A study published in the American Journal Of Medicine on April 15 of last year suggested that pot smokers are skinnier than the average person and have healthier metabolism.
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 Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have a negative effect on health, leading to reduced life expectancy and/or increased health problems.

Related Science 

The Endocannabinoid System

Endocannabinoids

Video - Obesity and the Endocannabinoid System

Video - Exploring the Endocannabinoid System

OBESITY and cannabis studies completed

Undated - News ~ Hemp & GLA: Good Fat Burns Bad Fat

2000 - Study ~ Low dose anandamide affects food intake, cognitive function, neurotransmitter and
corticosterone levels in diet-restricted mice.

2001 - Study ~ Dietary intake and nutritional status of US adult marijuana users: results from the Third
National Health and Nutrition Examination Survey.

2001 - News ~ Marijuana "Munchies" May Hold a Key to Obesity

2003 - Study ~ The endogenous cannabinoid system affects energy balance via central orexigenic drive
and peripheral lipogenesis

2003 - Study ~ Short-term fasting and prolonged semistarvation have opposite effects on 2-AG levels in
mouse brain.

2004 - Study ~ CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced
obesity and enhanced leptin sensitivity

2005 - Study ~ Activation of the Peripheral Endocannabinoid System in Human Obesity

2005 - Study ~ Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and
contributes to diet-induced obesity

2005 - Study ~ Food for thought: endocannabinoid modulation of lipogenesis

2005 - Study ~ Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and
contributes to diet-induced obesity

2005 - Study ~ Endocannabinoids and food intake: newborn suckling and appetite regulation in
adulthood.

2005 - Study ~ Endocannabinoids in the Regulation of Appetite and Body Weight.

2005 - News ~ Teens in Recovery Drop Drugs but Add Pounds

2006 - Study ~ Dysregulation of the Peripheral and Adipose Tissue Endocannabinoid System in Human
Abdominal Obesity

2006 - Study ~ Regulation, Function, and Dysregulation of Endocannabinoids in Models of Adipose and
ß-Pancreatic Cells and in Obesity and Hyperglycemia

2006 - Study ~ AM 251 produces sustained reductions in food intake and body weight that are resistant
to tolerance and conditioned taste aversion

2006 - Study ~ Weight Control in Individuals With Diabetes

2006 - Study ~ The emerging role of the endocannabinoid system in endocrine regulation and
energy balance.

2006 - Study ~ Does Cannabis Hold the Key to Treating Cardiometabolic Disease

2006 - Study ~ The impact of obesity on reproduction in women with polycystic ovary syndrome.

2006 - Study ~ Human adipose tissue binds and metabolizes the endocannabinoids anandamide and 2-
arachidonoylglycerol.

2006 - News ~ Obesity – Acomplia: loss of a few kilos, many questions

2007 - Study ~ Identification of Endocannabinoids and Related Compounds in Human Fat Cells

2007 - Study ~ Genetic variations at the endocannabinoid type 1 receptor gene (CNR1) are associated
with obesity phenotypes in men

2007 - Study ~ The endogenous cannabinoid system: a new player in the brain-gut-adipose axis

2007 - Study ~ No evidence for an involvement of variants in the cannabinoid receptor gene (CNR1) in
obesity in German children and adolescents.

2007 - Study ~ Immune-mediated Activation of the Endocannabinoid System in Visceral Adipose Tissue
in Obesity

2008 - Study ~ Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body
mass index in European populations

2008 - Study ~ GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes
and obesity

2008 - Study ~ Activating Parabrachial Cannabinoid CB1 Receptors Selectively Stimulates Feeding of
Palatable Foods in Rats

2008 - Study ~ Targeted enhancement of oleoylethanolamide production in proximal small intestine
induces across-meal satiety in rats.

2008 - Study ~ Endocannabinoids and the Control of Energy Homeostasis

2008 - Study ~ The lipid messenger OEA links dietary fat intake to satiety.

2008 - Study ~ The Role of Adipocyte Insulin Resistance in the Pathogenesis of Obesity-Related
Elevations in Endocannabinoids

2008 - Study ~ The discovery of taranabant, a selective cannabinoid-1 receptor inverse agonist for the
treatment of obesity.

2008 - Study ~ Dysregulation of peripheral endocannabinoid levels in hyperglycemia and obesity: Effect
of high fat diets.

2008 - Study ~ Emerging role of cannabinoids in gastrointestinal and liver diseases: basic and clinical
aspects

2008 - Study ~ Endocannabinoids and the neurochemistry of gluttony

2008 - Study ~ Dysregulation of peripheral endocannabinoid levels in hyperglycemia and obesity: Effect
of high fat diets.

2008 - Study ~ Dysregulation of the endocannabinoid system in obesity.

2008 - Study ~ Cholesterol-induced stimulation of platelet aggregation is prevented by a hempseed-
enriched diet

2008 - Study ~ Inhibitory effect of the anorexic compound oleoylethanolamide on gastric emptying in
control and overweight mice.

2009 - Study ~ Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties
in fasted and non-fasted mice

2009 - Study ~ Peripheral endocannabinoid dysregulation in obesity: relation to intestinal motility and
energy processing induced by food deprivation and re-feeding.

2009 - Study ~ Cannabinoid CB2 Receptor Potentiates Obesity-Associated Inflammation, Insulin
Resistance and Hepatic Steatosis

2009 - Study ~ Biomarkers of Endocannabinoid System Activation in Severe Obesity

2009 - Study ~ The endocanabinnoid system and diabetes - critical analyses of studies conducted with
rimonabant

2009 - Study ~ Cannabinoids for clinicians: the rise and fall of the cannabinoid antagonists

2009 - Study ~ Endocannabinoids and Their Receptors as Targets for Obesity Therapy

2009 - Study ~ The endocannabinoid system as a link between homoeostatic and hedonic pathways
involved in energy balance regulation

2009 - Study ~ Endocannabinoids and cardiovascular prevention: real progress?

2009 - Study ~ N-acylethanolamines, anandamide and food intake

2009 - Study ~ Effects of cannabinoid drugs on the reinforcing properties of food in gestationally
undernourished rats

2009 - Study ~ Anti-inflammatory effect of palmitoylethanolamide on human adipocytes.

2009 - News ~ Natural Pot-Like Compound Could Fight Obesity

2010 - Study ~ Alterations in the hippocampal endocannabinoid system in diet-induced obese mice.

2010 - Study ~ Differential alterations of the concentrations of endocannabinoids and related lipids in the
subcutaneous adipose tissue of obese diabetic patients

2010 - Study ~ Expression of cannabinoid CB1 receptors by vagal afferent neurons: kinetics and role in
influencing neurochemical phenotype

2010 - Study ~ Polymorphisms in the endocannabinoid receptor 1 in relation to fat mass distribution

2010 - Study ~ The endocannabinoid system links gut microbiota to adipogenesis

2010 - Study ~ CD36 gene deletion decreases oleoylethanolamide levels in small intestine of free-
feeding mice.

2010 - Study ~ A common CNR1 (cannabinoid receptor 1) haplotype attenuates the decrease in HDL
cholesterol that typically accompanies weight gain.

2010 - Study ~ The Effects of Rimonabant on Brown Adipose Tissue in Rat: Implications for Energy
Expenditure

2010 - Study ~ Differential alterations of the concentrations of endocannabinoids and related lipids in the
subcutaneous adipose tissue of obese diabetic patients.

2010 - Study ~ Cannabinoid receptor stimulation impairs mitochondrial biogenesis in mouse white
adipose tissue, muscle, and liver: the role of eNOS, p38 MAPK, and AMPK pathways.

2010 - Study ~ The novel cannabinoid CB1 antagonist AM6545 suppresses food intake and food-
reinforced behavior.

2010 - Study ~ Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse
models of obesity.

2010 - Study ~ A common polymorphism in the cannabinoid receptor 1 (CNR1) gene is associated with
antipsychotic-induced weight gain in Schizophrenia.

2010 - Study ~ Rehashing endocannabinoid antagonists: can we selectively target the periphery to safely
treat obesity and type 2 diabetes?

2010 - Study ~ Modulation of Adipocyte Biology by Δ9-Tetrahydrocannabinol

2010 - Study ~ Cannabidiol Attenuates the Appetitive Effects of Δ9-Tetrahydrocannabinol in Humans
Smoking Their Chosen Cannabis

2010 - Study ~ Perspectives of CB1 Antagonist in Treatment of Obesity: Experience of RIO-Asia

2010 - Study ~ A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food
intake and body weight, but does not cause malaise, in rodents

2010 - Study ~ Deficiency of CB2 cannabinoid receptor in mice improves insulin sensitivity but
increases food intake and obesity with age.

2010 - Study ~ A clinical trial assessing the safety and efficacy of the CB1R inverse agonist taranabant
in obese and overweight patients: low-dose study

2010 - Study ~ A one-year study to assess the safety and efficacy of the CB1R inverse agonist taranabant
in overweight and obese patients with type 2 diabetes.

2010 - Study ~ Analysis of gene expression pattern reveals potential targets of dietary
oleoylethanolamide in reducing body fat gain in C3H mice.

2010 - Study ~ G1359A polymorphism in the cannabinoid receptor-1 gene is associated with metabolic
syndrome in the Chinese Han population

2010 - Study ~ Effect of dietary fat on endocannabinoids and related mediators: consequences on energy
homeostasis, inflammation and mood.

2010 - Study ~ Cannabis Use and Obesity and Young Adults

2010 - Study ~ The endocannabinoid system modulates the valence of the emotion associated to food
ingestion

2011 - Study ~ Resistance to diet-induced adiposity in cannabinoid receptor-1 deficient mice is not due
to impaired adipocyte function

2011 - Study ~ Krill oil significantly decreases 2-arachidonoylglycerol plasma levels in obese subjects.

2011 - Study ~ Effect of dietary krill oil supplementation on the endocannabinoidome of metabolically
relevant tissues from high-fat-fed mice

2011 - Study ~ Lipid transport function is the main target of oral oleoylethanolamide to reduce adiposity
in high-fat-fed mice

2011 - Study ~ The activity of the endocannabinoid metabolising enzyme fatty acid amide hydrolase in
subcutaneous adipocytes correlates with BMI in metabolically healthy humans

2011 - Study ~ Sympathetic activity controls fat-induced oleoylethanolamide signaling in small intestine.

2011 - Study ~ The association of the rs1049353 polymorphism of the CNR1 gene with
hypoadiponectinemia.

2011 - Study ~ Gadolinium-HU-308-incorporated micelles.

2011 - Study ~ Adipose tissue endocannabinoid system gene expression: depot differences and effects of
diet and exercise

2011 - Study ~ 385 C/A polymorphism of the fatty acid amide hydrolase gene is associated with
metabolic syndrome in the Chinese Han population.

2011 - Study ~ Greasing the wheels of managing overweight and obesity with omega-3 fatty acids

2011 - Study ~ Obesity and Cannabis Use: Results From 2 Representative National Surveys

2011 - Letter ~ Sweet taste and (AAT)12 repeat in the cannabinoid receptor gene in obese females

2011 - Study ~ Psychiatric adverse effects of rimonobant in adults with Prader Willi syndrome.

2011 - Study ~ The neutral cannabinoid CB1 receptor antagonist AM4113 regulates body weight through
changes in energy intake in the rat.

2011 - Study ~ Effects of Chronic Oral Rimonabant Administration on Energy Budgets of Diet-Induced
Obese C57BL/6 Mice.

2011 - Study ~ The role of central CB2 cannabinoid receptors on food intake in neonatal chicks.

2011 - Study ~ Investigations of the human endocannabinoid system in two subcutaneous adipose tissue
depots in lean subjects and in obese subjects before and after weight loss

2011 - Study ~ Cannabidiol decreases body weight gain in rats: Involvement of CB2 receptors.

2011 - Study ~ Cannabinoid type 1 receptor mediates depot-specific effects on differentiation,
inflammation and oxidative metabolism in inguinal and epididymal white adipocytes.

2011 - Study ~ Are endocannabinoid type 1 receptor gene (CNR1) polymorphisms associated with
obesity and metabolic syndrome in postmenopausal Polish women?

2011 - Study ~ The central cannabinoid CB1 receptor is required for diet-induced obesity and
rimonabant's antiobesity effects in mice

2011 - News ~ Frequency Of Marijuana Use Associated With Lower Prevalence Of Obesity, Study Says

2011 - News ~ Smoking marijuana not linked to obesity: study

2011 - News ~ Body's natural marijuana-like chemicals make fatty foods hard to resist

2012 - Study ~ To Be or Not To Be—Obese

2012 - Study ~ The L-α-lysophosphatidylinositol/GPR55 system and its potential role in human obesity.

2012 - Study ~ Resistance to diet-induced adiposity in cannabinoid receptor-1 deficient mice is not due
to impaired adipocyte function.

2012 - Study ~ Homology modelling of CB1 receptor and selection of potential inhibitor against Obesity.

2012 - Study ~ Cannabinoid Receptor 1 (CNR1) 4895 C/T Genetic Polymorphism was Associated with
Obesity in Japanese Men.

2012 - Study ~ Relationships between glucose, energy intake and dietary composition in obese adults
with type 2 diabetes receiving the cannabinoid 1 (CB1) receptor antagonist, rimonabant

2012 - Study ~ Excess of the endocannabinoid anandamide during lactation induces overweight, fat
accumulation and insulin resistance in adult mice

2012 - Study ~ Hypothalamic 2-arachidonoylglycerol regulates multistage process of high-fat diet
preferences.

2012 - Study ~ Dietary linoleic acid elevates endogenous 2-AG and anandamide and induces obesity.

2012 - Study ~ Over-Expression of Monoacylglycerol Lipase (MGL) in Small Intestine Alters
Endocannabinoid Levels and Whole Body Energy Balance, Resulting in Obesity.

2012 - Study ~ Type 2 Diabetes Associated Changes in the Plasma Non-Esterified Fatty Acids,
Oxylipins and Endocannabinoids

2012 - Study ~ Endocannabinoids measurement in human saliva as potential biomarker of obesity.

2012 - Study ~ Metabolic effects of n-3 PUFA as phospholipids are superior to triglycerides in mice fed
a high-fat diet: possible role of endocannabinoids.

2012 - Study ~ The dynamic nature of type 1 cannabinoid receptor (CB1) gene transcription

2012 - Study ~ Gut microbiota and the development of obesity.

2012 - Study ~ 2-Arachidonoylglycerol Signaling in Forebrain Regulates Systemic Energy Metabolism

2012 - Study ~ CNR1 genotype influences HDL-cholesterol response to change in dietary fat intake.

2012 - Study ~ Hypothalamic CB1 Cannabinoid Receptors Regulate Energy Balance in Mice

2012 - Study ~ Dietary linoleic acid elevates endogenous 2-arachidonoylglycerol and anandamide in
Atlantic salmon (Salmo salar L.) and mice, and induces weight gain and inflammation in
mice.

2012 - Study ~ The atypical cannabinoid O-1602 stimulates food intake and adiposity in rats.

2012 - Study ~ Cannabinoid signalling regulates inflammation and energy balance: The importance of
the brain-gut axis

2012 - Study ~ Diet-dependent modulation of hippocampal expression of endocannabinoid signaling-
related proteins in cannabinoid antagonist-treated obese rats.

2012 - Study ~ Cannabis exposure associated with weight reduction and β-cell protection in an obese rat
model.

2012 - Study ~ Anti-obesity effects of the combined administration of CB1 receptor antagonist
rimonabant and melanin-concentrating hormone antagonist SNAP-94847 in diet-inudced
obese mice.

2012 - Study ~ Overexpression of cannabinoid CB2 receptor in the brain induces hyperglycaemia and a
lean phenotype in adult mice.

2012 - Study ~ Overexpression of cannabinoid CB2 receptor in the brain induces hyperglycaemia and a
lean phenotype in adult mice.

2012 - Study ~ Cannabinol and cannabidiol exert opposing effects on rat feeding patterns.

2012 - Study ~ The thrifty lipids: endocannabinoids and the neural control of energy conservation.

2012 - Study ~ Stimulation of acumbens shell cannabinoid CB(1) receptors by noladin ether, a putative
endocannabinoid, modulates food intake and dietary selection in rats.

2012 - Study ~ Associations of variants of CNR1 with obesity and obesity-related traits in Chinese
women.

2012 - Study ~ Photoperiodic Changes in Endocannabinoid Levels and Energetic Responses to Altered
Signalling at CB1 Receptors in Siberian Hamsters

2012 - Study ~ The role of the endocannabinoid system in eating disorders: pharmacological
implications.

2012 - Study ~ The potential use of cannabidiol in the therapy of metabolic syndrome

2012 - Study ~ GPR119 as a fat sensor.

2012 - Study ~ Hedonic eating is associated with increased peripheral levels of ghrelin and the
endocannabinoid 2-arachidonoyl-glycerol in healthy humans: a pilot study.

2012 - Study ~ Role of G1359A polymorphism of the cannabinoid receptor gene on weight loss and
adipocytokines levels after two different hypocaloric diets.

2012 - Study ~ Simultaneous postprandial deregulation of the orexigenic endocannabinoid anandamide
and the anorexigenic peptide YY in obesity

2012 - Study ~ The role of the endocannabinoid system in skeletal muscle and metabolic adaptations to
exercise: potential implications for the treatment of obesity.

2012 - Study ~ Childhood Obesity and the Role of Dopamine D2 Receptor and Cannabinoid Receptor-1
Gene Polymorphisms.

2012 - Study ~ Cannabinoid Type 1 Receptor Gene Polymorphism and Macronutrient Intake.

2012 - Study ~ New vistas for treatment of obesity and diabetes? Endocannabinoid signalling and
metabolism in the modulation of energy balance.

2012 - Study ~ Fatty acid flux and oxidation are increased by rimonabant in obese women

2012 - News ~ 'Cannabis' receptor discovery may help understanding of obesity and pain

2012 - News ~ How marijuana could help cure obesity-related diseases

2012 - News ~ Cannabis can help treat obesity

2012 - News ~ Marijuana Slims? Why Pot Smokers Are Less Obese

2012 - News ~ Fight obesity... with marijuana?

2012 - News ~ New Drug Could Help Maintain Long-Term Weight Loss

2013 - Study ~ Reduced endothelium-dependent relaxation to anandamide in mesenteric arteries from
young obese zucker rats.

2013 - Study ~ Chronic treatment with krill powder reduces plasma triglyceride and anandamide levels
in mildly obese men

2013 - Study ~ Alterations to Melanocortinergic, GABAergic and Cannabinoid Neurotransmission
Associated with Olanzapine-Induced Weight Gain

2013 - Study ~ Obesity-driven synaptic remodeling affects endocannabinoid control of orexinergic
neurons

2013 - Study ~ Hypothalamic 2-Arachidonoylglycerol Regulates Multistage Process of High-Fat Diet
Preferences

2013 - Study ~ Moderation of antipsychotic-induced weight gain by energy balance gene variants in the
RUPP autism network risperidone studies

2013 - Study ~ Orexin neurons use endocannabinoids to break obesity-induced inhibition

2013 - Study ~ Reduced Food Intake is the Major Contributor to the Protective Effect of Rimonabant on
Islet in Established Obesity-Associated Type 2 Diabetes.

2013 - Study ~ Developmental Role for Endocannabinoid Signaling in Regulating Glucose Metabolism
and Growth.

2013 - Study ~ Genetic variation in the cannabinoid receptor gene (CNR1) (G1359A polymorphism) and
their influence on anthropometric parameters and metabolic parameters under a high
monounsaturated vs. high polyunsaturated fat hypocaloric diets.

2013 - Study ~ Insulin induces long-term depression of ventral tegmental area dopamine neurons via
endocannabinoids

2013 - Study ~ Cannabis and Δ(9)-tetrahydrocannabinol (THC) for weight loss?

2013 - Study ~ Endocannabinoids and obesity.

2013 - Study ~ Novel antiobesity agents: Synthesis and pharmacological evaluation of analogues of
Rimonabant and of LH21

2013 - Study ~ Fat to treat fat: Emerging relationship between dietary PUFA, endocannabinoids, and
obesity.

2013 - Study ~ Improvement in coronary circulatory function in morbidly obese individuals after gastric
bypass-induced weight loss: relation to alterations in endocannabinoids and
adipocytokines

2013 - Study ~ The endocannabinoid system in obesity

2013 - Study ~ Effects of CB1 receptor blockade on monosodium glutamate induced hypometabolic and
hypothalamic obesity in rats.

2013 - Study ~ The cannabinoid Δ(9)-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in
two mouse models of obesity
.

2013 - Study ~ Activation of type 2 cannabinoid receptors (CB2R) promotes fatty acid oxidation through
the SIRT1/PGC-1α pathway.

2013 - Study ~ Polymorphism rs3123554 in CNR2 reveals gender-specific effects on body weight and
affects loss of body weight and cerebral insulin action.

2013 - Study ~ Analysis of the "endocannabinoidome" in peripheral tissues of obese Zucker rats

2013 - Study ~ The Role of the Endocannabinoid System in Eating Disorders: Neurochemical and
Behavioural Preclinical Evidence
.

2013 - Study ~ Novel effects of the cannabinoid inverse agonist AM 251 on parameters related to
metabolic syndrome in obese Zucker rats.

2013 - Study ~ Endocannabinoid crosstalk between placenta and maternal fat in a baboon model (Papio
spp.) of obesity.

2013 - Study ~ High fat diet and body weight have different effects on cannabinoid CB1 receptor
expression in rat nodose ganglia.

2013 - Study ~ Monounsaturated fatty acids generated via stearoyl CoA desaturase-1 are endogenous
inhibitors of fatty acid amide hydrolase.

2013 - Study ~ Food for thought: hormonal, experiential, and neural influences on feeding and obesity.

2013 - Study ~ Long-term supplementation of honokiol and magnolol ameliorates body fat
accumulation, insulin resistance, and adipose inflammation in high-fat fed mice.

2013 - Study ~ Role of Genetic Variation in the Cannabinoid Receptor Gene (CNR1) (G1359A
Polymorphism) on Weight Loss and Cardiovascular Risk Factors After Liraglutide
Treatment in Obese Patients With Diabetes Mellitus Type 2.

2013 - Study ~ Vascular targets for cannabinoids: animal and human studies

2013 - Study ~ Regulation of GPR55 in rat white adipose tissue and serum LPI by nutritional status,
gestation, gender and pituitary factors.

2013 - Study ~ Cannabinoids, eating behaviour, and energy homeostasis.

2013 - Study ~ The regulation of food intake by the gut-brain axis: implications for obesity

2013 - Study ~ A potential role for GPR55 in the regulation of energy homeostasis.

2013 - Study ~ Concurrent pharmacological modification of cannabinoid-1 and glucagon-like peptide-1
receptor activity affects feeding behavior and body weight in rats fed a free-choice, high-
carbohydrate diet.

2013 - Study ~ Effect of high fat-diet and obesity on gastrointestinal motility.

2013 - Study ~ Effects of C358A polymorphism of the endocannabinoid degrading enzyme fatty acid
amide hydrolase (FAAH) on weight loss, adipocytokines levels, and insulin resistance
after a high polyunsaturated fat diet in obese patients.

2013 - News ~ Key Shift in Brain That Creates Drive to Overeat Identified

2013 - News ~ Regular Marijuana Use is Associated With Favorable Indices to Diabetic Control, Say
Investigators

2013 - News ~ Marijuana Users Have Better Blood Sugar Control

2013 - News ~ Study: Why Pot Smokers Are Skinnier

2013 - News ~ Cannabis linked to prevention of diabetes

2013 - News ~ Study: Marijuana Smokers Are Thinner And Healthier Than Non-Users

2014 - Study ~ CB1 blockade-induced weight loss over 48 weeks decreases liver fat in proportion to
weight loss in humans

2014 - Study ~ Effect of intermittent cold exposure on brown fat activation, obesity, and energy
homeostasis in mice.

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