ACEA/ ARACHIDONYL-2'-CHL, a synthetic, CB1 agonist

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ACEA/ ARACHIDONYL-2'-CHLOROETHYLAMIDE - synthetic, CB1 agonist studies completed

Overview

Arachidonyl-2'-chloroethylamide (ACEA) is a synthetic agonist of the cannabinoid receptor 1 (CB1R). ACEA is considered to be a selective cannabinoid agonist as it binds primarily to the CB1R and has low affinity to the cannabinoid receptor 2 (CB2R) (Ki = 1.4 nM for CB1R; Ki = 3100 nM for CB2R).

Science & Research

2012 - Abstract Study ~ Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro.

Neurotoxicology.

2012 - Study ~ Opposing Roles for Cannabinoid Receptor Type-1 (CB(1)) and Transient Receptor Potential Vanilloid Type-1 Channel (TRPV1) on the Modulation of Panic-Like Responses in Rats.

Neuropsychopharmacology.

2012 - Study ~ Protective effect of cannabinoid CB1 receptor activation against altered intrinsic repetitive firing properties induced by Aβ neurotoxicity.

Neuroscience Letter.

2011 - Study ~ Changes in the cannabinoid (CB1) receptor expression level and G-protein activation in kainic acid induced seizures.

Epilepsy Research.

2011 - Study ~ L-Type Calcium Channel Mediates Anticonvulsant Effect of Cannabinoids in Acute and Chronic Murine Models of Seizure.

Neurochemical Research.

2011 - Study ~ Alkamides and a neolignan from Echinacea purpurea roots and the interaction of alkamides with G-protein-coupled cannabinoid receptors.

Phytochemistry.

2010 - Study ~ Regulatory Role of Cannabinoid Receptor 1 in Stress-InducedExcitotoxicity and Neuroinflammation.

Neuropsychopharmacology.

2009 - Abstract Study ~ Role of cannabinoid CB1 receptors on macronutrient selection and satiety in rats.

Physiology & Behavior.

2009 - Abstract Study ~ Effect of arachidonyl-2'-chloroethylamide, a selective cannabinoid CB1 receptor agonist, on the protective action of the various antiepileptic drugs in the mouse maximal electroshock-induced seizure model.

Neuropsychopharmacology and Biological Psychiatry.

2009 - Abstract Study ~ Involvement of nitric oxide in the gastroprotective effect of ACEA, a selective cannabinoid CB1 receptor agonist, on aspirin-induced gastric ulceration.

Parmazie.

2009 - Study ~ Involvement of nitrergic system in the anticonvulsant effect of the cannabinoid CB(1) agonist ACEA in the pentylenetetrazole-induced seizure in mice.

Epilepsy Research.

2009 - Full Study ~ The effects of intracerebroventricular AM-251, a CB1-receptor antagonist, and ACEA, a CB1-receptor agonist, on penicillin-induced epileptiform activity in rats.

Journal of the International League Against Epilepsy.

2009 - Study ~ Endogenous cannabinoids induce fever through the activation of CB1 receptors.

British Journal of Pharmacology.

2008 - Study ~ Cannabinoid receptor activation induces apoptosis through tumor necrosis factor alpha- mediated ceramide de novo synthesis in colon cancer cells.

Neuropsychopharmacology.

2008 - Study ~ Cannabinoid-mediated antinociception is enhanced in rat osteoarthritic knees.

American College of Rheumatology.

2008 - Study ~ Cannabinoid modulation of cutaneous Adelta nociceptors during inflammation.

Journal of Neurophysiology.

2008 - Study ~ Attenuation of Experimental Autoimmune Hepatitis by Exogenous and Endogenous Cannabinoids: Involvement of Regulatory T Cells. Molecular Pharmacology.

2007 - Study ~ Ultra-low dose cannabinoid antagonist AM251 enhances cannabinoid anticonvulsant effects in the pentylenetetrazole-induced seizure in mice.

Neuropsychopharmacology.

2007 - Study ~ Opposing control of cannabinoid receptor stimulation on amyloid-beta-induced reactive gliosis:

in vitro and in vivo evidence.

Journal of Pharmacology and Experimental Therapeutics.

2006 - Study ~ Arachidonyl-2'-chloroethylamide, a highly selective cannabinoid CB1 receptor agonist, enhances the anticonvulsant action of valproate in the mouse maximal electroshock induced seizure model.

Neuroscience Letter.

2006 - Study ~ In vivo effects of CB1 receptor ligands on lipid peroxidation and antioxidant defense systems in the rat brain of healthy and ethanol-treated rats.

Institute of Pharmacology Polish Academy of Sciences.

2002 - Study ~ The cannabinoids R(-)-7-hydroxy-delta-6-tetra-hydrocannabinol-dimethylheptyl (HU-210), 2-O-arachidonoylglycerylether (HU-310) and arachidonyl-2-chloroethylamide (ACEA) increase isoflurane provoked sleep duration by activation of cannabinoids 1 (CB1)-receptors in mice. Neuroscience Letter.