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 Is Cannabis An Appetite Stimulant?

Overview

Usually hunger enhancement is considered an undesirable side effect of certain drugs as it leads to unwanted weight gain, but sometimes it can be beneficial and cannabis may be prescribed solely for this purpose, especially when the patient is suffering from severe hunger loss or muscle wasting due to cystic fibrosis, anorexia, old age, cancer or AIDS.

There are several medications including cannabis, which can cause a boost in hunger. Tricyclic antidepressants (TCAs), tetracyclic antidepressants, natural or synthetic cannabinoids, first-generation antihistamines, most antipsychotics and many steroid hormones. source wikipedia

Cannabis Science & Medical Research Articles

2020 - Abstract ~ Effects of oral, smoked, and vaporized cannabis on endocrine pathways related to appetite and metabolism: a randomized, double-blind, placebo-controlled, human laboratory study.

Journal: Transnational Psychiatry.


2020 - Abstract ~ An Open-Label Pilot Study Testing the Feasibilityof Assessing Total Symptom Burden in Trialsof Cannabinoid Medications in Palliative Care.

Journal: Journal of Pallative Medicine.


2020 - Abstract ~ Pharmacists and the future of cannabis medicine.

Journal: Journal of the American Pharmacists Association.


2018 - Abstract ~ Hunger, ghrelin and the gut.

Journal: Brain Research.


2018 - Abstract ~ Salivary endocannabinoids and N-acylethanolamines upon mastication of a semisolid food: implications in fat taste, appetite and food liking.

Journal: Journal of Food & Function.


2017 - Study ~ Role of Endocannabinoids on Sweet Taste Perception, Food Preference, and Obesity related Disorders.

Journal: Oxford Academic- Chemical Senses.


2017 - Abstract ~ Are cannabinoids an alternative for cachexia-anorexia syndrome in patients with advanced cancer?

Journal: Medwave.


2017 - Abstract ~ Cannabinoids for the treatment of neuropsychiatric symptoms, pain and weight loss in dementia.
Journal: Current Opinion in Psychiatry.


2017 - Abstract ~ Anorexigenic effects induced by RVD-hemopressin(α) administration.

Journal: Pharmacological Reports.

2017 - Abstract ~ A behavioral and pharmacological characterization of palatable diet alternation in mice.

Journal: Pharmacology Biochemistry and Behavior.


2017 - Abstract ~ Consequence of dopamine D2 receptor blockade on the hyperphagic effect induced by cannabinoid CB1 and CB2 receptors in layers.

Journal: British Poultry Science.


2017 - Abstract ~ 2-Arachidonoylglycerol as a possible treatment for anorexia nervosa in animal model in mice.

Journal: Brain Research Journal.


2017 - Abstract ~ Endocannabinoid-dependent disinhibition of orexinergic neurons: Electrophysiological evidence in leptin-knockout obese mice.

Journal: Molecular Metabolism.


2017 - Abstract ~ Endocannabinoid modulation of homeostatic and non-homeostatic feeding circuits.

Journal: Neuropharmacology Journal.


2017 - Abstract ~ Effects of anandamide administration on components of reward processing during free choice.

Journal: Pharmacology Biochemistry and Behavior.

2017 - Abstract ~ The rewarding effects of ethanol are modulated by binge eating of a high-fat diet during adolescence.

Journal: Neuropharmacology Journal.


2017 - Abstract ~ Cannabinoids activate monoaminergic signaling to modulate key C. elegans behaviors.

Journal: JNeurosci- The Journal of Neuroscience.


2017 - Abstract ~ A cannabigerol-rich Cannabis sativa extract, devoid of [INCREMENT]9- tetrahydrocannabinol, elicits hyperphagia in rats.

Journal: Behavioral Pharmacology Journal.


2017 - Abstract ~ Peripheral endocannabinoid signaling controls hyperphagia in western diet-induced obesity.

Journal: Physiology & Behavior Journal.


2017 - Study ~ Central and peripheral control of food intake.

Journal: Endocrine Regulations Journal.


2017 - Study ~ A cannabinoid receptor antagonist attenuates ghrelin-induced activation of the mesolimbic dopamine system in mice.

Journal: Physiology & Behavior Journal.


2017 - Study ~ Blockade of CB1 cannabinoid receptor alters gut microbiota and attenuates inflammation and diet-induced obesity.

Journal: Nature Publishing: Scientific Reports.


2017 - Study ~ Pharmacological inhibition of cannabinoid receptor 1 stimulates gastric release of nesfatin-1 via the mTOR pathway.

Journal: World Journal of Gastroenterology.


2017 - Study ~ Hedonic eating in Prader-Willi syndrome is associated with blunted PYY secretion.

Journal: Food & Nutrition Journal.


2017 - Study ~ Cannabinoid Receptor Signaling in Central Regulation of Feeding Behavior: A MiniReview.

Journal: Frontiers in Neuroscience.


2017 - Study ~ Oral Administration of the Endocannabinoid Anandamide during Lactation: Effects on Hypothalamic Cannabinoid Type 1 Receptor and Food Intake in Adult Mice.

Journal: Journal of Nutrition and Metabolism.


2017 - Study ~ Inhibiting parabrachial fatty acid amide hydrolase activity selectively increases the intake of palatable food via cannabinoid CB1 receptors.

Journal: American Journal of Physiology.


2014 - Study ~ Dronabinol in severe, enduring anorexia nervosa: A randomized controlled trial.
Journal: International Journal of Eating Disorders.


2014 - Study ~ Rimonabant's reductive effects on high densities of food reinforcement, but not palatability, in lean and obese Zucker rats.

Journal: Psychopharmacology.


2014 - Study ~ Cannabinoid type-1 Receptors in The Paraventricular Nucleus of The Hypothalamus Inhibit Stimulated Food Intake.

Journal: Neuroscience.


2014 - Study ~ The endocannabinoid system controls food intake via olfactory processes.

Journal: Nature Neuroscience.


2014 - Study ~ Effect of intermittent cold exposure on brown fat activation, obesity, and energy homeostasis in mice.

Journal: PloS One.


2013 - Study ~ Ghrelin-Induced Orexigenic Effect in Rats Depends on the Metabolic Status and Is Counteracted by Peripheral CB1 Receptor Antagonism.
Journal: PloS One.


2013 - Study ~ Obesity-driven synaptic remodeling affects endocannabinoid control of orexinergic neurons.

Journal: Proceedings of the National Acadamy of Sciences of the USA.


2013 - Study ~ Hypothalamic 2-Arachidonoylglycerol Regulates Multistage Process of High-Fat Diet Preferences.
Journal: PloS One.


2013 - Study ~ Brain Molecules and Appetite: The Case of Oleoylethanolamide.

Journal: Central Nervous System Agents.


2013 - Study ~ Effect of Diet on Tissue Levels of Palmitoylethanolamide.
Journal: CNS & Neurological Disorders - Drug Targets.


2013 - Study ~ Reduced Food Intake is the Major Contributor to the Protective Effect of Rimonabant on Islet in Established Obesity-Associated Type 2 Diabetes.

Journal: Yonsei Medica Journal.


2013 - Study ~ The Gastric CB1 Receptor Modulates Ghrelin Production through the mTOR Pathway to Regulate Food Intake.
Journal: PloS One.


2013 - Study ~ Orexin neurons use endocannabinoids to break obesity-induced inhibition.

Journal: Proceedings of the National Acadamy of Sciences of the USA.


2013 - Study ~ Developmental Role for Endocannabinoid Signaling in Regulating Glucose Metabolism and Growth.

Journal: American Diabetis Association.


2013 - Study ~ Effects of glucagon-like peptide-1 receptor stimulation and blockade on food
consumption and body weight in rats treated with a cannabinoid CB1 receptor agonist
WIN 55,212-2

Journal: Medical Science Monitor Basic Research.


2013 - Study ~ Insulin induces long-term depression of ventral tegmental area dopamine neurons via endocannabinoids.

Journal: Nature Neurosscience.


2013 - Study ~ Cannabis and Δ(9)-tetrahydrocannabinol (THC) for weight loss?

Journal: Medical Hypothisis.


2013 - Study ~ Taste sensitivity to 6-n-propylthiouracil is associated with endocannabinoid plasma levels in normal-weight individuals.

Journal: Nutrition.


2013 - Study ~ Novel antiobesity agents: Synthesis and pharmacological evaluation of analogues of Rimonabant and of LH21.

Journal: Bio-organic Medical Chemistry.


2013 - Study ~ Endocannabinoid signaling in the gut mediates preference for dietary unsaturated fats.

Journal: Federation of American Societies for Experimental Biology.


2013 - Study ~ AM404 attenuates reinstatement of nicotine seeking induced by nicotine-associated cues and nicotine priming but does not affect nicotine- and food-taking.

Journal: Journal of Psychopharmacology.


2013 - Study ~ Endocannabinoid signaling in the gut mediates preference for dietary unsaturated fats.

Journal: Federation of American Societies for Experimental Biology.


2013 - Study ~ Long-term CB1 receptor blockade enhances vulnerability to anxiogenic-like effects of cannabinoids.

Journal: Neuropharmacology.


2013 - Study ~ Activation of the sympathetic nervous system mediates hypophagic and anxiety-like effects of CB1 receptor blockade.

Journal: Proceedings of the National Acadamy of Sciences of the USA.


2013 - Study ~ Fat to treat fat: Emerging relationship between dietary PUFA, endocannabinoids, and obesity.

Journal: Prostaglandins and Other Lipid Mediators.


2013 - Study ~ Activation of the sympathetic nervous system mediates hypophagic and anxiety-like effects of CB1 receptor blockade.

Journal: Proceedings of the National Acadamy of Sciences of the USA.


2013 - Study ~ Central functional response to the novel peptide cannabinoid, hemopressin.

Journal: Neuropharmacology.


2013 - Study ~ The inverse agonist of CB1 receptor SR141716 blocks compulsive eating of palatable food.

Journal: Addiction Biology.


2013 - Study ~ Cannabinoid receptors and cholecystokinin in feeding inhibition.

Journal: Vitamins and Hormones.


2013 - Study ~ The endocannabinoid system in obesity.

Journal: Revue Medicale Suisse.


2013 - Study ~ Rimonabant precipitates anxiety in rats withdrawn from palatable food: role of the central amygdale.

Journal: Neuropsychopharmacology.

2013 - Study ~ The satiety signal oleoylethanolamide stimulates oxytocin neurosecretion from rat hypothalamic neurons.

Journal: Peptides.


2013 - Study ~ The Role of the Endocannabinoid System in Eating Disorders: Neurochemical and Behavioural Preclinical Evidence.

Journal: Current Pharmaceutical Design.


2013 - Study ~ Therapeutic potential of cannabinoid medicines.

Journal: Drug Testing and Analysis.


2013 - Study ~ Food for thought: hormonal, experiential, and neural influences on feeding and obesity.

Journal: The Journal of Neuroscience.


2013 - Study ~ Cannabis withdrawal syndrome: An important diagnostic consideration in adolescents presenting with disordered eating.

Journal: The International Journal of Eating Disorders.


2013 - Study ~ Cannabinoids, eating behaviour, and energy homeostasis.

Journal: Drug Testing and Analysis.


2013 - Study ~ Concurrent pharmacological modification of cannabinoid-1 and glucagon-like peptide-1 receptor activity affects feeding behavior and body weight in rats fed a free-choice, high- carbohydrate diet.

Journal: Behavioural Pharmacology.


2013 - Study ~ Cannabinoids, eating behaviour, and energy homeostasis.

Journal: Drug Testing and Analysis.


2013 - Study ~ Concurrent pharmacological modification of cannabinoid-1 and glucagon-like peptide-1 receptor activity affects feeding behavior and body weight in rats fed a free-choice, high-carbohydrate diet.

Journal: Behavioural Pharmacology.


2012 - Study ~ Hypothalamic 2-arachidonoylglycerol regulates multistage process of high-fat diet preferences.
Journal: PloS One.


2012 - Study ~ Contrasting effects of different cannabinoid receptor ligands on mouse ingestive behavior.

Journal: Behavioural Pharmacology.


2012 - Study ~ Noladin ether, a putative endocannabinoid, enhances motivation to eat after acute systemic administration in rats.

Journal: British Journal of Pharmacology.


2012 - Study ~ Effects of the anandamide uptake blocker AM404 on food intake depend on feeding status and route of administration.

Journal: Pharmacology, Biochemistry, and Behavior.


2012 - Study ~ Rimonabant eliminates responsiveness to workload changes in a time-constrained food-reinforced progressive ratio procedure in rats.

Journal: Pharmacology, Biochemistry, and Behavior.


2012 - Study ~ Cannabinol and cannabidiol exert opposing effects on rat feeding patterns.

Journal: Psychopharmacology.


2012 - Study ~ The potential use of cannabidiol in the therapy of metabolic syndrome.

Journal: Orvosi Hetilap.


2012 - Study ~ The thrifty lipids: endocannabinoids and the neural control of energy conservation.

Journal: Trends in Neurosciences.


2012 - Study ~ Stimulation of acumbens shell cannabinoid CB(1) receptors by noladin ether, a putative endocannabinoid, modulates food intake and dietary selection in rats.

Journal: Pharmacological Research.


2012 - Study ~ Photoperiodic Changes in Endocannabinoid Levels and Energetic Responses to Altered Signalling at CB1 Receptors in Siberian Hamsters.
Journal: Journal of Neuroendocrinology.


2012 - Study ~ The role of the endocannabinoid system in eating disorders: pharmacological implications.

Journal: Behavioral Pharmacology.


2012 - Study ~ Hypothalamic CB1 Cannabinoid Receptors Regulate Energy Balance in Mice.

Journal: Endocrinology.


2012 - Study ~ 2-Arachidonoylglycerol Signaling in Forebrain Regulates Systemic Energy Metabolism.

Journal: Cell Metabolism.


2012 - Study ~ GPR119 as a fat sensor.

Journal: Trends in Pharmacological Sciences.


2012 - Study ~ Non-Δ⁹tetrahydrocannabinol phytocannabinoids stimulate feeding in rats.

Journal: Behavioral Pharmacology.


2012 - Study ~ Structural analogs of pyrazole and sulfonamide cannabinoids: Effects on acute food intake in mice.

Journal: European Journal of Pharmacology.


2012 - Study ~ Cannabinoid Type 1 Receptor Gene Polymorphism and Macronutrient Intake.

Journal: Journal of Nutrigenics and Nutrigenomics.


2012 - Study ~ The therapeutic potential of cannabis and cannabinoids.

Journal: Deutsches Arzteblatt International.


2012 - Study ~ Pharmacological modulation of the endocannabinoid signalling alters binge-type eating behaviour in female rats.

Journal: British Journal of Pharmacology.


2011 - Study ~ Cannabidiol inhibits the hyperphagia induced by cannabinoid-1 or serotonin-1A receptor agonists.

Journal: Pharmacology, Biochemistry, and Behavior.


2011 - Study ~ Cannabis sativa and the endogenous cannabinoid system: therapeutic potential for appetite regulation.

Journal: Phytotherapy Research: PTR


2011 - Study ~ The neutral cannabinoid CB₁ receptor antagonist AM4113 regulates body weight through changes in energy intake in the rat.

Journal: Pharmacology, Biochemistry, and Behavior.


2011 - Study ~ Cannabidiol potentiates Δ(9)-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats.

Journal: Psychopharmacology. (Berlin)


2011 - Study ~ Fish oil promotes survival and protects against cognitive decline in severely undernourished mice by normalizing satiety signals.

Journal: Journal of Nutritional Biochemistry.


2011 - Study ~ Non-Δ9 tetrahydrocannabinol phytocannabinoids stimulate feeding in rats.

Journal: Behavioural Pharmacology.


2011 - Study ~ Cannabinoids in children.
Journal: Angewandte Schmerztherapie und Palliativmedizin.


2011 - Study ~ Gut fat sensing in the negative feedback control of energy balance--recent advances.

Journal: Physiology and Behavior.


2010 - Study ~ The fat-induced satiety factor oleoylethanolamide suppresses feeding through central release of oxytocin.

Journal: Journal of Neuroscience.


2010 - Study ~ The multiple functions of the endocannabinoid system: a focus on the regulation of food intake.

Journal: Diabetology & Metabolic Syndrome.


2010 - Study ~ Expression of cannabinoid CB1 receptors by vagal afferent neurons: kinetics and role in influencing neurochemical phenotype.

Journal: Gastrointestinal and Liver Physiology.


2010 - Study ~ CD36 gene decreases oleoylethanolamide levels in small intestine of free-feeding mice.

Journal: Department of Pharmacology. (California)


2010 - Study ~ Cannabis constituents modulate delta 9-tetrahydrocannabinol-induced hyperphagia in rats.

Journal: Phychopharmacology. (Berlin)


2010 - Study ~ A nonsynonymous polymorphism in cannabinoid CB2 receptor gene is associated with eating disorders in humans and food intake is modified in mice by its ligands.

Journal: Synapse. (New York)


2010 - Study ~ Oleoylethanolamide affects food intake and sleep-waking cycle through a hypothalamic modulation.

Journal: Pharmacological Research.


2010 - France - Study ~ Bimodal control of stimulated food intake by the endocannabinoid system.

Journal: Nature Neuroscience.


2010 - Italy - Study ~ Anandamide and AM251, via water, modulate food intake at central and peripheral level in fish.

Journal: General and Comparative Endocrinology.


2010 - France - Abstract ~ Analysis of gene expression pattern reveals potential targets of dietary oleoylethanolamide in reducing body fat gain in C3H mice.

Journal: The Journal of Nutritional Biochemistry.


2010 - United Kingdom - Abstract ~ A low- delta 9 tetrahydrocannabinol cannabis extract induces hyperphagia in rats.

Journal: Behavioural Pharmacology.


2010 - United Kingdom - Abstract ~ The endocannabinoid system modulates the valence of the emotion associated to food ingestion.

Journal: Society for the Study of Addiction.


2010 - Study ~ Efficacy and tolerability of high-dose dronabinol maintenance in HIV-positive marijuana smokers: a controlled laboratory study.

Journal: Psychopharmacology.


2009 - Study ~ Endocannabinoids selectively enhance sweet taste.

Journal: British Journal of Pharmacology.


2009 - Study ~ Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice.

Journal: American Diabetes Association.


2009 - Study ~ Bidirectional regulation of novelty-induced behavioral inhibition by the endocannabinoid system.

Journal: Neuropharmacology.


2009 - Study ~ N-acylethanolamines, anandamide and food intake.

Journal: Biochemical Pharmacology.


2009 - Study ~ Cannabinoids and appetite: food craving and food pleasure.

Journal: International Review of Psychiatry.


2009 - Study ~ Effects of cannabinoid drugs on the reinforcing properties of food in gestationally undernourished rats.

Journal: Pharmacology, Biochemistry, and Behavior.


2009 - Study ~ Role of cannabinoid CB1 receptors on macronutrient selection and satiety in rats.

Journal: Physiology, and Behavior.


2008 - Study ~ Targeted enhancement of oleoylethanolamide production in proximal small intestine induces across-meal satiety in rats.

Journal:


2008 - Study ~ Feeding induced by cannabinoids is mediated independently of the melanocortin system.

Journal: Regulatory, Integrative and Comparative Physiology.


2008 - Study ~ Activating Parabrachial Cannabinoid CB1 Receptors Selectively Stimulates Feeding of Palatable Foods in Rats.

Journal: JNeurosci (The Journal of Neuroscience)


2008 - Study ~ Endocannabinoids and the Control of Energy Homeostasis.

Journal: Journal of Biological Chemistry.


2008 - Study ~ The role of endocannabinoids in the regulation of gastric emptying: alterations in mice fed a high-fat diet.

Journal: British Journal of Pharmacology.


2008 - Study ~ Biological functions and metabolism of oleoylethanolamide.

Journal: Lipids. Journal of Molecular Medicine.


2008 - Study ~ Inhibitory effect of the anorexic compound oleoylethanolamide on gastric emptying in control and overweight mice.

Journal: Journal of Molecular Medicine.


2008 - Study ~ Behavioral effects of CB2 cannabinoid receptor activation and its influence on food and alcohol consumption.

Journal: Annals of the New York Acadamy of Sciences.


2008 - Study ~ Role of endocannabinoids and their analogues in obesity and eating disorders.

Journal: Eating and Weight Disorders (EWD)


2007 - Study ~ The endogenous cannabinoid system: a new player in the brain-gut-adipose axis.

Journal: Behavioral Sciences and Molecular Biology.


2007 - Study ~ Cannabinol induced hyperphagia: correlation with inhibition of proopiomelaanocortin neutrons.

Journal: Physiology Behavior.


2006 - Study ~ Lack of tolerance to the suppressing effect of rimonabant on chocolate intake in rats.
Journal: Psychopharmacology.


2006 - Study ~ Effect of a cannabinoid agonist on gastrointestinal transit and postprandial satiation in healthy human subjects: a randomized, placebo-controlled study.
Journal: Brain Research Bulletin.


2006 - Study ~ Methods evaluating cannabinoid and endocannabinoid effects on gastrointestinal functions.

Journal: Methods in Molecular Medicine.


2005 - Study ~ Cannabinoids augment the release of neuropeptide Y in the rat hypothalamus.

Journal: Brain Research Bulletin.


2005 - Study ~ Effects of the endocannabinoid noladin ether on body weight, food consumption, locomotor activity, and cognitive index in mice.
Journal: Neuropharmacology.


2004 - Study ~ Very low doses of delta 8-THC increase food consumption and alter neurotransmitter levels following weight loss.

Journal: Pharmacology, Biochemistry, and Behavior.


2003 - Study ~ The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis.
Journal: The Journal of Clinical Investigation.


2003 - Study ~ The cannabinoid system: a role in both the homeostatic and hedonic control of eating?
Journal: British Journal of Nutrition.


2003 - Study ~ Short-term fasting and prolonged semistarvation have opposite effects on 2-AG levels in mouse brain.
Journal: Brain Research.


Journal: European Jourmal of Pharmacology.

2002 - Study ~ A Peripheral Mechanism for CB1 Cannabinoid Receptor-Dependent Modulation of Feeding.

Journal: JNeurosci (The Journal of Neuroscience)


2001 - Study - Therapeutic Aspects of Cannabis and Cannabinoids.

Journal: British Jourmal of Pharmacology.


2001 - Study ~ Dietary intake and nutritional status of US adult marijuana users: results from the Third National Health and Nutrition Examination Survey.

Journal: Public Health Nutrition.


2001 - Study ~ Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats.

Journal: British Jourmal of Pharmacology.


2001 - Study ~ Neuroprotection by Delta 9-Tetrahydrocannabinol, the Main Active Compound in Marijuana, against Ouabain-Induced In Vivo Excitotoxicity.
Journal: JNeurosci (The Journal of Neuroscience)


2000 - Study ~ Low dose anandamide affects food intake, cognitive function, neurotransmitter and corticosterone levels in diet-restricted mice.

Journal: European Jourmal of Pharmacology.


Journal: Nutrition Research Reviews.


1994 - Study - Cannabinoids and appetite stimulation.
Journal: Pharmacology, Biochemistry, and Behavior.


1982 - Study ~ Anorexia and hyperphagia produced by five pharmacologic classes of hallucinogens.

Journal: Pharmacology, Biochemistry, and Behavior.


1976 - Study ~ Marihuana use. Biologic and behavioral aspects.

Journal: Postgraguate Medicine.


1972 - Study - Factors influencing the aggressiveness elicited by marihuana in food-deprived rats.

Journal: British Jourmal of Pharmacology.


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