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ARTHRITIS & Cannabis studies completed

Overview

Arthritis is a form of joint disorder that involves inflammation of one or more joints. There are over 100 different forms of arthritis.The most common form of arthritis is osteoarthritis (degenerative joint disease), a result of trauma to the joint, infection of the joint, or age. Other arthritis forms are rheumatoid arthritis, psoriatic arthritis, and related autoimmune diseases. Septic arthritis is caused by joint infection.

The major complaint by individuals who have arthritis is joint pain. Pain is often a constant and may be localized to the joint affected. The pain from arthritis is due to inflammation that occurs around the joint, damage to the joint from disease, daily wear and tear of joint, muscle strains caused by forceful movements against stiff painful joints and fatigue. wikipedia

Science and Research

2014 - Study ~ Expression of cannabinoid receptor 2 and its inhibitory effects on synovial fibroblasts in rheumatoid arthritis.



2014 - Study ~ Clue to role of cannabinoid receptors in RA


2014 - Study ~ Drugs Related to Cannabis Have Pain-Relieving Potential for Osteoarthritis


2014 - Study ~ Synthetic cannabinoid molecule created for osteoarthritis


2013 - Study ~ Electroacupuncture inhibition of hyperalgesia in rats with adjuvant arthritis: involvement of cannabinoid receptor 1 and dopamine receptor subtypes in striatum.


2013 - Study ~ Cannabinoid CB2 Receptors Regulate Central Sensitization and Pain Responses

2013 - Study ~ Palmitoylethanolamide and luteolin ameliorate development of arthritis caused by injection of collagen type II in mice



2013 - Study ~ Osteoarthritis pain mechanisms: basic studies in animal models.



2013 - Study ~ Honokiol, a low molecular weight natural product, prevents inflammatory response and cartilage matrix degradation in human osteoarthritis chondrocytes


2012 - Study ~ Platelet-rich plasma loaded hydrogel scaffold enhances chondrogenic differentiation and maturation with up-regulation of CB1 and CB2.


2012 - Study ~ Effects of Peptide and Lipid Endocannabinoids on Arthritic Pain at Spinal Level.


2012 - Study ~ Lack of effect of chronic pre-treatment with the FAAH inhibitor URB597 on inflammatory pain behaviour: evidence for plastic changes in the endocannabinoid system.


2012 - Study ~ Cannabinoids: novel therapies for arthritis?


2012 - Study ~ The effects of peptide and lipid endocannabinoids on arthritic pain at the spinal level.


2012 - Study ~ Dynamic changes to the endocannabinoid system in models of chronic pain


2012 - Study ~ Cortisol-mediated adhesion of synovial fibroblasts is dependent on the degradation of anandamide and activation of the endocannabinoid system



2012 - Study ~ CB1 and CB2 contribute to antinociceptive and anti-inflammatory effects of
electroacupuncture on experimental arthritis of the rat temporomandibular joint.


2012 - Study ~ Neuromodulators for pain management in rheumatoid arthritis


2011 - Study ~ Cannabinoids for Treatment of Chronic Non-Cancer Pain; a Systematic Review of Randomized Trials.


2011 - Study ~ Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress.


2011 - Study ~ The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55.


2011 - Study ~ Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice.


2010 - Study ~ Tissue Engineering of Cartilage; Can Cannabinoids Help


2010 - Study ~ Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression.


2010 - Study ~ Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain.


2010 - Study ~ Local application of the endocannabinoid hydrolysis inhibitor URB597 reduces nociception in spontaneous and chemically induced models of osteoarthritis.



2009 - Study ~ Ajulemic acid, a synthetic cannabinoid, increases formation of the endogenous proresolving and anti-inflammatory eicosanoid, lipoxin A4.


2009 - Study ~ Cannabinoids as novel anti-inflammatory drugs.


2008 - Study ~ Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis.


2008 - Study ~ In vivo effects of CB2 receptor-selective cannabinoids on the vasculature of normal and arthritic rat knee joints.


2008 - Study ~ Cannabinoid-mediated antinociception is enhanced in rat osteoarthritic knees.


2008 - Study ~ CB2 cannabinoid receptor agonist JWH-015 modulates human monocyte migration through defined intracellular signaling pathways.


2008 - Study ~ Suppression of human macrophage interleukin-6 by a nonpsychoactive cannabinoid acid.


2008 - Study ~ Ajulemic acid, a nonpsychoactive cannabinoid acid, suppresses osteoclastogenesis in mononuclear precursor cells and induces apoptosis in mature osteoclast-like cells.


2007 - Study - Suppression of fibroblast metalloproteinases by ajulemic acid, a nonpsychoactive cannabinoid acid.


2007 - Study - The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat involves the CB(2) cannabinoid receptor.


2007 - Study - Synergy between Delta(9)-tetrahydrocannabinol and morphine in the arthritic rat.


2007 - Study -  In vivo effects of CB2 receptor-selective cannabinoids on the vasculature of normal and arthritic rat knee joints.


2007 - Study ~ Arthritis and pain. Future targets to control osteoarthritis pain.


2007 - Study ~ INHIBITORY EFFECT OF CANNABINOID AGONISTS ON CYTOKINE PRODUCTION IN HUMAN OSTEOARTRITHIC AND RHEUMATOID FIBROBLAST-LIKE SYNOVIOCYTES.


2006 - Study - The Cannabinergic System as a Target for Anti-inflammatory Therapies.


2006 - Study - Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis.


2006 - Study ~ Arthritis and cannabinoids: HU-210 and Win-55,212-2 prevent IL-1alpha-induced matrix degradation in bovine articular chondrocytes in-vitro.


2006 - Study ~ SAFETY AND TOLERABILITY OF LONG-TERM TREATMENT WITH A CANNABIS-BASED MEDICINE (SATIVEX) IN PATIENTS WITH RHEUMATOID ARTHRITIS.



2005 - Study ~ Ajulemic acid (IP-751): Synthesis, proof of principle, toxicity studies, and clinical trials.


2004 - Study ~ A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis


2003 - Study ~ Cannabidiol-transdermal delivery and anti-inflammatory effect in a murine model.


2002 - Study - The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis.


2001 - Study ~ Anandamide activates peripheral nociceptors in normal and arthritic rat knee joints.


2000 - Study - US Patent 6132762 - Transcutaneous application of marijuana.


2000 - Study - Immunoactive cannabinoids: Therapeutic prospects for marijuana constituents.


1988 - Study - ANALGESIC AND ANTIINFLAMMATORY ACTIVITY OF CONSTITUENTS OF CANNABIS SATIVA L.