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Fever and Cannabis Research Medical Journal Articles


Fever (also known as pyrexia) is one of the most common medical signs and is characterized by an elevation of body temperature above the normal range of 36.5-37.5 C (98-100 F) due to an increase in the temperature regulatory set-point.

2017 - Study ~ Thermolytic degradation of synthetic cannabinoids: chemical exposures and pharmacological consequences.

Journal of Pharmacology and Experimental Therapeutics.

2016 - Study ~ Short-term effects of cannabidiol after global hypoxia-ischemia in newborn piglets. Pediatric Research.

2016 - Study ~ Pharmacological hypothermia: a potential for future stroke therapy?

Journal of Progress in Neurosurgery, Neurology and Neurosciences.

2016 - Study ~ Endocannabinoids, through opioids and prostaglandins, contribute to fever induced by key pyrogenic mediators.

Brain, Behavior, and Immunity.

2016 - Study ~ Effect of JWH-250, JWH-073 and their interaction on "tetrad", sensorimotor, neurological and neurochemical responses in mice.

Progress in Neuro-Psychopharmacology and Biological Psychiatry.

2016 - Study ~ Behavioral Characterization of Kappa Opioid Receptor Agonist Spiradoline and Cannabinoid Receptor Agonist CP55940 Mixtures in Rats.
Journal of Pharmacology and Experimental Therapeutics.

2016 - Study ~ α/β-Hydrolase Domain 6 in the Ventromedial Hypothalamus Controls Energy Metabolism Flexibility.

Open Access - Cell Reports.

2016 - Study ~ Acetaminophen Use for Fever in Children Associated with Autism Spectrum Disorder. Department of Physiology, School of Medicine, University of Texas.

2016 - Study ~ Turning Up the Heat on Endocannabinoid Signaling.

American Epilepsy Society.

2016 - Study ~ Effects of Cannabidiol and Hypothermia on Short-Term Brain Damage in New-Born Piglets after  Acute Hypoxia-Ischemia.

Frontiers in Neuroscience.

2016 - Study ~ Hypothermic activity of acetaminophen; involvement of GABAA receptor, theoretical and experimental studies.

Iranian Journal of Basic Medical Sciences.

2016 - Study ~ A Curious Case of Inhalation Fever Caused by Synthetic Cannabinoid.

American Journal of Case Reports.

2016 - Study ~ Prostaglandin E2 that triggers fever is synthesized through an endocannabinoid dependent pathway.

Taylor & Francis.

2016 - Study ~ Case Series of Synthetic Cannabinoid Intoxication from One Toxicology Center. Department of Emergency Medicine, Allentown, Pennsylvania.

2016 - Study ~ Transient increase of interleukin-1β after prolonged febrile seizures promotes adult epileptogenesis through long-lasting upregulating endocannabinoid signaling.
Scientific Reports.

Pharmacological Research.

American Journal of Respiratory and Critical Care Medicine.

Brain, Behavior, and Immunity.

Pharmacology Biochemistry and Behavior.

Journal of Neuroimmune Pharmacology.

American Journal of Emergency Medicine.

PLOS Biology.

British Journal of Pharmacology.

2013 - Study ~ Dissociation of the pharmacological effects of THC by mTOR blockade. Neuropsychopharmacology.

2013 - Study ~ Behavioral responses to acute and sub-chronic administration of the synthetic cannabinoid JWH-018 in adult mice prenatally exposed to corticosterone.

Neurotoxicity Research.

2013 - Study ~ Tolerance and cross-tolerance among high-efficacy synthetic cannabinoids JWH-018 and JWH-073 and low-efficacy phytocannabinoid Δ9-THC.

Journal of the Federation of American Societies for Experimental Biology. (FASEB)

2013 - Study ~ Cannabinoid 1 receptors are critical for the innate immune response to TLR4 stimulation. American Physiological Society.

2013 - Study ~ Improved cardiac and neurologic outcomes with postresuscitation infusion of cannabinoid receptor agonist WIN55, 212-2 depend on hypothermia in a rat model of cardiac arrest. Critical Care Medicine.

2012 - Study ~ Contribution of hypothermia and CB1 receptor activation to protective effects of TAK-937, a cannabinoid receptor agonist, in rat transient MCAO model.


2012 - Study ~ Cannabinoid 1 (CB1) receptor mediates WIN55, 212-2 induced hypothermia and improved survival in a rat post-cardiac arrest model.

Journal of the European Resuscitation Council.

2012 - Study ~ Δ(9)-Tetrahydrocannabinol acts as a partial agonist/antagonist in mice.

Behavioral Pharmacology.

2012 - Study ~ Determination of naphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-018) in mouse blood and tissue after inhalation exposure to ‘buzz’ smoke by HPLC/MS/MS.

National Institute of Health, Biomed Chromatography.

2010 - Study ~ Pharmacologically induced hypothermia with cannabinoid receptor agonist WIN55, 212-2 after cardiopulmonary resuscitation.

Critical Care Medicine.

2009 - Study ~ Endogenous cannabinoids induce fever through the activation of CB1 receptors.

British Journal of Pharmacology.

2008 - Study ~ Behavioral and temperature effects of delta 9-tetrahydrocannabinol in human-relevant doses in rats.

National Institute of Health, Brain Research.

2007 - Study ~ Effects of a Selective Cannabinoid Agonist and Antagonist on Body Temperature

in Rats.

Journal of the Federation of American Societies for Experimental Biology. (FASEB)


2007 - Study ~ A Novel Role of Cannabinoids: Implication in the Fever Induced by Bacterial Lipopolysaccharide.

Journal of Pharmacology and Experimental Therapeutics.

American Stroke Association.

2002 - Study ~ CB1 Receptors in the Preoptic Anterior Hypothalamus Regulate WIN 55212-2 [(4,5-Dihydro-2-methyl-4(4-morpholinylmethyl)-1-(1-naphthalenyl-carbonyl)-6H-pyrrolo[3,2,1ij]quinolin-6-one]-Induced Hypothermia.

Journal of Pharmacology and Experimental Therapeutics.

Journal of Toxicology. Clinical Toxicology.


1982- Study ~ Changes in body temperature and oxygen consumption rate of conscious mice produced by intrahypothalamic and intracerebroventricular injections of delta 9-tetrahydrocannabinol.

Department of Pharmacology, University of Aberdeen.

1978 - Study ~ The effects of cannabinoids on body temperature and brain catecholamine synthesis. Research Communications in Chemical Pathology and Pharmacology.

1977 - Study ~ Effects of delta9-tetrahydrocannabinol on the rates of oxygen consumption of mice. Department of Pharmacology, University Medical Buildings, Foresterhill, Aberdeen.

Federation Proceedings.

Aviation, Space, and Enviromental Medicine.

1975 - Study ~ Absence of interaction between delta9-tetrahydrocannabinol (delta-THC) and cannabidiol (CBD) in aggression, muscle control and body temperature experiments in mice.


1973 - Study ~ The effects of (-)-Δ9-tetrahydrocannabinol on reserpine-induced hypothermia in rats. British Journal of Pharmacology.

1973 - Study ~ Evaluation valuation of the hypothermic action of tetrahydrocannabinoids in a squiiel monkeys.

Journal of Pharmacology and Experimental Therapeutics.

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