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OSTEOPOROSIS (BONES) & Cannabis studies completed

Overview

Osteoporosis occurs when there is a loss in the peak bone mass and loss of calcium, leading to hip, knee and shoulder fractures.Cannabis therapies prove to be a beneficial treatment option.


The active component of cannabis Delta(9
-tetrahydrocannabinol,
activates the CB1 and CB2 cannabinoid receptors, thus mimicking the action of endogenous cannabinoids. It appears that the topical use of cannabis oil  may indeed be curative in many dermatologic applications. It makes sense because phytocannabinoids are potent anti-inflammatory compounds.

Science & Research

2005 - Study ~ Cannabinoid receptor type 2 gene is associated with human osteoporosis

2005 - Study ~ Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors

2006 - Study ~ Peripheral cannabinoid receptor, CB2, regulates bone mass

2006 - Study ~ Involvement of Neuronal Cannabinoid Receptor CB1 in Regulation of Bone Mass and Bone Remodeling

2006 - News ~ Women with a variant of the CB2 gene have a three-fold higher risk of osteoporosis

2006 - News ~ New hope for osteoporosis sufferers

2006 - News ~ Researchers from the Hebrew University Discover New Drug for Osteoporosis

2006 - News ~ Prototype drug to prevent osteoporosis based on cannabinoids found in the body

2006 - News ~ Hebrew U. Researchers Find Cannabis Can Strengthen Bones

2006 - News ~ Scientists Develop Prototype Drug To Prevent Osteoporosis Based On Cannabinoids Produced By Body

2006 - News ~ New Weapon In Battle Against Osteoporosis

2006 - News ~ Activation of CB2 receptor attenuates bone loss in osteoporosis

2006 - News ~ Cannabis-like compound prevents bone loss

2007 - Study ~ Regulation of skeletal remodeling by the endocannabinoid system.

2007 - Study ~ Cannabinoids stimulate fibroblastic colony formation by bone marrow cells indirectly via CB2 receptors.

2008 - Study ~ Cannabinoid receptors and the regulation of bone mass

2008 - Study ~ Regulation of Bone Mass, Osteoclast Function, and Ovariectomy-Induced Bone Loss by the Type 2 Cannabinoid Receptor

2008 - Study ~ The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling.

2008 - Study ~ Role of cannabinoid receptors in bone disorders: alternatives for treatment

2008 - Study ~ Ajulemic acid, a nonpsychoactive cannabinoid acid, suppresses osteoclastogenesis in mononuclear precursor cells and induces apoptosis in mature osteoclast-like cells.

2009 - Study ~ The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo

2009 - Study ~ Cannabidiol decreases bone resorption by inhibiting RANK/RANKL expression and pro-inflammatory cytokines during experimental periodontitis in rats.

2009 - Study ~ Cannabinoids and the skeleton: From marijuana to reversal of bone loss.

2009 - Study ~ Activation of CB2 cannabinoid receptors: a novel therapeutic strategy to accelerate osseointegration of dental implants.

2009 - News ~ Marijuana/Cannabis may protect against osteoporosis

2009 - News ~ Cannabis may prevent osteoporosis

2010 - Study ~ Hypothalamic regulation of bone.

2010 - Study ~ Cannabinoid Receptors as Target for Treatment of Osteoporosis: A Tale of Two Therapies

2010 - Study ~ Tissue Engineering of Cartilage; Can Cannabinoids Help?

2010 - Study ~ A cannabinoid 2 receptor agonist attenuates bone cancer-induced pain and bone loss.

2010 - Study ~ Cannabinoids and Bone: Friend or Foe?

2010 - Study ~ The endocannabinoid signaling system: a marriage of PUFA and musculoskeletal health.

2010 - Study ~ Control of bone remodeling by nervous system. Nervous system and bone

2010 - Study ~ Endocannabinoids are expressed in bone marrow stromal niches and play a role in interactions of hematopoietic stem and progenitor cells with the bone marrow microenvironment

2011 - Study ~ The Type 2 Cannabinoid Receptor Regulates Bone Mass and Ovariectomy-Induced Bone Loss by Affecting Osteoblast Differentiation and Bone Formation

2011 - Study ~ The endovanilloid/endocannabinoid system: A new potential target for osteoporosis therapy.

2011 - Study ~ The role of cannabinoid receptors in bone remodeling in a CB1/2 double knockout mouse

2011 - Study ~ CANNABINOIDS AND BONE: ENDOCANNABINOIDS MODULATE HUMAN OSTEOCLAST FUNCTION IN VITRO.

2011 - Study ~ Skeletal lipidomics: regulation of bone metabolism by fatty acid amide family.

2012 - Study ~ Platelet-rich plasma loaded hydrogel scaffold enhances chondrogenic differentiation and maturation with up-regulation of CB1 and CB2.

2012 - Study ~ THE CO-EXPRESSION OF THE ENDOCANNABINOID SYSTEM AND THE RANK/RANKL SIGNALLING PATHWAY IN HUMAN BONE AND OSTEOCLAST CULTURE

2012 - Study ~ Cannabinoids: novel therapies for arthritis?

2012 - Study ~ Role of cannabinoids in the regulation of bone remodeling

2012 - Study ~ THE CO-EXPRESSION OF THE ENDOCANNABINOID SYSTEM AND THE RANK/RANKL SIGNALLING PATHWAY IN HUMAN BONE AND OSTEOCLAST CULTURE

2013 - Study ~ Magnolol Ameliorates Ligature-Induced Periodontitis in Rats and Osteoclastogenesis: In Vivo and In Vitro Study

2013 - Study ~ Cannabinoid WIN-55,212-2 Mesylate Inhibits Interleukin-1β Induced Matrix
Metalloproteinase and Tissue Inhibitor of Matrix Metalloproteinase Expression in Human
Chondrocytes.

2013 - Study ~ Increase of mesenchymal stem cell migration by Cannabidiol via activation of p42/44 MAPK.

2013 - Study ~ Modulation of Strain-Specific Differences in Gene Expression by Cannabinoid Type 2 Receptor Deficiency.