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SLEEP MODULATION & Cannabis studies completed

Science and Research

2001 - Study ~ Therapeutic aspects of cannabis and cannabinoids.

2002 - Study ~ Functional role for cannabinoids in respiratory stability during sleep.

2002 - Study ~ The cannabinoids R(-)-7-hydroxy-delta-6-tetra-hydrocannabinol-dimethylheptyl (HU- 210), 2-O-arachidonoylglycerylether (HU-310) and arachidonyl-2-chloroethylamide
(ACEA) increase isoflurane provoked sleep duration by activation of cannabinoids 1
(CB1)-receptors in mice.

2003 - Study ~ Anandamide enhances extracellular levels of adenosine and induces sleep: an in vivo microdialysis study.

2004 - Study ~ Effect of Delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults.

2004 - Study ~ Efficacy of two cannabis based medicinal extracts for relief of central neuropathic pain from brachial plexus avulsion: results of a randomised controlled trial.

2005 - Study ~ Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis

2006 - Study ~ Cannabinoids attenuate norepinephrine-induced melatonin biosynthesis in the rat pineal gland by reducing arylalkylamine N-acetyltransferase activity without involvement of
cannabinoid receptors.

2006 - Study ~ Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats.

2006 - Study ~ The synthetic cannabinoid nabilone improves pain and symptom management in cancer patients

2007 - Study ~ Cannabis, pain, and sleep: lessons from therapeutic clinical trials of Sativex, a cannabis- based medicine.

2007 - Study ~ Dronabinol and marijuana in HIV-positive marijuana smokers. Caloric intake, mood, and sleep.

2007 - News ~ Cannabinoids Associated With "More Restful Sleep," Study Says

2008 - Study ~ The nonpsychoactive cannabis constituent cannabidiol is a wake-inducing agent.

2008 - Study ~ Effect of illicit recreational drugs upon sleep: Cocaine, ecstasy and marijuana.

2008 - Study ~ The modulatory role of endocannabinoids in sleep

2008 - Study ~ The role of the CB1 receptor in the regulation of sleep.

2009 - Study ~ Sleep deprivation increases oleoylethanolamide in human cerebrospinal fluid.

2009 - News ~ Medical Marijuana and Nightmares

2009 - News ~ Medical Marijuana and Persistent Insomnia

2009 - News ~ Medical Marijuana and Sleep Disorders

2010 - Study ~ Smoked cannabis for chronic neuropathic pain: a randomized controlled trial

2010 - Study ~ Endocannabinoid signalling: has it got rhythm?

2010 - Study ~ The Maternal Lifestyle Study: Sleep Problems in Children with Prenatal Substance Exposure

2010 - Study ~ The Effects of Nabilone on Sleep in Fibromyalgia: Results of a Randomized Controlled Trial.

2010 - Study ~ Sleep and Medicinal Cannabis

2010 - Study ~ Oleoylethanolamide affects food intake and sleep-waking cycle through a hypothalamic modulation.

2010 - Study ~ Dreams, endocannabinoids and itinerant dynamics in neural networks: re elaborating Crick-Mitchison unlearning hypothesis

2010 - News ~ Smoking pot may ease chronic pain

2011 - Study ~ Administration of URB597, oleoylethanolamide or palmitoylethanolamide increases waking and dopamine in rats.

2011 - Study ~ A Pilot Study into the Effects of the CB1 Cannabinoid Receptor Agonist WIN55,212-2 or the Antagonist/Inverse Agonist AM251 on Sleep in Rats

2011 - Study ~ Effect of cannabidiol on sleep disruption induced by the repeated combination tests consisting of open field and elevated plus-maze in rats.

2011 - Study ~ Effects on sleep and dopamine levels of microdialysis perfusion of cannabidiol into the lateral hypothalamus of rats.

2011 - News ~ Medical marijuana turns former soldier's life around

2012 - Study ~ CADTH Rapid Response Report: Cannabinoids for the treatment of post-traumatic stress disorder

2012 - Study ~ A Randomized, Double-Blind, Placebo Controlled, Parallel Assignment, Flexible Dose, Efficacy Study of Nabilone as Adjuvant in the Treatment of Diabetic Peripheral
Neuropathic Pain Using an Enriched Enrollment Randomized Withdrawal Design (S38.003)

2012 - Study ~ Neuromodulators for pain management in rheumatoid arthritis

2012 - News ~ Marijuana Helps Ease MS Symptoms, Study Finds

2013 - Study ~ Effects of acute systemic administration of cannabidiol on sleep-wake cycle in rats.

2013 - Study ~ Entopeduncular nucleus endocannabinoid system modulates sleep-waking cycle and mood in rats.

2013 - Study ~ 2-AG into the lateral hypothalamus increases REM sleep and cFos expression in melanin concentrating hormone neurons in rats.

2013 - Study ~ Cardiorespiratory control as a function of wake-sleep behavior and diet in mice lacking CB1 cannabinoid receptors

2013 - Study ~ The administration of endocannabinoid uptake inhibitors OMDM-2 or VDM-11
promotes sleep and decreases extracellular levels of dopamine in rats.

2012 - Study ~ Sleep Quality Moderates the Relation between Depression Symptoms and Problematic Cannabis Use among Medical Cannabis Users.

2001 - Study ~ Around-the-clock oral THC effects on sleep in male chronic daily cannabis smokers.

2013 - Study ~ Effects of acute systemic administration of cannabidiol on sleep-wake cycle in rats.

2013 - Study ~ Using cannabis to help you sleep: Heightened frequency of medical cannabis use among those with PTSD

2013 - Study ~ The impact of perceived sleep quality and sleep efficiency/duration on cannabis use during a self-guided quit attempt

2013 - News ~ Federal Government Reports Marijuana Effective in Combatting Certain Cancers Reports ADSI

2013 - News ~ Medical marijuana helps senior sleep, contend with other problems of aging

2013 - News ~ Poor Sleep Quality Makes It Harder To Quit Marijuana — Here’s Why

2013 - News ~ Medical Marajuana: Consortium of Multiple Sclerosis Centers

2013 - News ~ Too little sleep may trigger the 'munchies' by raising levels of an appetite-controlling molecule

2013 - Study ~ Smoking Pot Eases Tremors in Parkinson's

2014 - Study ~ A double-blind, randomized, placebo-controlled, parallel group study of THC/CBD spray in peripheral neuropathic pain treatment.