Cannabis Research A-Z

Heart disease describes a range of conditions that affect your heart. Diseases under the heart disease umbrella include blood vessel diseases, such as coronary artery disease; heart rhythm problems (arrhythmias); and heart defects you're born with (congenital heart defects), among others.

The term "heart disease" is often used interchangeably with the term "cardiovascular disease."

 Cardiovascular disease generally refers to conditions that involve narrowed or blocked blood vessels that can lead to a heart attack, chest pain (angina) or stroke. Other heart conditions, such as those that affect your heart's muscle, valves or rhythm, also are considered forms of heart disease.

Many forms of heart disease can be prevented or treated with healthy lifestyle choices.

Related science
ENDOCANNABINOIDS 

ENDOCANNABINOID SYSTEM (ECS) (Video

2018 - Full ~ Caloric restriction lowers endocannabinoid tonus and improves cardiac function in type 2 diabetes.

Nutrition & Diabetes.

2018 - Full ~ Retrospective Chart Review of Synthetic Cannabinoid Intoxication with Toxicologic
Analysis.
Western Journal of Emergency Medicine.

2018 - Full ~ Ischaemic cardiomyopathy and embolic stroke in a young adult with suspected synthetic cannabinoid use.

BMJ Journals.

2018 - Full ~ Cannabinoids in arterial, pulmonary and portal hypertension – mechanisms of action and potential therapeutic significance.

British Journal of Pharmacology.

2018 - Full ~ A Systematic Review of the Complex Effects of Cannabinoids on Cerebral and
Peripheral Circulation in Animal Models.

Frontiers in Physiology.

2018 - Full ~ Pediatric Death Due to Myocarditis After Exposure to Cannabis.

Clinical Practice and Cases in Emergency Medicine.

2018 - Full ~ Cannabinoids, the Heart of the Matter.

Journal of the American Heart Association.

2012 - Study ~ Cannabinoids and atherosclerotic coronary heart disease.

2012 - Study ~ Cannabinoid 1 (CB1) receptor mediates WIN55, 212-2 induced hypothermia and improved survival in a rat post-cardiac arrest model.

2012 - Study ~ G1359A polymorphism in the cannabinoid receptor-1 gene is associated with the presence of coronary artery disease in patients with type 2 diabetes.

2012 - Study ~ Angiotensin II induces vascular endocannabinoid release, which attenuates its vasoconstrictor effect via CB1 cannabinoid receptors.

2012 - Study ~ Vascular metabolism of anandamide to arachidonic acid affects myogenic constriction in response to intraluminal pressure elevation.

2012 - Study ~ Subjective, cognitive and cardiovascular dose-effect profile of nabilone and dronabinol in marijuana smokers.

2012 - Study ~ Cannabinoid receptor CB2 protects against balloon-induced neointima formation.

2012 - Study ~ Targeting cannabinoid receptor CB(2 ) in cardiovascular disorders: promises and controversies.

2012 - Study ~ Vascular metabolism of anandamide to arachidonic acid affects myogenic constriction in response to intraluminal pressure elevation.

2011 - Study ~ The potential for clinical use of cannabinoids in treatment of cardiovascular diseases.

2011 - Study ~ Endocannabinoid system in cardiovascular disorders - new pharmacotherapeutic opportunities.

2011 - Study ~ Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion.

2011 - Study ~ Cannabidiol as an anti-arrhythmic, the role of the CB1 receptors.

2011 - Study ~ Distinctive effects of plant protein sources on renal disease progression and associated cardiac hypertrophy in experimental kidney disease.

2011 - Study ~ Deficiency of type 1 cannabinoid receptors worsens acute heart failure induced by pressure overload in mice.

2011 - Study ~ G1359A polymorphism in the cannabinoid receptor-1 gene is associated with coronary artery disease in the Chinese Han population.

2011 - Study ~ The effects of hempseed meal intake and linoleic acid on Drosophila models of neurodegenerative diseases and hypercholesterolemia.

2011 - Study ~ Win 55,212-2 reduces cardiac ischaemia-reperfusion injury in zucker diabetic fatty rats: role of cb2 receptors and cardiac inos/enos expression.

2011 - Study ~ Cannabinoid-2 Receptor Activation Protects against Infarct and Ischemia/Reperfusion Heart Injury.

2011 - Study ~ Endocannabinoids and the cardiovascular response to stress.

2011 - Study ~ Cardiotoxicity associated with the synthetic cannabinoid, K9, with laboratory confirmation.

2011 - Study ~ Effects of intracisternal administration of cannabidiol on the cardiovascular and behavioral responses to acute restraint stress.

2011 - Study ~ The effect of dietary hempseed on atherogenesis and contractile function in aortae from hypercholesterolemic rabbits.

2011 - Study ~ Targeting the Endocannabinod System to Limit Myocardial and Cerebral Ischemic and Reperfusion Injury.

2011 - Study ~ Cannabidiol (CBD) as an Anti-Arrhythmic.

2011 - Study ~ Endocannabinoid type 1 receptor gene (CNR1) polymorphisms (rs806381, rs10485170, rs6454674, rs2023239) and cardiovascular risk factors in postmenopausal women.

2010 - Study ~ Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion.

2010 - Study ~ The cardiac and haemostatic effects of dietary hempseed.

2010 - Study ~ Endogenous cannabinoid signaling is essential for stress adaptation.

2010 - Study ~ Pharmacologically induced hypothermia with cannabinoid receptor agonist WIN55, 212-2 after cardiopulmonary resuscitation.

2010 - Study ~ Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion.

2010 - Study ~ Substantially altered expression pattern of cannabinoid receptor 2 and activated endocannabinoid system in patients with severe heart failure.

2010 - Study ~ Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery.

2010 - Patent ~ US Patent Application 20100158973 - THERAPEUTIC USES OF CANNABIDIOL COMPOUNDS.

2009 - Study - Cannabinoids and atherosclerosis.

2009 - Study ~ Endocannabinoids and cardiac contractile function: pathophysiological implications.

2009 - Study ~ Endocannabinoids and cannabinoid analogues block cardiac hKv1.5 channels in a cannabinoid receptor-independent manner.

2009 - Study ~ Endocannabinoids and the Heart.

2009 - Study ~ The emerging role of the endocannabinoid system in cardiovascular disease.

2009 - Study ~ Endocannabinoid signalling as an anti-inflammatory therapeutic target in atherosclerosis: does it work?

2009 - Study ~ CB1 and CB2 cannabinoid receptors differentially regulate the production of reactive oxygen species by macrophages.

2009 - Study ~ Time-dependent vascular actions of cannabidiol in the rat aorta.

2009 - Study ~ Cannabidiol Attenuates Myocardial Dysfunction, Fibrosis, Inflammation, Cell Death and Interrelated Signaling Pathways Associated With Diabetic Cardiomyopathy.

2009 - Study ~ Endocannabinoids and cardiovascular prevention: real progress?

2008 - Study - Function of cannabinoids in heart failure.

2008 - Study ~ The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin.

2008 - Study ~ Cannabinoid receptors in acute and chronic complications of atherosclerosis.

2008 - Study ~ Endocannabinoids and Liver Disease. V. Endocannabinoids as mediators of vascular and cardiac abnormalities in cirrhosis.

2008 - Study ~ CB1 Cannabinoid Receptor Inhibition: Promising Approach for Heart Failure?

2008 - Study ~ 'Entourage' effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors.

2008 - Study ~ Modulation of the Endocannabinoid System in Cardiovascular Disease.

2008 - Study ~ Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats.

2008 - Study ~ Endocannabinoids and cannabinoid receptors in ischaemia–reperfusion injury and preconditioning.

2008 - Study ~ Virodhamine relaxes the human pulmonary artery through the endothelial cannabinoid receptor and indirectly through a COX product.

2008 - Study ~ Endocannabinoids, blood pressure and the human heart.

2008 - Study ~ Function of cannabinoids in heart failure.

2008 - Study ~ The endocannabinoid system: an osteopathic perspective.

2008 - Study ~ Dexanabinol prevents development of vasospasm in the rat femoral artery model.

2007 - Study - Cannabinoids and cardiovascular disease.

2007 - Study - Cannabinoids as therapeutic agents in cardiovascular disease.

2007 - Study - The in vitro and in vivo cardiovascular effects of {Delta}9-tetrahydrocannabinol.

2007 - Study - Cannabidiol protects against myocardial ischemic reperfusion injury.

2007 - Study - Cannabinoids as therapeutic agents in cardiovascular disease: a tale of passions and illusions.

2007 - Study ~ Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta.

2007 - Study ~ The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effects.

2007 - Study ~ Endocannabinoids acting at CB1 receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic rats.

2007 - Study ~ Endocannabinoids and the haematological system.

2007 - Study ~ Cannabinoids and cardiovascular disease: a tale of passions and illusions.

2007 - Study ~ Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase.

2007 - Study ~ GPR55 and the vascular receptors for cannabinoids.

2007 - Study ~ Cannabidiol , a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury.

2007 - Study ~ Cardiovascular effects of cannabinoids in conscious spontaneously hypertensive rats.

2007 - Study ~ Effect of dietary hempseed intake on cardiac ischemia-reperfusion injury.

2006 - Study ~ Illicit Drug Use in Young Adults and Subsequent Decline in General Health: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.

2006 - Study ~ Signaling pathways involved in the cardioprotective effects of cannabinoids.

2006 - Study - The endogenous cardiac cannabinoid system: a new protective mechanism.

2006 - Study - Delta-9-tetrahydrocannabinol protects cardiac cells from hypoxia via CB2 receptor activation and nitric oxide production.

2006 - Study - Does Cannabis Hold the Key to Treating Cardiometabolic Disease?

2006 - Study - Marijuana use, diet, body mass index, and cardiovascular risk factors.

2005 - Study - Cardiovascular pharmacology of cannabinoids.

2005 - Study ~ Anandamide reduces infarct size in rat isolated hearts subjected to ischaemia–reperfusion by a novel cannabinoid mechanism.

2005 - Study ~ Effects of AM281, a cannabinoid antagonist, on systemic haemodynamics, internal carotid artery blood flow and mortality in septic shock in rats.

2005 - Study ~ The cardiovascular actions of anandamide: more targets?

2005 - Study ~ Increased anandamide induced relaxation in mesenteric arteries of cirrhotic rats: role of cannabinoid and vanilloid receptors.

2005 - Study ~ Cardiac and vascular effects of cannabinoids: toward a therapeutic use?

2005 - Study ~ CARDIOVASCULAR Effects of AM281, a cannabinoid antagonist, on systemic haemodynamics, internal carotid artery blood flow and mortality in septic shock in rats.

2005 - Study ~ Influence of Anandamide, the Endogenous Agonist of Cannabinoid Receptors on the Circulatory System.

2004 - Study ~ Endocannabinoids Acting at Cannabinoid-1 Receptors Regulate Cardiovascular Function in Hypertension.

2004 - Study ~ Vasorelaxant activities of the putative endocannabinoid virodhamine in rat isolated small mesenteric artery.

2003 - Study ~ Endocannabinoids protect the rat isolated heart against ischaemia.

2003 - Study ~ Vasodilator actions of abnormal-cannabidiol in rat isolated small mesenteric artery.

2003 - Study ~ CB1 cannabinoid receptor antagonism promotes remodeling and cannabinoid treatment prevents endothelial dysfunction and hypotension in rats with myocardial infarction.

2003 - Study ~ Cannabinoid CB2 receptor activation reduces mouse myocardial ischemia-reperfusion injury: involvement of cytokine/chemokines and PMN.

2003 - Study ~ A new endothelial target for cannabinoids.

2003 - Study ~ Endocannabinoids as mediators in the heart: a potential target for therapy of remodelling after myocardial infarction?

2002 - Study ~ Influence of the CB1 receptor antagonist, AM 251, on the regional haemodynamic effects of WIN-55212-2 or HU 210 in conscious rats.

2002 - Study ~ Endocannabinoids are implicated in the infarct size-reducing effect conferred by heat stress preconditioning in isolated rat hearts.

2002 - Study ~ Estrogen stimulates arachidonoylethanolamide release from human endothelial cells and platelet activation.

2002 - Study ~ Activation of cannabinoid receptors decreases the area of ischemic myocardial necrosis.

2002 - Study ~ Anandamide and R-(+)-methanandamide prevent development of ischemic and reperfusion arrhythmia in rats by stimulation of CB2-receptors.

2002 - Study ~ Increase of the heart arrhythmogenic resistance and decrease of the myocardial necrosis zone during activation of cannabinoid receptors.

2002 - Study ~ Endogenous cannabinoids improve myocardial resistance to arrhythmogenic effects of coronary occlusion and reperfusion: a possible mechanism.

2001 - Study ~ Endogenous cannabinoids mediate hypotension after experimental myocardial infarction.

2001 - Study ~ Mechanisms of anandamide-induced vasorelaxation in rat isolated coronary arteries.

2001 - Study ~ Endocannabinoids are implicated in the infarct size-reducing effect conferred by heat stress preconditioning in isolated rat hearts.

2000 - Study ~ Cardiovascular effects of endocannabinoids--the plot thickens.

2000 - Study ~ Involvement of central and peripheral cannabinoid receptors in the regulation of heart resistance to arrhythmogenic effects of epinephrine.

2000 - Study ~ Cardiovascular effects of endocannabinoids--the plot thickens.

2000 - Study ~ Involvement of central and peripheral cannabinoid receptors in the regulation of heart resistance to arrhythmogenic effects of epinephrine.

1997 - Study ~ Cannabinoid-Induced Hypotension and Bradycardia in Rats Is Mediated by CB1-Like Cannabinoid Receptors.

1995 - Study ~ Development of HU-211 as a neuroprotectant for ischemic brain damage.

1995 - Study ~ Novel antagonist implicates the CB1 cannabinoid receptor in the hypotensive action of anandamide.

1992 - Study - Changes in middle cerebral artery velocity after marijuana.

1989 - Study ~ The inhibitory effects of cannabinoids, the active constituents of Cannabis sativa L. on human and rabbit platelet aggregation.

1986 - Study ~ Effects of acute marijuana smoking in post-menopausal women.

1981 - Study ~ The cardiovascular and autonomic effects of repeated administration of delta-9-tetrahydrocannabinol to rhesus monkeys.

1980 - Study ~ Cannabinoids. II. Cardiovascular Effects.

1977 - Study ~ Propranolol Effects on Acute Marihuana Intoxication in Man.

1977 - Study ~ Short-term effects of smoked marihuana on left ventricular function in man.

1976 - Study ~ The Effects of Delta-9-Tetrahydrocannabinol (Cannabis) on Cardiac Performance with and without Beta Blockade.

1975 - Study ~ Intravenous delta9-Tetrahydrocannabinol: Effects of ventilatory control and cardiovascular dynamics.

1973 - Letter ~ Effects of cannabis roots on the heart

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