ARTHRITIS & Cannabis studies completed

Can Arthritis Sufferers Get Relief Using Medical Cannabis?

Overview

Arthritis is a form of joint disorder that involves inflammation of one or more joints. There are over 100 different forms of arthritis.The most common form of arthritis is osteoarthritis (degenerative joint disease), a result of trauma to the joint, infection of the joint, or age. Other arthritis forms are rheumatoid arthritis, psoriatic arthritis, and related autoimmune diseases. Septic arthritis is caused by joint infection.

The major complaint by individuals who have arthritis is joint pain. Pain is often a constant and may be localized to the joint affected. The pain from arthritis is due to inflammation that occurs around the joint, damage to the joint from disease, daily wear and tear of joint, muscle strains caused by forceful movements against stiff painful joints and fatigue. wikipedia

Cannabis Science and Related Medical Research Articles

2014 - Study ~ Expression of cannabinoid receptor 2 and its inhibitory effects on synovial fibroblasts in rheumatoid arthritis.

2014 - Study ~ Involvement of the endocannabinoid system in osteoarthritis pain.

2014 - Study ~ Clue to role of cannabinoid receptors in RA

2014 - Study ~ Drugs Related to Cannabis Have Pain-Relieving Potential for Osteoarthritis

2014 - Study ~ Synthetic cannabinoid molecule created for osteoarthritis

2013 - Study ~ Electroacupuncture inhibition of hyperalgesia in rats with adjuvant arthritis: involvement of cannabinoid receptor 1 and dopamine receptor subtypes in striatum.

2013 - Study ~ Cannabinoid CB2 Receptors Regulate Central Sensitization and Pain Responses

Associated with Osteoarthritis of the Knee Joint.

2013 - Study ~ Palmitoylethanolamide and luteolin ameliorate development of arthritis caused by injection of collagen type II in mice

2013 - Study ~ Selective Cannabinoid Receptor Type 2 (CB2) Agonists: Optimization of a Series of Purines Leading to the Identification of a Clinical Candidate for the Treatment of Osteoarthritic Pain.

2013 - Study ~ Osteoarthritis pain mechanisms: basic studies in animal models.

2013 - Study ~ Cannabinoid WIN-55,212-2 Mesylate Inhibits Interleukin-1β Induced Matrix Metalloproteinase and Tissue Inhibitor of Matrix Metalloproteinase Expression in Human Chondrocytes.

2013 - Study ~ Honokiol, a low molecular weight natural product, prevents inflammatory response and cartilage matrix degradation in human osteoarthritis chondrocytes

2012 - Study ~ Platelet-rich plasma loaded hydrogel scaffold enhances chondrogenic differentiation and maturation with up-regulation of CB1 and CB2.

2012 - Study ~ Effects of Peptide and Lipid Endocannabinoids on Arthritic Pain at Spinal Level

2012 - Study ~ Lack of effect of chronic pre-treatment with the FAAH inhibitor URB597 on inflammatory pain behaviour: evidence for plastic changes in the endocannabinoid system

2012 - Study ~ Cannabinoids: novel therapies for arthritis?

2012 - Study ~ The effects of peptide and lipid endocannabinoids on arthritic pain at the spinal level.

2012 - Study ~ Dynamic changes to the endocannabinoid system in models of chronic pain

2012 - Study ~ Cortisol-mediated adhesion of synovial fibroblasts is dependent on the degradation of anandamide and activation of the endocannabinoid system

2012 - Study ~ Role of CB1 and CB2 cannabinoid receptors in the development of joint pain induced by monosodium iodoacetate.

2012 - Study ~ CB1 and CB2 contribute to antinociceptive and anti-inflammatory effects of
electroacupuncture on experimental arthritis of the rat temporomandibular joint.

2012 - Study ~ Neuromodulators for pain management in rheumatoid arthritis

2011 - Study ~ Cannabinoids for Treatment of Chronic Non-Cancer Pain; a Systematic Review of Randomized Trials

2011 - Study ~ Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress

2011 - Study ~ The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55

2011 - Study ~ Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice

2010 - Study ~ Tissue Engineering of Cartilage; Can Cannabinoids Help

2010 - Study ~ Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression

2010 - Study ~ Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain

2010 - Study ~ Local application of the endocannabinoid hydrolysis inhibitor URB597 reduces nociception in spontaneous and chemically induced models of osteoarthritis

2010 - Study ~ Paradoxical effects of the cannabinoid CB2 receptor agonist GW405833 on rat osteoarthritic knee joint pain

2009 - Study ~ Ajulemic acid, a synthetic cannabinoid, increases formation of the endogenous proresolving and anti-inflammatory eicosanoid, lipoxin A4

2009 - Study ~ Cannabinoids as novel anti-inflammatory drugs

2008 - Study ~ Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis

2008 - Study ~ In vivo effects of CB2 receptor-selective cannabinoids on the vasculature of normal and arthritic rat knee joints

2008 - Study ~ Cannabinoid-mediated antinociception is enhanced in rat osteoarthritic knees

2008 - Study ~ CB2 cannabinoid receptor agonist JWH-015 modulates human monocyte migration through defined intracellular signaling pathways

2008 - Study ~ Suppression of human macrophage interleukin-6 by a nonpsychoactive cannabinoid acid

2008 - Study ~ Ajulemic acid, a nonpsychoactive cannabinoid acid, suppresses osteoclastogenesis in mononuclear precursor cells and induces apoptosis in mature osteoclast-like cells

2007 - Study - Suppression of fibroblast metalloproteinases by ajulemic acid, a nonpsychoactive cannabinoid acid

2007 - Study - The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat involves the CB(2) cannabinoid receptor

2007 - Study - Synergy between Delta(9)-tetrahydrocannabinol and morphine in the arthritic rat

2007 - Study - In vivo effects of CB2 receptor-selective cannabinoids on the vasculature of normal and arthritic rat knee joints

2007 - Study ~ Arthritis and pain. Future targets to control osteoarthritis pain

2007 - Study ~ INHIBITORY EFFECT OF CANNABINOID AGONISTS ON CYTOKINE PRODUCTION IN HUMAN OSTEOARTRITHIC AND RHEUMATOID FIBROBLAST-LIKE SYNOVIOCYTE S

2006 - Study - The Cannabinergic System as a Target for Anti-inflammatory Therapies

2006 - Study - Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis

2006 - Study ~ Arthritis and cannabinoids: HU-210 and Win-55,212-2 prevent IL-1alpha-induced matrix degradation in bovine articular chondrocytes in-vitro

2006 - Study ~ SAFETY AND TOLERABILITY OF LONG-TERM TREATMENT WITH A CANNABIS-BASED MEDICINE (SATIVEX) IN PATIENTS WITH RHEUMATOID ARTHRITIS

2006 - Letter ~ The use of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis

2005 - Study ~ Ajulemic acid (IP-751): Synthesis, proof of principle, toxicity studies, and clinical trials

2004 - Study ~ A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis

2003 - Study ~ Cannabidiol-transdermal delivery and anti-inflammatory effect in a murine model

2002 - Study - The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis.

2001 - Study ~ Anandamide activates peripheral nociceptors in normal and arthritic rat knee joints

2000 - Study - US Patent 6132762 - Transcutaneous application of marijuana

2000 - Study - Immunoactive cannabinoids: Therapeutic prospects for marijuana constituents

1988 - Study - ANALGESIC AND ANTIINFLAMMATORY ACTIVITY OF CONSTITUENTS OF CANNABIS SATIVA L

1973 - Study ~ A NTI-EDEMA AND ANALGESIC PROPERTIES OF Δ9-TETRAHYDROCANNABINOL (THC)