is an electrically excitable cell
that processes and transmits information through electrical and
After you inhale marijuana smoke, its chemicals
distributed throughout the body. CB1 receptors are most common in the
NEURONS (BRAIN CELLS) and cannabis studies completed
1990 - Study ~ Cannabinoid Receptor Localization in Brain
1994 - Letter ~ Formation and inactivation of endogenous cannabinoid anandamide in central neurons.
1995 - Study ~ Anandamide amidohydrolase activity in rat brain microsomes. Identification and partial characterization.
1995 - Study ~ The CB1 cannabinoid receptor antagonist SR 141716A affects A9 dopamine neuronal activity in the rat.
1996 - Study ~ Genetic differences in delta 9-tetrahydrocannabinol-induced facilitation of brain stimulation reward as measured by a rate-frequency curve-shift electrical brain stimulation paradigm in three different rat strains.
1998 - Study ~ Cannabinoid Receptor Agonists Protect Cultured Rat Hippocampal Neurons from Excitotoxicity
1998 - Study ~ Potent Effects of a Selective Cannabinoid Receptor Agonist on Some Guinea Pig Medial Vestibular Nucleus Neurons.
1998 - Study ~ Loss of Cannabinoid Receptor Binding and Messenger Rna Levels and Cannabinoid Agonist-stimulated [35s]guanylyl-5'o-(Thio)-triphosphate Binding in the Basal Ganglia of Aged Rats.
1999 - Study ~ Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain.
2000 - Study ~ Neuroprotective Antioxidants from Marijuana
2002 - Study ~ Endocannabinoids in the central nervous system--an overview.
2003 - Study ~ Neurons on cannabinoids: dead or alive?
2003 - Study ~ Role of Endogenous Cannabinoids in Synaptic Signaling
2003 - Study ~ Cannabis and the brain.
2003 - Study ~ Cannabinoid receptor type 1 modulates excitatory and inhibitory neurotransmission in mouse colon
2003 - Study ~ Post-ischemic Treatment with Cannabidiol Prevents Electroencephalographic Flattening, Hyperlocomotion and Neuronal Injury in Gerbils.
2003 - Study ~ Cannabinoid Modulation of Peripheral Autonomic and Sensory Neurotransmission.
2004 - Study ~ Cannabinoids and neuroinflammation
2004 - Study ~ Defective adult neurogenesis in CB1 cannabinoid receptor knockout mice.
2004 - News ~ Marijuana-Like Chemicals in the Brain Calm Neurons
2005 - Study ~ Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects
2005 - Study ~ Identification and functional characterization of brainstem cannabinoid CB2 receptors.
2005 - Study ~ The endocannabinoid system drives neural progenitor proliferation.
2005 - Study ~ Sex differences in the cannabinoid modulation of an A-type K+ current in neurons of the mammalian hypothalamus.
2005 - News ~ High-dose cannabis stimulates growth of brain cells in rats
2005 - News ~ Marijuana Promotes Neuron Growth
2005 - News ~ Marijuana May Spur New Brain Cells
2005 - News ~ Good News For The Medical Marijuana Movement: Pot Proliferates Brain Cells And Boosts Mood
2005 - News ~ Marijuana May Grow Neurons in the Brain
2005 - News ~ Marijuana might cause new cell growth in the brain
2006 - Study ~ Non-psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferation
2006 - Study ~ Differential effect of cannabinoid agonists and endocannabinoids on histamine release from distinct regions of the rat brain.
2006 - Study ~ Differential effects of cannabis extracts and pure plant cannabinoids on hippocampal neurones and glia.
2006 - Study ~ Neuromodulatory functions of the endocannabinoid system.
2007 - Study ~ The synthetic cannabinoid HU210 induces spatial memory deficits and suppresses hippocampal firing rate in rats
2007 - Study ~ CB2 cannabinoid receptors promote mouse neural stem cell proliferation.
2007 - Study ~ The endocannabinoid system and neurogenesis in health and disease.
2008 - Study ~ The CB2 Cannabinoid Receptor Controls Myeloid Progenitor Trafficking:
INVOLVEMENT IN THE PATHOGENESIS OF AN ANIMAL MODEL OF MULTIPLE SCLEROSIS
2008 - Study ~ Design Logic of a Cannabinoid Receptor Signaling Network That Triggers Neurite Outgrowth
2008 - News ~ New brain cells implicated in machinery of cannabinoid signaling
2009 - Study ~ Delta 9-tetrahydrocannabinol induces dopamine release in the human striatum.
2009 - Study ~ Cannabinoid agonist WIN-55,212-2 partially restores neurogenesis in the aged rat brain
2009 - Study ~ Endocannabinoid-mediated control of synaptic transmission.
2009 - Study ~ Cannabinoids attenuate the effects of aging upon neuroinflammation and neurogenesis.
2009 - Study ~ Endocannabinoid signaling in neurotoxicity and neuroprotection.
2009 - Study ~ Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania
2009 - Study ~ Oleoylethanolamide exerts partial and dose-dependent neuroprotection of substantia nigra dopamine neurons.
2009 - Study ~ Cannabinoid receptors in brain: pharmacogenetics, neuropharmacology, neurotoxicology, and potential therapeutic applications.
2010 - Study ~ Cyclooxygenase-2 Mediates Anandamide Metabolism in the Mouse Brain
2010 - Study ~ Cannabinoids Excite Circadian Clock Neurons
2010 - Study ~ Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis
2010 - Study ~ AAV vector-mediated overexpression of CB1 cannabinoid receptor in pyramidal neurons of the hippocampus protects against seizure-induced excitoxicity.
2010 - Study ~ Sex difference in cell proliferation in developing rat amygdala mediated by endocannabinoids has implications for social behavior.
2010 - Study ~ CB1 cannabinoid receptors increase neuronal precursor proliferation through AKT/glycogen synthase kinase-3beta/beta-catenin signaling.
2010 - Study ~ Cannabidiol protects retinal neurons by preserving glutamine synthetase activity in diabetes.
2010 - Study ~ Regulatory Role of Cannabinoid Receptor 1 in Stress-Induced Excitotoxicity and Neuroinflammation
2010 - Study ~ Palmitoylethanolamide and other anandamide congeners. Proposed role in the diseased brain.
2010 - Study ~ Endocannabinoids Prevent β-Amyloid-mediated Lysosomal Destabilization in Cultured Neurons
2010 - Study ~ PP-014 Control of receptor expression in vagal afferent neurons by activation of cannabinoid 1 receptors
2010 - Study ~ Protective effects of the synthetic cannabinoids CP55,940 and JWH-015 on rat brain mitochondria upon paraquat exposure.
2010 - Study ~ Delta9-tetrahydrocannabinol is a full agonist at CB1 receptors on GABA neuron axon terminals in the hippocampus.
2010 - News ~ Chronic Low Doses of a Cannabinoid Causes New Brain Cell Formation
2011 - Study ~ Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement
2011 - Study ~ Sex difference in cell proliferation in developing rat amygdala mediated by endocannabinoids has implications for social behavior
2011 - Study ~ Dual inhibition of alpha/beta hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons.
2011 - Study ~ Cannabinoid receptor agonist protects cultured dopaminergic neurons from the death by the proteasomal dysfunction.
2011 - Study ~ Endocannabinoid signaling in the amygdala: anatomy, synaptic signaling, behavior, and adaptations to stress.
2011 - Study ~ The Dopamine and Cannabinoid Interaction in the Modulation of Emotions and Cognition: Assessing the Role of Cannabinoid CB1 Receptor in Neurons Expressing Dopamine D1 Receptors.
2011 - Study ~ History of cannabis use is not associated with alterations in striatal dopamine D2/D3 receptor availability.
2011 - Study ~ The G protein-coupled cannabinoid-1 (CB(1)) receptor of mammalian brain: Inhibition by phthalate esters in vitro.
2011 - Study ~ α-Tocopherol and α-tocopheryl phosphate interact with the cannabinoid system in the rodent hippocampus.
2011 - Study ~ Effects of synthetic cannabinoids on electroencephalogram power spectra in rats.
2011 - Study ~ Pharmacological activation/inhibition of the cannabinoid system affects alcohol withdrawal-induced neuronal hypersensitivity to excitotoxic insults.
2011 - Study ~ CB2 Cannabinoid Receptors Promote Neural Progenitor Cell Proliferation via mTORC1 Signaling
2011 - Study ~ Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions.
2011 - Study ~ Δ(9)-THC and WIN55,212-2 affect brain tissue levels of excitatory amino acids in a phenotype-, compound-, dose-, and region-specific manner
2011 - Study ~ Cannabinoid Receptor Type 1 Protects Nigrostriatal Dopaminergic Neurons against MPTP Neurotoxicity by Inhibiting Microglial Activation
2011 - Study ~ Activation of Cannabinoid Type 2 Receptors Inhibits HIV-1 Envelope Glycoprotein gp120-Induced Synapse Loss
2011 - News ~ A Brain Wrought Without Omega-3
2012 - Study ~ Role of CB1 cannabinoid receptors on GABAergic neurons in brain aging
2012 - Study ~ Type-1 Cannabinoid Receptor Signaling in Neuronal Development.
2012 - Study ~ Endocannabinoids and the processing of value-related signals.
2012 - Study ~ Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α.
2012 - Study ~ Mitochondrial CB(1) receptors regulate neuronal energy metabolism.
2012 - Study ~ Effects of cannabinoids Δ(9)-tetrahydrocannabinol, Δ(9)-tetrahydrocannabinolic acid and cannabidiol in MPP(+) affected murine mesencephalic cultures.
2012 - Study ~ Cannabinoid modulation of midbrain urocortin 1 neurones during acute and chronic stress.
2012 - Study ~ Long-lasting potentiation of hippocampal synaptic transmission by direct cortical input is mediated via endocannabinoids
2012 - Study ~ Excitability of prefrontal cortical pyramidal neurons is modulated by activation of 98 intracellular type-2 cannabinoid receptors.