TOLERANCE and cannabis studies completed
Tolerance at all levels of complexity in the brain involves
"learning" in the sense of the acquisition of compensatory adaptations
to the consequences of the presence of a drug-produced disturbance in
function. Depending on the function, species, and dose of cannabis,
"tissue tolerance," behaviorally augmented (to provide the presence of
the disturbed function) or not, develops at different rates or not all
(e.g., to impairment of the logical sequence of thoughts, to which no
tolerance has yet been demonstrated). "Dispositional tolerance"
(increased rate of metabolism of delta 9-THC due to enzyme induction)
may play a role in the development of tolerance or "reverse tolerance"
to cannabis in man.
Video - Does Marijuana Tolerance Rise?2011 - Study ~ The schizophrenia susceptibility gene neuregulin 1 modulates tolerance to the effects of cannabinoids.
2009 - Study ~ Prolonged exposure to WIN55,212-2 causes downregulation of the CB1 receptor and the development of tolerance to its anticonvulsant effects in the hippocampal neuronal culture model of acquired epilepsy.
2007 - Study ~ A Molecular Basis of Analgesic Tolerance to Cannabinoids
1973 - Study ~ Lack of tolerance to 9 -tetrahydrocannabinol in chimpanzees
Does Marijuana Tolerance Rise?
Marijuana in the Body
Every time a user smokes a marijuana cigarette or ingests marijuana in some other form, THC and other chemicals enter the user's body. The chemicals make their way through the bloodstream to the brain and then to the rest of the body. The most powerful chemical in marijuana is THC (delta-9-tetrahydrocannabinol), which is primarily responsible for the "high" associated with the drug.
most common way of using marijuana is smoking. Smoking is also the
most expedient way to get the THC and other chemicals into the
bloodstream. When the smoke from marijuana is inhaled, the THC goes
directly to the lungs. Your lungs are lined with millions of alveoli,
the tiny air sacs where gas exchange occurs. These alveoli have an
enormous surface area -- 90 times greater than that of your skin -- so
they make it easy for THC and other compounds to enter the body.
The smoke is absorbed by the lungs just seconds after inhaling.
can also eat marijuana. In this case, the marijuana enters the stomach
and the blood absorbs it there. The blood then carries it to the liver
and the rest of the body.
The stomach absorbs THC more slowly than the lungs. When marijuana is eaten, the levels of THC in the body are lower, but the effects last longer.