CRA-Z 

2017 - Study ~ Social factors in marijuana use for medical and recreational purposes.

Epilepsy and Behavior.

2017 - Study ~ Neuroimaging studies towards understanding the central effects of pharmacological cannabis products on patients with epilepsy.

Epilepsy and Behavior.

2017 - Study ~ Historical perspective on the medical use of cannabis for epilepsy: Ancient times to the 1980s.
Epilepsy and Behavior.

2017 - Study ~ Synaptic Reorganization of the Perisomatic Inhibitory Network in Hippocampi of
Temporal Lobe Epileptic Patients.

BioMed Research International.

2016 - Study ~ The Pharmacological Basis of Cannabis Therapy for Epilepsy: Using Medical Marijuana to Stop Childhood Seizures.
Pharmacology and Experimental Therapeutics.

2016 - Study ~ Cannabis and epilepsy: An ancient treatment returns to the fore.

Epilepsy and Behavior.

2016 - Study ~ Endogenous cannabinoid system alterations and their role in epileptogenesis after brain injury in rat.

Epilepsy Research.

2016 - Study ~ Pharmacokinetic-pharmacodynamic influence of N-palmitoylethanolamine, arachidonyl-2′-chloroethylamide and WIN 55,212-2 on the anticonvulsant activity of antiepileptic
drugs against audiogenic seizures in DBA/2 mice.
European Journal of Pharmacology.

2016 - Study ~ Effects of Marijuana on ictal and interictal EEG activity in idiopathic generalized
epilepsy.

Journal of Clinical Neurophysiology: Official Publication of The American Electroencephalographic Society.

2016 - Study ~ From cannabis to cannabidiol to treat epilepsy, where are we?

Current Pharmaceutical Design.

2016 - Study ~ Marijuana use in adults admitted to a Canadian epilepsy monitoring unit.
Epilepsy and Behavior.

2016 - Study ~ The cannabinoid receptor agonist WIN55.212 reduces consequences of status epilepticus in rats.

2016 - Study ~ Acute Toxicity Associated with Use of 5F-Derivations of Synthetic Cannabinoid
Receptor Agonists with Analytical Confirmation.
Journal of Medical Toxicology.

2016 - Study ~ Current Status and Prospects for Cannabidiol Preparations as New Therapeutic Agents.

Pharmacotherapy.

2016 - Study ~ Aberrant epilepsy-associated mutant Nav1.6 sodium channel activity can be targeted with cannabidiol.

Oxford Academic: BRAIN, A Journal of Neurology.

2016 - Study ~ CB1 Receptor Antagonism Prevents Long-Term Hyperexcitability after Head Injury by
of Dynorphin-KOR System and mGluR5 in Rat Hippocampus.

2016 - Study ~ Cannabidiol and epilepsy: rationale and therapeutic potential.

2016 - Study ~ Involvement of TRPV1 channels in the activity of the cannabinoid WIN 55,212-2 in an
acute rat model of temporal lobe epilepsy.

2016 - Study ~ Anticonvulsant activity of β-caryophyllene against pentylenetetrazol-induced seizures.
Epilepsy & Behavior.

2016 - Study ~ Dentate cannabinoid-sensitive interneurons undergo unique and selective strengthening of mutual synaptic inhibition in experimental epilepsy.

2016 - Study ~ Effect of JWH-250, JWH-073 and their interaction on "tetrad", sensorimotor,
neurological and neurochemical responses in mice.

2016 - Study ~ Adverse effects after the use of JWH-210 - a case series from the EU Spice II plus
project.

Drug Testing & Analysis.

2016 - Study ~ Cannabidiol Post-Treatment Alleviates Rat Epileptic-Related Behaviors and Activates
Hippocampal Cell Autophagy Pathway Along with Antioxidant Defense in Chronic Phase
of Pilocarpine-Induced Seizure.
Journal of Molecular Neuroscience.

2016 - Study ~ Cannabis and Cannabinoids.
From The Medical Letter on Drugs and Therapeutics.

2016 - Study ~ Investigational new drugs for focal epilepsy.

2016 - Study ~ Medical Marijuana for Epilepsy?

Innovations in Clinical Neuroscience.

2016 - Study ~ THC Intoxication by Cannabidiol Enriched Cannabis Extract in Two Children with
Refractory Epilepsy: Full Remission after Switching to Purified Cannabidiol.

Frontiers in Pharmacology.

2016 - Study ~ Turning Up the Heat on Endocannabinoid Signaling.

American Epilepsy Society.

2016 - Study ~ Crucial Roles of the Endocannabinoid 2-Arachidonoylglycerol in the Suppression of
Epileptic Seizures.

Cell Reports.

2016 - Study ~ Endocannabinoid control of glutamate NMDA receptors: the therapeutic potential and consequences of dysfunction.

Department of Molecular, Cellular and Developmental Neurobiology, Laboratory of Neuropharmacology, Madrid, Spain.

2016 - Study ~ Fatty Acid Binding Proteins are Intracellular Carriers for THC and CBD.

Journal of Biological Chemistry.

2016 - Study ~ Is the medical use of cannabis a therapeutic option for children?

Paediatrics and Child Health.

2016 - Study ~ Synthetic cannabinoids revealing adrenoleukodystrophy.

2016 - Study ~ Case Series of Synthetic Cannabinoid Intoxication from One Toxicology Center.

2016 - Study ~ CBD-enriched medical cannabis for intractable pediatric epilepsy: The current Israeli
experience.

Seizure Journal.

2016 - Study ~ ABC transporters P-gp and Bcrp do not limit the brain uptake of the novel antipsychotic and anticonvulsant drug cannabidiol in mice.

PeerJ: Peer Reviewed & Open Access.

2016 - Study ~ Analysis of endocannabinoid signaling elements and related proteins in lymphocytes of patients with Dravet syndrome.

British Pharmacological Society: Pharmacology Research & Perspectives.

2016 - Study ~ Transient increase of interleukin-1β after prolonged febrile seizures promotes adult
epileptogenesis through long-lasting upregulating endocannabinoid signaling.

Nature: Scientific Reports.

2016 - Study ~ The Pharmacological Basis of Cannabis Therapy for Epilepsy.

Journal of Pharmacology and Experimental Therapeutics.

2015 - Study ~ The cannabinoid CB2 receptor-specific agonist AM1241 increases

pentylenetetrazole induced seizure severity in Wistar rats.

2015 - Study ~ Convulsant effects of high efficacy synthetic cannabinoid JWH-018 in mice.

The FASEB Journal.

2015 - Study ~ The effects of adolescent cannabinoid exposure on seizure susceptibility and lethality in adult male rats.

2015 - Study ~ Cannabidiol as potential treatment in refractory pediatric epilepsy.

2015 - Study ~ Polypharmacology Shakes Hands with Complex Aetiopathology.

Trends in Pharmacological Sciences.

2015 - Study ~ Cannabis and Endocannabinoid Signaling in Epilepsy.

Handbook of Experimental Pharmacology.

2015 - Study ~ Palmitoylethanolamide attenuates PTZ-induced seizures through CB1 and CB2 receptors.

2015 - Study ~ Cytochrome P450-mediated metabolism of the synthetic cannabinoids UR-144 and XLR-11.

Drug Testing and Analysis.

2015 - Study ~ Issues and promise in clinical studies of botanicals with anticonvulsant potential.

Department of Neurology, University Medical Center, Jerusalem, Israel.

2015 - Study ~ Marijuana Use in Epilepsy: The Myth and the Reality.
Current Neurology and Neuroscience Reports.

2015 - Study ~ Cannabidiol, a Cannabis sativa constituent, inhibits cocaine-induced seizures in mice: Possible role of the mTOR pathway and reduction in glutamate release.

2015 - Study ~ ACEA (a highly selective cannabinoid CB1 receptor agonist) stimulates hippocampal
neurogenesis in mice treated with antiepileptic drugs.

2015 - Study ~ Changes over time of cannabinoid receptor 1 in hippocampus of status epilepticus rats.

Zhonghua Yi Xue Za Zhi journal.

2015 - Study ~ JWH-018 impairs sensorimotor functions in mice.

2013 - Article ~ Comes Now Epidiolex (FDA approves IND studies of CBD).

Cannabidiols: Potential Use in Epilepsy & Other Neurological Disorders.

2013 - Study ~ Pharmaceuticals Provides Update on Orphan Program in Childhood Epilepsy for
Epidiolex.

GW Pharmaceuticals.

2013 - Study ~ Alterations of endocannabinoids in cerebrospinal fluid of dogs with epileptic seizure disorder.

Gesell et al. BMC Veterinary Research.

2013 - Study ~ Cannabidivarin (CBDV) suppresses pentylenetetrazole (PTZ)-induced increases in epilepsy-related gene expression.

PeerJ.

2013 - Study ~ Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment- resistant epilepsy.

National Institutes of Health: Epilepsy Behavior, Department of Neurology, Stanford University.

2013 - Study ~ Cannabis and other illicit drug use in epilepsy patients.

European Journal of Neurology.

2013 - Study ~ The Role of CB1-Receptors in the Proconvulsant Effect of Leptin on Penicillin-Induced Epileptiform Activity in Rats.

CNS: Neuroscience & Therapeutics.

2013 - Study ~ The role of potassium BK channels in anticonvulsant effect of cannabidiol in
pentylenetetrazole and maximal electroshock models of seizure in mice.

Journal of Epilepsy Behavior.

2013 - Study ~ Cannabinoid 1 receptor as therapeutic target in preventing chronic epilepsy.

FASEB Journal.

2013 - Study ~ The du2J mouse model of ataxia and absence epilepsy has deficient cannabinoid CB1 receptor-mediated signalling.

Journal of Physiology.

2013 - Study ~ The role of α2-adrenoceptors in the anti-convulsant effects of cannabinoids on
pentylenetetrazole-induced seizure threshold in mice.

European Journal of Pharmacology.

2013 - Study ~ CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations.

Epilepsy Research.

2013 - Study ~ The secret "spice": an undetectable toxic cause of seizure.
The Neurohospitalist.

2013 - Study ~ Effects of WIN 55,212-2 mesylate on the anticonvulsant action of lamotrigine,
oxcarbazepine, pregabalin and topiramate against maximal electroshock-induced seizures
in mice.

European Journal of Pharmacology.

2013 - Study ~ Therapeutic potential of cannabinoid medicines.

2013 - Study ~ Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism.

British Journal of Pharmacology.

2012 - Patent Application ~ Use of the phytocannabinoid cannabidivarin (CBDV) in the treatment of epilepsy: Patent Application 20120004251

Fresh Patents.

2012 - Study ~ Inverse relationship of cannabimimetic (R+)WIN 55, 212 on behavior and seizure threshold during the juvenile period.

Pharmacology, Biochemistry, and Behavior.

2012 - Study ~ Equipotent Inhibition of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase - Dual Targets of the Endocannabinoid System to Protect against Seizure Pathology.

Journal of Neurotherapeutics.

2012 - Study ~ Epileptiform activity in the CA1 region of the hippocampus becomes refractory to attenuation by cannabinoids in part because of endogenous γ-aminobutyric acid type B receptor activity.

Journal of Neuroscience Research.

2012 - Study ~ Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?

British Journal of Clinical Pharmacology.

2012 - Study ~ Statistical parametric mapping reveals regional alterations in cannabinoid CB1 receptor distribution and G-protein activation in the 3D reconstructed epileptic rat brain.

Epilepsia.

2012 - Study ~ Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures.

Seizure: European Journal of Epilepsy.

2012 - Study ~ Internet Highs-Seizures After Consumption of Synthetic Cannabinoids Purchased Online.

Journal of Addiction Medicine.

2012 - Study ~ Cannabinoid receptor 1 inhibition causes seizures during anesthesia induction in experimental sepsis.

Journal of Anesthesia & Analgesia.

2012 - Study ~ Effect of ACEA-a selective cannabinoid CB1 receptor agonist on the protective action of different antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model.

2011 - Study ~ Endocannabinoid system protects against cryptogenic seizures.

Pharmacological Reports.

2011 - Study ~ Convulsions Associated with the Use of a Synthetic Cannabinoid Product.

Journal of Medical Toxicology.

2011 - Study ~ Pro-epileptic effects of the cannabinoid receptor antagonist SR141716 in a model of audiogenic epilepsy.

Epilepsy Research.

2011 - Study ~ Synthetic cannabinoid WIN 55,212-2 mesylate enhances the protective action of four classical antiepileptic drugs against maximal electroshock-induced seizures in mice.

2011 - Study ~ Protective effects of CB1 receptor agonist WIN 55.212-2 in seizure activity in the model of temporal lobe epilepsy.

Outbound Medicine.

2011 - Study ~ L-Type Calcium Channel Mediates Anticonvulsant Effect of Cannabinoids in Acute and Chronic Murine Models of Seizure.

Neurochemical Research.

2011 - Study ~ Changes in the cannabinoid (CB1) receptor expression level and G-protein activation in kainic acid induced seizures.
Epilepsy Research.

2011 - Study ~ Marijuana, endocannabinoids, and epilepsy: Potential and challenges for improved therapeutic intervention.

Experimental Neurology, a Journal of Neuroscience Research.

2010 - Study ~ Cannabidiol Displays Antiepileptiform and Antiseizure Properties In Vitro and In Vivo.

The American Society for Pharmacology and Experimental Therapeutics.

2010 - Study ~ Cannabinoid-mediated inhibition of recurrent excitatory circuitry in the dentate gyrus in a mouse model of temporal lobe epilepsy.

PLOS ONE: A Peer-reviewed, Open Access Journal.

2010 - Study ~ AAV vector-mediated overexpression of CB1 cannabinoid receptor in pyramidal neurons of the hippocampus protects against seizure-induced excitoxicity.

Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

2010 - Study ~ Delta 9-Tetrahydrocannabivarin suppresses in vitro epileptiform and in vivo seizure activity in adult rats.

Epilepsia.

2010 - Study ~ Anticonvulsant effects of GWP42006 in vitro and in vivo in rat.

The Physiological Society: Cellular Neurophysiology Abstracts.

2010 - Study ~ Dynamic changes of CB1-receptor expression in hippocampi of epileptic mice and humans.

Epilepsia. Hungarian Academy of Sciences.

2009 - Study ~ The effects of intracerebroventricular AM-251, a CB1-receptor antagonist, and ACEA, a CB1-receptor agonist, on penicillin-induced epileptiform activity in rats.

Epilepsia: Department of Physiology, Faculty of Medicine, University of Ondokuz Mayis, Samsun, Turkey.

2009 - Study ~ Prolonged exposure to WIN55,212-2 causes downregulation of the CB1 receptor and the development of tolerance to its anticonvulsant effects in the hippocampal neuronal culture model of acquired epilepsy.

Neuropharmacology.

2009 - Study ~ The effects of intracerebroventricular AM‐251, a CB1‐receptor antagonist, and ACEA, a CB1‐receptor agonist, on penicillin‐induced epileptiform activity in rats.

Epilepsia: Department of Physiology, Faculty of Medicine, University of Ondokuz Mayis, Samsun, Turkey.

2009 - Study ~ Involvement of nitrergic system in the anticonvulsant effect of the cannabinoid CB1 agonist ACEA in the pentylenetetrazole-induced seizure in mice.

2008 - Study ~ The cannabinoid anticonvulsant effect on pentylenetetrazole-induced seizure is potentiated by ultra-low dose naltrexone in mice.
Epilepsy Research.

2007 - Study ~ Development of pharmacoresistance to benzodiazepines but not cannabinoids in the hippocampal neuronal culture model of status epilepticus.

Commonwealth University, Richmond, Virginia.

2007 - Study ~ Endocannabinoids block status epilepticus in cultured hippocampal neurons.
European Journal of Pharmacology.

2007 - Study ~ Downregulation of the CB1 Cannabinoid Receptor and Related Molecular Elements of the Endocannabinoid System in Epileptic Human Hippocampus.

Neurobiology of Disease: Institute of Experimental Medicine, Hungarian Academy of Sciences.

2007 - Study ~ Ultra-low dose cannabinoid antagonist AM251 enhances cannabinoid anticonvulsant effects in the pentylenetetrazole-induced seizure in mice.

2006 - Study ~ Not Too Excited? Thank Your Endocannabinoids.

Neuron: Open Article.

2006 - Study ~ Forebrain-Specific Inactivation of Gq/G11 Family G Proteins Results in Age-Dependent Epilepsy and Impaired Endocannabinoid Formation.

Molecular and Cellular Biology: University of Heidelberg, Germany.

2006 - Study ~ The Endocannabinoid System Controls Key Epileptogenic Circuits in the Hippocampus.

Neuron: Department of Physiological Chemistry, Johannes Gutenberg University, Germany.

2006 - Study ~ Cannabinoid CB1 receptor antagonists cause status epilepticus-like activity in the hippocampal neuronal culture model of acquired epilepsy.

Neuroscience Letter: Virginia Commonwealth University, Richmond, Virginia.

2006 - Study ~ Activation of the Cannabinoid Type-1 Receptor Mediates the Anticonvulsant Properties of Cannabinoids in the Hippocampal Neuronal Culture Models of Acquired Epilepsy and Status Epilepticus.

Journal of Pharmacology and Experimental Therapeutics.

2006 - Study ~ Cannabinoids In Medicine: A Review Of Their Therapeutic Potential.

Journal of Ethnopharmacology.

2006 - Study ~ Arachidonyl-2′-chloroethylamide, a highly selective cannabinoid CB1 receptor agonist, enhances the anticonvulsant action of valproate in the mouse maximal electroshock-induced seizure model.

2005 - Study ~ Selective antiepileptic effects of N-palmitoylethanolamide, a putative endocannabinoid.

Epilepsia: Department of Anatomy and Cell Biology, College of Medicine, University of Saskatchewan.

2005 - Study ~ Treatment with CBD in oily solution of drug-resistant paediatric epilepsies.
The Netherlands: International Association for Cannabis as Medicine.

2005 - Study ~ Cannabinoids as potential anti-epileptic drugs.

Current Opinion investigational Drugs, London England.

2004 - Study ~ Endocannabinoids and Their Implications for Epilepsy.

American Epilepsy Society:

2004 - Study ~ Cannabinoids: Defending the Epileptic Brain.

Epilepsy Currents: American Epilepsy Society.

2004 - Study ~ Marijuana use and epilepsy - Prevalence in patients of a tertiary care epilepsy center.

Neurology Journal.

2003 - Study ~ The Endogenous Cannabinoid System Regulates Seizure Frequency and Duration in a Model of Temporal Lobe Epilepsy.
Journal of Pharmacology and Experimental Therapeutics.

2003 - Study ~ On the application of cannabis in paediatrics and epileptology.

Neuro Endocrinology Letters Journal.

2001 - Study ~ Anticonvulsant activity of N-palmitoylethanolamide, a putative endocannabinoid, in mice.
Epilepsia.

2001 - Study ~ Alcohol and marijuana: effects on epilepsy and use by patients with epilepsy.
Epilepsia.

1999 - Study ~ Therapeutic aspects of cannabis and cannabinoids.

British Journal of Psychiatry.

1992 - Study ~ Marijuana use and the risk of new onset seizures.

Transactions of the American and Climatological Association.

1990 - Study ~ Illicit drug use and the risk of new onset seizures.
American Journal of Epidemiology.

1982 - Study ~ Anticonvulsant effects of the (-) and (+)isomers of cannabidiol and their dimethylheptyl homologs.

Pharmacology.

1982 - Study ~ Effects of cannabidiol on behavioral seizures caused by convulsant drugs or current in mice.

1981 - Study ~ Hypnotic and antiepileptic effects of cannabidiol.

Journal of Clinical Pharmacology.

1981 - Study ~ Antiepileptic potential of cannabidiol analogs.

Journal of Clinical Pharmacology.

1981 - Study ~ The cannabinoids as potential antiepileptics.

Journal of Clinical Pharmacology.

1980 - Study ~ Chronic administration of cannabidiol to healthy volunteers and epileptic patients.

Pharmacology.

1978 - Study ~ Anticonvulsant Action of Cannabis in the Rat: Role of Brain Monoamines.
Psychopharmacology (Berl).

1977 - Study ~ Cannabidiol--antiepileptic drug comparisons and interactions in experimentally induced seizures in rats.
Journal of Pharmacology and Experimental Therapeutics.

1976 - Study ~ Anticonvulsant activity of delta9-tetrahydrocannabinol compared with three other drugs.
European Journal of Pharmacology.

1975 - Study ~ Antiepileptic and prophylactic effects of tetrahydrocannabinols in amygdaloid kindled cats.

Epilepsia.

1975 - Study ~ Anticonvulsant activity of four oxygenated cannabidiol derivatives.
Research Communications in Chemical Pathology and Pharmacology.

1975 - Study ~ Epileptiform seizures in domestic fowl. V. The anticonvulsant activity of delta9-tetrahydrocannabinol.
Canadian Journal of Physiology and Pharmacology.

1949 - Study ~ Anti-epileptic Action of Marijuana-Active Substances.

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