DYSTONIA: Cannabis Research
Science & Research
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Journal, Volume,Issue - Abstract IACM 2nd Conference on Cannabinoids in Medicine, September 12-13, 2003, Cologne
Major outcome(s) - Positive effects of THC in children with severe neurological disorders
Indication - Spasticity; Dystonia; Epilepsy; Anxiety.
Medication - Delta-9-THC
Routes(s) - Oral
Dose(s) - 0.04 - 0.14 mg/kg body weight
Duration (days) - Unavailable
Participant(s) - 8 children with different neurological disorders
Design - Uncontrolled case report
Type of publication - Meeting abstract
Address of author(s) - Paediatrician, Brunnenstrasse 54, 34537 Bad Wildungen, Germany
8 patients – children or adolescents aged 3 to 14 years – have been treated with delta 9 THC, dosages ranged from 0.04 mg/kg body weight to 0.14 mg/kg body weight.
In an 8 year-old-boy with NCL Jansky-Bielschowsky spasticity was diminished, he became more alert and his mood improved.
In a 12 year-old-girl, who had suffered from severe hypoxia during birth, mood improved, awareness was increased and focal seizures (presenting as nystagmus and versive movement) but not tonic-clonic seizures were reduced.
A 12 year-old-girl with PDHC-deficiency became more interested in her surroundings and society. Nodding spasms and tonic seizures decreased.
In a 14 year-old-girl with marked dystonia due to NCL Spielmeyer-Vogt a reduction of abnormal movement patterns was observed. In addition the girl had more initiative.
In a 13 year-old-boy presenting with spasticity, athetosis, myoclonic movements and epileptic seizures of unknown cause interest in his surroundings was improved, myoclonic movements were less intense but of similar frequency. Frequency and duration of his focal and generalized seizures were not influenced.
In an 11 year-old-girl with a traumatic paraplegia a significant improvement of symptoms of a post traumatic reaction presenting as an eating disorder and negative behaviour was observed. Taking higher doses the girl started to develop side effects including inappropriate language (concerning sexual content) and very associative thinking. Therapy was discontinued without signs of withdrawal.
In a 3 10/12 year-old-boy with a traumatic paraplegia a significant improvement in his behaviour and eating disorder was observed.
In a 14 year-old-boy suffering from intractable epilepsy and severe mental retardation appetite and mood improved. Frequency of seizures seemed not to be influenced, but clear assessment was not possible because antiepileptic drugs were changed.
Conclusion: In severly disabled children and adolescents delta 9 THC medication can have positive psychotropic effects, influences the degree of spasticity and dystonia and-occasionally-seems to have an anticonvulsant action.