Amyotrophic Lateral Sclerosis (ALS) and cannabis studies completed
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease and Charcot disease, is a specific disorder that involves the death of neurons. The cause is not known in 90% to 95% of cases. There is no cure for ALS.
or amyotrophic lateral sclerosis, is a progressive neurodegenerative
disease that affects nerve cells in the brain and the spinal cord.
A-myo-trophic comes from the Greek language. "A" means no. "Myo" refers
to muscle, and "Trophic" means nourishment – "No muscle nourishment."
When a muscle has no nourishment, it "atrophies" or wastes away.
"Lateral" identifies the areas in a person's spinal cord where portions of the nerve cells that signal and control the muscles are located. As this area degenerates it leads to scarring or hardening ("sclerosis") in the region.
There are two different types of ALS, sporadic and familial. Sporadic which is the most common form of the disease in the U.S., is 90 – 95 percent of all cases. It may affect anyone, anywhere. Familial ALS (FALS) accounts for 5 to 10 percent of all cases in the U.S. Familial ALS means the disease is inherited. In those families, there is a 50% chance each offspring will inherit the gene mutation and may develop the disease. French neurologist Jean-Martin Charcot discovered the disease in 1869.
Hall of Fame first baseman Lou Gehrig
played for the New York Yankees in the 1920s and 1930s, setting the
mark for consecutive games played. He was diagnosed with ALS in 1939
and retired from baseball. He died in 1941. source ALS Association
Video Cannabis and ALS Therapy
Science & Research
2018 - Abstract ~ Analysis of endocannabinoid receptors and
enzymes in the post-mortem motor cortex and spinal cord of amyotrophic
lateral sclerosis patients.
Spain: Journal of Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration.
Switzerland: European Journal of Medicinal Chemistry.
2017 - Study ~ Essential Dietary Bioactive Lipids in Noninflammatory Diseases.
Italy: Antioxidants & Redox Signaling.
Journal of Neuropharmacology.
USA: Disease Models & Mechanisms.
2016 - Abstract ~ Pain in amyotrophic lateral sclerosis.
The Lanclet: Neurology.
Journal of Cellular Biochemistry.
Neural Regeneration Research.
USA: National Academy of Sciences.
Spain: Frontiers in Neuroscience - Neurodegeneration.
Handbook of Experimental Pharmacology: Endocannabinoids.
2015 - Study ~ Changes in the endocannabinoid signaling
system in CNS structures of TDP-43 transgenic mice: relevance for a
neuroprotective therapy in TDP-43-related disorders.
Journal of Neuroimmune Pharmacology.
2015 - Abstract ~ Cannabinoid Signaling and Neuroinflammatory Diseases: A Melting pot for the Regulation of Brain Immune Responses.
Journal of Neuroimmune Pharmacology.
2015 - Study ~ Cannabinoids in Neurodegenerative Disorders and Stroke/Brain Trauma: From Preclinical Models to Clinical Applications.
Addiction Science & Clinical Practice.
2014 - Abstract ~ Changes in Endocannabinoid Receptors and Enzymes in the Spinal Cord of SOD1G93A Transgenic Mice and Evaluation of a Sativex -like Combination of Phytocannabinoids: Interest for Future Therapies in Amyotrophic Lateral Sclerosis.
CNS Neuroscience & Therapeutics.
Italy: Open Access - Molecules Journal.
Italy: International Journal of High Risk Behaviors & Addiction.
2012 - News/ Anecdotal ~ Medical Cannabis Helps ALS Patient Outlive her Own Doctors
2009 - Study ~ Cannabinoids and neurodegenerative diseases.
2009 - News ~ Medical Marijuana and Lou Gehrig's Disease.
2007 - Study ~ Cannabinoids and neuroprotection in motor-related disorders.
2004 - Study - Cannabis use in patients with amyotrophic lateral sclerosis.
2004 - News ~ Cannabis Relieves Lou Gehrigs Symptoms - New Study.