ACEA/ ARACHIDONYL-2'-CHLOROETHYLAMIDE - synthetic, CB1 agonist studies completed
ACEA/ ARACHIDONYL-2'-CHLOROETHYLAMIDE - synthetic, CB1 agonist studies completed
Overview
Arachidonyl-2'-chloroethylamide (ACEA) is a synthetic
agonist of the cannabinoid receptor 1
(CB1R). ACEA is considered to be a selective cannabinoid agonist as it
binds primarily to the CB1R and has low affinity to the cannabinoid receptor 2 (CB2R) (Ki
= 1.4 nM for CB1R; Ki = 3100 nM for CB2R).
ACEA / Science & Research Articles
2012 - Abstract Study ~ Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro.
Neurotoxicology.
Neuropsychopharmacology.
Neuroscience Letter.
2011 - Study ~ Changes in the cannabinoid (CB1) receptor expression level and G-protein activation in kainic acid induced seizures.
Epilepsy Research.
Neurochemical Research.
2011 - Study ~ Alkamides and a neolignan from Echinacea purpurea roots and the interaction of alkamides with G-protein-coupled cannabinoid receptors.
Phytochemistry.
2010 - Study ~ Regulatory Role of Cannabinoid Receptor 1 in Stress-InducedExcitotoxicity and Neuroinflammation.
Neuropsychopharmacology.
2009 - Abstract Study ~ Role of cannabinoid CB1 receptors on macronutrient selection and satiety in rats.
Physiology & Behavior.
2009 - Abstract Study ~ Effect of arachidonyl-2'-chloroethylamide, a selective cannabinoid CB1 receptor agonist, on the protective action of the various antiepileptic drugs in the mouse maximal electroshock-induced seizure model.
Neuropsychopharmacology and Biological Psychiatry.
2009 - Abstract Study ~ Involvement of nitric oxide in the gastroprotective effect of ACEA, a selective cannabinoid CB1 receptor agonist, on aspirin-induced gastric ulceration.
Parmazie.
Epilepsy Research.
2009 - Full Study ~ The effects of intracerebroventricular AM-251, a CB1-receptor antagonist, and ACEA, a CB1-receptor agonist, on penicillin-induced epileptiform activity in rats.
Journal of the International League Against Epilepsy.
British Journal of Pharmacology.
2008 - Study ~ Cannabinoid receptor activation induces apoptosis through tumor necrosis factor alpha- mediated ceramide de novo synthesis in colon cancer cells.
Neuropsychopharmacology.
American College of Rheumatology.
Journal of Neurophysiology.
2008 - Study ~ Attenuation of Experimental Autoimmune Hepatitis by Exogenous and Endogenous Cannabinoids: Involvement of Regulatory T Cells.
Molecular Pharmacology.
Neuropsychopharmacology.
Journal of Pharmacology and Experimental Therapeutics.
Neuroscience Letter.
Institute of Pharmacology Polish Academy of Sciences.
Neuroscience Letter.