Cannabis Research A-Z

Open Access to Science

Can Cannabis Help Persons with Bipolar Disorder?

Bipolar disorder or Bipolar Affective Disorder, and historically known as Manic-Depressive disorder or manic depression, is a psychiatric diagnosis. Bipolar disorder causes extreme mood swings in persons suffering from this mental illness.

Depression, and bipolar disorder are both mental illnesses that change the way people feel, and make it hard for them to go about their daily cognitive routines.

Various Bipolar Global Medical Journal Articles Related to Cannabis

 *All links are Open Access .pdf files whenever possible.

Undated - Anecdotal ~ Bipolar Disorder and Endometriosis by Anonymous.

2022 - Full Study (Poland) ~ Cannabinoids: Perspectives for Individual Treatment in Selected Patients: Analysis of the Case Series.

Biomedicines Journal.

2022 - Abstract (USA) ~ Multimodal Correlates of Cannabis Use among U.S. Veterans with Bipolar Disorder: An Integrated Study of Clinical, Cognitive, and Functional Outcomes.

Journal of Dual Diagnostics.


2021 - Full Study (USA) ~ A Change in Blood Carbamazepine Levels Associated With Cannabis Use: Implications for Clinical Practice.

The Journal of Clinical Psychiatry.

2021 - Full Study (Germany) ~ Sphingolipid and Endocannabinoid Profiles in Adult Attention Deficit Hyperactivity Disorder.

Biomedicines Journal.

2021 - Full Study (Canada / UK) ~ Cannabis and mental health: Prevalence of use and modes of cannabis administration by mental health status.

Addictive Behaviors.

2021 - Full Study (Denmark) ~ Bipolar disorder and cannabis use: A bidirectional two‐sample Mendelian randomization study.

Department of Affective Disorders, Aarhus University Hospital.

2021 - Abstract (France) ~ Handedness in bipolar disorders is associated with specific neurodevelopmental features: results of the BD-FACE cohort.

European Archives of Psychiatry and Clinical Neuroscience.

2021 - Abstract (USA) ~ Consumer Experiences with Delta-8-THC: Medical Use, Pharmaceutical Substitution, and Comparisons with Delta-9-THC.

Cannabis and Cannabinoid Research.

2020 - Full Study (Australia / UK) ~  Medicinal cannabis for psychiatric disorders: a clinically-focused systematic review.

BMC Psychiatry.

2020 - Full Study (Norway) ~ Cannabis Use Is Associated With Increased Levels of Soluble gp130 in Schizophrenia but Not in Bipolar Disorder.


2016 - Full Study (USA) ~ Brain circuitry associated with the development of substance use in bipolar disorder and preliminary evidence for sexual dimorphism in adolescents.

Journal of Neuroscience Research.

2016 - Full Study (USA) ~ Pros and cons of medical cannabis use by people with chronic brain disorders.

Current Neuropharmacology.

2016 - Abstact ~ The Effects of Cannabis on Inpatient Agitation, Aggression, and Length of Stay.

Journal of Dual Diagnosis.

2016 - Full Study (Canada) ~ Cannabinoid hyperemesis syndrome and the onset of a manic episode.

BMJ Case Reports.

2016 - Full Study (USA) ~ Cognitive Function in Individuals With Psychosis: Moderation by Adolescent Cannabis Use.

Schizophrenia Bulletin Journal.

2016 - Full Study (USA) ~ Gender Differences in Associations Between Attention-Deficit/Hyperactivity Disorder and Substance Use Disorder.

Journal of the American Academy of Child & Adolescent Psychiatry.

2016 - Abstract (Germany) ~ Lipids in psychiatric disorders and preventive medicine.

Neuroscience & Biobehavioral Reviews.

2016 - Full Study (USA) ~ Endocannabinoid signaling in social functioning: an RDoC perspective.

Translational Psychiatry.

2016 - Full Study (USA) ~ Pilot Investigation of the Impact of Bipolar Disorder and Marijuana Use on Cognitive Function and Mood.


2015 - Abstract ~ Endocannabinoids and Mental Disorders.
Handbook of Experimental Pharmacology: Endocannabinoids.

2014 - Full Study ~ The association between cannabis use and mood disorders: A longitudinal study.

Journal of Affective Disorders.

2014 - Abstract~ Is there a role for palmitoylethanolamide in the treatment of depression?

Medical Hypotheses.

2013 - Abstract ~ No association of endocannabinoid genes with bipolar disorder or lithium response in a Sardinian sample.

Psychiatry Research.

2012 - Full Study (UK) ~ Cognitive and clinical outcomes associated with cannabis use in patients with bipolar disorder.
Psychiatry Research.

2011 - Abstract ~ Genetic association between bipolar disorder and 524A>C (Leu133Ile) polymorphism of CNR2 gene, encoding for CB2 cannabinoid receptor.

Journal of Affective Disorders.

2009 - Abstract (UK)~ Opposite relationships between cannabis use and neurocognitive functioning in bipolar disorder and schizophrenia.

Cambridge University: Psychological Medicine.

2007 - Abstract (USA) ~ The effect of extreme marijuana use on the long-term course of bipolar I illness: a single case study.

Journal of Psychoactive Drugs.

2005 - Study (UK) ~ Cannabinoids in bipolar affective disorder: a review and discussion of their therapeutic potential.

Oxford: Journal of Psychopharmacology.

Journal of Psychoactive Drugs.

Video - Cannabis and Bipolar Disorder