Angiogenesis (the formation of new blood vessels)


Angiogenesis is the formation of new blood vessels. This process involves the migration, growth, and differentiation of endothelial cells,  which line the inside wall of blood vessels.

The process of angiogenesis is controlled by chemical signals in the body. These signals can stimulate both the repair of damaged blood vessels and the formation of new blood vessels.

 Other chemical signals, called angiogenesis inhibitors, interfere with blood vessel formation.

Normally, the stimulating and inhibiting effects of these chemical signals are balanced so that blood vessels form only when and where they are needed.

Cannabis Science and Medical Research Articles

2003 - Study ~ Inhibition of tumor angiogenesis by cannabinoids

2003 - Study ~ Inhibitory effects of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading: actions on signals involved in angiogenesis and metastasis1

2006 - Study ~ Inhibitory effects of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading: actions on signals involved in angiogenesis and metastasis

2006 - Study ~ A cannabinoid quinone inhibits angiogenesis by targeting vascular endothelial cells.

2007 - Review - Endocannabinoids as emerging suppressors of angiogenesis and tumor invasion

2007 - Study ~ Cannabinoid receptors agonist WIN-55,212-2 inhibits angiogenesis, metastasis and tumor growth of androgen-sensitive prostate cancer cell CWR22R{nu}1 xenograft in athymic nude mice

2007 - Study ~ Antiangiogenic activity of the endocannabinoid anandamide: correlation to its tumor- suppressor efficacy.

2008 - Study ~ Local administration of WIN 55,212-2 reduces chronic granuloma-associated angiogenesis in rat by inhibiting NF-kappaB activation.

2008 - Study ~ Cannabinoids reduce granuloma-associated angiogenesis in rats by controlling transcription and expression of mast cell protease-5.

2009 - Study ~ Cannabidiol As a Putative Novel Therapy for Diabetic Retinopathy: A Postulated Mechanism of Action as an Entry Point for Biomarker-Guided Clinical Development

2009 - Study ~ Hexahydrocannabinols, novel synthetic cannabinoid derivatives, suppress the tumor growth by inhibiting the VEGF secretion and angiogenesis

2010 - Study ~ Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation.

2010 - Study ~ Endocannabinoid-like N-arachidonoyl serine is a novel pro-angiogenic mediator.

2010 - Study ~ Angiogenesis: a new physiological role for N-arachidonoyl serine and GPR55?

2011 - Study ~ Genetic and pharmacological inactivation of cannabinoid CB1 receptor inhibits angiogenesis.

2011 - Study ~ Novel hexahydrocannabinol analogs as potential anti-cancer agents inhibit cell proliferation and tumor angiogenesis.

2012 - Study ~ Anti-proliferative and Anti-angiogenic Effects of CB2R Agonist (JWH-133) in Non- small Lung Cancer Cells (A549) and Human Umbilical Vein Endothelial Cells: an in Vitro Investigation.

2012 - Study ~ Cannabidiol inhibits angiogenesis by multiple mechanisms.

2012 - Study ~ Cannabinoid receptor 2 agonist ameliorates mesenteric angiogenesis and portosystemic collaterals in cirrhotic rats.

2013 - Study - Suppression of vascular endothelial growth factor expression by cannabinoids in a canine osteosarcoma cell line

2013 - Study ~ Magnolol suppresses vascular endothelial growth factor-induced angiogenesis by inhibiting ras-dependent mitogen-activated protein kinase and phosphatidylinositol 3- kinase/akt signaling pathways.

2013 - Study ~ A new strategy to block tumor angiogenesis by inhibiting endocannabinoid inactivation

2013 - Study ~ Blockade of cannabinoid receptors reduces inflammation, leukocyte accumulation and neovascularization in a model of sponge-induced inflammatory angiogenesis.

2013 - Study ~ Autophagy triggered by magnolol derivative negatively regulates angiogenesis.

2013 - Study ~ Magnolol inhibits angiogenesis by regulating ROS-mediated apoptosis and the PI3K/AKT/mTOR signaling pathway in mES/EB-derived endothelial-like cells.

2013 - Study ~ Magnolol suppresses hypoxia-induced angiogenesis via inhibition of HIF-1α/VEGF signaling pathway in human bladder cancer cells