HU-210- a synthetic cannabinoid & Cannabis studies completed

Overview

HU-210 is a synthetic cannabinoid that was first synthesized in 1988 from (1R,5S)-myrteno by a group led by Professor Raphael Mechoulam at the Hebrew University.

HU-210 is 100 to 800 times more potent than natural THC from cannabis and has an extended duration of action. HU-210 is the (-)-1,1-dimethylheptyl analog of 11-hydroxy- delta 8- tetrahydrocannabinol; in some references it is called 1,1-dimethylheptyl- 11-hydroxytetrahydrocannabinol.

The abbreviation "HU" stands for Hebrew University.

Science and Research

2012 - Study ~ Contrasting effects of different cannabinoid receptor ligands on mouse ingestive behavior.

2012 - Study ~ Long-term use of HU210 adversely affects spermatogenesis in rats by modulating the endocannabinoid system.

2012 - Study ~ Simultaneous analysis of several synthetic cannabinoids, THC, CBD and CBN, in hair by ultra-high performance liquid chromatography tandem mass spectrometry. Method validation and application to real samples.

2012 - Study ~ The spice in France: mixed herbs containing synthetic cannabinoids.

2012 - Study ~ Analgesic effects of cannabinoids on central pain syndrome

2011 - Study ~ The potential for clinical use of cannabinoids in treatment of cardiovascular diseases.

2011 - Study ~ Beyond THC: The New Generation of Cannabinoid Designer Drugs.

2011 - Study ~ Investigating a not-so-natural high.

2011 - Study ~ Pharmacological activation/inhibition of the cannabinoid system affects alcohol withdrawal-induced neuronal hypersensitivity to excitotoxic insults.

2011 - Study ~ Regulation of nausea and vomiting by cannabinoids.

2011 - Study ~ Cannabinoid Receptor Type 1 Protects Nigrostriatal Dopaminergic Neurons against MPTP Neurotoxicity by Inhibiting Microglial Activation

2011 - Study ~ The effects of cannabinoid drugs on abnormal involuntary movements in dyskinetic and non-dyskinetic 6-hydroxydopamine lesioned rats.

2011 - Study ~ Increased brain metabolism after acute administration of the synthetic cannabinoid HU210: A small animal PET imaging study with (18)F-FDG.

2010 - Study ~ Involvement of cannabinoid-1 and cannabinoid-2 receptors in septic ileus.

2010 - Study ~ Antitumorigenic Effects of Cannabinoids beyond Apoptosis

2010 - Study ~ Regulation of nausea and vomiting by cannabinoids

2010 - News ~ Now, There's a Test for That -- Norchem's "Fake Marijuana" Test Reveals Significantly Increased Abuse of Spice/K2

2009 - Study - Spice drugs: cannabinoids as a new designer drugs

2009 - Study ~ Cannabinoid receptor 1 is a potential drug target for treatment of translocation-positive rhabdomyosarcoma

2008 - Study ~ Repeated Cannabinoid Injections into the Rat Periaqueductal Gray Enhances Subsequent Morphine Antinociception

2007 - Study ~ Cannabinoids Induce Glioma Stem-like Cell Differentiation and Inhibit Gliomagenesis

2007 - Study ~ The synthetic cannabinoid HU210 induces spatial memory deficits and suppresses hippocampal firing rate in rats

2007 - Study ~ The synthetic cannabinoids attenuate allodynia and hyperalgesia in a rat model of trigeminal neuropathic pain.

2007 - Study ~ Excitotoxicity in a chronic model of multiple sclerosis: Neuroprotective effects of cannabinoids through CB1 and CB2 receptor activation.

2007 - Study - The synthetic cannabinoid HU-210 attenuates neural damage in diabetic mice and hyperglycemic pheochromocytoma PC12 cells

2007 - Study - Cannabinoids Ameliorate Pain and Reduce Disease Pathology in Cerulein-Induced Acute Pancreatitis

2007 - Study ~ Arthritis and cannabinoids: HU-210 and Win-55,212-2 prevent IL-1alpha-induced matrix degradation in bovine articular chondrocytes in-vitro.

2006 - Study ~ Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models

2005 - Study - Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects

2005 - Study ~ Direct cerebrovascular effects of CB1 receptor activation by the synthetic endocannabinoid HU-210 in vivo

2005 - Study ~ Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson's disease.

2005 - News - Marijuana May Spur New Brain Cells

2005 - News - Study Shows Marijuana Promotes Neuron Growth

2005 - News ~ Is cannabis good for your brain?

2005 - News ~ Surprising Brain Effects From Pot-Like Drug

2005 - News ~ Marijuana might cause new cell growth in the brain

2004 - Study ~ The endogenous cannabinoid system protects against colonic inflammation

2004 - News ~ Cannabinoids spell relief in colon inflammation

2003 - Study ~ Inhibition of tumor angiogenesis by cannabinoids

2003 - Study ~ CB1 cannabinoid receptor antagonism promotes remodeling and cannabinoid treatment prevents endothelial dysfunction and hypotension in rats with myocardial infarction

2003 - Study ~ Drug-induced hypothermia reduces ischemic damage: effects of the cannabinoid HU-210.

2002 - Study ~ Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease

2002 - Study ~ Influence of the CB1 receptor antagonist, AM 251, on the regional haemodynamic effects of WIN-55212-2 or HU 210 in conscious rats

2002 - Study ~ Activation of cannabinoid receptors decreases the area of ischemic myocardial necrosis.

2002 - Study ~ Increase of the heart arrhythmogenic resistance and decrease of the myocardial necrosis zone during activation of cannabinoid receptors

2002 - Study ~ The cannabinoids R(-)-7-hydroxy-delta-6-tetra-hydrocannabinol-dimethylheptyl (HU-210), 2-O-arachidonoylglycerylether (HU-310) and arachidonyl-2-chloroethylamide (ACEA) increase isoflurane provoked sleep duration by activation of cannabinoids 1 (CB1)-receptors in mice.

2000 - Study ~ Suppression of Nerve Growth Factor Trk Receptors and Prolactin Receptors by Endocannabinoids Leads to Inhibition of Human Breast and Prostate Cancer Cell Proliferation
2000 - Study ~ Effects of cannabinoid receptor agonists on neuronally-evoked contractions of urinary bladder tissues isolated from rat, mouse, pig, dog, monkey and human.

2000 - Study ~ Involvement of central and peripheral cannabinoid receptors in the regulation of heart resistance to arrhythmogenic effects of epinephrine.
2000 - Study ~ Histamine induced responses are attenuated by a cannabinoid receptor agonist in human skin.

2000 - Study ~ Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon

2000 - Study ~ Inhibitory effects of the cannabinoid agonist HU 210 on rat sexual behaviour.

1999 - Study ~ Learning impairment produced in rats by the cannabinoid agonist HU 210 in a water-maze task.