CRA-Z 

Medical Hypotheses.

2017 - Study ~ Beta-caryophyllene protects against alcoholic steatohepatitis by attenuating inflammation and metabolic dysregulation in mice.

2017 - Study ~ URB597 and the Cannabinoid WIN55,212-2 Reduce Behavioral and Neurochemical Deficits Induced by MPTP in Mice: Possible Role of Redox Modulation and NMDA
Receptors.

Neurotoxicity Research.

2017 - Study ~ N-acylethanolamine-hydrolyzing acid amidase and fatty acid amide hydrolase inhibition differentially affect N-acylethanolamine levels and macrophage activation.

2017 - Study ~ Serum endocannabinoids and N-acyl ethanolamines and the influence of simulated solar UVR exposure in humans in vivo.

2017 - Study ~ Endocannabinoid 2-arachidonoylglycerol protects inflammatory insults from sulfur dioxide inhalation via cannabinoid receptors in the brain.

2017 - Study ~ Cannabinoids: Possible agents for treatment of psoriasis via suppression of angiogenesis and inflammation.

Medical Hypotheses.

2017 - Study ~ Involvement of the endocannabinoid system in the physiological response to transient common carotid artery occlusion and reperfusion.

2017 - Study ~ Compensatory Activation of Cannabinoid CB2 Receptor Inhibition of GABA Release in the Rostral Ventromedial Medulla in Inflammatory Pain.

JNeurosci: The Journal of Neuroscience.

2017 - Study ~ Targeting Cutaneous Cannabinoid Signaling in Inflammation - A “High”-way to Heal?

EBioMedicine.

2017 - Study ~ WWL70 attenuates PGE2 production derived from 2-arachidonoylglycerol in

microglia by ABHD6-independent mechanism.

2016 - Study ~ The role of perivascular adipose tissue in obesity-induced vascular dysfunction.
British Journal of Pharmacology.

2016 - Study ~ Anti-inflammatory and antioxidant effects of a combination of cannabidiol and moringin in LPS-stimulated macrophages.

2016 - Study ~ Mn-SOD Upregulation by Electroacupuncture Attenuates Ischemic Oxidative Damage via CB1R-Mediated STAT3 Phosphorylation.
Molecular Neurobiology.

2016 - Study ~ β-Caryophyllene, a natural sesquiterpene lactone attenuates hyperglycemia

mediated oxidative and inflammatory stress in experimental diabetic rats.

2016 - Study ~ Cannabidiol attenuates OGD/R-induced damage by enhancing mitochondrial
bioenergetics and modulating glucose metabolism via pentose-phosphate pathway in
hippocampal neurons.

2016 - Study ~ Cannabinoid Type 2 (CB2) Receptors Activation Protects against Oxidative Stress and Neuroinflammation Associated Dopaminergic Neurodegeneration in Rotenone Model of Parkinson's Disease.

Frontiers in Neuroscience.

2016 - Study ~ Cannabidiol Prevents Motor and Cognitive Impairments Induced by Reserpine in Rats.

Frontiers in Pharmacology: Neuropharmacology.

2016 - Study ~ Delta-9-tetrahydrocannabinol protects against MPP+ toxicity in SH-SY5Y cells by restoring proteins involved in mitochondrial biogenesis.
Oncotarget.

2016 - Study ~ Inflammation of peripheral tissues and injury to peripheral nerves induce diferring effects in the expression of the calcium-sensitive anandamide-synthesising enzyme and related molecules in rat primary sensory neurons.

The Journal of Comparative Neurology.

2015 - Study ~ Effect of Cannabis sativa extract on gastric acid secretion, oxidative stress and

gastric mucosal integrity in rats.
Comparative Clinical Pathology.

2014 - Study ~ Endocannabinoid degradation inhibition improves neurobehavioral function, blood brain barrier integrity, and neuroinflammation following mild traumatic brain injury.

Journal of Neurotrauma.

2014 - Study ~ The endocannabinoid system: an emerging key player in inflammation.

2014 - Study ~ Trans-Caryophyllene Suppresses Hypoxia-Induced Neuroinflammatory Responses by Inhibiting NF-κB Activation in Microglia.

2014 - Study ~ Endocannabinoids affect innate immunity of Muller glia during HIV-1 Tat cytotoxicity.

2013 - Study ~ Molecular evidence for the involvement of PPAR-δ and PPAR-γ in anti-inflammatory and neuroprotective activities of palmitoylethanolamide after spinal cord trauma

2013 - Study ~ The cannabinoid receptor type 2 as mediator of mesenchymal stromal cell immunosuppressive properties.

2013 - Study ~ Monoacylglycerol Lipase (MAGL) Inhibition Attenuates Acute Lung Injury in Mice.

2013 - Study ~ The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model.

2013 - Study ~ The cannabinoid CB2 receptor-selective phytocannabinoid beta-caryophyllene exerts analgesic effects in mouse models of inflammatory and neuropathic pain

2013 - Study ~ The Dual Effect of Cannabinoid Receptor-1 Deficiency on the Murine Postoperative Ileus

2013 - Study ~ Effects on Immune Cells of a New 1,8-Naphthyridin-2-One Derivative and Its Analogues as Selective CB2 Agonists: Implications in Multiple Sclerosis

2013 - Study ~ Glia and Mast Cells as Targets for Palmitoylethanolamide, an Anti-inflammatory and Neuroprotective Lipid Mediator.

2013 - Study ~ Cannabinoid receptor modulation of the endothelial cell inflammatory response

2013 - Study ~ Cannabinoid CB2 receptors as novel target for inhibiting house dust mite induced allergic airway inflammation

2013 - Study ~ Palmitoylethanolamide is a New Possible Pharmacological Treatment for the Inflammation Associated with Trauma

2013 - Study ~ Amyotrophic Lateral Sclerosis Treatment with Ultramicronized Palmitoylethanolamide

2013 - Study ~ Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: A role for A2A receptors.

2013 - Study ~ Controlling 2-arachidonoylglycerol metabolism as an anti-inflammatory strategy.

2013 - Study ~ Anti-inflammatory activity of topical THC in DNFB-mediated mouse allergic contact dermatitis independent of CB1 and CB2 receptors

2013 - Study ~ Prospects for cannabinoid therapies in viral encephalitis.

2013 - Study ~ Selective Activation of Cannabinoid Receptor 2 in Leukocytes Suppresses Their Engagement of the Brain Endothelium and Protects the Blood-Brain Barrier.

2013 - Study ~ The Influence of Cannabinoids on Generic Traits of Neurodegeneration.

2013 - Study ~ Cannabidiol in inflammatory bowel diseases: a brief overview.

2013 - Study ~ Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: a role for A2A receptors.

2013 - Study ~ Long-term supplementation of honokiol and magnolol ameliorates body fat accumulation, insulin resistance, and adipose inflammation in high-fat fed mice.

2013 - Study ~ Magnolol inhibits LPS-induced inflammatory response in uterine epithelial cells : magnolol inhibits LPS-induced inflammatory response.

2013 - Study ~ Inhibition of fatty acid amide hydrolase (FAAH) as a novel therapeutic strategy in the treatment of pain and inflammatory diseases in the gastrointestinal tract

2013 - Study ~ Anti-inflammatory effects of Cannabinoid 2 Receptor activation in endotoxin-induced uveitis.

2013 - Study ~ The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis.

2013 - Study ~ Endocannabinoids: a unique opportunity to develop multitarget analgesics.

2013 - Study ~ Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine inflammatory pain model.

2013 - News ~ Sending multiple sclerosis up in smoke

2013 - News ~ 5 Health Benefits Of Cannabichromene (CBC)

2013 - News ~ New Study: THC May Treat Inflammatory Diseases and Cancer By Altering Genes

2012 - Study ~ Prolonged oral Cannabinoid Administration prevents Neuroinflammation, lowers beta-amyloid Levels and improves Cognitive Performance in Tg APP 2576 Mice

2012 - Study ~ Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain

2012 - Study ~ The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α

2012 - Study ~ Update on the role of cannabinoid receptors after ischemic stroke

2012 - Study ~ Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α

2012 - Study ~ Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a ` murine model of acute lung injury: Role for the adenosine A(2A) receptor

2012 - Study ~ Endocannabinoids limit excessive mast cell maturation and activation in human skin

2012 - Study ~ The endocannabinoid system: a revolving plate in neuro-immune interaction in health and disease

2012 - Study ~ Cannabinoid signalling regulates inflammation and energy balance: The importance of the brain-gut axis

2012 - Study ~ The Role of Cannabinoids In Inflammatory Modulation of Allergic Respiratory Disorders, Inflammatory Pain and Ischemic Stroke

2012 - Study ~ WIN55212-2 attenuates amyloid-beta-induced neuroinflammation in rats through activation of cannabinoid receptors and PPAR-γ pathway

2012 - Study ~ Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?

2012 - Study ~ Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors

2012 - Study ~ Effects of palmitoylethanolamide on intestinal injury and inflammation caused by ischemia-reperfusion in mice

2012 - Study ~ Differential migratory properties of monocytes isolated from human subjects naïve and non-naïve to Cannabis

2012 - Study ~ Cannabinoid receptor-2-selective agonists improve recovery in experimental autoimmune encephalomyelitis

2012 - Study ~ Anti-Inflammatory Effect of the Endocannabinoid Anandamide in Experimental Periodontitis and Stress in the Rat

2012 - Study ~ Activation of cannabinoid receptor 2 attenuates leukocyte-endothelial cell interactions and blood-brain barrier dysfunction under inflammatory conditions

2012 - Study ~ Palmitoylethanolamide is a new possible pharmacological treatment for the inflammation associated with trauma

2012 - Study ~ Endocannabinoids alleviate proinflammatory conditions by modulating innate immune response in muller glia during inflammation

2012 - Study ~ Cannabinoids inhibit peptidoglycan-induced phosphorylation of NF-κB and cell growth in U87MG human malignant glioma cells.

2012 - Study ~ Differential Modulation by Delta(9)-Tetrahydrocannabinol (∆ (9)-THC) of CD40 Ligand (CD40L) Expression in Activated Mouse Splenic CD4(+) T cells.

2012 - Study ~ Cannabidiol treatment ameliorates ischemia/reperfusion renal injury in rats

2012 - Study ~ A cannabinoid type 2 receptor agonist attenuates blood-brain barrier damage and neurodegeneration in a murine model of traumatic brain injury.

2012 - Study ~ Activation of Cannabinoid Receptor 2 reduces inflammation in acute experimental pancreatitis via intra-acinar activation of p38 and MK2-dependent mechanisms.

2012 - Study ~ N-acyl amines of docosahexaenoic acid and other n-3 polyunsatured fatty acids – From fishy endocannabinoids to potential leads

2012 - Study ~ N-arachidonoyl glycine induces macrophage apoptosis via GPR18

2012 - Study ~ Anti-Inflammatory Effect of the Endocannabinoid Anandamide in Experimental Periodontitis and Stress in the Rat

2012 - Study ~ Palmitoylethanolamide is a new possible pharmacological treatment for the inflammation associated with trauma

2012 - Study ~ CD200-CD200R1 interaction contributes to neuroprotective effects of anandamide on experimentally induced inflammation

2012 - Study ~ Update on the endocannabinoid-mediated regulation of gelatinase release in arterial wall physiology and atherosclerotic pathophysiology

2012 - Study ~ Cannabidiol (CBD) enhances lipopolysaccharide (LPS)-induced pulmonary inflammation in C57BL/6 mice.

2012 - Study ~ Cannabidiol reduces host immune response and prevents cognitive impairments in Wistar rats submitted to pneumococcal meningitis

2012 - Study ~ Electroacupuncture reduces the expression of proinflammatory cytokines in inflamed skin tissues through activation of cannabinoid CB2 receptors.

2011 - Study ~ Cannabidiol reduces lipopolysaccharide-induced vascular changes and inflammation in the mouse brain: an intravital microscopy study

2011 - Study ~ Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement

2011 - Study ~ Evaluation of the Cyclooxygenase Inhibiting Effects of Six Major Cannabinoids Isolated from Cannabis sativa

2011 - Study ~ Gut feelings about the endocannabinoid system

2011 - Study ~ Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis

2011 - Study ~ Local activation of cannabinoid CB1 receptors in the urinary bladder reduces the inflammation-induced sensitization of bladder afferents

2011 - Study ~ Cannabinoid CB2 Receptors Contribute to Upregulation of β-endorphin in Inflamed Skin Tissues by Electroacupuncture

2011 - Study ~ The Antinociceptive Effects of JWH-015 in Chronic Inflammatory Pain Are Produced by Nitric Oxide-cGMP-PKG-KATP Pathway Activation Mediated by Opioids

2011 - Study ~ Cannabinoids and Innate Immunity: Taking a Toll on Neuroinflammation

2011 - Study ~ Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation

2011 - Study ~ Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress

2011 - Study ~ GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils

2011 - Study ~ Cannabinoid Receptor Type 1 Protects Nigrostriatal Dopaminergic Neurons against MPTP Neurotoxicity by Inhibiting Microglial Activation

2011 - Study ~ Differential transcriptional profiles mediated by exposure to the cannabinoids cannabidiol and Δ(9) -tetrahydrocannabinol in BV-2 microglial cells

2011 - Study ~ Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress, and cell death

2011 - Study ~ Deletion of cannabinoid receptors 1 and 2 exacerbates APC function to increase inflammation and cellular immunity during influenza infection

2011 - Study ~ A synthetic cannabinoid, CP55940, inhibits lipopolysaccharide-induced cytokine mRNA expression in a cannabinoid receptor-independent mechanism in rat cerebellar granule cells

2011 - Study ~ Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes

2011 - Study ~ Allergen Challenge Increases Anandamide in Bronchoalveolar Fluid of Patients With Allergic Asthma

2010 - Study ~ Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression

2010 - Study ~ Cannabinoids and Viral Infections

2010 - Study ~ US Patent Application 20100222437 - COMPOSITION CONTAINING NON-PSYCHOTROPIC CANNABINOIDS FOR THE TREATMENT OF INFLAMMATORY DISEASES

2010 - Study ~ The endocannabinoid system as a target for the treatment of neurodegenerative disease

2010 - Study ~ The effects of Delta-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis

2010 - Study ~ Regulatory Role of Cannabinoid Receptor 1 in Stress-Induced Excitotoxicity and Neuroinflammation

2010- Study ~ Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion

2010 - Study ~ WIN55212-2 ameliorates atherosclerosis associated with suppression of pro-inflammatory responses in ApoE-knockout mice

2010 - Study ~ Beneficial effects of cannabinoids (CB) in a murine model of allergen-induced airway inflammation: Role of CB(1)/CB(2) receptors

2010 - Study ~ Levels of endocannabinoids and palmitoylethanolamide and their pharmacological manipulation in chronic granulomatous inflammation in rats

2010 - News ~ Hemp Oil Benefits for Skin

2009 - Study - Cannabinoids, endocannabinoids, and related analogs in inflammation

2009 - Study - Cannabidiol decreases bone resorption by inhibiting RANK/RANKL expression and pro-inflammatory cytokines during experimental periodontitis in rats

2009 - Study ~ Emerging Role of the CB2 Cannabinoid Receptor in Immune Regulation and Therapeutic Prospects

2009 - Study ~ Cannabinoid CB2 Receptor Potentiates Obesity-Associated Inflammation, Insulin Resistance and Hepatic Steatosis

2009 - Study ~ Cannabinoids Δ9-Tetrahydrocannabinol and Cannabidiol Differentially Inhibit the Lipopolysaccharide-activated NF-κB and Interferon-β/STAT Proinflammatory Pathways in BV-2 Microglial Cells

2009 - Study ~ Ajulemic acid, a synthetic cannabinoid, increases formation of the endogenous proresolving and anti-inflammatory eicosanoid, lipoxin A4

2009 - Study ~ Cannabinoids as Therapeutic Agents for Ablating Neuroinflammatory Disease

2009 - Study ~ Cannabidiol Attenuates Cisplatin-Induced Nephrotoxicity by Decreasing Oxidative/Nitrosative Stress, Inflammation, and Cell Death

2009 - Study ~ Cannabinoids as novel anti-inflammatory drugs

2009 - Study ~ The nonpsychotropic cannabinoid cannabidiol modulates and directly activates alpha-1 and alpha-1-Beta glycine receptor function

2009 - Study ~ Endocannabinoid signalling as an anti-inflammatory therapeutic target in atherosclerosis: does it work?

2009 - Study ~ Cannabinoids attenuate the effects of aging upon neuroinflammation and neurogenesis

2008 - Study - Inflammation and aging: can endocannabinoids help?

2008 - Study - Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders

2008 - Study ~ Anti-inflammatory cannabinoids in diet

2008 - Study ~ Cannabinoid receptors in acute and chronic complications of atherosclerosis

2008 - Study ~ Cannabinoid receptor stimulation is anti-inflammatory and improves memory in old rats

2008 - Study ~ Cannabinoid CB2 receptors in human brain inflammation

2008- Study ~ Cannabinoid Modulation of Cutaneous A{delta} Nociceptors During Inflammation

2008 - Study ~ Scientists are High on Idea that Cannabis Reduces Memory Impairment

2007 - Study ~ Endocannabinoid metabolism and uptake: novel targets for neuropathic and inflammatory pain

2007 - Study ~ Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis

2007 - Study ~ Cannabidiol in vivo blunts β-amyloid induced neuroinflammation by suppressing IL-1β and iNOS expression (Alzheimer's)

2007 - Study ~ Opposing control of cannabinoid receptor stimulation on amyloid-beta-induced reactive gliosis: in vitro and in vivo evidence.

2007 - Study ~ Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro

2007 - Study ~ Honokiol, a natural plant product, inhibits inflammatory signals and alleviates inflammatory arthritis.

2007 - Study ~ Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of chronic brain inflammation

2007 - Study ~ The endocannabinoid system in targeting inflammatory neurodegenerative diseases

2007 - Study ~ Cannabinoid CB2 receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain

2007 - Study ~ Cannabinoids and neuroprotection in motor-related disorders.

2007 - Study ~ A cannabinoid agonist differentially attenuates deep tissue hyperalgesia in animal models of cancer and inflammatory muscle pain.

2007 - Interview ~ Endocannabinoids, cannabinoid receptors and inflammatory stress: an interview with Dr. Pál Pacher

2006 - Study ~ Involvement of the Cannabinoid CB2 Receptor and Its Endogenous Ligand 2- Arachidonoylglycerol in Oxazolone-Induced Contact Dermatitis in Mice

2006 - Study ~ The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells.

2006 - Study ~ Cannabinoid-Induced Immune Suppression and Modulation of Antigen-Presenting Cells

2006 - News ~ Anandamide, an endocannabinoid, protects neurons from inflammation after brain damage

2005 - Study ~ Ajulemic acid (IP-751): Synthesis, proof of principle, toxicity studies, and clinical trials

2005 - Study ~ Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation

2005 - Study ~ Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson's disease.

2005 - Study ~ Endogenous cannabinoid receptor agonists inhibit neurogenic inflammations in guinea pig airways.

2004 - Study ~ New perspectives in the studies on endocannabinoid and cannabis: 2- arachidonoylglycerol as a possible novel mediator of inflammation

2004 - Study ~ Cannabinoids and neuroinflammation

2004 - Study ~ Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation.

2004 - Study ~ A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis.

2003 - Study ~ Inhibition of Inflammatory Hyperalgesia by Activation of Peripheral CB2 Cannabinoid Receptors

2003 - Study ~ Cannabidiol-transdermal delivery and anti-inflammatory effect in a murine model.

2002 - Study ~ Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat

2000 - Study ~ Endocannabinoids and fatty acid amides in cancer, inflammation and related disorders.

1999 - Study ~ 1′,1′-Dimethylheptyl-Δ-8-tetrahydrocannabinol-11-oic Acid: A Novel, Orally Effective Cannabinoid with Analgesic and Anti-inflammatory Properties

1989 - Study ~ Antiinflammatory and antimicrobial compounds and compositions
United States Patent 4837228

1988 - Study - Analgestic and anti-inflammatory activity of constittuents of cannabis sativa L

1981 - Study ~ Biological activity of cannabichromene, its homologs and isomers

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