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NEUROPATHY & Cannabis studies completed

Overview

Neuropathy is not a single disease - instead, it is a complication found in a number of different underlying medical conditions. It can also be seen without the cause being diagnosed, when doctors called it "diopathic."


The term neuropathy is short for peripheral neuropathy, meaning nerve damage in the peripheral nervous system. Only nerves outside of the brain and spinal cord are involved, so peripheral neuropathy does not include nerve damage in the central nervous system.

Science and Research

1997- Study ~ The perceived effects of smoked cannabis on patients with multiple sclerosis

1997 - Study ~ Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain.

1999 - Study ~ Analgesic effect of the cannabinoid analogue nabilone is not mediated by opioid receptors.

2000 - Study ~ Cannabinoid Receptor Messenger Rna Levels Decrease in a Subset of Neurons of the Lateral Striatum, Cortex and Hippocampus of Transgenic Huntington's Disease Mice.

2001 - Study ~ The synthetic cannabinoid WIN55,212-2 attenuates hyperalgesia and allodynia in a rat model of neuropathic pain.

2002 - Study ~ The potent emetogenic effects of the endocannabinoid, 2-AG (2-arachidonoylglycerol) are blocked by delta(9)-tetrahydrocannabinol and other cannnabinoids.

2003 - Study ~ Whether whole plant Cannabis extracts can improve intractable neurogenic symptoms?

2003- Study ~ Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: Pain inhibition by receptors not present in the CNS

2003 - Study ~ Analgesic effect of the synthetic cannabinoid CT-3 on chronic neuropathic pain: a randomized controlled trial.

2003 - Study ~ Randomised controlled trial of cannabis based medicinal extracts (CBME) in central neuropathic pain due to multiple sclerosis.

2003- Study ~ The effects of smoked cannabis in painful peripheral neuropathy and cancer pain refractory to opiods.

2003 - News ~ New Compound That Acts On Peripheral Receptors May Be Promising Treatment For Some Nerve Pain

2004 - Study ~ Initial experiences with medicinal extracts of cannabis for chronic pain: Results from 34 ‘N of 1’ studies

2004- Study ~ Efficacy of two cannabis based medicinal extracts for relief of central neuropathic pain from brachial plexus avulsion: results of a randomised controlled trial

2004 - Study ~ Are oral cannabinoids safe and effective in refractory neuropathic pain?

2003 - News ~ Marijuana-like compounds may aid array of debiliating conditions ranging from Parkinson's to pain

2005- Study ~ Ajulemic acid (IP-751): Synthesis, proof of principle, toxicity studies, and clinical trials

2003 - Study ~ Smoked cannabis therapy for HIV-related painful peripheral neuropathy: results of a randomized, placebo-controlled clinical trial.

2005 - Study ~ Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis

2006- Study ~ Effects of a Cannabinoid Agonist on Spinal Nociceptive Neurons in a Rodent Model of Neuropathic Pain

2006 - Study ~ Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models

2006 - Study ~ Cannabinoids In Medicine: A Review Of Their Therapeutic Potential

2006- Study ~ CB1 receptor selective activation inhibits beta-amyloid-induced iNOS protein expression in C6 cells and subsequently blunts tau protein hyperphosphorylation in co-cultured neurons.

2006 - News ~ In MedPanel Summit, Leading Pain Experts Name Cannabinoids Among Most Promising Approaches to Treating Neuropathic Pain, Assert That Sociopolitical Climate Will Hamper Drug Approvals

2007 - Study ~ Endocannabinoid metabolism and uptake: novel targets for neuropathic and inflammatory pain

2007- Study ~ The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice.

2007 - Study ~ Cannabinoid CB2 receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain

2007 - Study ~ Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain.

2007- Study ~ Sativex successfully treats neuropathic pain characterised by allodynia: A randomised, double-blind, placebo-controlled clinical trial

2007 - Study ~ Oromucosal delta9-tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: an uncontrolled, open-label, 2-year extension trial.

2007 - Study ~ The synthetic cannabinoids attenuate allodynia and hyperalgesia in a rat model of trigeminal neuropathic pain.

2007 - Study ~ Cannabis in painful HIV-associated sensory neuropathy: A randomized placebo-controlled trial.

2007 - News ~  Study Supports Medical Marijuana Use

2007 - News ~ Smoked Cannabis Reduces Foot Pain Associated With HIV In Placebo Trial

2007 - News ~ Marijuana gives relief from chronic pain for AIDS sufferers

2007 - News ~ Cannabis may be safe and effective for HIV-related neuropathic pain

2007 - News ~ Marijuana, Very Efficient in Cutting Off HIV Related Nerve Pain

2007 - Study ~ Smoked Cannabis Proven Effective In Treating Neuropathic Pain

2008 - Study ~ Selective Activation of Cannabinoid CB2 Receptors Suppresses Neuropathic Nociception Induced by Treatment with the Chemotherapeutic Agent Paclitaxel in Rats

2008 - Study ~ Crucial Role of CB2 Cannabinoid Receptor in the Regulation of Central Immune Responses during Neuropathic Pain

2008 - Study ~ Double Blind, Placebo Controlled Trial of Smoked Marijuana on Neuropathic Pain

2008 - Study ~ Comparison of analgesic effects and patient tolerability of nabilone and dihydrocodeine for chronic neuropathic pain: randomised, crossover, double blind study.

2008 - Study ~ Design and synthesis of a novel series of N-alkyl isatin acylhydrazone derivatives that act as selective cannabinoid receptor 2 agonists for the treatment of neuropathic pain.

2008 - Study ~ Differential effects of repeated low dose treatment with the cannabinoid agonist WIN 55,212-2 in experimental models of bone cancer pain and neuropathic pain.

2008- Study ~ Antihyperalgesic effect of a Cannabis sativa extract in a rat model of neuropathic pain: mechanisms involved.

2008 - News ~ Medicinal Marijuana Effective For Neuropathic Pain In HIV, Study Finds

2008 - News ~ Marijuana May Be Effective For Neuropathic Pain

2009 - Study ~ Tetrahydrocannabinol (Delta 9-THC) Treatment in Chronic Central Neuropathic Pain and Fibromyalgia Patients: Results of a Multicenter Survey

2009 - Study ~ Sustained antinociceptive effect of cannabinoid receptor agonist WIN 55,212-2 over time in rat model of neuropathic spinal cord injury pain

2009 - Study ~ Neuropathic Pain and Endocannabinoid-Degradation Blockade

2009 - Study ~ Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain.

2009 - Study ~  Cannabinoids as pharmacotherapies for neuropathic pain: from the bench to the bedside.

2009- Study ~ Beneficial effects of a Cannabis sativa extract treatment on diabetes-induced neuropathy and oxidative stress.

2009 - News ~ Medical Marijuana and Peripheral Neuropathy

2010 - Study ~ Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain

2010 Study ~ R-Flurbiprofen Reduces Neuropathic Pain in Rodents by Restoring Endogenous Cannabinoids

2010 - Study ~ Pharmacological Treatment of Painful HIV-Associated Sensory Neuropathy: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

2010 - Study ~ Smoked cannabis for chronic neuropathic pain: a randomized controlled trial

2010 - Study ~ Pharmacological characterization of a novel cannabinoid ligand, MDA19, for treatment of neuropathic pain.

2010 - Study ~ Misdiagnosed chronic pelvic pain: pudendal neuralgia responding to a novel use of palmitoylethanolamide.

2010- Study ~ An Open-Label Comparison of Nabilone and Gabapentin as Adjuvant Therapy or Monotherapy in the Management of Neuropathic Pain in Patients with Peripheral Neuropathy.

2010 - Study ~ Effect of dronabinol on central neuropathic pain after spinal cord injury: a pilot study.

2010- Study ~ Cannabinoid subtype-2 receptors modulate the antihyperalgesic effect of WIN 55,212-2 in rats with neuropathic spinal cord injury pain.

2010 - News ~ Study Claims Cannabis Reduces Chronic Pain

2010 - News ~ Cannabinoids inhibit and may prevent neuropathic pain in diabetes.

2010 - News ~ Study: Smoking pot may ease chronic pain

2011 - Study ~ Cannabinoid Agonists Inhibit Neuropathic Pain Induced by Brachial Plexus Avulsion in Mice by Affecting Glial Cells and MAP Kinases.

2011 - Study ~ Mutations in ABHD12 cause the neurodegenerative disease PHARC: An inborn error of endocannabinoid metabolism.

2011 - Study ~ Spinal cannabinoid CB2 receptors as a target for neuropathic pain: an investigation using chronic constriction injury.

2011 - Study ~ Cannabinoids for Treatment of Chronic Non-Cancer Pain; a Systematic Review of Randomized Trials.

2011 - Study ~ Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress.

2011 - Study ~ Self-medication of a cannabinoid CB(2) agonist in an animal model of neuropathic pain.

2011 - Study ~ Activation of spinal and supraspinal cannabinoid-1 receptors leads to antinociception in a rat model of neuropathic spinal cord injury pain.

2011 - News ~ Cannabinoid 'Completely' Prevents Chemotherapy-Induced Neuropathy, Study Says

2011 - News ~ Marijuana component may ease pain from chemo therapy drugs

2012 - Study ~ Prescribing Cannabis for Harm Reduction.

2012 - Study ~ The atypical cannabinoid O-1602 increases hind paw sensitisation in the chronic constriction injury model of neuropathic pain.

2012 - Study ~ Cannabinoid agonist WIN 55,212-2 prevents the development of paclitaxel-induced peripheral neuropathy in rats. Possible involvement of spinal glial cells.

2012 - Study ~ Low brain penetrant CB1 receptor agonists for the treatment of neuropathic pain.

2012 - Study ~ Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors.

2012 - Study ~ Characterization of cannabinoid-induced relief of neuropathic pain in rat models of type 1 and type 2 diabetes.

2012 - Study ~ Prevention of Paclitaxel-Induced Neuropathy Through Activation of the Central Cannabinoid Type 2 Receptor System

2012 - Study ~ A Randomized, Double-Blind, Placebo Controlled, Parallel Assignment, Flexible Dose, Efficacy Study of Nabilone as Adjuvant in the Treatment of Diabetic Peripheral Neuropathic Pain Using an Enriched Enrollment Randomized Withdrawal Design

2012 - Study ~ The Novel Reversible Fatty Acid Amide Hydrolase Inhibitor ST4070 Increases Endocannabinoid Brain Levels and Counteracts Neuropathic Pain in Different Animal Models