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FERTILITY & Cannabis studies completed


Did you know there is actually a cannabis strain named Sex Bud?

Fertility is the natural capability to produce offspring. As a measure, fertility rate is the number of offspring born per mating pair, individual or population. Fertility differs from fecundity, which is defined as the potential for reproduction (influenced by gamete production, fertilization and carrying a pregnancy to term). A lack of fertility is infertility while a lack of fecundity would be called sterility.

Human fertility depends on factors of nutrition, sexual behavior, consanguinity, culture, instinct, endocrinology, timing, economics, way of life, and emotions. source wikipedia

Cannabis Science & Fertility Research

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2012 - Study ~ Long-term use of HU210 adversely affects spermatogenesis in rats by modulating the endocannabinoid system

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2011 - Study ~ Effect of capacitation on the endocannabinoid system of mouse sperm.

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2010 - Study ~ Cannabinoids and Reproduction: A Lasting and Intriguing History.

2010 - Study ~ Localization and function of cannabinoid receptors in the corpus cavernosum: basis for modulation of nitric oxide synthase nerve activity.

2009 - Study ~ Localisation and Function of the Endocannabinoid System in the Human Ovary.

2009 - Study ~ The endocannabinoid system in bull sperm and bovine oviductal epithelium: role of anandamide in sperm-oviduct interaction.

2009 - Study ~ The endocannabinoid 2-arachidonoylglycerol promotes sperm developement through activation of cannabinoid-2 receptors.

2009 - Study ~ The endocannabinoid system: an ancient signaling involved in the control of male fertility.

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2006 - Study ~ Stage-variations of anandamide hydrolase activity in the mouse uterus during the natural oestrus cycle.

2006 - Study ~ Jekyll and Hyde: Two Faces of Cannabinoid Signaling in Male and Female Fertility.

2006 - News ~ Acomplia may be dangerous for women of reproductive age.

2006 - News ~ Marijuana Improves Fertility in Tobacco Smokers.

2006 - News ~ Cannabis-based boost for smokers' suffering sperm.

2006 - News - Synthetic Cannabinoid May Aid Fertility In Smokers.

2004 - Study ~ Plasma Levels of the Endocannabinoid Anandamide in Women—A Potential Role in Pregnancy Maintenance and Labor?

2002 - Study ~ Contrasting effects of WIN 55212-2 on motility of the rat bladder and uterus.

2002 - Study ~ Endocannabinoids, hormone-cytokine networks and human fertility.

2001 - Study ~ Dysregulated Cannabinoid Signaling Disrupts Uterine Receptivity for Embryo Implantation.

2001 - Study ~ Cannabis-induced Koro in Americans.

2000 - Study ~ Inhibitory effects of the cannabinoid agonist HU 210 on rat sexual behaviour.

1991 - Study ~ Molecular cloning of a human cannabinoid receptor which is also expressed in testis.

1986 - Study ~ Acute effects of smoking marijuana on hormones, subjective effects and performance in male human subjects.

1986 - Study ~ Tolerance to the luteinizing hormone and prolactin suppressive effects of delta-9-tetrahydrocannabinol develops during chronic prepubertal treatment of female rats.

1984 - Study ~ Endocrine effects of marijuana in the male: preclinical studies.

1979 - Study ~  An attitude survey of the effects of marijuana on sexual enjoyment.

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Synthetic Cannabinoid May Aid Fertility In Smokers

From University at Buffalo

Article Date: 05 Dec 2006 - 15:00 PDT

 A reproductive medicine specialist at the University at Buffalo has shown that a new compound may improve the fertility of tobacco smokers who have low sperm count and low percentage sperm motility.

The sperm from male smokers were washed with a synthetic chemical called AM-1346. After incubation, there was a doubling in the fertilizing capacity of sperm from poor quality semen, results showed.

Lani Burkman, Ph.D., and colleagues presented the findings at the 2006 meeting of the American Society of Reproductive Medicine held recently in New Orleans. "Based on our previous data and published literature, it is clear that most tobacco smokers will exhibit a small or a significant decline in fertility," she stated. "Nicotine addiction is quite powerful. The best solution is to stop smoking and then wean yourself off of all nicotine products. But for smokers who can't quit, the in vitro use of AM-1346 may significantly improve their fertilizing capacity."

Burkman, associate professor in the departments of gynecology/obstetrics and urology and head of the Section on Andrology in the UB School of Medicine and Biomedical Sciences, previously demonstrated that sperm functions critical for fertilization are altered by nicotine exposure, whether in vitro, or through long-term tobacco use. Two-thirds of the male smokers studied had decreased fertility; some showed a serious loss.

The new study involved nine selected smokers (22 experiments) who had been evaluated previously for sperm fertilizing potential using the outside cover of a human egg, called the zona pellucida. Four men had a high number of sperm attaching to the zona (normal, Group I), while five other smokers had sperm with poor egg binding (poor fertilizing potential, Group II).

The new experiments were designed to evaluate whether sperm with poor fertilizing capacity from smokers could be treated so that egg binding was improved. Specifically, the researchers studied a potential interaction between two chemical systems that control sperm.

"Human sperm carry the cholinergic receptor, which responds to the neurotransmitter acetylcholine," noted Burkman. "Nicotine mimics acetylcholine and binds to the cholinergic receptor." In earlier research, Burkman and colleagues also showed that human sperm contain cannabinoid receptors, which respond to marijuana, as well as natural cannabinoids occurring in the body.

"Research from other scientists indicates that the cholinergic system and the cannabinoid system naturally regulate human sperm and help prepare them for fertilizing an egg," she said. "Our research suggests that this natural regulation is out of balance for the majority of smokers when sperm are continuously exposed to nicotine.

"We think there is an important communication between the cannabinoid and cholinergic receptor systems in human sperm," said Burkman. "No one has shown this interaction before when looking at human tissue. AM-1346, the drug that we tested, is a synthetic version of a natural cannabinoid found in the body.

"In 22 Hemizona tests, we showed that the response to AM-1346 depended on the initial fertility of the tobacco smoker, and if his semen showed poor quality, meaning low sperm count and low percentage motility."

The sperm from Group II volunteers were incubated with AM-1346 for several hours and then retested in the Hemizona Assay. Six experiments in Group II started with semen of low quality and all six resulted in stimulation of sperm binding to the zona ranging from 133 percent to 330 percent, with a mean of 201 percent, when compared to their own untreated sperm, results showed.

"In contrast," said Burkman, "samples from Group I (normal fertility, normal semen quality) reacted in the opposite manner. This two-way, or biphasic, response is common for cannabinoid action. With Group I, the drug AM-1346 caused a substantial decrease in sperm binding to the zona for eight out of nine samples.

"This opposite response must be studied further," Burkman said. "It might be tied to early-versus-late steps in fertilization, where it is expected that one process is slowed down while another process is stimulated.

"It does appear that sperm functioning in tobacco smokers with low fertility and low semen quality is quite different when compared to smokers with higher fertility and good semen quality. Nicotine appears to change the sperm membranes and sperm receptors. It also raises the question of why sperm from some smokers are protected from the effects of tobacco and nicotine."

Article adapted by Medical News Today from original press release.

Roxanne Mroz and MaryLou Bodziak, UB research associates, contributed to this work, along with UB undergraduate students Stuti Tambar and Brian Telesz. Alexandros Makriyannis, Ph.D., from Northeastern University, created AM-1346.

The University at Buffalo is a premier research-intensive public university, the largest and most comprehensive campus in the State University of New York. The School of Medicine and Biomedical Sciences is one of five schools that constitute UB's Academic Health Center.

Contact: Lois J Baker

Senior Health Sciences Editor

University Communications
330 Crofts Hall 
(716) 645-4606
(716) 645-3765

University at Buffalo


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