CANCER- CERVICAL & Cannabis studies completed
Recommended Cannabis Strains That May Benefit Cervical Cancer
Science & Research
2010 - Study ~ Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1.
2009 - Study ~ R(+)-methanandamide-induced apoptosis of human cervical carcinoma cells involves a cyclooxygenase-2-dependent pathway.
- Eat a plant-based diet focusing on a wide variety of coloured fruits and vegetables. Cruciferous vegetables such as broccoli, cauliflower and cabbage contain a cancer-preventing compound so potent that is being investigated as a chemotherapy agent. Berries are rich in beneficial phytonutrients and antioxidants. Overall, a diet that emphasizes fruits and vegetables, whole grains, nuts, cold water fish that provide omega-3 fatty acids (fish eaters have a reduced risk of cancer) is the best nutritional strategy.
- Decrease your intake of animal fats in general and red meat and dairy products in particular to control cancer-promoting inflammation in the body.
- Avoid refined sugar and highly processed carbohydrates, which are not beneficial for individuals living with cancer because of their effect on insulin production and insulin-like growth factors, which promote inflammation and are also associated with cancer cell division.
- Choose organic fruits and vegetables. While expensive, they are the best options for cancer patients, not only because they're grown without pesticides and other agricultural chemicals but because plants grown outdoors organically need to protect themselves from other plants, predators (insects, birds and animals) and the sun. Organically grown plants do this by producing more intense protective chemicals, known as phytonutrients, which are beneficial to us.
WebMD Health News
Dec. 26, 2007 -- THC and another marijuana-derived compound slow the spread of cervical and lung cancers, test-tube studies suggest.
The new findings add to the fast-growing number of animal and cell-culture studies showing different anticancer effects for cannabinoids, chemical compounds derived from marijuana.
Cannabinoids, and sometimes marijuana itself, are currently used to lessen the nausea and pain experienced by many cancer patients. The new findings -- yet to be proven in human studies -- suggest that cannabinoids may have a direct anticancer effect.
"Cannabinoids' ... potential therapeutic benefit in the treatment of highly invasive cancers should be addressed in clinical trials," conclude Robert Ramer, PhD, and Burkhard Hinz, PhD, of the University of Rostock, Germany.
Might cannabinoids keep dangerous tumors from spreading throughout the body? Ramer and Hinz set up an experiment in which invasive cervical and lung cancer cells had make their way through a tissue-like gel. Even at very low concentrations, the marijuana compounds THC and methanandamide (MA) significantly slowed the invading cancer cells.
Doses of THC that reduce pain in cancer patients yield blood concentrations much higher than the concentrations needed to inhibit cancer invasion.
"Thus the effects of THC on cell invasion occurred at therapeutically relevant concentrations," Ramer and Hinz note.
The researchers are quick to point out that much more study is needed to find out whether these test-tube results apply to tumor growth in animals and in humans.
Ramer and Hinz report the findings in the Jan. 2, 2008 issue of the Journal of the National Cancer Institute.
Arachidonyl ethanolamide induces apoptosis of uterine cervix cancer cells via aberrantly expressed vanilloid receptor-1
CONTASSOT, EMMANUEL PhD; WILMOTTE, RICK PhD; TENAN, MIRNA; BELKOUCH, MARIE-CLAUDE; SCHNÜRIGER, VALÉRIE; DE TRIBOLET, NICOLAS MD; BOURKHARDT, KARIM MD; DIETRICH, PIERRE-YVES MD
The anti-tumor properties of cannabinoids have recently been evidenced, mainly with Δ9-tetrahydrocannabinol (THC). However, the clinical application of this drug is limited by possible undesirable side effects due to a broad expression of cannabinoid receptors (CB1 and CB2).
An attractive field of research therefore is to identify molecules with more selective tumor targeting. This is particularly important for malignant gliomas, considering their poor prognosis and their location in the brain.
Here we investigated whether the most potent endogenous cannabinoid, arachidonylethanolamide (AEA), could be a candidate. We observed that AEA induced apoptosis in long-term and recently established glioma cell lines via aberrantly expressed vanilloid receptor-1 (VR1).
In contrast with their role in THC-mediated death, both CB1 and CB2 partially protected glioma against AEA-induced apoptosis. These data show that the selective targeting of VR1 by AEA or more stable analogues is an attractive research area for the treatment of glioma.