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Idiopathic intracranial hypertension (IIH) is a disorder of unknown etiology that predominantly affects obese women of childbearing age.

Cannabis smoking may cause a temporary increase in blood pressure upon first smoking, but that with chronic use it will actually lower blood pressure. It is also known to cause orthostatic type hypotension, whereby even if it temporarily raises your blood pressure when first smoked.

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Science & Research

Dronabinol reduces signs and symptoms of idiopathic intracranial hypertension

J Ocul Pharmacol Ther. 2006 Feb;22(1):68-75.



New York State Psychiatric Institute, Substance Abuse Division, The S.T.A.R.S. Clinic, New York, NY 10032, USA.


A case is presented in which a woman diagnosed with a longstanding history of idiopathic intracranial hypertension reported improvement of frontal headaches, photophobia, transient blindness, enlarged blind spots, and tinnitus after smoking marijuana. All these symptoms and signs were associated with increased intracranial pressure (220-425 mm of water). Treatment with dronabinol at a dose of 10 mg twice a day, then reduced to 5 mg twice a day, relieved all of her symptoms. Previously noted papilledema and enlargement of blind spots also resolved, and this, in the absence of psychoactive effect or weight gain.



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