Medical Cannabis and Leukemia studies completed

Cancer / Leukemia & Cannabis

Overview

Leukemia is a cancer that starts in blood stem cells (immature blood cells) in the bone marrow. Bone marrow is the soft, spongy material that fills the center of most bones. Blood cells are made in the bone marrow. Blood stem cells develop into either myeloid stem cells or lymphoid stem cells.

In the year 2000, approximately 256,000 children and adults around the world developed some form of leukemia, and 209,000 died from it. About 90% of all leukemia new cases are diagnosed in adults.

Science & Research Studies

2020 - Full Study ~ An Approach to Biomarker Discovery of Cannabis Use Utilizing Proteomic, Metabolomic, and Lipidomic Analyses.

Cannabis and Cannabinoid Research.

2020 - Full Study ~ Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis.

Journal: Cancers.

2019 - Abstract ~ A Comprehensive Review of Cannabis in Patients with Cancer: Availability in the USA, General Efficacy, and Safety.

Current Oncology Reports.

2019 - Abstract ~ Using Cannabis to Treat Cancer-Related Pain.

Seminars in Oncology Nursing.

2019 - Article ~ Medical Cannabis Certification in a Large Pediatric Oncology Center.

Journal: Children.

2018 - Abstract ~ Cannabis for cancer – illusion or the tip of an iceberg: a review of the evidence for the use of Cannabis and synthetic cannabinoids in oncology.

Journal: Expert Opinion on Investigational Drugs.

2018 - Full Study ~ A Review on the Chemical versus Alternative Treatments of Leukemia.

Department of Biological Sciences, University of Toronto.

2018 - Full Study ~ Cannabis sativa L. and Nonpsychoactive Cannabinoids: Their Chemistry and Role against Oxidative Stress, Inflammation, and Cancer.

Biomed Research International.

2017 - Abstract ~ Anticancer effects of phytocannabinoids used with chemotherapy in leukaemia cells can
be improved by altering the sequence of their administration.

International Journal of Oncology.

2017 - Full Study ~ Metabolic gatekeeper function of B-lymphoid transcription factors.

Nature Journal.

2017 - Full Study ~ Cannabidiol Reduces Leukemic Cell Size - But Is It Important?

Frontiers in Pharmacology.

2016 - Abstract ~ Phytochemicals as adjunctive with conventional anticancer therapies.

Current Pharmaceutical Design.

2016 - Abstract ~ Endocannabinoid system: a promising therapeutic target for the treatment of
haematological malignancies?

Current Medicinal Chemistry: National Library of Medicine. (National Center of Biotechnology Information)

2016 - Full Study ~ Cannabinoid Receptors Are Overexpressed in CLL but of Limited Potential for
Therapeutic Exploitation.

Plos One Journal.

2016 - Full Study ~ Dronabinol has preferential antileukemic activity in acute lymphoblastic and myeloid
leukemia with lymphoid differentiation patterns.

BMC Cancer Journal.

2015 - Abstract ~ Downstream effects of endocannabinoid on blood cells: implications for health and
disease.

Cellular and Molecular Life Sciences.

2015 - Pilot Study ~ Circulating endocannabinoids during hematopoietic stem cell transplantation: A pilot
study.
Neurobiology of Stress.

2015 - Phase Two Study Results ~ Cannabidiol for the Prevention of Graft-Versus-Host-Disease after Allogeneic
Hematopoietic Cell Transplantation.

Biology of Blood and Marrow Transplantation.

2014 - Full Study ~ Synthesis of Tetrahydrohonokiol Derivates and Their Evaluation for Cytotoxic Activity against CCRF-CEM Leukemia, U251 Glioblastoma and HCT-116 Colon Cancer Cells.

Mulecules Journal.

2013 - Full Study ~ Cannabis extract treatment for terminal acute lymphoblastic leukemia with a Philadelphia chromosome mutation.

Case Reports on Oncology.

2013 - Abstract ~ Enhancing the Activity of Cannabidiol and Other Cannabinoids In Vitro Through
Modifications to Drug Combinations and Treatment Schedules.

National Library of Medicine.

2012 - Full Study ~ Tumor necrosis factor activation of vagal afferent terminal calcium is blocked by cannabinoids.

Journal of Neuroscience.

2011 - Abstract ~ Cannabidiol induced a contrasting pro-apoptotic effect between freshly isolated and precultured human monocytes.

Toxicology and Applied Pharmacology.

2010 - Full Study ~ Substance use and survival after treatment for chronic myelogenous leukemia (CML) or myelodysplastic syndrome (MDS).

American Journal of Drug and Alcohol Abuse.

2008 - Abstract ~ Enhancing the in vitro cytotoxic activity of Delta9-tetrahydrocannabinol in leukemic cells through a combinatorial approach.

Journal of Leukemia and Lymphoma.

2008 - Full Study ~ Medical Marijuana Cannabis Use and Research.

Leukemia & Lymphoma Society.

2007 - Full Study ~ HU-331, a novel cannabinoid-based anticancer topoisomerase II inhibitor.

Molecular Cancer Theropeutics.

2006 - Abstract ~ Cannabidiol-Induced Apoptosis in Human Leukemia Cells: A Novel Role of Cannabidiol in the Regulation of p22phox and Nox4 Expression.

Molecular Pharmacology.

2006 - Abstract ~ Delta9-tetrahydrocannabinol-induced apoptosis in Jurkat leukemia T cells is regulated by translocation of Bad to mitochondria.

National Library of Medicine.

2006 - Full Study ~ Is there a temperature-dependent uptake of anandamide into cells?

British Journal Of Pharmacology.

2006 - Abstract ~ Parental marijuana use and risk of childhood acute myeloid leukaemia: a report from the Children's Cancer Group (United States and Canada)

Nationa;l Library of Medicine.

2006 - Abstract ~ The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells.

Biochemical Pharmacology.

2005 - Abstract ~ Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway.

National Center of Biotechnology Information.

2003 - Abstract ~ Gamma-irradiation enhances apoptosis induced by cannabidiol, a non-psychotropic cannabinoid, in cultured HL-60 myeloblastic leukemia cells.

National Center of Biotechnology Information.

2002 - Abstract ~ Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease.

Blood Journal.

2000 - Full Study ~ Anandamide Induces Apoptosis in Human Cells via Vanilloid Receptors. (EVIDENCE FOR A PROTECTIVE ROLE OF CANNABINOID RECEPTORS.)

Journal of Biological Chemistry.

1988 - Full Study ~ Fatal aspergillosis associated with smoking contaminated marijuana, in a marrow transplant recipient.

Chest Journal.

1987 - Full Study ~ Cannabinoids induce incomplete maturation of cultured human leukemia cells.

Proceedings of the National Academy of Sciences of the United States of America.

1977 - Abstract ~ Effects of cannabinoids on L1210 murine leukemia. 1. Inhibition of DNA synthesis.

Research Communications of Chemical Pathology and Pharmacology.