors in the regulation of heart resistance to arrhythmogenic effects of epinephrine.

1999 - Study ~ Case report: adverse effects of taking tricyclic antidepressants and smoking marijuana.

1996 - Study ~ Marijuana and chocolate.

1995 - Study ~ Anandamide and delta 9-THC dilation of cerebral arterioles is blocked by indomethacin

1994 - Study ~ Marihuana smoking increases plasma cocaine levels and subjective reports of euphoria in male volunteers.

1992 - Study ~ Marihuana attenuates the rise in plasma ethanol levels in human subjects.

1991 - Study - Dronabinol and prochlorperazine in combination for treatment of cancer chemotherapy-induced nausea and vomiting.

1991 - Study ~ Flashback Following Use of Cannabis--a Review

1987 - Study ~ Respiratory effects of cocaine "freebasing" among habitual users of marijuana with or without tobacco

1983 - Study ~ Adverse Interaction Between Disulfiram and Marijuana: a Case Report.

1983 - Study ~ Adverse Interaction Between Disulfiram and Marijuana: a Case Report.

1981 - Study ~ Tetrahydrocannabinol potentiates reserpine-induced hypokinesia.

1980 - Study ~ Effects of drugs on behavior in pigeons tolerant to delta 9-tetrahydrocannabinol.

1978 - Study ~ Enhanced Biotransformation of Theophylline in Marihuana and Tobacco Smokers.

1977 - Study ~ Cannabidiol --antiepileptic drug comparisons and interactions in experimentally induced seizures in rats.

1977 - Study ~ The effect of delta 9-tetrahydrocannabinol, cannabidiol, and cannabinol on the anaesthesia induced by various anaesthetic agents in mice.

1977 - Study ~ Propranolol Effects on Acute Marihuana Intoxication in Man.

1976 - Study ~ The Effects of Delta-9-Tetrahydrocannabinol (Cannabis) on Cardiac Performance with and without Beta Blockade

1975 - Study - The analgesic properties of delta-9-tetrahydrocannabinol and codeine

1975 - Study ~ Combination of delta9-tetrahydrocannabinol with oxymorphone or pentobarbital: Effects on ventilatory control and cardiovascular dynamics.

1975 - Study ~ Interactions in man of delta-9-tetrahydrocannabinol. II. Cannabinol and cannabidiol.

1974 - Study - Interaction of cannabis and general anaesthetic agents in mice

1973 - Study ~ Cardiovascular and respiratory effects of cannabis extracts and 1-tetra-hydrocannabinol

1972 - Study -  Effect of cannabis and certain of its constituents on pentobarbitone sleeping time and phenazone metabolism

1972 - Study ~ Proceedings: Effects of chronic and acute cannabis treatment upon thiopentone anaesthesia in rabbits.