NAUSEA and cannabis studies completed


Nausea is the sensation of unease and discomfort in the upper stomach and head with an urge to vomit. An attack of nausea is known as a qualm.

Science & Research


1975 - Study ~ Antiemetic effect of delta-9-tetrahydrocannabinol in patients receiving cancer chemotherapy.

1979 - Study ~ Delta-9-Tetrahydrocannibinol as an Antiemetic in Cancer Patients Receiving High-Dose Methotrexate.

1979 - Study ~ Delta-9-tetrahydrocannabinol (THC) as an antiemetic in patients treated with cancer chemotherapy; a double-blind cross-over trial against placebo.

1979 - Study ~ Amelioration of cancer chemotherapy-induced nausea and vomiting by delta-9-tetrahydrocannabinol.

1979 - Study ~ Superiority of nabilone over prochlorperazine as an antiemetic in patients receiving cancer chemotherapy.

1979 - Study ~ Delta-9-tetrahydrocannabinol as an antiemetic for patients receiving cancer chemotherapy. A comparison with prochlorperazine and a placebo.

1980 - Study ~ Double-blind comparison of the antiemetic effects of nabilone and prochlorperazine on chemotherapy-induced emesis.

1980 - Study ~ Antiemetic effect of tetrahydrocannabinol. Compared with placebo and prochlorperazine in chemotherapy-associated nausea and emesis.

1980 - Study ~ The antiemetic activity of tetrahydrocanabinol versus metoclopramide and thiethylperazine in patients undergoing cancer chemotherapy.

1980 - Study ~ Antiemetics in patients receiving chemotherapy for cancer: a randomized comparison of delta-9-tetrahydrocannabinol and prochlorperazine.

1981 - Study ~ Dose vs response of tetrahydroannabinol (THC) vs prochlorperazine as chemotherapy antiemetics.

1981 - Study ~ Physiologic observations in a controlled clinical trial of the antiemetic effectiveness of 5, 10, and 15 mg of delta 9-tetrahydrocannabinol in cancer chemotherapy. Ophthalmologic implications.

1981 - Study ~ Clinical experience with levonantradol hydrochloride in the prevention of cancer chemotherapy-induced nausea and vomiting.

1981 - Study ~ Comparative trial of the antiemetic effects of THC and haloperidol.

1982 - Study ~ A double-blind, controlled trial of nabilone vs. prochlorperazine for refractory emesis induced by cancer chemotherapy.

1982 - Study ~ Cannabis and cancer chemotherapy: a comparison of oral delta-9-THC and prochlorperazine.

1982 - Study ~ A multi-institutional Phase III study of nabilone vs. placebo in chemotherapy-induced nausea and vomiting.

1983 - Study ~ Anti-emetic efficacy and toxicity of nabilone, a synthetic cannabinoid, in lung cancer chemotherapy.

1983 - Study ~ Levonantradol: a synthetic cannabinoid in the treatment of severe chemotherapy-induced nausea and vomiting resistant to conventional anti-emetic therapy.

1985 - Study ~ THC or Compazine for the cancer chemotherapy patient--the UCLA study. Part II: Patient drug preference.

1985 - Study ~ A cross-over comparison of nabilone and prochlorperazine for emesis induced by cancer chemotherapy.

1985 - Study ~ Antiemetic efficacy of levonantradol compared to delta-9-tetrahydrocannabinol for chemotherapy-induced nausea and vomiting.

1986 - Study ~ Nabilone and metoclopramide in the treatment of nausea and vomiting due to cisplatinum: a double blind study.

1986 - Study ~ Nabilone: an alternative antiemetic for cancer chemotherapy.

1986 - Study ~ Crossover comparison of the antiemetic efficacy of nabilone and alizapride in patients with nonseminomatous testicular cancer receiving cisplatin therapy.

1986 - Study ~ Prospective randomized double-blind trial of nabilone versus domperidone in the treatment of cytotoxic-induced emesis.

1987 - Study ~ Nabilone versus prochlorperazine for control of cancer chemotherapy-induced emesis in children: a double-blind, crossover trial.

1987 - Study ~ A double-blind randomised cross-over comparison of nabilone and metoclopramide in the control of radiation-induced nausea.

1988 - Study ~ Oral vs. Inhaled Cannabinoids for Nausea/Vomiting from Cancer Chemotherapy.

1988 - Study ~ Efficacy of tetrahydrocannabinol in patients refractory to standard anti-emetic therapy.

1988 - Study ~ A randomized trial of oral nabilone and prochlorperazine compared to intravenous metoclopramide and dexamethasone in the treatment of nausea and vomiting induced by chemotherapy regimens containing cisplatin or cisplatin analogues.

1991 - Study ~ Marijuana as antiemetic medicine: a survey of oncologists' experiences and attitudes.

1994 - Study ~ Effect of nabilone on nausea and vomiting after total abdominal hysterectomy.

1995 - Letter ~ Effect of nabilone on nausea and vomiting.

1995 - Study ~ An efficient new cannabinoid antiemetic in pediatric oncology.

1997 - Patent ~ Patent 5605928 - Antiemetic compositions.

1997 - Study ~ Intractable nausea and vomiting due to gastrointestinal mucosal metastases relieved by tetrahydrocannabinol (dronabinol).

2001 - Study ~ Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic review.

2001 - Study ~ Therapeutic Aspects of Cannabis and Cannabinoids.

2001 - Study ~ Delta(9)-tetrahydrocannabinol and synthetic cannabinoids prevent emesis produced by the cannabinoid CB(1) receptor antagonist/inverse agonist SR 141716A.

2001 - Study ~ The cannabinoids: an overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection.

2001 - Study ~ The cannabinoid agonist WIN55,212-2 suppresses opioid-induced emesis in ferrets.

2001 - Study ~ The cannabinoid CB1 receptor antagonist SR 141716A reverses the antiemetic and motor depressant actions of WIN 55, 212-2.

2001 - Study ~ Antiemetic efficacy of smoked marijuana: subjective and behavioral effects on nausea induced by syrup of ipecac.

2002 - Study ~ Hyperemesis Gravidarum and Clinical Cannabis: To Eat or Not to Eat?

2003- Study ~ Delta9-tetrahydrocannabinol selectively acts on CB1 receptors in specific regions of dorsal vagal complex to inhibit emesis in ferrets.

2004 - Study ~ Cannabinoids suppress synaptic input to neurones of the rat dorsal motor nucleus of the vagus nerve.

2004 - Study ~ A comparative analysis of the potential of cannabinoids and ondansetron to suppress cisplatin-induced emesis in the Suncus murinus (house musk shrew).

2005 - Patent ~ US Patent Application 20050165088 - Compositions comprising cannabinoids for treatment of nausea, vomiting, emesis, motion sickness or like conditions.

2006 - Study ~ Cannabinoids In Medicine: A Review Of Their Therapeutic Potential.

2006 - Study ~ Delta-9-tetrahydrocannabinol and cannabidiol, but not ondansetron, interfere with conditioned retching reactions elicited by a lithium-paired context in Suncus murinus: An animal model of anticipatory nausea and vomiting.

2006 - Study ~ Prevention of nausea and vomiting following breast surgery.

2006 - Study ~ The synthetic cannabinoid nabilone improves pain and symptom management in cancer patients.

2006 - Study ~ Experience with the Synthetic Cannabinoid Nabilone in Chronic Noncancer Pain.

2006 - Study ~ Methods evaluating cannabinoid and endocannabinoid effects on gastrointestinal functions.

2006 - Study ~ Dronabinol for supportive therapy in patients with malignant melanoma and liver metastases.

2007 - Patent ~ US Patent Application 20070049645 - Anti-nausea and anti-vomiting activity of cannabidiol compounds.

2007 - Study ~ THC improves appetite and reverses weight loss in AIDS patients.

2007 - Study ~ Cannabinoids in the treatment of chemotherapy-induced nausea and vomiting: beyond prevention of acute emesis.

2007 - Study ~ Efficacy of dronabinol alone and in combination with ondansetron versus ondansetron alone for delayed chemotherapy-induced nausea and vomiting.

2007 - Study ~ Dronabinol and marijuana in HIV-positive marijuana smokers: caloric intake, mood, and sleep.

2007 - Study ~ Receptor mechanism and antiemetic activity of structurally-diverse cannabinoids against radiation-induced emesis in the least shrew.

2008 - Study ~ Emerging role of cannabinoids in gastrointestinal and liver diseases: basic and clinical aspects.

2008 - News ~ Medical marijuana: a surprising solution to severe morning sickness.

2009- News ~ Medical Marijuana and Severe Nausea.

2010 - Study ~ Mechanisms of Broad-Spectrum Antiemetic Efficacy of Cannabinoids against Chemotherapy-Induced Acute and Delayed Vomiting.

2010- Study ~ Preliminary efficacy and safety of an oromucosal standardized cannabis extract in chemotherapy-induced nausea and vomiting.

2010 - Study ~ The abuse potential of the synthetic cannabinoid nabilone.

2010 - Study ~ Regulation of nausea and vomiting by cannabinoids.

2010- Study ~ Motion Sickness, Stress and the Endocannabinoid System.

2011 - Article ~ Medical Marijuana: Can Pot Help Pregnant Women With Vomiting and Nausea?

2011 - Study ~ Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews.

2011 - Study ~ Cannabidiol, a Non-Psychotropic Component of Cannabis, Attenuates Vomiting and Nausea-like Behaviour via Indirect Agonism of 5-HT(1A) Somatodendritic: Autoreceptors in the Dorsal Raphe Nucleus.

2011 - Study ~ Regulation of nausea and vomiting by cannabinoids.

2011 - News ~ How Does Marijuana Help Cancer Patients?

2011 - News ~ Medical Marijuana: Clearing Away the Smoke.

2012 - Study ~ Cannabinoids in the treatment of chemotherapy-induced nausea and vomiting.

2012 - Study ~ Tumor necrosis factor activation of vagal afferent terminal calcium is blocked by cannabinoids.

2012 - Study ~ Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?