Sickle-cell disease (SCD),
or sickle-cell anaemia (SCA) or drepanocytosis,
is a hereditary blood disorder,
characterized by red blood cells that assume an abnormal,
rigid, sickle shape.
Sickling decreases the cells'
flexibility and results in a risk of various complications. The
sickling occurs because of a mutation
in the haemoglobin gene.
Individuals with one copy of the defunct gene display both normal and
abnormal haemoglobin. This is an example of codominance.
Life expectancy is shortened. In
1994, in the US, the average life expectancy of persons with this
condition was estimated to be 42 years in males and 48 years in females,
but today, thanks to better management of the
disease, patients can live into their 70s or beyond.
SICKLE DISEASE (SCA)(DRPANOCYTOSIS) & Cannabis studies completed
Undated - Diagram of Sickle Cell Disease
2005 - Study ~ Cannabis use in sickle cell disease: a questionnaire study.
2005 - News ~ Medical use of cannabis in sickle cell disease
2006 - Study ~ The prevalence of marijuana smoking in young adults with sickle cell disease: a longitudinal study
2007 - News ~ Marijuana Use Prevalent Among Sickle Cell Patients
2008 - Study ~ Marijuana Use and Sickle Cell Disease
2009 - Study ~ Cannabinoids as Analgesics for Pain in Sickle Cell Disease.
2010 - Study ~ New Era Dawns on Sickle Cell Pain
2010 - Study ~ Pain related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids.
2010 - News ~ Cannibinoids Offer Novel Treatment for Pain in Sickle Cell Disease, Study Suggests
2010 - News ~ UM researcher identifies novel treatment for pain in sickle cell disease
2011 - Study ~ Mouse models for studying pain in sickle disease: effects of strain, age, and acuteness.