Given the highly favorable safety profile of whole-plant
cannabis, and the severely debilitating symptoms caused by Parkinson's
Disease, it may be a safe and useful additional therapy for patients
with Parkinson's Disease who are finding it difficult to control their
symptoms with standard therapies.
Parkinson's disease (PD also known as idiopathic or primary parkinsonism, hypokinetic rigid syndrome/HRS, or paralysis agitans) is a degenerative disorder of the central nervous system..
PARKINSON'S DISEASE & Cannabis studies completed
1981 - Study ~ Tetrahydrocannabinol potentiates reserpine-induced hypokinesia.
1985 - Study ~ Beneficial and adverse effects of cannabidiol in a Parkinson patient with sinemet-induced dystonic dyskinesia.
1986 - Study ~ Open label evaluation of cannabidiol in dystonic movement disorders.
1998 - Study ~ The effects of the cannabinoid receptor agonist nabilone on L-DOPA induced dyskinesia in patients with idiopathic Parkinson's disease (PD).
1999 - Study ~ Cannabinoids in parkinsonism
1999 - Study ~ Cannabis in movement disorders.
1999 - News ~ Why your brain is primed for a high
2000 - Study ~ Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson’s disease
2002 - Study ~ Experimental parkinsonism alters endocannabinoid degradation: implications for striatal glutamatergic transmission.
2003 - Patent ~ US Patent 6630507 - Cannabinoids as antioxidants and neuroprotectants
2003 - Study ~ Therapeutic potential of cannabinoids in CNS disease.
2004 - Study ~ Survey on cannabis use in Parkinson's disease: subjective improvement of motor symptoms.
2004 - News ~ Marijuana Compounds May Aid Parkinson's Disease
2005 - Study ~ Depression in Parkinson's disease is related to a genetic polymorphism of the cannabinoid receptor gene (CNR1)
2005 - Study ~ Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson's disease.
2005 - Study ~ Cannabinoid control of motor function at the basal ganglia.
2006 - Study ~ Cannabinoids In Medicine: A Review Of Their Therapeutic Potential
2007 - Study ~ Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson's disease: role of CB1 and TRPV1 receptors
2007 - Study ~ The endocannabinoid system in targeting inflammatory neurodegenerative diseases
2007 - Study ~ Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: importance of antioxidant and cannabinoid receptor-independent properties.
2007 - Study ~ Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models.
2007 - Study ~ Cannabinoids and neuroprotection in motor-related disorders.
2007 - News ~ Marijuana Against Parkinson?
2007 - News ~ Marijuana-Like Chemicals Helps Treat Parkinson's
2007 - News ~ Parkinsons' Helped By Marijuana-Like Chemicals In Brain
2007 - News ~ Enhancing Activity Of Marijuana-Like Chemicals In Brain Helps Treat Parkinson's Symptoms In Mice
2008 - Study ~ Paraquat induces apoptosis in human lymphocytes: protective and rescue effects of glucose, cannabinoids and insulin-like growth factor-1.
2008 - Study ~ The cannabinoid CP55,940 prolongs survival and improves locomotor activity in Drosophila melanogaster against paraquat: implications in Parkinson's disease.
2008 - News ~ LSUHSC research reports new method to protect brain cells from diseases like Alzheimer's
2009 - Study ~ WIN55,212-2, a Cannabinoid Receptor Agonist, Protects Against Nigrostriatal Cell Loss in the MPTP Mouse Model of Parkinson’s Disease
2009 - Study ~ Cannabidiol: a promising drug for neurodegenerative disorders?
2009 - Study ~ The endocannabinoid system as a target for the treatment of motor dysfunction.
2009 - Study ~ Cannabidiol for the treatment of psychosis in Parkinson’s disease
2009 - News ~ Medical Marijuana and Parkinson's Disease
2010 - Study ~ Cannabinoids and Dementia: A Review of Clinical and Preclinical Data
2010 - Study ~ Cannabinoid–Dopamine Interaction in the Pathophysiology and Treatment of CNS Disorders
2010 - Study ~ Enhancement of endocannabinoid signaling by fatty acid amide hydrolase inhibition: a neuroprotective therapeutic modality.
2010 - Study ~ Loss of cannabinoid CB1 receptor expression in the 6-hydroxydopamine-induced nigrostriatal terminal lesion model of Parkinson's disease in the rat.
2011 - Study ~ Cannabinoid receptor agonist protects cultured dopaminergic neurons from the death by the proteasomal dysfunction.
2011 - Study ~ Therapeutic Potential of Cannabinoids in the Treatment of Neuroinflammation Associated with Parkinson's Disease
2011 - Study ~ Regional changes in type 1 cannabinoid receptor availability in Parkinson's disease in vivo
2011 - Study ~ Homeostatic changes of the endocannabinoid system in Parkinson's disease.
2011 - Study ~ Prospects for cannabinoid therapies in basal ganglia disorders.
2011 - Study ~ Symptom-relieving and neuroprotective effects of the phytocannabinoid D(9) -THCV in animal models of Parkinson's disease
2011 - Study ~ Cannabinoid Receptor Type 1 Protects Nigrostriatal Dopaminergic Neurons against MPTP Neurotoxicity by Inhibiting Microglial Activation.
2011 - News ~ New metabolic pathway for controlling brain inflammation
2012 - Study ~ The cannabinoid agonist WIN55212-2 decreases l-DOPA-induced PKA activation and dyskinetic behavior in 6-OHDA-treated rats.
2012 - Study ~ Δ(9) -THC exerts a direct neuroprotective effect in a human cell culture model of Parkinson's disease.
2012 - Study ~ The decrease of dopamine D(2)/D(3) receptor densities in the putamen and nucleus caudatus goes parallel with maintained levels of CB(1) cannabinoid receptors in Parkinson's disease: A preliminary autoradiographic study with the selective dopamine D(2)/D(3) antagonist [(3)H]raclopride and the novel CB(1) inverse agonist [(125)I]SD7015.
2012 - Study ~ Cannabinoids and value-based decision making: implications for neurodegenerative
2012 - Study ~ Contribution of genetic variants to pain susceptibility in Parkinson disease
2012 - News ~ 5 Marijuana Compounds That Could Help Combat Cancer, Alzheimers, Parkinsons
2013 - Study ~ Natural Cannabinoids Improve Dopamine Neurotransmission and Tau and Amyloid
Pathology in a Mouse Model of Tauopathy.
2013 - Study ~ Striatal Molecular Signature of Subchronic Subthalamic Nucleus High Frequency
Stimulation in Parkinsonian Rat.
2013 - Study ~ A spontaneous deletion of α-Synuclein is associated with an increase in CB1 mRNA
transcript and receptor expression in the hippocampus and amygdala: Effects on alcohol consumption
2013 - Study ~ Cannabidiol attenuates catalepsy induced by distinct pharmacological mechanisms via 5-
HT1A receptors activation in mice.
2013 - Study ~ Therapeutic Potential of Cannabinoids in Neurodegenerative Disorders: A Selective
2013 - Study ~ Evaluation of the role of striatal cannabinoid CB1 receptors on movement activity of
parkinsonian rats induced by reserpine
2013 - Study ~ Δ9-TETRAHYDROCANNABINOL IS PROTECTIVE THROUGH PPARγ DEPENDENT MITOCHONDRIAL BIOGENESIS IN A CELL CULTURE MODEL OF PARKINSON'S DISEASE.
2013 - Study ~ Oleoylethanolamide reduces L-DOPA-induced dyskinesia via TRPV1 receptor in a
mouse model of Parkinson ́s disease.
2013 - Study ~ The Influence of Cannabinoids on Generic Traits of Neurodegeneration.
2013 - Study ~ The combination of oral L-DOPA/rimonabant for effective dyskinesia treatment and
cytological preservation in a rat model of Parkinson's disease and L-DOPA-induced dyskinesia
2013 - News ~ Smoking Pot Eases Tremors in Parkinson's
2014 - Study ~ L-DOPA disrupts adenosine A2A-cannabinoid CB1-dopamine D2 receptor heteromer
cross-talk in the striatum of hemiparkinsonian rats: Biochemical and behavioral studies.