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Alzheimer’s Disease & Cannabis Studies Completed

Published in the June 2016 issue of Nature, the study found that tetrahydrocannabinol (THC), the main psychoactive compound in marijuana, and other active cannabis compounds could block the progression of the disease.

Overview

Alzheimer’s disease is an irreversible, progressive brain disorder that slowly destroys memory and thinking skills, and eventually the ability to carry out the simplest tasks. In most people with Alzheimer’s, symptoms first appear in their mid-60s. Estimates vary, but experts suggest that more than 5 million Americans may have Alzheimer’s.


Alzheimer's disease is currently ranked as the sixth leading cause of death in the United States, but recent estimates indicate that the disorder may rank third, just behind heart disease and cancer, as a cause of death for older people. 

Science & Research

2014- Study ~ ltered Expression of the CB1 Cannabinoid Receptor in the Triple Transgenic Mouse Model of Alzheimer's Disease


2013- Study ~ CB2 Receptor Deficiency Increases Amyloid Pathology and Alters Tau Processing in a Transgenic Mouse Model of Alzheimer's Disease.


2013- Study ~ Neuroglial Roots of Neurodegenerative Diseases: Therapeutic Potential of
Palmitoylethanolamide in Models of Alzheimer’s Disease


2013- Study ~ Effects of magnolol on impairment of learning and memory abilities induced by

2013- Study ~ Activation of the CB(2) receptor system reverses amyloid-induced memory deficiency



2013- Study ~ CB2 Cannabinoid Receptor Agonist Ameliorates Alzheimer-Like Phenotype in AβPP/PS1 Mice.



2013- Study ~ Implication of JNK pathway on tau pathology and cognitive decline in a senescence- accelerated mouse model.







2013- Study ~ Cannabinoid agonists showing BuChE inhibition as potential therapeutic agents for Alzheimer's disease.



2013- News ~ Still Believe Nature Got It Wrong? Top 10 Health Benefits of Marijuana



2013- News ~ New Study Shows Cannabinoids Improve Efficiency Of Mitochondria And Remove
Damaged Brain Cells



2013- News ~ Marijuana's Memory Paradox


2013- News ~ New Study Finds Marijuana Could Help Treat Alzheimer’s Disease



2012 - Study ~ Prolonged oral Cannabinoid Administration prevents Neuroinflammation, lowers beta-amyloid Levels and improves Cognitive Performance in Tg APP 2576 Mice


2012 - Study ~ Can the benefits of cannabinoid receptor stimulation on neuroinflammation, neurogenesis and memory during normal aging be useful in AD prevention?


2012 - Study ~ Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α


2012 - Study ~ Activation of the CB(2) receptor system reverses amyloid-induced memory deficiency


2012 - Study ~ Protective effect of cannabinoid CB1 receptor activation against altered intrinsic repetitive firing properties induced by Aβ neurotoxicity


2012 - Study ~ Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro


2012 - Study ~ [(125)I]SD-7015 reveals fine modalities of CB(1) cannabinoid receptor density in the prefrontal cortex during progression of Alzheimer's disease


2012 - Study ~ CB1 Agonist ACEA Protects Neurons and Reduces the Cognitive Impairment of AβPP/PS1 Mice


2012 - Study ~ CB1 cannabinoid receptor activation rescues amyloid β-induced alterations in behaviour and intrinsic electrophysiological properties of rat hippocampal CA1 pyramidal neurones


2012 - Study ~ The therapeutic potential of the endocannabinoid system for Alzheimer's disease


2012 - Study ~ WIN55212-2 attenuates amyloid-beta-induced neuroinflammation in rats through activation of cannabinoid receptors and PPAR-γ pathway


2012- Study ~ CB(2) receptor and amyloid pathology in frontal cortex of Alzheimer's disease patients


2012 - Study ~ In vivo type 1 cannabinoid receptor availability in Alzheimer’s diseas


2012 - Book Excerpt ~ How Weed Can Protect Us From Cancer and Alzheimer's


2012- News ~ Marijuana Compound Found Superior To Drugs For Alzheimer's


2012- News ~ How Cannabinoids May Slow Brain Aging


2012- News ~ 5 Marijuana Compounds That Could Help Combat Cancer, Alzheimers, Parkinsons (If Only They Were Legal)


2012- News ~ Cannabinoid Receptor Stimulator Reverses Symptoms of Alzheimer's Disease in Animal Model


2012- News ~ Researchers investigating potential drug for treatement of Alzheimer's disease


2012- News ~ LSUHSC research identifies new therapeutic target for Alzheimer's disease


2012- News ~ Natural Cannabinoids Improve Dopamine Neurotransmission and Tau and Amyloid
Pathology in a Mouse Model of Tauopathy


2011 - Patent ~ US Patent Application 20110257256 - CANNABINOIDS FOR USE IN TREATING OR PREVENTING COGNITIVE IMPAIRMENT AND DEMENTIA


2011 - Study ~ Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimers' disease


2011 - Study ~ Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement


2011 - Study ~ Gadolinium-HU-308-incorporated micelles


2011 - Study ~ Anandamide and its congeners inhibit human plasma butyrylcholinesterase. Possible new roles for these endocannabinoids?


2011 - Study ~ Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress


2011- Study ~ An amyloid β(42)-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease


2011 - Study ~ Molecular reorganization of endocannabinoid signalling in Alzheimer's disease


2011 - Study ~ Palmitoylethanolamide counteracts reactive astrogliosis induced by beta-amyloid peptide


2011 - Study ~ The role of phytochemicals in the treatment and prevention of dementia


2011 - Study ~ Early onset of aging-like changes is restricted to cognitive abilities and skin structure in Cnr1(-/-) mice


2011 - Study ~ Intact cannabinoid CB1 receptors in the Alzheimer's disease cortex


2011- Study ~ The effects of hempseed meal intake and linoleic acid on Drosophila models of neurodegenerative diseases and hypercholesterolemia.

2011 - Study ~ Endocannabinoid 2-arachidonoylglycerol protects neurons against β-amyloid insults


2011 - News ~ New metabolic pathway for controlling brain inflammation


2010 - Study ~ Enhancement of endocannabinoid signaling by fatty acid amide hydrolase inhibition: a neuroprotective therapeutic modality


2010 - Study ~ Cannabinoid agonist WIN-55,212-2 partially restores neurogenesis in the aged rat brain


2010 - Study ~ Cannabinoids and Dementia: A Review of Clinical and Preclinical Data


2010 - Study ~ The development of cannabinoid CBII receptor agonists for the treatment of central neuropathies


2010 - Study ~ Endocannabinoids Prevent β-Amyloid-mediated Lysosomal Destabilization in Cultured Neurons


2010 - Study ~ The endocannabinoid system in gp120-mediated insults and HIV-associated dementia


2010 - Study ~ The Multiplicity of Action of Cannabinoids: Implications for Treating Neurodegeneration


2010 - News ~ Marijuana could prevent Alzheimer's


2010 - News ~ Newly discovered mechanism controls levels and efficacy of a marijuana-like substance in the brain


2009 - Study - The activation of cannabinoid CB2 receptors stimulates in situ and in vitro beta-amyloid removal by human macrophages


2009 - Study ~ Emerging Role of the CB2 Cannabinoid Receptor in Immune Regulation and Therapeutic Prospects


2009 - Study ~ Cannabidiol: a promising drug for neurodegenerative disorders?


2009 - Study ~ Endocannabinoids prevent lysosomal membrane destabilisation evoked by treatment with β-amyloid in cultured rat cortical neurons


2009 - News ~ Medical Marijuana and Alzheimer's Disease


2008 - Study - Cannabinoid receptor stimulation is anti-inflammatory and improves memory in old rats


2008 - Study - Inflammation and aging: can endocannabinoids help?


2008 - Study ~ Cannabinoid CB2 receptors in human brain inflammation


2008 - Study ~ Cannabinoids as Therapeutic Agents for Ablating Neuroinflammatory Disease


2008 - Study ~ Amyloid precursor protein 96-110 and beta-amyloid 1-42 elicit developmental anomalies in sea urchin embryos and larvae that are alleviated by neurotransmitter analogs for acetylcholine, serotonin and cannabinoids


2008 - Study ~ Role of CB2 receptors in neuroprotective effects of cannabinoids


2008 - Study ~ The role of the endocannabinoid system in Alzheimer's disease: facts and hypotheses


2008 - News - Pot joins the fight against Alzheimer's, memory loss


2008 - News - Attacking Alzheimer's with Red Wine and Marijuana


2008 - News - Marijuana reduces memory impairment


2008 - News ~ Scientists are High on Idea that Cannabis Reduces Memory Impairment


2008 - News ~ Israeli Research Shows Cannabidiol May Slow Alzheimer's Disease


2008 - News ~ Marijuana may be good for the aging brain.

2008 - News ~ Alzheimer's sufferers may benefit from cannabis compound


2008 - News ~ Cannabis 'could stop dementia in its tracks'


2008 - News ~ LSUHSC research reports new method to protect brain cells from diseases like Alzheimer's


2008 - News ~ Could Marijuana Substance Help Prevent Or Delay Memory Impairment In The Aging Brain?


2008 - News ~ Attacking Alzheimer's with Red Wine and Marijuana


2008 - News ~ Can cannabis offer hope for Alzheimer's?


2007 - Study - Cannabidiol in vivo blunts β-amyloid induced neuroinflammation by suppressing IL-1β and iNOS expression


2007 - Study - Alzheimer's disease; taking the edge off with cannabinoids?


2007 - Study - Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of chronic brain inflammation


2007 - Study ~ Opposing control of cannabinoid receptor stimulation on amyloid-beta-induced reactive gliosis: in vitro and in vivo evidence



2006 - Study ~ Delta-9-tetrahydrocannabinol for nighttime agitation in severe dementia


2006 - Study ~ Endocannabinoids and beta-amyloid-induced neurotoxicity in vivo: effect of pharmacological elevation of endocannabinoid levels


2006 - Study ~ Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement


2006 - Study ~ The marijuana component cannabidiol inhibits beta-amyloid-induced tau protein hyperphosphorylation through Wnt/beta-catenin pathway rescue in PC12 cells


2006 - Study ~ CB1 receptor selective activation inhibits beta-amyloid-induced iNOS protein expression in C6 cells and subsequently blunts tau protein hyperphosphorylation in co-cultured neurons


2006 - Study - Molecular Link between the Active Component of Marijuana and Alzheimer's Disease Pathology


2006 - News - Marijuana's Active Ingredient Shown to Inhibit Primary Marker of Alzheimer's Disease


2006 - News - THC inhibits primary marker of Alzheimer's disease


2006 - News ~ Marijuana Compound Efficient Against Alzheimer's Disease


2006 - News ~ Marijuana's Active Ingredient May Slow Progression Of Alzheimer's Disease


2006 - News ~ Marijuana may help stave off Alzheimer’s


2006 - News ~ Marijuana May Slow Alzheimer's


2006 - News ~ Pot-Like Compound May Slow Alzheimer's



2005 - Study - Prevention of Alzheimer's Disease Pathology by Cannabinoids


2005 - Study ~ Early age-related cognitive impairment in mice lacking cannabinoid CB1 receptors


2005 - Study ~ Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation


2005 - Study ~ Avoidance of Abeta[(25-35)] / (H(2)O(2)) -induced apoptosis in lymphocytes by the cannabinoid agonists CP55,940 and JWH-015 via receptor-independent and PI3K-dependent mechanisms: role of NF-kappaB and p53


2005 - Study ~ Phosphorylated amyloid-beta: the toxic intermediate in alzheimer's disease neurodegeneration


2005 - Study ~ Cannabinoid control of motor function at the basal ganglia


2005 - News ~ Marijuana Ingredient May Stall Decline From Alzheimer's


2005 - News - Marijuana may block Alzheimer's


2005 - News - Cannabinoids reduce the progression of Alzheimer's disease in animals


2005 - News ~ Research shows preventive effects of cannabinoids on Alzheimer's disease


2005 - News ~ Marijuana Slows Alzheimer's Decline


2005 - News ~ Pass the Doobie, pops

2004 - Study ~ Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on β-amyloid-induced toxicity in PC12 cells


2003 - Study ~ Anandamide and noladin ether prevent neurotoxicity of the human amyloid-beta peptide


2003 - Patent ~ US Patent 6630507 - Cannabinoids as antioxidants and neuroprotectants


2003 - Study - Open-label study of Dronabinol in the treatment of refractory agitation in Alzheimer's disease


2003 - Study - Safety and efficacy of Dronabinol in the treatment of agitation in patients with Alzheimer's disease with anorexia


2003 - Study ~ Cannabinoid CB2 Receptors and Fatty Acid Amide Hydrolase Are Selectively Overexpressed in Neuritic Plaque-Associated Glia in Alzheimer's Disease Brains


1997 - Study - Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer's disease.


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