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CANNABICHROMENE / CBC & Cannabis studies completed

Overview

Cannabichromene, or CBC, doesn’t get a lot of praise or attention, but it has shown to have profound benefits. Similar to cannbidiol (CBD) and tetrahydrocannabinol (THC), CBC stems from the all-important cannabigerolic acid (CBGa).

From there, enzymes cause it to convert into or cannabichrome carboxylic acid (CBCa). In this case of CBCa, it passes through the CBC synthase (the enzymes that gets the specific process underway).  Over time, or if exposed to heat CBCa with break down and become cannabichromene, through a process known as decarboxylation.


 

Science and Research

Undated - News ~ Phytocannabinoids.
2012 - Study ~ Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice

2011 - Study ~ The endocannabinoid system and cancer: therapeutic implication.

2011 - Study ~ Phytocannabinoids for use in the treatment of cancer - Patent GB2478595 (A) ― 2011-09-14.

2011 - Study ~ Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes.

2011 - Study ~ The intersection between cannabis and cancer in the United States.

2011 - Study ~ Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action.

2011 - Study ~ Cannabinoids in children.

2011 - News ~ Cannabis Science Reports: National Cancer Institute Updates Confirm Successful Cancer Treatments with Medical Cannabis.

2010 - Study ~ Antidepressant-like effect of Delta(9)-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L.

2010 - Study ~ Disposition of Cannabichromene, Cannabidiol, and Δ9-Tetrahydrocannabinol and its Metabolites in Mouse Brain following Marijuana Inhalation Determined by High-Performance Liquid Chromatography-Tandem Mass Spectrometry.

2010 - Study ~ Pharmacological evaluation of the natural constituent of Cannabis sativa, cannabichromene and its modulation by Δ9-tetrahydrocannabinol.

2009 - Study ~ Evaluation of Prevalent Phytocannabinoids in the Acetic Acid Model of Visceral Nociception.

2009 - Study ~ TRB3 links ER stress to autophagy in cannabinoid anti-tumoral action.

2008 - Study ~ Antibacterial cannabinoids from Cannabis sativa: a structure-activity study.
1990 - Study ~ In vitro metabolism of cannabichromene in seven common laboratory animals
1989 - Study ~ Antiinflammatory and antimicrobial compounds and compositions
United States Patent 4837228
1989 - Study ~ Antiinflammatory and antimicrobial compounds and compositions
United States Patent 4837228
1984 - Study ~ Intraocular pressure, ocular toxicity and neurotoxicity after administration of delta 9-tetrahydrocannabinol or cannabichromene

1983 - Study ~ Neurobehavioral actions of cannabichromene and interactions with delta 9-tetrahydrocannabinol.

1983 - Study - Allergenic properties of naturally occurring cannabinoids.

1983 - Study ~ Neurobehavioral actions of cannabichromene and interactions with delta 9-tetrahydrocannabinol
1982 - Study ~ Process for preparing cannabichromene.

1981 - Study - Biological activity of cannabichromene, its homologs and isomers.

1975 - Study ~ Constituents of Cannabis sativa L. VIII: Possible biological application of a new method to separate cannabidiol and cannabichromene.



CBC is effective in a range of benefits which include:

  • Antimicrobial – CBC Fights Bacteria and Fungi. It exhibits “strong” antibacterial effects on a variety of gram-positive, gram-negative and acid-fast bacteria; CBC shows “mild to moderate” activity against different types of fungi too.

  • Anti-Viral – It may play a role in the anti-viral effects of cannabis.

  • Anti-inflammatory Properties – CBC can reduce edema (swelling) as well as inflammation of the intestinal tract. CBC appears to fight inflammation without activating cannabinoid receptors, CBC produces a stronger effect when combined with other cannabinoids.

  • Analgesic – Reduces pain, although it is not as strong as THC. CBC contributes to the overall analgesic effects of cannabis. CBC fights pain by “interacting with several targets involved in the control of pain” at the spinal level. CBC is non-psychoactive, scientists are hopeful that these cannabis compounds can be used to treat pain – without the high.

  • Anti-Depressant– It fights depression. CBC and a number of other cannabinoids may “contribute to the overall mood-elevating properties of cannabis.” It doesn’t seem to activate the same pathways in the brain as THC.

  • Stimulates Brain Growth – CBC appeared to increase the viability of developing brain cells – a process known as neurogenesis.

  • Anti-Proliferative – inhibits the growth of cancerous tumours. This could be a result of its interaction with anandamide (an endocannabinoid, which means our body produces it naturally). It affects the CB1 receptors, as well as the CB2 receptors, and has been found to fight against human breast cancer. CBC inhibits the uptake of anandamide, which allows it to stay in the bloodstream longer.

  • Migraines – CBC has also been a successful remedy for migraines.
Where Can I Find CBC?

CBC is a minor cannabinoid that can be found in the cannabis plant which makes it difficult to obtain in large quantities. Generally CBC is found in only tropical strains of cannabis.

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