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Alzheimer’s Disease & Cannabis Studies Completed

Published in the June 2016 issue of Nature, the study found that tetrahydrocannabinol (THC), the main psychoactive compound in marijuana, and other active cannabis compounds could block the progression of the disease.


Alzheimer’s disease is an irreversible, progressive brain disorder that slowly destroys memory and thinking skills, and eventually the ability to carry out the simplest tasks. In most people with Alzheimer’s, symptoms first appear in their mid-60s. Estimates vary, but experts suggest that more than 5 million Americans may have Alzheimer’s.

Alzheimer's disease is currently ranked as the sixth leading cause of death in the United States, but recent estimates indicate that the disorder may rank third, just behind heart disease and cancer, as a cause of death for older people. 

Science & Research

2014- Study ~ ltered Expression of the CB1 Cannabinoid Receptor in the Triple Transgenic Mouse Model of Alzheimer's Disease

2013- Study ~ CB2 Receptor Deficiency Increases Amyloid Pathology and Alters Tau Processing in a Transgenic Mouse Model of Alzheimer's Disease.

2013- Study ~ Neuroglial Roots of Neurodegenerative Diseases: Therapeutic Potential of
Palmitoylethanolamide in Models of Alzheimer’s Disease

2013- Study ~ Effects of magnolol on impairment of learning and memory abilities induced by

2013- Study ~ Activation of the CB(2) receptor system reverses amyloid-induced memory deficiency

2013- Study ~ CB2 Cannabinoid Receptor Agonist Ameliorates Alzheimer-Like Phenotype in AβPP/PS1 Mice.

2013- Study ~ Implication of JNK pathway on tau pathology and cognitive decline in a senescence- accelerated mouse model.

2013- Study ~ Cannabinoid agonists showing BuChE inhibition as potential therapeutic agents for Alzheimer's disease.

2013- News ~ Still Believe Nature Got It Wrong? Top 10 Health Benefits of Marijuana

2013- News ~ New Study Shows Cannabinoids Improve Efficiency Of Mitochondria And Remove
Damaged Brain Cells

2013- News ~ Marijuana's Memory Paradox

2013- News ~ New Study Finds Marijuana Could Help Treat Alzheimer’s Disease

2012 - Study ~ Prolonged oral Cannabinoid Administration prevents Neuroinflammation, lowers beta-amyloid Levels and improves Cognitive Performance in Tg APP 2576 Mice

2012 - Study ~ Can the benefits of cannabinoid receptor stimulation on neuroinflammation, neurogenesis and memory during normal aging be useful in AD prevention?

2012 - Study ~ Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α

2012 - Study ~ Activation of the CB(2) receptor system reverses amyloid-induced memory deficiency

2012 - Study ~ Protective effect of cannabinoid CB1 receptor activation against altered intrinsic repetitive firing properties induced by Aβ neurotoxicity

2012 - Study ~ Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro

2012 - Study ~ [(125)I]SD-7015 reveals fine modalities of CB(1) cannabinoid receptor density in the prefrontal cortex during progression of Alzheimer's disease

2012 - Study ~ CB1 Agonist ACEA Protects Neurons and Reduces the Cognitive Impairment of AβPP/PS1 Mice

2012 - Study ~ CB1 cannabinoid receptor activation rescues amyloid β-induced alterations in behaviour and intrinsic electrophysiological properties of rat hippocampal CA1 pyramidal neurones

2012 - Study ~ The therapeutic potential of the endocannabinoid system for Alzheimer's disease

2012 - Study ~ WIN55212-2 attenuates amyloid-beta-induced neuroinflammation in rats through activation of cannabinoid receptors and PPAR-γ pathway

2012- Study ~ CB(2) receptor and amyloid pathology in frontal cortex of Alzheimer's disease patients

2012 - Study ~ In vivo type 1 cannabinoid receptor availability in Alzheimer’s diseas

2012 - Book Excerpt ~ How Weed Can Protect Us From Cancer and Alzheimer's

2012- News ~ Marijuana Compound Found Superior To Drugs For Alzheimer's

2012- News ~ How Cannabinoids May Slow Brain Aging

2012- News ~ 5 Marijuana Compounds That Could Help Combat Cancer, Alzheimers, Parkinsons (If Only They Were Legal)

2012- News ~ Cannabinoid Receptor Stimulator Reverses Symptoms of Alzheimer's Disease in Animal Model

2012- News ~ Researchers investigating potential drug for treatement of Alzheimer's disease

2012- News ~ LSUHSC research identifies new therapeutic target for Alzheimer's disease

2012- News ~ Natural Cannabinoids Improve Dopamine Neurotransmission and Tau and Amyloid
Pathology in a Mouse Model of Tauopathy


2011 - Study ~ Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimers' disease

2011 - Study ~ Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement

2011 - Study ~ Gadolinium-HU-308-incorporated micelles

2011 - Study ~ Anandamide and its congeners inhibit human plasma butyrylcholinesterase. Possible new roles for these endocannabinoids?

2011 - Study ~ Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress

2011- Study ~ An amyloid β(42)-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease

2011 - Study ~ Molecular reorganization of endocannabinoid signalling in Alzheimer's disease

2011 - Study ~ Palmitoylethanolamide counteracts reactive astrogliosis induced by beta-amyloid peptide

2011 - Study ~ The role of phytochemicals in the treatment and prevention of dementia

2011 - Study ~ Early onset of aging-like changes is restricted to cognitive abilities and skin structure in Cnr1(-/-) mice

2011 - Study ~ Intact cannabinoid CB1 receptors in the Alzheimer's disease cortex

2011- Study ~ The effects of hempseed meal intake and linoleic acid on Drosophila models of neurodegenerative diseases and hypercholesterolemia.

2011 - Study ~ Endocannabinoid 2-arachidonoylglycerol protects neurons against β-amyloid insults

2011 - News ~ New metabolic pathway for controlling brain inflammation

2010 - Study ~ Enhancement of endocannabinoid signaling by fatty acid amide hydrolase inhibition: a neuroprotective therapeutic modality

2010 - Study ~ Cannabinoid agonist WIN-55,212-2 partially restores neurogenesis in the aged rat brain

2010 - Study ~ Cannabinoids and Dementia: A Review of Clinical and Preclinical Data

2010 - Study ~ The development of cannabinoid CBII receptor agonists for the treatment of central neuropathies

2010 - Study ~ Endocannabinoids Prevent β-Amyloid-mediated Lysosomal Destabilization in Cultured Neurons

2010 - Study ~ The endocannabinoid system in gp120-mediated insults and HIV-associated dementia

2010 - Study ~ The Multiplicity of Action of Cannabinoids: Implications for Treating Neurodegeneration

2010 - News ~ Marijuana could prevent Alzheimer's

2010 - News ~ Newly discovered mechanism controls levels and efficacy of a marijuana-like substance in the brain

2009 - Study - The activation of cannabinoid CB2 receptors stimulates in situ and in vitro beta-amyloid removal by human macrophages

2009 - Study ~ Emerging Role of the CB2 Cannabinoid Receptor in Immune Regulation and Therapeutic Prospects

2009 - Study ~ Cannabidiol: a promising drug for neurodegenerative disorders?

2009 - Study ~ Endocannabinoids prevent lysosomal membrane destabilisation evoked by treatment with β-amyloid in cultured rat cortical neurons

2009 - News ~ Medical Marijuana and Alzheimer's Disease

2008 - Study - Cannabinoid receptor stimulation is anti-inflammatory and improves memory in old rats

2008 - Study - Inflammation and aging: can endocannabinoids help?

2008 - Study ~ Cannabinoid CB2 receptors in human brain inflammation

2008 - Study ~ Cannabinoids as Therapeutic Agents for Ablating Neuroinflammatory Disease

2008 - Study ~ Amyloid precursor protein 96-110 and beta-amyloid 1-42 elicit developmental anomalies in sea urchin embryos and larvae that are alleviated by neurotransmitter analogs for acetylcholine, serotonin and cannabinoids

2008 - Study ~ Role of CB2 receptors in neuroprotective effects of cannabinoids

2008 - Study ~ The role of the endocannabinoid system in Alzheimer's disease: facts and hypotheses

2008 - News - Pot joins the fight against Alzheimer's, memory loss

2008 - News - Attacking Alzheimer's with Red Wine and Marijuana

2008 - News - Marijuana reduces memory impairment

2008 - News ~ Scientists are High on Idea that Cannabis Reduces Memory Impairment

2008 - News ~ Israeli Research Shows Cannabidiol May Slow Alzheimer's Disease

2008 - News ~ Marijuana may be good for the aging brain.

2008 - News ~ Alzheimer's sufferers may benefit from cannabis compound

2008 - News ~ Cannabis 'could stop dementia in its tracks'

2008 - News ~ LSUHSC research reports new method to protect brain cells from diseases like Alzheimer's

2008 - News ~ Could Marijuana Substance Help Prevent Or Delay Memory Impairment In The Aging Brain?

2008 - News ~ Attacking Alzheimer's with Red Wine and Marijuana

2008 - News ~ Can cannabis offer hope for Alzheimer's?

2007 - Study - Cannabidiol in vivo blunts β-amyloid induced neuroinflammation by suppressing IL-1β and iNOS expression

2007 - Study - Alzheimer's disease; taking the edge off with cannabinoids?

2007 - Study - Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of chronic brain inflammation

2007 - Study ~ Opposing control of cannabinoid receptor stimulation on amyloid-beta-induced reactive gliosis: in vitro and in vivo evidence

2006 - Study ~ Delta-9-tetrahydrocannabinol for nighttime agitation in severe dementia

2006 - Study ~ Endocannabinoids and beta-amyloid-induced neurotoxicity in vivo: effect of pharmacological elevation of endocannabinoid levels

2006 - Study ~ Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement

2006 - Study ~ The marijuana component cannabidiol inhibits beta-amyloid-induced tau protein hyperphosphorylation through Wnt/beta-catenin pathway rescue in PC12 cells

2006 - Study ~ CB1 receptor selective activation inhibits beta-amyloid-induced iNOS protein expression in C6 cells and subsequently blunts tau protein hyperphosphorylation in co-cultured neurons

2006 - Study - Molecular Link between the Active Component of Marijuana and Alzheimer's Disease Pathology

2006 - News - Marijuana's Active Ingredient Shown to Inhibit Primary Marker of Alzheimer's Disease

2006 - News - THC inhibits primary marker of Alzheimer's disease

2006 - News ~ Marijuana Compound Efficient Against Alzheimer's Disease

2006 - News ~ Marijuana's Active Ingredient May Slow Progression Of Alzheimer's Disease

2006 - News ~ Marijuana may help stave off Alzheimer’s

2006 - News ~ Marijuana May Slow Alzheimer's

2006 - News ~ Pot-Like Compound May Slow Alzheimer's

2005 - Study - Prevention of Alzheimer's Disease Pathology by Cannabinoids

2005 - Study ~ Early age-related cognitive impairment in mice lacking cannabinoid CB1 receptors

2005 - Study ~ Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation

2005 - Study ~ Avoidance of Abeta[(25-35)] / (H(2)O(2)) -induced apoptosis in lymphocytes by the cannabinoid agonists CP55,940 and JWH-015 via receptor-independent and PI3K-dependent mechanisms: role of NF-kappaB and p53

2005 - Study ~ Phosphorylated amyloid-beta: the toxic intermediate in alzheimer's disease neurodegeneration

2005 - Study ~ Cannabinoid control of motor function at the basal ganglia

2005 - News ~ Marijuana Ingredient May Stall Decline From Alzheimer's

2005 - News - Marijuana may block Alzheimer's

2005 - News - Cannabinoids reduce the progression of Alzheimer's disease in animals

2005 - News ~ Research shows preventive effects of cannabinoids on Alzheimer's disease

2005 - News ~ Marijuana Slows Alzheimer's Decline

2005 - News ~ Pass the Doobie, pops

2004 - Study ~ Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on β-amyloid-induced toxicity in PC12 cells

2003 - Study ~ Anandamide and noladin ether prevent neurotoxicity of the human amyloid-beta peptide

2003 - Patent ~ US Patent 6630507 - Cannabinoids as antioxidants and neuroprotectants

2003 - Study - Open-label study of Dronabinol in the treatment of refractory agitation in Alzheimer's disease

2003 - Study - Safety and efficacy of Dronabinol in the treatment of agitation in patients with Alzheimer's disease with anorexia

2003 - Study ~ Cannabinoid CB2 Receptors and Fatty Acid Amide Hydrolase Are Selectively Overexpressed in Neuritic Plaque-Associated Glia in Alzheimer's Disease Brains

1997 - Study - Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer's disease.