Alzheimer’s Disease & Cannabis Studies Completed
Overview
Alzheimer’s disease is an irreversible, progressive brain disorder that slowly destroys memory and thinking skills, and eventually the ability to carry out the simplest tasks. In most people with Alzheimer’s, symptoms first appear in their mid-60s. Estimates vary, but experts suggest that more than 5 million Americans may have Alzheimer’s.
Alzheimer's disease is currently ranked as the sixth leading cause of death in the United States, but recent estimates indicate that the disorder may rank third, just behind heart disease and cancer, as a cause of death for older people.
Science & Research
2014- Study ~ ltered Expression of the CB1 Cannabinoid Receptor in the Triple Transgenic Mouse Model of Alzheimer's Disease
2013- Study ~ Neuroglial Roots of Neurodegenerative Diseases: Therapeutic Potential of
Palmitoylethanolamide in Models of Alzheimer’s Disease
2013- Study ~ Activation of the CB(2) receptor system reverses amyloid-induced memory deficiency
2013- Study ~ CB2 Cannabinoid Receptor Agonist Ameliorates Alzheimer-Like Phenotype in AβPP/PS1 Mice.
2013- Study ~ Implication of JNK pathway on tau pathology and cognitive decline in a senescence- accelerated mouse model.
2013- Study ~ Therapeutic Potential of Cannabinoids in Neurodegenerative Disorders: A Selective Review.
Microglial-Activated Neurotoxicity In Vitro
2013- Study ~ The Influence of Cannabinoids on Generic Traits of Neurodegeneration.
2013- Study ~ Cannabinoid agonists showing BuChE inhibition as potential therapeutic agents for Alzheimer's disease.
2013- News ~ Still Believe Nature Got It Wrong? Top 10 Health Benefits of Marijuana
2013- News ~ New Study Shows Cannabinoids Improve Efficiency Of Mitochondria And Remove
Damaged Brain Cells
2013- News ~ Marijuana's Memory Paradox
2013- News ~ New Study Finds Marijuana Could Help Treat Alzheimer’s Disease
2012 - Study ~ Activation of the CB(2) receptor system reverses amyloid-induced memory deficiency
2012 - Study ~ Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro
2012 - Study ~ CB1 Agonist ACEA Protects Neurons and Reduces the Cognitive Impairment of AβPP/PS1 Mice
2012 - Study ~ The therapeutic potential of the endocannabinoid system for Alzheimer's disease
2012 - Study ~ WIN55212-2
attenuates amyloid-beta-induced neuroinflammation in rats through
activation of cannabinoid receptors and PPAR-γ pathway
2012- Study ~ CB(2) receptor and amyloid pathology in frontal cortex of Alzheimer's disease patients
2012 - Study ~ In vivo type 1 cannabinoid receptor availability in Alzheimer’s diseas
2012 - Book Excerpt ~ How Weed Can Protect Us From Cancer and Alzheimer's
2012- News ~ Marijuana Compound Found Superior To Drugs For Alzheimer's
2012- News ~ How Cannabinoids May Slow Brain Aging
2012- News ~ 5 Marijuana Compounds That Could Help Combat Cancer, Alzheimers, Parkinsons (If Only They Were Legal)
2012- News ~ Cannabinoid Receptor Stimulator Reverses Symptoms of Alzheimer's Disease in Animal Model
2012- News ~ Researchers investigating potential drug for treatement of Alzheimer's disease
2012- News ~ LSUHSC research identifies new therapeutic target for Alzheimer's disease
2012- News ~ Natural Cannabinoids Improve Dopamine Neurotransmission and Tau and Amyloid
Pathology in a Mouse Model of Tauopathy
2011 - Patent ~ US Patent Application 20110257256 - CANNABINOIDS FOR USE IN TREATING OR PREVENTING COGNITIVE IMPAIRMENT AND DEMENTIA
2011 - Study ~ Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimers' disease
2011 - Study ~ Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement
2011 - Study ~ Gadolinium-HU-308-incorporated micelles
2011 - Study ~ Anandamide and its congeners inhibit human plasma butyrylcholinesterase. Possible new roles for these endocannabinoids?
2011 - Study ~ Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress
2011- Study ~ An amyloid β(42)-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease
2011 - Study ~ Molecular reorganization of endocannabinoid signalling in Alzheimer's disease
2011 - Study ~ Palmitoylethanolamide counteracts reactive astrogliosis induced by beta-amyloid peptide
2011 - Study ~ The role of phytochemicals in the treatment and prevention of dementia
2011 - Study ~ Early onset of aging-like changes is restricted to cognitive abilities and skin structure in Cnr1(-/-) mice
2011 - Study ~ Intact cannabinoid CB1 receptors in the Alzheimer's disease cortex
2011- Study ~ The effects of hempseed meal intake and linoleic acid on Drosophila models of neurodegenerative diseases and hypercholesterolemia.
2011 - Study ~ Endocannabinoid 2-arachidonoylglycerol protects neurons against β-amyloid insults
2011 - News ~ New metabolic pathway for controlling brain inflammation
2010 - Study ~ Enhancement of endocannabinoid signaling by fatty acid amide hydrolase inhibition: a neuroprotective therapeutic modality
2010 - Study ~ Cannabinoid agonist WIN-55,212-2 partially restores neurogenesis in the aged rat brain
2010 - Study ~ Cannabinoids and Dementia: A Review of Clinical and Preclinical Data
2010 - Study ~ The development of cannabinoid CBII receptor agonists for the treatment of central neuropathies
2010 - Study ~ Endocannabinoids Prevent β-Amyloid-mediated Lysosomal Destabilization in Cultured Neurons
2010 - Study ~ The endocannabinoid system in gp120-mediated insults and HIV-associated dementia
2010 - Study ~ The Multiplicity of Action of Cannabinoids: Implications for Treating Neurodegeneration
2010 - News ~ Marijuana could prevent Alzheimer's
2010 - News ~ Newly discovered mechanism controls levels and efficacy of a marijuana-like substance in the brain
2009 - Study - The activation of cannabinoid CB2 receptors stimulates in situ and in vitro beta-amyloid removal by human macrophages
2009 - Study ~ Emerging Role of the CB2 Cannabinoid Receptor in Immune Regulation and Therapeutic Prospects
2009 - Study ~ Cannabidiol: a promising drug for neurodegenerative disorders?
2009 - Study ~ Endocannabinoids prevent lysosomal membrane destabilisation evoked by treatment with β-amyloid in cultured rat cortical neurons
2009 - News ~ Medical Marijuana and Alzheimer's Disease
2008 - Study - Cannabinoid receptor stimulation is anti-inflammatory and improves memory in old rats
2008 - Study - Inflammation and aging: can endocannabinoids help?
2008 - Study ~ Cannabinoid CB2 receptors in human brain inflammation
2008 - Study ~ Cannabinoids as Therapeutic Agents for Ablating Neuroinflammatory Disease
2008 - Study ~ Role of CB2 receptors in neuroprotective effects of cannabinoids
2008 - Study ~ The role of the endocannabinoid system in Alzheimer's disease: facts and hypotheses
2008 - News - Pot joins the fight against Alzheimer's, memory loss
2008 - News - Attacking Alzheimer's with Red Wine and Marijuana
2008 - News - Marijuana reduces memory impairment
2008 - News ~ Scientists are High on Idea that Cannabis Reduces Memory Impairment
2008 - News ~ Israeli Research Shows Cannabidiol May Slow Alzheimer's Disease
2008 - News ~ Marijuana may be good for the aging brain.
2008 - News ~ Alzheimer's sufferers may benefit from cannabis compound
2008 - News ~ Cannabis 'could stop dementia in its tracks'
2008 - News ~ LSUHSC research reports new method to protect brain cells from diseases like Alzheimer's
2008 - News ~ Could Marijuana Substance Help Prevent Or Delay Memory Impairment In The Aging Brain?
2008 - News ~ Attacking Alzheimer's with Red Wine and Marijuana
2008 - News ~ Can cannabis offer hope for Alzheimer's?
2007 - Study - Cannabidiol in vivo blunts β-amyloid induced neuroinflammation by suppressing IL-1β and iNOS expression
2007 - Study - Alzheimer's disease; taking the edge off with cannabinoids?
2007 - Study - Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of chronic brain inflammation
2007 - Study ~ Opposing control of cannabinoid receptor stimulation on amyloid-beta-induced reactive gliosis: in vitro and in vivo evidence
2006 - Study ~ Delta-9-tetrahydrocannabinol for nighttime agitation in severe dementia
2006 - Study ~ Endocannabinoids and beta-amyloid-induced neurotoxicity in vivo: effect of pharmacological elevation of endocannabinoid levels
2006 - Study - Molecular Link between the Active Component of Marijuana and Alzheimer's Disease Pathology
2006 - News - Marijuana's Active Ingredient Shown to Inhibit Primary Marker of Alzheimer's Disease
2006 - News - THC inhibits primary marker of Alzheimer's disease
2006 - News ~ Marijuana Compound Efficient Against Alzheimer's Disease
2006 - News ~ Marijuana's Active Ingredient May Slow Progression Of Alzheimer's Disease
2006 - News ~ Marijuana may help stave off Alzheimer’s
2006 - News ~ Marijuana May Slow Alzheimer's
2006 - News ~ Pot-Like Compound May Slow Alzheimer's
2005 - Study - Prevention of Alzheimer's Disease Pathology by Cannabinoids
2005 - Study ~ Early age-related cognitive impairment in mice lacking cannabinoid CB1 receptors
2005 - Study ~ Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation
2005 - Study ~ Phosphorylated amyloid-beta: the toxic intermediate in alzheimer's disease neurodegeneration
2005 - Study ~ Cannabinoid control of motor function at the basal ganglia
2005 - News ~ Marijuana Ingredient May Stall Decline From Alzheimer's
2005 - News - Marijuana may block Alzheimer's
2005 - News - Cannabinoids reduce the progression of Alzheimer's disease in animals
2005 - News ~ Research shows preventive effects of cannabinoids on Alzheimer's disease
2005 - News ~ Marijuana Slows Alzheimer's Decline
2004 - Study ~ Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on β-amyloid-induced toxicity in PC12 cells
2003 - Study ~ Anandamide and noladin ether prevent neurotoxicity of the human amyloid-beta peptide
2003 - Patent ~ US Patent 6630507 - Cannabinoids as antioxidants and neuroprotectants
2003 - Study - Open-label study of Dronabinol in the treatment of refractory agitation in Alzheimer's disease
2003 - Study - Safety and efficacy of Dronabinol in the treatment of agitation in patients with Alzheimer's disease with anorexia
1997 - Study - Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer's disease.