Cannabis Research A-Z

Open Access to Science

Research Papers: Treating Depression with Cannabis

There are more than 350 million people worldwide that suffer from depression. It's a business. Period. One of the saddest things about depression is the lack of effective medications that a person can take.

Luckily, cannabis gives a chemical free alternative for thousands of patients who suffer from depression.

Doctors almost always prescribe pharmaceuticals for depression, many of which have harmful side effects such as suicide. Just think about that for a second.

A pharmaceutical solution for depression may come with side effects that can depress you. The scary thing is that there are millions of people on these sometimes harmful medications.

Many studies have been released which found that cannabis can be an effective treatment for depression.

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Science & Research
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2018 - Full ~ The selective reversible FAAH inhibitor, SSR411298, restores the development of maladaptive behaviors to acute and chronic stress in rodents.

Scientific Reports Journal.

2018 - Full ~ Cannabis Essential Oil: A Preliminary Study for the Evaluation of the Brain Effects.

Hindawi: Evidence-Based Complementary and Alternative Medicine.

2018 - Full ~ Detection of Significant Association Between Variants in Cannabinoid Receptor 1 Gene (CNR1) and Personality in African-American Population.

Frontiers In Genetics.

2018 - Full ~ Negative urgency partially accounts for the relationship between major depressive disorder and marijuana problems.

Borderline Personality Disorder and Emotional Dysregulation.

2018 - Full ~ Prolonged Cannabidiol Treatment Effects on Hippocampal Subfield Volumes in Current Cannabis Users.

Cannabis and Cannabinoid Research.

2018 - Abstract ~ CB1 cannabinoid receptor ligands augment the antidepressant-like activity of biometals (magnesium and zinc) in the behavioural tests.

Journal of Pharmacy and Pharmacology.

2018 - Abstract ~ Prospects of Cannabidiol for Easing Status Epilepticus-Induced Epileptogenesis and Related Comorbidities.

Molecular Neurobiology.

2018 - Abstract ~ Evaluation of different drug classes on transient sciatic nerve injury-depressed marble burying in mice.

Pain Journal.

2018 - Abstract ~ Impacts of cannabinoid receptor ligands on nicotine- and chronic mild stress-induced cognitive and depression-like effects in mice.

Behavioural Brain Research.

2018 - Abstract ~ The association between lifetime cannabis use and dysthymia (persistent mild depression) across six birth decades.

Journal of Affective Disorders.

2018 - Abstract ~ Circulating endocannabinoids and affect regulation in human subjects.

Journal of Psychoneuroendocrinology.

2018 - Abstract ~ Substance Use and Suicide in Pacific Islander, American Indian, and Multiracial Youth. 

American Journal of Preventative Medicine.

2018 - Abstract ~ The role of depressive symptoms in treatment of adolescent cannabis use disorder with N-Acetylcysteine.

Addictive Behaviors.

2018 - Abstract ~ Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex.

Molecular Neurobiology.

2018 - Abstract ~ Association of Cannabis With Long-Term Clinical Symptoms in Anxiety and Mood Disorders: A Systematic Review of Prospective Studies.

Journal of Clinical Psychiatry.

2018 - Abstract ~ Sub-chronic treatment with cannabidiol but not with URB597 induced a mild antidepressant-like effect in diabetic rats.

Neuroscience Letters.

2018 - Abstract ~ Antidepressant-like effect induced by Cannabidiol is dependent on brain serotonin levels.

Progress in Neuro-Psychopharmacology and Biological Psychiatry.

2018 - Abstract ~ Inhibition of Fatty Acid Amide Hydrolase Improves Depressive-Like Behaviors Independent of Its Peripheral Antinociceptive Effects in a Rat Model of NeuropathicPain.

OVID: Anesthesia & Analgesia.

2018 - Abstract ~ Itch and psyche: psychiatric aspects of pruritus.

International Journal of Dermatology.

2018 - Abstract ~ Relationships between substance abuse/dependence and psychiatric disorders based on polygenic scores.

International Behavioural and Neural Genetics Society: Genes, Brains, and Behavior.

2018 - Abstract ~ Effects of rTMS on Hippocampal Endocannabinoids and Depressive-like Behaviors in Adolescent Rats.

Neurochemical Research.

2018 - Abstract ~ Integrating endocannabinoid signaling in the regulation of anxiety and depression.

APS: Acta Pharmacologica Sinica.

2018 - Abstract ~ Orbitofrontal connectivity is associated with depression and anxiety in marijuana-using adolescents.

Journal of Affective Disorders.

2018 - Abstract ~ Risks and Benefits of Marijuana Use: A National Survey of U.S. Adults.

Annals of Internal Medicine.

2018 - Abstract ~ The endocannabinoid system in mental disorders: Evidence from human brain studies.

Biochemical Pharmacology.

JAMA Otolaryngology: Head and Neck Surgery.

Neurotoxicity Research.

Nature Communications.

Frontiers: Ethnpharmacology.

Nature Communications.

Journal of Pain Research.

Scientific Reports.

Translational Psychiatry.

2017 - Full ~ Role of cannabinoid receptor 1-mediated synaptic plasticity in neuropathic pain and  associated depression.
Department of Anethesiology, Jinling Hospital, Medical School of Nanjing University.

European Archives of Psychiatry and Clinical Neuroscience.


Brain Research Journal.

Molecular Psychiatry .

eLife Sciences.



Cell Reports.

Translational Psychiatry.



Neuroscience & Biobehavioral Reviews.

Drug & Alcohol Dependence.

U.S.A Academy of Science.
American Journal of Drug & Alcohol Abuse.

Brain Research Bulletin.

Behavioural Brain Research.

Journal of NeuroChemistry.

2016 - Abstract ~ Prohedonic Effect of Cannabidiol in a Rat Model of Depression.
International Journal of Neuropsychopharmacology.

2014 - Study ~ Monoacylglycerol Lipase Inhibition Blocks Chronic Stress-Induced Depressive-Like Behaviors via Activation of mTOR Signaling

2014 - Study ~ Anti-depressive mechanism of repetitive transcranial magnetic stimulation in rat: The role of the endocannabinoid system.

2013 - Study ~ Effect of dietary fat type on anxiety-like and depression-like behavior in mice

2013 - Study ~ Translational evidence for the involvement of the endocannabinoid system in stress-related psychiatric illnesses

2013 - Study ~ Screening genetic variability at the CNR1 gene in both major depression etiology and clinical response to citalopram treatment.

2013 - Study ~ Additive effect of rimonabant and citalopram on extracellular serotonin levels monitored with in vivo microdialysis in rat brain.

2013 - Study ~ Entopeduncular nucleus endocannabinoid system modulates sleep-waking cycle and mood in rats.

2013 - Study ~ Can Marijuana Reduce Social Pain?

2013 - Study ~ Sleep Quality Moderates the Relation between Depression Symptoms and Problematic Cannabis Use among Medical Cannabis Users

2013 - Study ~ The effects of anandamide signaling enhanced by the FAAH inhibitor URB597 on coping styles in rats.

2013 - Study ~ Cannabinoids, Neurogenesis and Antidepressant Drugs: Is there a Link?

2013 - Study ~ The endocannabinoid system and emotional processing: A pharmacological fMRI study with ∆9-tetrahydrocannabino

2013 - Study ~ Cannabinoid Receptor Activation Prevents the Effects of Chronic Mild Stress on
Emotional Learning and LTP in a Rat Model of Depression.

2013 - Study ~ Endocannabinoid Signaling in the Etiology and Treatment of Major Depressive Illness.

2013 - Study ~ The endocannabinoid system and its possible role in neurobiology of psychiatric

2013 - Study ~ Low frequency stimulation evokes serotonin release in the nucleus accumbens and induces long-term depression via production of endocannabinoid.

2013 - Study ~ Testing bidirectional effects between cannabis use and depressive symptoms: moderation by the serotonin transporter gene

2012 - Study ~ High on Life? Medical Marijuana Laws and Suicide.

2012 - Study ~ Serum contents of endocannabinoids are correlated with blood pressure in depressed women.

2012 - Study ~ Cannabinoid Receptor Genotype Moderation of the Effects of Childhood Physical Abuse on Anhedonia and Depression.

2012 - Study ~ Effect of delta-9-tetrahydrocannabinol on behavioral despair and on presynaptic and postsynaptic serotonergic transmission.

2012 - Study ~ Nature Against Depression.

2012 - Study ~ Lower levels of cannabinoid 1 receptor mRNA in female eating disorder patients: Association with wrist cutting as impulsive self-injurious behavior.

2012 - Study ~ Expression pattern of the cannabinoid receptor genes in the frontal cortex of mood disorder patients and mice selectively bred for high and low fear.

2012 - Study ~ The combined effects of parental divorce and parental history of depression on cannabis use in young adults in France.

2012 - Study ~ Genetic variability in the endocannabinoid system and 12-week clinical response to citalopram treatment: the role of the CNR1, CNR2 and FAAH genes

2012 - Study ~ Opposing local effects of endocannabinoids on the activity of noradrenergic neurons and release of noradrenaline: relevance for their role in depression and in the actions of CB(1) receptor antagonists.

2012 - Study ~ Essential fatty acids and lipid mediators. Endocannabinoids

2012 - Study ~ Endocannabinoid system and mood disorders: Priming a target for new therapies.

2011 - Study ~ Gadolinium-HU-308-incorporated micelles.

2011 - Study ~ Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions.

2011 - Study ~ Endocannabinoid system dysfunction in mood and related disorders.

2011 - Study ~ Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress.

2011 - Study ~ Cannabinoids and emotionality: a neuroanatomical perspective.

2011 - Study ~ Testing bidirectional effects between cannabis use and depressive symptoms: moderation by the serotonin transporter gene.

2010 - Study ~ Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L.

2010 - Study ~ Brain CB2 Receptors: Implications for Neuropsychiatric Disorders.

2010 - Study ~ Uni-Morbid and Co-Occurring Marijuana and Tobacco Use: Examination of Concurrent Associations with Negative Mood States.

2010 - Study ~ Genes differentially expressed in CB1 knockout mice: involvement in the depressive-like phenotype.

2010 - Study ~ Deficiency in Endocannabinoid Signaling in the Nucleus Accumbens Induced by Chronic Unpredictable Stress.

2009 - Study ~ Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress.

2009 - Study ~ Impairments in Endocannabinoid Signaling and Depressive Illness.

2009 - Study ~ Protracted cannabinoid administration elicits antidepressant behavioral responses in rats: role of gender and noradrenergic transmission.

2009 - Study ~ Cannabis and suicide: longitudinal study.

2008 - Study ~ Treating depression with cannabinoids.

2008 - Study ~ Nicotine (NC)-induced "depressive" behavioral symptoms and effects of antidepressants including cannabinoids (CBs).

2008 - Study ~ Animal research highlights a therapeutic potential of cannabinoids for the treatment of depression.

2007 - Study ~ Chronologically overlapping occurrences of nicotine-induced anxiety- and depression-related behavioral symptoms: effects of anxiolytic and cannabinoid drugs.

2007 - Study ~ Cannabinoids elicit antidepressant-like behavior and activate serotonergic neurons through the medial prefrontal cortex.

2007 - Study ~ Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress.

2007 - Study ~ Dronabinol and marijuana in HIV-positive marijuana smokers: caloric intake, mood, and sleep.

2006 - Study ~ Decreased depression in marijuana users.

2006 - Study ~ The synthetic cannabinoid nabilone improves pain and symptom management in cancer patients.

2006 - Study ~ Marijuana use and depression among adults: Testing for causal associations.

2006 - Study ~ Do patients use marijuana as an antidepressant?

2006 - Study ~ A possible role for the endocannabinoid system in the neurobiology of depression.

2005 - Study ~ Cannabinoids promote hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects.

2005 - Study ~ Antidepressant-like activity by blockade of anandamide hydrolysis.

2005 - Study ~ Depression in Parkinson's disease is related to a genetic polymorphism of the cannabinoid receptor gene (CNR1).

2005 - Study ~ Antidepressant-like Activity and Modulation of Brain Monoaminergic Transmission by Blockade of Anandamide Hydrolysis.

2005 - Study ~ Decreased Depression in Marijuana Users.

2004 - Study ~ Association between cannabis use and depression may not be causal, study says.

2001 - Study ~ Therapeutic Aspects of Cannabis and Cannabinoids.

2000 - Study ~ Anxiety with Depression Research Review.