APPETITE STIMULANT & Cannabis studies completed


Usually hunger enhancement is considered an undesirable side effect of certain drugs as it leads to unwanted weight gain, but sometimes it can be beneficial and cannabis may be prescribed solely for this purpose, especially when the patient is suffering from severe hunger loss or muscle wasting due to cystic fibrosis, anorexia, old age, cancer or AIDS.

There are several medications including cannabis, which can cause a boost in hunger. Tricyclic antidepressants (TCAs), tetracyclic antidepressants, natural or synthetic cannabinoids, first-generation antihistamines, most antipsychotics and many steroid hormones. source wikipedia

Science & Research

2018 - Study ~ Hunger, ghrelin and the gut.

Science Direct: Brain Research.

2018 - Abstract ~ Salivary endocannabinoids and N-acylethanolamines upon mastication of a semisolid food: implications in fat taste, appetite and food liking.

Journal of Food & Function.

2017 - Study ~ Role of Endocannabinoids on Sweet Taste Perception, Food Preference, and Obesity related Disorders.

Oxford Academic: Chemical Senses.

2017 - Abstract ~ Are cannabinoids an alternative for cachexia-anorexia syndrome in patients with advanced cancer?


2017 - Abstract ~ Cannabinoids for the treatment of neuropsychiatric symptoms, pain and weight loss in dementia.
Current Opinion in Psychiatry.

2017 - Abstract ~ Anorexigenic effects induced by RVD-hemopressin(α) administration.

Pharmacological Reports.

2017 - Abstract ~ A behavioral and pharmacological characterization of palatable diet alternation in mice.

Pharmacology Biochemistry and Behavior.

2017 - Abstract ~ Consequence of dopamine D2 receptor blockade on the hyperphagic effect induced by cannabinoid CB1 and CB2 receptors in layers.

British Poultry Science.

2017 - Abstract ~ 2-Arachidonoylglycerol as a possible treatment for anorexia nervosa in animal model in mice.

Brain Research Journal.

2017 - Abstract ~ Endocannabinoid-dependent disinhibition of orexinergic neurons: Electrophysiological evidence in leptin-knockout obese mice.

Molecular Metabolism.

2017 - Abstract ~ Endocannabinoid modulation of homeostatic and non-homeostatic feeding circuits.

Science Direct: Neuropharmacology Journal.

2017 - Abstract ~ Effects of anandamide administration on components of reward processing during free choice.

Pharmacology Biochemistry and Behavior.

2017 - Abstract ~ The rewarding effects of ethanol are modulated by binge eating of a high-fat diet during adolescence.

Science Direct: Neuropharmacology Journal.

2017 - Abstract ~ Cannabinoids activate monoaminergic signaling to modulate key C. elegans behaviors.

JNeurosci: The Journal of Neuroscience.

2017 - Abstract ~ A cannabigerol-rich Cannabis sativa extract, devoid of [INCREMENT]9- tetrahydrocannabinol, elicits hyperphagia in rats.

Behavioral Pharmacology Journal.

2017 - Abstract ~ Peripheral endocannabinoid signaling controls hyperphagia in western diet-induced obesity.

Science Direct: Physiology & Behavior Journal.

2017 - Study ~ Central and peripheral control of food intake.

Endocrine Regulations Journal.

2017 - Study ~ A cannabinoid receptor antagonist attenuates ghrelin-induced activation of the mesolimbic dopamine system in mice.

Science Direct: Physiology & Behavior Journal.

2017 - Study ~ Blockade of CB1 cannabinoid receptor alters gut microbiota and attenuates inflammation and diet-induced obesity.

Nature Publishing: Scientific Reports.

2017 - Study ~ Pharmacological inhibition of cannabinoid receptor 1 stimulates gastric release of nesfatin-1 via the mTOR pathway.

World Journal of Gastroenterology.

2017 - Study ~ Hedonic eating in Prader-Willi syndrome is associated with blunted PYY secretion.

Food & Nutrition Journal.

2017 - Study ~ Cannabinoid Receptor Signaling in Central Regulation of Feeding Behavior: A MiniReview.

Frontiers in Neuroscience.

2017 - Study ~ Oral Administration of the Endocannabinoid Anandamide during Lactation: Effects on Hypothalamic Cannabinoid Type 1 Receptor and Food Intake in Adult Mice.

Journal of Nutrition and Metabolism.

2017 - Study ~ Inhibiting parabrachial fatty acid amide hydrolase activity selectively increases the intake of palatable food via cannabinoid CB1 receptors.

American Journal of Physiology.

2014 - Study ~ Dronabinol in severe, enduring anorexia nervosa: A randomized controlled trial

2014 - Study ~ Rimonabant's reductive effects on high densities of food reinforcement, but not palatability, in lean and obese Zucker rats.

2014 - Study ~ Cannabinoid type-1 Receptors in The Paraventricular Nucleus of The Hypothalamus Inhibit Stimulated Food Intake.

2014 - Study ~ The endocannabinoid system controls food intake via olfactory processes.

2014 - Study ~ Effect of intermittent cold exposure on brown fat activation, obesity, and energy homeostasis in mice.

2013 - Study ~ Ghrelin-Induced Orexigenic Effect in Rats Depends on the Metabolic Status and Is Counteracted by Peripheral CB1 Receptor Antagonism.

2013 - Study ~ Obesity-driven synaptic remodeling affects endocannabinoid control of orexinergic neurons

2013 - Study ~ Hypothalamic 2-Arachidonoylglycerol Regulates Multistage Process of High-Fat Diet Preferences

2013 - Study ~ Brain Molecules and Appetite: The Case of Oleoylethanolamide

2013 - Study ~ Effect of Diet on Tissue Levels of Palmitoylethanolamide

2013 - Study ~ Reduced Food Intake is the Major Contributor to the Protective Effect of Rimonabant on Islet in Established Obesity-Associated Type 2 Diabetes.

2013 - Study ~ The Gastric CB1 Receptor Modulates Ghrelin Production through the mTOR Pathway to Regulate Food Intake.

2013 - Study ~ Orexin neurons use endocannabinoids to break obesity-induced inhibition

2013 - Study ~ Developmental Role for Endocannabinoid Signaling in Regulating Glucose Metabolism and Growth.

2013 - Study ~ Effects of glucagon-like peptide-1 receptor stimulation and blockade on food
consumption and body weight in rats treated with a cannabinoid CB1 receptor agonist
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2013 - Study ~ Insulin induces long-term depression of ventral tegmental area dopamine neurons via endocannabinoids

2013 - Study ~ Cannabis and Δ(9)-tetrahydrocannabinol (THC) for weight loss?

2013 - Study ~ Taste sensitivity to 6-n-propylthiouracil is associated with endocannabinoid plasma levels in normal-weight individuals.

2013 - Study ~ Novel antiobesity agents: Synthesis and pharmacological evaluation of analogues of Rimonabant and of LH21.

2013 - Study ~ Endocannabinoid signaling in the gut mediates preference for dietary unsaturated fats.

2013 - Study ~ AM404 attenuates reinstatement of nicotine seeking induced by nicotine-associated cues and nicotine priming but does not affect nicotine- and food-taking.

2013 - Study ~ Endocannabinoid signaling in the gut mediates preference for dietary unsaturated fats.

2013 - Study ~ Long-term CB1 receptor blockade enhances vulnerability to anxiogenic-like effects of cannabinoids.

2013 - Study ~ Activation of the sympathetic nervous system mediates hypophagic and anxiety-like effects of CB1 receptor blockade.

2013 - Study ~ Fat to treat fat: Emerging relationship between dietary PUFA, endocannabinoids, and obesity.

2013 - Study ~ Activation of the sympathetic nervous system mediates hypophagic and anxiety-like effects of CB1 receptor blockade.

2013 - Study ~ Central functional response to the novel peptide cannabinoid, hemopressin.

2013 - Study ~ The inverse agonist of CB1 receptor SR141716 blocks compulsive eating of palatable food.

2013 - Study ~ Cannabinoid receptors and cholecystokinin in feeding inhibition.

2013 - Study ~ The endocannabinoid system in obesity

2013 - Study ~ Rimonabant precipitates anxiety in rats withdrawn from palatable food: role of the central amygdale.

2013 - Study ~ The satiety signal oleoylethanolamide stimulates oxytocin neurosecretion from rat hypothalamic neurons.

2013 - Study ~ The Role of the Endocannabinoid System in Eating Disorders: Neurochemical and Behavioural Preclinical Evidence.

2013 - Study ~ Therapeutic potential of cannabinoid medicines.

2013 - Study ~ Food for thought: hormonal, experiential, and neural influences on feeding and obesity.

2013 - Study ~ Cannabis withdrawal syndrome: An important diagnostic consideration in adolescents presenting with disordered eating.

2013 - Study ~ The regulation of food intake by the gut-brain axis: implications for obesity

2013 - Study ~ Cannabinoids, eating behaviour, and energy homeostasis.

2013 - Study ~ Concurrent pharmacological modification of cannabinoid-1 and glucagon-like peptide-1 receptor activity affects feeding behavior and body weight in rats fed a free-choice, high- carbohydrate diet.

2013 - Study ~ The regulation of food intake by the gut-brain axis: implications for obesity

2013 - Study ~ Cannabinoids, eating behaviour, and energy homeostasis.

2013 - Study ~ Concurrent pharmacological modification of cannabinoid-1 and glucagon-like peptide-1 receptor activity affects feeding behavior and body weight in rats fed a free-choice, high-carbohydrate diet.

2012 - Study ~ Hypothalamic 2-arachidonoylglycerol regulates multistage process of high-fat diet preferences.

2012 - Study ~ Contrasting effects of different cannabinoid receptor ligands on mouse ingestive behavior.

2012 - Study ~ Noladin ether, a putative endocannabinoid, enhances motivation to eat after acute systemic administration in rats.

2012 - Study ~ Effects of the anandamide uptake blocker AM404 on food intake depend on feeding status and route of administration.

2012 - Study ~ Rimonabant eliminates responsiveness to workload changes in a time-constrained food-reinforced progressive ratio procedure in rats.

2012 - Study ~ Cannabinol and cannabidiol exert opposing effects on rat feeding patterns.

2012 - Study ~ The potential use of cannabidiol in the therapy of metabolic syndrome.

2012 - Study ~ The thrifty lipids: endocannabinoids and the neural control of energy conservation.

2012 - Study ~ Stimulation of acumbens shell cannabinoid CB(1) receptors by noladin ether, a putative endocannabinoid, modulates food intake and dietary selection in rats.

2012 - Study ~ Photoperiodic Changes in Endocannabinoid Levels and Energetic Responses to Altered Signalling at CB1 Receptors in Siberian Hamsters.

2012 - Study ~ The role of the endocannabinoid system in eating disorders: pharmacological implications.

2012 - Study ~ Hypothalamic CB1 Cannabinoid Receptors Regulate Energy Balance in Mice.

2012 - Study ~ 2-Arachidonoylglycerol Signaling in Forebrain Regulates Systemic Energy Metabolism.

2012 - Study ~ GPR119 as a fat sensor.

2012 - Study ~ Non-Δ⁹tetrahydrocannabinol phytocannabinoids stimulate feeding in rats.

2012 - Study ~ Structural analogs of pyrazole and sulfonamide cannabinoids: Effects on acute food intake in mice.

2012 - Study ~ Cannabinoid Type 1 Receptor Gene Polymorphism and Macronutrient Intake.

2012 - Study ~ The therapeutic potential of cannabis and cannabinoids.

2012 - Study ~ Simultaneous postprandial deregulation of the orexigenic endocannabinoid anandamide and the anorexigenic peptide YY in obesity

2012 - Study ~ Pharmacological modulation of the endocannabinoid signalling alters binge-type eating behaviour in female rats

2011 - Study ~ Delta-9-tetrahydrocannabinol may palliate altered chemosensory perception in cancer patients: results of a randomized, double-blind, placebo-controlled pilot trial.

2011 - Study ~ Cannabidiol inhibits the hyperphagia induced by cannabinoid-1 or serotonin-1A receptor agonists.

2011 - Study ~ Cannabidiol decreases body weight gain in rats: Involvement of CB2 receptors.

2011 - Study ~ Cannabis sativa and the endogenous cannabinoid system: therapeutic potential for appetite regulation.

2011 - Study ~ The neutral cannabinoid CB₁ receptor antagonist AM4113 regulates body weight through changes in energy intake in the rat.

2011 - Study ~ Cannabidiol potentiates Δ(9)-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats.

2011 - Study ~ Fish oil promotes survival and protects against cognitive decline in severely undernourished mice by normalizing satiety signals.

2011 - Study ~ Non-Δ9tetrahydrocannabinol phytocannabinoids stimulate feeding in rats.

2011 - Study ~ Increment of hypothalamic 2-arachidonoylglycerol induces the preference for a high-fat diet via activation of cannabinoid 1 receptors.

2011 - Study ~ Cannabinoids in children.

2011 - Study ~ Gut fat sensing in the negative feedback control of energy balance--recent advances.

2011 - Anecdotal ~ Father: Medical marijuana eased pain of my cancer-battling son.

2010 - Study ~ The fat-induced satiety factor oleoylethanolamide suppresses feeding through central release of oxytocin.

2010 - Study ~ The multiple functions of the endocannabinoid system: a focus on the regulation of food intake.

2010 - Study ~ Expression of cannabinoid CB1 receptors by vagal afferent neurons: kinetics and role in influencing neurochemical phenotype.

2010 - Study ~ CD36 gene deletion decreases oleoylethanolamide levels in small intestine of free-feeding mice.

2010 - Study ~ Cannabis constituents modulate δ9-tetrahydrocannabinol-induced hyperphagia in rats.

2010 - Study ~ A nonsynonymous polymorphism in cannabinoid CB2 receptor gene is associated with eating disorders in humans and food intake is modified in mice by its ligands.

2010 - Study ~ Cannabidiol Attenuates the Appetitive Effects of Δ9-Tetrahydrocannabinol in Humans Smoking Their Chosen Cannabis.

2010 - Study ~ Oleoylethanolamide affects food intake and sleep-waking cycle through a hypothalamic modulation.

2010 - Study ~ PP-014 Control of receptor expression in vagal afferent neurons by activation of cannabinoid 1 receptors.

2010 - Study ~ Bimodal control of stimulated food intake by the endocannabinoid system.

2010 - Study ~ Anandamide and AM251, via water, modulate food intake at central and peripheral level in fish.

2010 - Study ~ Analysis of gene expression pattern reveals potential targets of dietary oleoylethanolamide in reducing body fat gain in C3H mice.

2010 - Study ~ A low-Δ9tetrahydrocannabinol cannabis extract induces hyperphagia in rats.

2010 - Study ~ Deficiency of CB2 cannabinoid receptor in mice improves insulin sensitivity but increases food intake and obesity with age.

2010 - Study ~ The endocannabinoid system modulates the valence of the emotion associated to food ingestion.

2010 - Study ~ Efficacy and tolerability of high-dose dronabinol maintenance in HIV-positive marijuana smokers: a controlled laboratory study.

2009 - Study ~ Endocannabinoids selectively enhance sweet taste.

2009 - Study ~ Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice.

2009 - Study ~ GPR119 is essential for oleoylethanolamide-induced glucagon-like peptide-1 secretion from the intestinal enteroendocrine L-cell.

2009 - Study ~ Endocannabinoids and Their Receptors as Targets for Obesity Therapy.

2009 - Study ~ Bidirectional regulation of novelty-induced behavioral inhibition by the endocannabinoid system.

2009 - Study ~ Endogenous cannabinoid signalling and energy balance.

2009 - Study ~ N-acylethanolamines, anandamide and food intake.

2009 - Study ~ Cannabinoids and appetite: food craving and food pleasure.

2009 - Study ~ Effects of cannabinoid drugs on the reinforcing properties of food in gestationally undernourished rats.

2009 - Study ~ Role of cannabinoid CB1 receptors on macronutrient selection and satiety in rats.

2008 - Study ~ Cannabinoids enhance gastric X/A-like cells activity.

2008 - Study ~ The lipid messenger OEA links dietary fat intake to satiety.

2008 - Study ~ Targeted enhancement of oleoylethanolamide production in proximal small intestine induces across-meal satiety in rats.

2008 - Study ~ Feeding induced by cannabinoids is mediated independently of the melanocortin system.

2008 - Study ~ Activating Parabrachial Cannabinoid CB1 Receptors Selectively Stimulates Feeding of Palatable Foods in Rats.

2008 - Study ~ Endocannabinoids and the Control of Energy Homeostasis.

2008 - Study ~ The role of endocannabinoids in the regulation of gastric emptying: alterations in mice fed a high-fat diet.

2008 - Study ~ Endocannabinoids and the neurochemistry of gluttony.

2008 - Study ~ Biological functions and metabolism of oleoylethanolamide.

2008 - Study ~ Inhibitory effect of the anorexic compound oleoylethanolamide on gastric emptying in control and overweight mice.

2008 - Study ~ Behavioral effects of CB2 cannabinoid receptor activation and its influence on food and alcohol consumption.

2008 - Study ~ Role of endocannabinoids and their analogues in obesity and eating disorders.

2007 - Study ~ The endogenous cannabinoid system: a new player in the brain-gut-adipose axis.

2007 - Study ~ Cannabinol induced hyperphagia: correlation with inhibition of proopiomelaanocortin neutrons.

2007 - Study ~ Endocannabinoid hedonic hotspot for sensory pleasure: anandamide in nucleus accumbens shell enhances 'liking' of a sweet reward.

2007 - Study - Dronabinol an effective appetite stimulant.

2007 - Study ~ Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c-Fos expression in the hypothalamus.

2007 - Study - THC improves appetite and reverses weight loss in AIDS patients.

2007 - Study - Efficacy of dronabinol alone and in combination with ondansetron versus ondansetron alone for delayed chemotherapy-induced nausea and vomiting.

2007 - Study - Dronabinol and marijuana in HIV-positive marijuana smokers: caloric intake, mood, and sleep.

2007 - Study ~ Anorexia of aging in long term care: is dronabinol an effective appetite stimulant? A pilot study.

2006 - Study - Cancer related anorexia cachexia syndrome.

2006 - Study - The synthetic cannabinoid nabilone improves pain and symptom management in cancer patients.

2006 - Study -Dronabinol for supportive therapy in patients with malignant melanoma and liver metastases.

2006 - Study ~ Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled clinical trial from the Cannabis-In-Cachexia-Study-Group.

2006 - Study ~ Lack of tolerance to the suppressing effect of rimonabant on chocolate intake in rats.

2006 - Study ~ Effect of a cannabinoid agonist on gastrointestinal transit and postprandial satiation in healthy human subjects: a randomized, placebo-controlled study.

2006 - Study ~ Methods evaluating cannabinoid and endocannabinoid effects on gastrointestinal functions.

2005 - Study ~ Endocannabinoids and food intake: newborn suckling and appetite regulation in adulthood.

2005 - Study ~ Food for thought: endocannabinoid modulation of lipogenesis.

2005 - Study ~ Endocannabinoids in the Regulation of Appetite and Body Weight.

2005 - Study ~ Cannabinoids augment the release of neuropeptide Y in the rat hypothalamus.

2005 - Study ~ Effects of the endocannabinoid noladin ether on body weight, food consumption, locomotor activity, and cognitive index in mice.

2004 - Study ~ Endocannabinoids: Getting the message across.

2004 - Study ~ Very low doses of delta 8-THC increase food consumption and alter neurotransmitter levels following weight loss.

2004 - Study ~ Overeating, Alcohol and Sucrose Consumption Decrease in Cb1 Receptor Deleted Mice.

2003 - Study - Safety and efficacy of dronabinol in the treatment of agitation in patients with Alzheimer's disease.

2003 - Study ~ The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis.

2003 - Study ~ Endogenous cannabinoid system as a modulator of food intake.

2003 - Study ~ The cannabinoid system: a role in both the homeostatic and hedonic control of eating?

2003 - Study ~ Short-term fasting and prolonged semistarvation have opposite effects on 2-AG levels in mouse brain.

2002 - Study ~ A Peripheral Mechanism for CB1 Cannabinoid Receptor-Dependent Modulation of Feeding.

2002 - Study ~ Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol.

2001 - Study - Therapeutic Aspects of Cannabis and Cannabinoids.

2001 - Study ~ Dietary intake and nutritional status of US adult marijuana users: results from the Third National Health and Nutrition Examination Survey.

2001 - Study ~ Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats.

2001 - Study ~ Neuroprotection by Delta 9-Tetrahydrocannabinol, the Main Active Compound in Marijuana, against Ouabain-Induced In Vivo Excitotoxicity.

2001 - Letter ~ Leptin-regulated endocannabinoids are involved in maintaining food intake.

2000 - Study - Immunoactive cannabinoids: Therapeutic prospects for marijuana constituents.

2000 - Study ~ Low dose anandamide affects food intake, cognitive function, neurotransmitter and corticosterone levels in diet-restricted mice.

1997 - Study - The perceived effects of smoked cannabis on patients with multiple sclerosis.

1997 - Study - Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer's disease.

1995 - Study - Dronabinol as a treatment for anorexia associated with weight loss in patients with AIDS.

1994 - Study - Delta-9-tetrahydrocannabinol for appetite stimulation in cancer-associated anorexia.

1994 - Study - Cannabinoids and appetite stimulation.

1993 - Study - Effect of dronabinol on nutritional status in HIV infection.

1992 - Study - Dronabinol stimulates appetite and causes weight gain in HIV patients.

1992 - Study - Dronabinol effects on weight in patients with HIV infection.

1991 - Study - Recent clinical experience with dronabinol.

1990 - Study - Dronabinol enhancement of appetite in cancer patients.

1988 - Study - Effects of smoked marijuana on food intake and body weight.

1986 - Study - Behavioral analysis of marijuana effects on food intake in humans.

1982 - Study ~ Anorexia and hyperphagia produced by five pharmacologic classes of hallucinogens.

1976 - Study ~ Marihuana use. Biologic and behavioral aspects.

1972 - Study - Factors influencing the aggressiveness elicited by marihuana in food-deprived rats.