Medical Marijuana: In Canada, the United States, the United Kingdom and Mexico, nabilone is marketed as Cesamet. It was approved in 1985 by the U.S. Food and Drug Administration (FDA) for treatment of chemotherapy-induced nausea and vomiting that has not responded to conventional antiemetics.

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Nabilone is chemically related to marijuana and belongs to the class of medications called cannabinoids.

NABILONE / CESAMET a synthetic THC, CB 1 & CB 2 agonist and cannabis studies completed

Undated - Monograph ~ GENERIC NAME: NABILONE - ORAL (NAB-ih-lone)
Brand Names : Cesamet

1979 - Study ~ Microbiological transformations of nabilone, a synthetic cannabinoid.

1979 - Study ~ Superiority of nabilone over prochlorperazine as an antiemetic in patients receiving cancer chemotherapy.

1980 - Study ~ Cannabinoids. II. Cardiovascular Effects

1980 - Study ~ Double-blind comparison of the antiemetic effects of nabilone and prochlorperazine on chemotherapy-induced emesis.

1981 - Study ~ The efficacy and safety of nabilone (a synthetic cannabinoid) in the treatment of anxiety

1982 - Study ~ A double-blind, controlled trial of nabilone vs. prochlorperazine for refractory emesis induced by cancer chemotherapy.

1982 - Study ~ A multi-institutional Phase III study of nabilone vs. placebo in chemotherapy-induced nausea and vomiting.

1983 - Study ~ Anti-emetic efficacy and toxicity of nabilone, a synthetic cannabinoid, in lung cancer chemotherapy.

1983 - Study ~ Comparison of bronchial effects of nabilone and terbutaline in healthy and asthmatic subjects.

1983 - Study ~ Respiratory and cardiovascular depressant effects of nabilone, N-methyllevonantradol and delta 9-tetrahydrocannabinol in anesthetized cats.

1984 - Study ~ Acute Effects of Natural and Synthetic Cannabis Compounds on Prolactin Levels in anesthetized cats.

1985 - Study ~ A cross-over comparison of nabilone and prochlorperazine for emesis induced by cancer chemotherapy.

1986 - Study ~ Nabilone: an alternative antiemetic for cancer chemotherapy.

1986 - Study ~ Nabilone and metoclopramide in the treatment of nausea and vomiting due to cisplatinum: a double blind study.

1986 - Study ~ Crossover comparison of the antiemetic efficacy of nabilone and alizapride in patients with nonseminomatous testicular cancer receiving cisplatin therapy.

1986 - Study ~ Prospective randomized double-blind trial of nabilone versus domperidone in the treatment of cytotoxic-induced emesis.

1986 - Study ~ Nabilone: an alternative antiemetic for cancer chemotherapy.

1987 - Study ~ Nabilone versus prochlorperazine for control of cancer chemotherapy-induced emesis in children: a double-blind, crossover trial.

1987 - Study ~ A species comparison of the toxicity of nabilone, a new synthetic cannabinoid.

1987 - Study ~ Species specificity in the metabolism of nabilone. Relationship between toxicity and metabolic routes.

1987 - Study ~ A double-blind randomised cross-over comparison of nabilone and metoclopramide in the control of radiation-induced nausea.

1988 - Study ~ A randomized trial of oral nabilone and prochlorperazine compared to intravenous metoclopramide and dexamethasone in the treatment of nausea and vomiting induced by chemotherapy regimens containing cisplatin or cisplatin analogues.

1995 - Study ~ Nabilone in the treatment of multiple sclerosis.

1995 - Letter ~ Effect of nabilone on nausea and vomiting after total abdominal hysterectomy

1998 - Study ~ The effects of the cannabinoid receptor agonist nabilone on L-DOPA induced dyskinesia in patients with idiopathic Parkinson's disease (PD).

1999 - Study ~ Analgesic effect of the cannabinoid analogue nabilone is not mediated by opioid receptors.

2000 - Study ~ Cannabis and cannabinoids: pharmacology and rationale for clinical use

2000 - Study ~ Different effects of nabilone and cannabidiol on binocular depth inversion in Man.

2001 - Study ~ Delta(9)-tetrahydrocannabinol and synthetic cannabinoids prevent emesis produced by the cannabinoid CB(1) receptor antagonist/inverse agonist SR 141716A.

2001 - Study ~ Cannabinoids reduce levodopa-induced dyskinesia in Parkinson's disease: a pilot study.

2002 - Study ~ Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat

2002 - Study ~ Cannabinoids and multiple sclerosis.

2002 - Study ~ Cannabinoid rotation in a young woman with chronic cystitis

2003 - Study ~ Therapeutic potential of cannabinoids in CNS disease.

2006 - Study ~ Nabilone significantly reduces spasticity-related pain

2006 - Study ~ The synthetic cannabinoid nabilone improves pain and symptom management in cancer patients

2006 - Study ~ Low dose treatment with the synthetic cannabinoid Nabilone significantly reduces spasticity-related pain : A double-blind placebo-controlled cross-over trial.

2006 - Study ~ Synthetic cannabinomimetic nabilone on patients with chronic pain

2006 - Study ~ The synthetic cannabinoid nabilone improves pain and symptom management in cancer patients

2006 - Study ~ Low dose treatment with the synthetic cannabinoid Nabilone significantly reduces spasticity-related pain : A double-blind placebo-controlled cross-over trial.

2006 - Study ~ The synthetic cannabinoid nabilone improves pain and symptom management in cancer patients

2006 - Study ~ Nabilone improves pain and symptom management in cancer patients

2006 - Study ~ Synthetic cannabinomimetic nabilone on patients with chronic pain

2006 - Letter ~ Nabilone Could Treat Chorea and Irritability in Huntington’s Disease

2006 - News ~ 2nd synthetic marijuana drug OK'd for chemo effects

2007 - Study ~ Cesamet (nabilone) capsule

2007 - Study ~ Cannabinoids in the treatment of chemotherapy-induced nausea and vomiting: beyond prevention of acute emesis.

2007 - Study ~ Symptomatic treatment of multiple sclerosis using cannabinoids: recent advances.

2007 - News ~ Synthetic Cannabis for Fibromyalgia Pain?

2007 - News ~ Nabilone relieves many advanced Ca symptoms

2008 - Study ~ Cannabinoids in the management of difficult to treat pain

2008 - Study ~ Comparison of analgesic effects and patient tolerability of nabilone and dihydrocodeine for chronic neuropathic pain: randomised, crossover, double blind study.

2008 - Study ~ Nabilone for the treatment of pain in fibromyalgia.

2008 - Study ~ Nabilone for the treatment of paraneoplastic night sweats: a report of four cases

2008 - News ~ Science: Nabilone effective in the treatment of night sweats of four patients with advanced cancer

2008 - News ~ Marijuana Derivative Called Effective in Fibromyalgia

2008 - News ~ Marijuana-Based Drug Reduces Fibromyalgia Pain, Study Suggests

2008 - Study ~ Two New Approaches for Fibromyalgia

2009 - Study ~ Cannabinoids, Endocannabinoids, and Related Analogs in Inflammation

2009 - Study ~ The Effects of Nabilone on Sleep in Fibromyalgia: Results of a Randomized Controlled Trial.

2009 - Study ~ Emerging strategies for exploiting cannabinoid receptor agonists as medicines.

2009 - Study ~ A pilot study using nabilone for symptomatic treatment in Huntington's disease.

2009 - Study ~ The use of a synthetic cannabinoid in the management of treatment-resistant nightmares in posttraumatic stress disorder (PTSD).

2010 - Study ~ CESAMET® CII (nabilone) Capsules For Oral Administration
(Archived drug label)

2010 - Study ~ A randomized, double-blinded, crossover pilot study assessing the effect of nabilone on spasticity in persons with spinal cord injury.

2010 - Study ~ An Open-Label Comparison of Nabilone and Gabapentin as Adjuvant Therapy or Monotherapy in the Management of Neuropathic Pain in Patients with Peripheral Neuropathy.

2011 - News ~ What Are Prescription Drugs That Are a Substitute for Marijuana?

2012 - Study ~ Subjective, cognitive and cardiovascular dose-effect profile of nabilone and dronabinol in marijuana smokers.

2012 - Study ~ Cannabinoids in the treatment of chemotherapy-induced nausea and vomiting.

2012 - Study ~ A Randomized, Double-Blind, Placebo Controlled, Parallel Assignment, Flexible Dose, Efficacy Study of Nabilone as Adjuvant in the Treatment of Diabetic Peripheral Neuropathic Pain Using an Enriched Enrollment Randomized Withdrawal Design


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