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N Index - Cannabis health studies completed

 

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NABILONE

Undated - Monograph ~ GENERIC NAME: NABILONE - ORAL (NAB-ih-lone)
Brand Names : Cesamet

1979 - Study ~ Microbiological transformations of nabilone, a synthetic cannabinoid.

1979 - Study ~ Superiority of nabilone over prochlorperazine as an antiemetic in patients receiving cancer chemotherapy.

1980 - Study ~ Cannabinoids. II. Cardiovascular Effects

1980 - Study ~ Double-blind comparison of the antiemetic effects of nabilone and prochlorperazine on chemotherapy-induced emesis.

1981 - Study ~ The efficacy and safety of nabilone (a synthetic cannabinoid) in the treatment of anxiety

1982 - Study ~ A double-blind, controlled trial of nabilone vs. prochlorperazine for refractory emesis induced by cancer chemotherapy.

1982 - Study ~ A multi-institutional Phase III study of nabilone vs. placebo in chemotherapy-induced nausea and vomiting.

1983 - Study ~ Anti-emetic efficacy and toxicity of nabilone, a synthetic cannabinoid, in lung cancer chemotherapy.

1983 - Study ~ Comparison of bronchial effects of nabilone and terbutaline in healthy and asthmatic subjects.

1983 - Study ~ Respiratory and cardiovascular depressant effects of nabilone, N-methyllevonantradol and delta 9-tetrahydrocannabinol in anesthetized cats.

1984 - Study ~ Acute Effects of Natural and Synthetic Cannabis Compounds on Prolactin Levels in anesthetized cats.

1985 - Study ~ A cross-over comparison of nabilone and prochlorperazine for emesis induced by cancer chemotherapy.

1986 - Study ~ Nabilone: an alternative antiemetic for cancer chemotherapy.

1986 - Study ~ Nabilone and metoclopramide in the treatment of nausea and vomiting due to cisplatinum: a double blind study.

1986 - Study ~ Crossover comparison of the antiemetic efficacy of nabilone and alizapride in patients with nonseminomatous testicular cancer receiving cisplatin therapy.

1986 - Study ~ Prospective randomized double-blind trial of nabilone versus domperidone in the treatment of cytotoxic-induced emesis.

1986 - Study ~ Nabilone: an alternative antiemetic for cancer chemotherapy.

1987 - Study ~ Nabilone versus prochlorperazine for control of cancer chemotherapy-induced emesis in children: a double-blind, crossover trial.

1987 - Study ~ A species comparison of the toxicity of nabilone, a new synthetic cannabinoid.

1987 - Study ~ Species specificity in the metabolism of nabilone. Relationship between toxicity and metabolic routes.

1987 - Study ~ A double-blind randomised cross-over comparison of nabilone and metoclopramide in the control of radiation-induced nausea.

1988 - Study ~ A randomized trial of oral nabilone and prochlorperazine compared to intravenous metoclopramide and dexamethasone in the treatment of nausea and vomiting induced by chemotherapy regimens containing cisplatin or cisplatin analogues.

1995 - Study ~ Nabilone in the treatment of multiple sclerosis.

1995 - Letter ~ Effect of nabilone on nausea and vomiting after total abdominal hysterectomy

1998 - Study ~ The effects of the cannabinoid receptor agonist nabilone on L-DOPA induced dyskinesia in patients with idiopathic Parkinson's disease (PD).

1999 - Study ~ Analgesic effect of the cannabinoid analogue nabilone is not mediated by opioid receptors.

2000 - Study ~ Cannabis and cannabinoids: pharmacology and rationale for clinical use

2000 - Study ~ Different effects of nabilone and cannabidiol on binocular depth inversion in Man.

2001 - Study ~ Delta(9)-tetrahydrocannabinol and synthetic cannabinoids prevent emesis produced by the cannabinoid CB(1) receptor antagonist/inverse agonist SR 141716A.

2001 - Study ~ Cannabinoids reduce levodopa-induced dyskinesia in Parkinson's disease: a pilot study.

2002 - Study ~ Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat

2002 - Study ~ Cannabinoids and multiple sclerosis.

2002 - Study ~ Cannabinoid rotation in a young woman with chronic cystitis

2003 - Study ~ Therapeutic potential of cannabinoids in CNS disease.

2006 - Study ~ Nabilone significantly reduces spasticity-related pain

2006 - Study ~ The synthetic cannabinoid nabilone improves pain and symptom management in cancer patients

2006 - Study ~ Low dose treatment with the synthetic cannabinoid Nabilone significantly reduces spasticity-related pain : A double-blind placebo-controlled cross-over trial.

2006 - Study ~ Synthetic cannabinomimetic nabilone on patients with chronic pain

2006 - Study ~ The synthetic cannabinoid nabilone improves pain and symptom management in cancer patients

2006 - Study ~ Low dose treatment with the synthetic cannabinoid Nabilone significantly reduces spasticity-related pain : A double-blind placebo-controlled cross-over trial.

2006 - Study ~ The synthetic cannabinoid nabilone improves pain and symptom management in cancer patients

2006 - Study ~ Nabilone improves pain and symptom management in cancer patients

2006 - Study ~ Synthetic cannabinomimetic nabilone on patients with chronic pain

2006 - Letter ~ Nabilone Could Treat Chorea and Irritability in Huntington’s Disease

2006 - News ~ 2nd synthetic marijuana drug OK'd for chemo effects

2007 - Study ~ Cesamet (nabilone) capsule

2007 - Study ~ Cannabinoids in the treatment of chemotherapy-induced nausea and vomiting: beyond prevention of acute emesis.

2007 - Study ~ Symptomatic treatment of multiple sclerosis using cannabinoids: recent advances.

2007 - News ~ Synthetic Cannabis for Fibromyalgia Pain?

2007 - News ~ Nabilone relieves many advanced Ca symptoms

2008 - Study ~ Cannabinoids in the management of difficult to treat pain

2008 - Study ~ Comparison of analgesic effects and patient tolerability of nabilone and dihydrocodeine for chronic neuropathic pain: randomised, crossover, double blind study.

2008 - Study ~ Nabilone for the treatment of pain in fibromyalgia.

2008 - Study ~ Nabilone for the treatment of paraneoplastic night sweats: a report of four cases

2008 - News ~ Science: Nabilone effective in the treatment of night sweats of four patients with advanced cancer

2008 - News ~ Marijuana Derivative Called Effective in Fibromyalgia

2008 - News ~ Marijuana-Based Drug Reduces Fibromyalgia Pain, Study Suggests

2008 - Study ~ Two New Approaches for Fibromyalgia

2009 - Study ~ Cannabinoids, Endocannabinoids, and Related Analogs in Inflammation

2009 - Study ~ The Effects of Nabilone on Sleep in Fibromyalgia: Results of a Randomized Controlled Trial.

2009 - Study ~ Emerging strategies for exploiting cannabinoid receptor agonists as medicines.

2009 - Study ~ A pilot study using nabilone for symptomatic treatment in Huntington's disease.

2009 - Study ~ The use of a synthetic cannabinoid in the management of treatment-resistant nightmares in posttraumatic stress disorder (PTSD).

2010 - Study ~ CESAMET® CII (nabilone) Capsules For Oral Administration
(Archived drug label)

2010 - Study ~ A randomized, double-blinded, crossover pilot study assessing the effect of nabilone on spasticity in persons with spinal cord injury.

2010 - Study ~ An Open-Label Comparison of Nabilone and Gabapentin as Adjuvant Therapy or Monotherapy in the Management of Neuropathic Pain in Patients with Peripheral Neuropathy.

2011 - News ~ What Are Prescription Drugs That Are a Substitute for Marijuana?

2012 - Study ~ Subjective, cognitive and cardiovascular dose-effect profile of nabilone and dronabinol in marijuana smokers.

2012 - Study ~ Cannabinoids in the treatment of chemotherapy-induced nausea and vomiting.

2012 - Study ~ A Randomized, Double-Blind, Placebo Controlled, Parallel Assignment, Flexible Dose, Efficacy Study of Nabilone as Adjuvant in the Treatment of Diabetic Peripheral Neuropathic Pain Using an Enriched Enrollment Randomized Withdrawal Design

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NAUSEA

Also see MORNING SICKNESS, RADIATION-INDUCED NAUSEA.

1975 - Study ~ Antiemetic effect of delta-9-tetrahydrocannabinol in patients receiving cancer chemotherapy.

1979 - Study ~ Delta-9-Tetrahydrocannibinol as an Antiemetic in Cancer Patients Receiving High-Dose Methotrexate.

1979 - Study ~ Delta-9-tetrahydrocannabinol (THC) as an antiemetic in patients treated with cancer chemotherapy; a double-blind cross-over trial against placebo.

1979 - Study ~ Amelioration of cancer chemotherapy-induced nausea and vomiting by delta-9-tetrahydrocannabinol.

1979 - Study ~ Superiority of nabilone over prochlorperazine as an antiemetic in patients receiving cancer chemotherapy.

1979 - Study ~ Delta-9-tetrahydrocannabinol as an antiemetic for patients receiving cancer chemotherapy. A comparison with prochlorperazine and a placebo.

1980 - Study ~ Double-blind comparison of the antiemetic effects of nabilone and prochlorperazine on chemotherapy-induced emesis.

1980 - Study ~ Antiemetic effect of tetrahydrocannabinol. Compared with placebo and prochlorperazine in chemotherapy-associated nausea and emesis.

1980 - Study ~ The antiemetic activity of tetrahydrocanabinol versus metoclopramide and thiethylperazine in patients undergoing cancer chemotherapy.

1980 - Study ~ Antiemetics in patients receiving chemotherapy for cancer: a randomized comparison of delta-9-tetrahydrocannabinol and prochlorperazine.

1981 - Study ~ Dose vs response of tetrahydroannabinol (THC) vs prochlorperazine as chemotherapy antiemetics.

1981 - Study ~ Physiologic observations in a controlled clinical trial of the antiemetic effectiveness of 5, 10, and 15 mg of delta 9-tetrahydrocannabinol in cancer chemotherapy. Ophthalmologic implications.

1981 - Study ~ Clinical experience with levonantradol hydrochloride in the prevention of cancer chemotherapy-induced nausea and vomiting.

1981 - Study ~ Comparative trial of the antiemetic effects of THC and haloperidol.

1982 - Study ~ A double-blind, controlled trial of nabilone vs. prochlorperazine for refractory emesis induced by cancer chemotherapy.

1982 - Study ~ Cannabis and cancer chemotherapy: a comparison of oral delta-9-THC and prochlorperazine.

1982 - Study ~ A multi-institutional Phase III study of nabilone vs. placebo in chemotherapy-induced nausea and vomiting.

1983 - Study ~ Anti-emetic efficacy and toxicity of nabilone, a synthetic cannabinoid, in lung cancer chemotherapy.

1983 - Study ~ Levonantradol: a synthetic cannabinoid in the treatment of severe chemotherapy-induced nausea and vomiting resistant to conventional anti-emetic therapy.

1985 - Study ~ THC or Compazine for the cancer chemotherapy patient--the UCLA study. Part II: Patient drug preference.

1985 - Study ~ A cross-over comparison of nabilone and prochlorperazine for emesis induced by cancer chemotherapy.

1985 - Study ~ Antiemetic efficacy of levonantradol compared to delta-9-tetrahydrocannabinol for chemotherapy-induced nausea and vomiting.

1986 - Study ~ Nabilone and metoclopramide in the treatment of nausea and vomiting due to cisplatinum: a double blind study.

1986 - Study ~ Nabilone: an alternative antiemetic for cancer chemotherapy.

1986 - Study ~ Crossover comparison of the antiemetic efficacy of nabilone and alizapride in patients with nonseminomatous testicular cancer receiving cisplatin therapy.

1986 - Study ~ Prospective randomized double-blind trial of nabilone versus domperidone in the treatment of cytotoxic-induced emesis.

1987 - Study ~ Nabilone versus prochlorperazine for control of cancer chemotherapy-induced emesis in children: a double-blind, crossover trial.

1987 - Study ~ A double-blind randomised cross-over comparison of nabilone and metoclopramide in the control of radiation-induced nausea.

1988 - Study ~ Oral vs. Inhaled Cannabinoids for Nausea/Vomiting from Cancer Chemotherapy.

1988 - Study ~ Efficacy of tetrahydrocannabinol in patients refractory to standard anti-emetic therapy.

1988 - Study ~ A randomized trial of oral nabilone and prochlorperazine compared to intravenous metoclopramide and dexamethasone in the treatment of nausea and vomiting induced by chemotherapy regimens containing cisplatin or cisplatin analogues.

1991 - Study ~ Marijuana as antiemetic medicine: a survey of oncologists' experiences and attitudes.

1994 - Study ~ Effect of nabilone on nausea and vomiting after total abdominal hysterectomy.

1995 - Letter ~ Effect of nabilone on nausea and vomiting.

1995 - Study ~ An efficient new cannabinoid antiemetic in pediatric oncology.

1997 - Patent ~ Patent 5605928 - Antiemetic compositions.

1997 - Study ~ Intractable nausea and vomiting due to gastrointestinal mucosal metastases relieved by tetrahydrocannabinol (dronabinol).

2001 - Study ~ Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic review.

2001 - Study ~ Therapeutic Aspects of Cannabis and Cannabinoids.

2001 - Study ~ Delta(9)-tetrahydrocannabinol and synthetic cannabinoids prevent emesis produced by the cannabinoid CB(1) receptor antagonist/inverse agonist SR 141716A.

2001 - Study ~ The cannabinoids: an overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection.

2001 - Study ~ The cannabinoid agonist WIN55,212-2 suppresses opioid-induced emesis in ferrets.

2001 - Study ~ The cannabinoid CB1 receptor antagonist SR 141716A reverses the antiemetic and motor depressant actions of WIN 55, 212-2.

2001 - Study ~ Antiemetic efficacy of smoked marijuana: subjective and behavioral effects on nausea induced by syrup of ipecac.

2002 - Study ~ Hyperemesis Gravidarum and Clinical Cannabis: To Eat or Not to Eat?

2003- Study ~ Delta9-tetrahydrocannabinol selectively acts on CB1 receptors in specific regions of dorsal vagal complex to inhibit emesis in ferrets.

2004 - Study ~ Cannabinoids suppress synaptic input to neurones of the rat dorsal motor nucleus of the vagus nerve.

2004 - Study ~ A comparative analysis of the potential of cannabinoids and ondansetron to suppress cisplatin-induced emesis in the Suncus murinus (house musk shrew).

2005 - Patent ~ US Patent Application 20050165088 - Compositions comprising cannabinoids for treatment of nausea, vomiting, emesis, motion sickness or like conditions.

2006 - Study ~ Cannabinoids In Medicine: A Review Of Their Therapeutic Potential.

2006 - Study ~ Delta-9-tetrahydrocannabinol and cannabidiol, but not ondansetron, interfere with conditioned retching reactions elicited by a lithium-paired context in Suncus murinus: An animal model of anticipatory nausea and vomiting.

2006 - Study ~ Prevention of nausea and vomiting following breast surgery.

2006 - Study ~ The synthetic cannabinoid nabilone improves pain and symptom management in cancer patients.

2006 - Study ~ Experience with the Synthetic Cannabinoid Nabilone in Chronic Noncancer Pain.

2006 - Study ~ Methods evaluating cannabinoid and endocannabinoid effects on gastrointestinal functions.

2006 - Study ~ Dronabinol for supportive therapy in patients with malignant melanoma and liver metastases.

2007 - Patent ~ US Patent Application 20070049645 - Anti-nausea and anti-vomiting activity of cannabidiol compounds.

2007 - Study ~ THC improves appetite and reverses weight loss in AIDS patients.

2007 - Study ~ Cannabinoids in the treatment of chemotherapy-induced nausea and vomiting: beyond prevention of acute emesis.

2007 - Study ~ Efficacy of dronabinol alone and in combination with ondansetron versus ondansetron alone for delayed chemotherapy-induced nausea and vomiting.

2007 - Study ~ Dronabinol and marijuana in HIV-positive marijuana smokers: caloric intake, mood, and sleep.

2007 - Study ~ Receptor mechanism and antiemetic activity of structurally-diverse cannabinoids against radiation-induced emesis in the least shrew.

2008 - Study ~ Emerging role of cannabinoids in gastrointestinal and liver diseases: basic and clinical aspects.

2008 - News ~ Medical marijuana: a surprising solution to severe morning sickness.

2009- News ~ Medical Marijuana and Severe Nausea.

2010 - Study ~ Mechanisms of Broad-Spectrum Antiemetic Efficacy of Cannabinoids against Chemotherapy-Induced Acute and Delayed Vomiting.

2010- Study ~ Preliminary efficacy and safety of an oromucosal standardized cannabis extract in chemotherapy-induced nausea and vomiting.

2010 - Study ~ The abuse potential of the synthetic cannabinoid nabilone.

2010 - Study ~ Regulation of nausea and vomiting by cannabinoids.

2010- Study ~ Motion Sickness, Stress and the Endocannabinoid System.

2011 - Article ~ Medical Marijuana: Can Pot Help Pregnant Women With Vomiting and Nausea?

2011 - Study ~ Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews.

2011 - Study ~ Cannabidiol, a Non-Psychotropic Component of Cannabis, Attenuates Vomiting and Nausea-like Behaviour via Indirect Agonism of 5-HT(1A) Somatodendritic: Autoreceptors in the Dorsal Raphe Nucleus.

2011 - Study ~ Regulation of nausea and vomiting by cannabinoids.

2011 - News ~ How Does Marijuana Help Cancer Patients?

2011 - News ~ Medical Marijuana: Clearing Away the Smoke.

2012 - Study ~ Cannabinoids in the treatment of chemotherapy-induced nausea and vomiting.

2012 - Study ~ Tumor necrosis factor activation of vagal afferent terminal calcium is blocked by cannabinoids.

2012 - Study ~ Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?

 


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NEURONS/ BRAIN CELLS

1990 - Study ~ Cannabinoid Receptor Localization in Brain

1994 - Letter ~ Formation and inactivation of endogenous cannabinoid anandamide in central neurons.

1995 - Study ~ Anandamide amidohydrolase activity in rat brain microsomes. Identification and partial characterization.

1995 - Study ~ The CB1 cannabinoid receptor antagonist SR 141716A affects A9 dopamine neuronal activity in the rat.

1996 - Study ~ Genetic differences in delta 9-tetrahydrocannabinol-induced facilitation of brain stimulation reward as measured by a rate-frequency curve-shift electrical brain stimulation paradigm in three different rat strains.

1998 - Study ~ Cannabinoid Receptor Agonists Protect Cultured Rat Hippocampal Neurons from Excitotoxicity

1998 - Study ~ Potent Effects of a Selective Cannabinoid Receptor Agonist on Some Guinea Pig Medial Vestibular Nucleus Neurons.

1998 - Study ~ Loss of Cannabinoid Receptor Binding and Messenger Rna Levels and Cannabinoid Agonist-stimulated [35s]guanylyl-5'o-(Thio)-triphosphate Binding in the Basal Ganglia of Aged Rats.

1999- Study ~ Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain.

2000 - Study ~ Neuroprotective Antioxidants from Marijuana

2000 - Study ~ Endocannabinoids in the central nervous system--an overview.

2003 - Study ~ Neurons on cannabinoids: dead or alive?

2003 - Study ~ Role of Endogenous Cannabinoids in Synaptic Signaling

2003 - Study ~ Cannabis and the brain.

2003 - Study ~ Cannabinoid receptor type 1 modulates excitatory and inhibitory neurotransmission in mouse colon

2003 - Study ~ Post-ischemic Treatment with Cannabidiol Prevents Electroencephalographic Flattening, Hyperlocomotion and Neuronal Injury in Gerbils.

2003 - Study ~ Cannabinoid Modulation of Peripheral Autonomic and Sensory Neurotransmission.

2004 - Study ~ Cannabinoids and neuroinflammation

2004 - Study ~ Defective adult neurogenesis in CB1 cannabinoid receptor knockout mice.

2004 - News ~ Marijuana-Like Chemicals in the Brain Calm Neurons

2005 - Study ~ Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects

2005 - Study ~ Identification and functional characterization of brainstem cannabinoid CB2 receptors.

2005 - Study ~ The endocannabinoid system drives neural progenitor proliferation.

2005 - Study ~ Sex differences in the cannabinoid modulation of an A-type K+ current in neurons of the mammalian hypothalamus.

2005 - News ~ High-dose cannabis stimulates growth of brain cells in rats

2005 - News ~ Marijuana Promotes Neuron Growth

2005 - News Forum ~ Marijuana May Spur New Brain Cells

2005 - News ~ Good News For The Medical Marijuana Movement: Pot Proliferates Brain Cells And Boosts Mood

2005 - News ~ Marijuana May Grow Neurons in the Brain

2006 - Study ~ Non-psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferation

2006 - Study ~ Differential effect of cannabinoid agonists and endocannabinoids on histamine release from distinct regions of the rat brain.

2006 - Study ~ Differential effects of cannabis extracts and pure plant cannabinoids on hippocampal neurones and glia.

2006 - Study ~ Neuromodulatory functions of the endocannabinoid system.

2007 - Study ~ The synthetic cannabinoid HU210 induces spatial memory deficits and suppresses hippocampal firing rate in rats

2007 - Study ~ CB2 cannabinoid receptors promote mouse neural stem cell proliferation.

2007 - Study ~ The endocannabinoid system and neurogenesis in health and disease.

2008 - Study ~ The CB2 Cannabinoid Receptor Controls Myeloid Progenitor Trafficking:
INVOLVEMENT IN THE PATHOGENESIS OF AN ANIMAL MODEL OF MULTIPLE SCLEROSIS

2008 - Study ~ Design Logic of a Cannabinoid Receptor Signaling Network That Triggers Neurite Outgrowth

2008 - News ~ New brain cells implicated in machinery of cannabinoid signaling

2009 - Study ~ Delta 9-tetrahydrocannabinol induces dopamine release in the human striatum.

2009 - Study ~ Cannabinoid agonist WIN-55,212-2 partially restores neurogenesis in the aged rat brain

2009- Study ~ Endocannabinoid-mediated control of synaptic transmission.

2009 - Study ~ Cannabinoids attenuate the effects of aging upon neuroinflammation and neurogenesis

2009 - Study ~ Endocannabinoid signaling in neurotoxicity and neuroprotection.

2009 - Study ~ Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania

2009 - Study ~ Oleoylethanolamide exerts partial and dose-dependent neuroprotection of substantia nigra dopamine neurons.

2009 - Study ~ Cannabinoid receptors in brain: pharmacogenetics, neuropharmacology, neurotoxicology, and potential therapeutic applications.

2010- Study ~ Cyclooxygenase-2 Mediates Anandamide Metabolism in the Mouse Brain

2010 - Study ~ Cannabinoids Excite Circadian Clock Neurons

2010 - Study ~ Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis

2010 - Study ~ AAV vector-mediated overexpression of CB1 cannabinoid receptor in pyramidal neurons of the hippocampus protects against seizure-induced excitoxicity.

2010 - Study ~ Sex difference in cell proliferation in developing rat amygdala mediated by endocannabinoids has implications for social behavior.

2010 - Study ~ CB1 cannabinoid receptors increase neuronal precursor proliferation through AKT/glycogen synthase kinase-3beta/beta-catenin signaling.

2010- Study ~ Cannabidiol protects retinal neurons by preserving glutamine synthetase activity in diabetes.

2010 - Study ~ Regulatory Role of Cannabinoid Receptor 1 in Stress-Induced Excitotoxicity and Neuroinflammation

2010 - Study ~ Palmitoylethanolamide and other anandamide congeners. Proposed role in the diseased brain.

2010 - Study ~ Endocannabinoids Prevent β-Amyloid-mediated Lysosomal Destabilization in Cultured Neurons

2010 - Study ~ PP-014 Control of receptor expression in vagal afferent neurons by activation of cannabinoid 1 receptors

2010 - Study ~ Protective effects of the synthetic cannabinoids CP55,940 and JWH-015 on rat brain mitochondria upon paraquat exposure.

2010 - Study ~ Delta9-tetrahydrocannabinol is a full agonist at CB1 receptors on GABA neuron axon terminals in the hippocampus.

2010 - News ~ Chronic Low Doses of a Cannabinoid Causes New Brain Cell Formation

2011 - Study ~ Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement

2011 - Study ~ Sex difference in cell proliferation in developing rat amygdala mediated by endocannabinoids has implications for social behavior

2011 - Study ~ Dual inhibition of alpha/beta hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons.

2011 - Study ~ Cannabinoid receptor agonist protects cultured dopaminergic neurons from the death by the proteasomal dysfunction

2011 - Study ~ Endocannabinoid signaling in the amygdala: anatomy, synaptic signaling, behavior, and adaptations to stress.

2011 - Study ~ The Dopamine and Cannabinoid Interaction in the Modulation of Emotions and Cognition: Assessing the Role of Cannabinoid CB1 Receptor in Neurons Expressing Dopamine D1 Receptors.

2011 - Study ~ History of cannabis use is not associated with alterations in striatal dopamine D2/D3 receptor availability.

2011- Study ~ The G protein-coupled cannabinoid-1 (CB(1)) receptor of mammalian brain: Inhibition by phthalate esters in vitro.

2011 - Study ~ α-Tocopherol and α-tocopheryl phosphate interact with the cannabinoid system in the rodent hippocampus.

2011 - Study ~ Effects of synthetic cannabinoids on electroencephalogram power spectra in rats.

2011 - Study ~ Pharmacological activation/inhibition of the cannabinoid system affects alcohol withdrawal-induced neuronal hypersensitivity to excitotoxic insults.

2011 - Study ~ CB2 Cannabinoid Receptors Promote Neural Progenitor Cell Proliferation via mTORC1 Signaling

2011 - Study ~ Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions

2011 - Study ~ Δ(9)-THC and WIN55,212-2 affect brain tissue levels of excitatory amino acids in a phenotype-, compound-, dose-, and region-specific manner

2011 - Study ~ Cannabinoid Receptor Type 1 Protects Nigrostriatal Dopaminergic Neurons against MPTP Neurotoxicity by Inhibiting Microglial Activation

2011 - Study ~ Activation of Cannabinoid Type 2 Receptors Inhibits HIV-1 Envelope Glycoprotein gp120-Induced Synapse Loss

2011- News ~ A Brain Wrought Without Omega-3

2012 - Study ~ Role of CB1 cannabinoid receptors on GABAergic neurons in brain aging

2012 - Study ~ Type-1 Cannabinoid Receptor Signaling in Neuronal Development.

2012- Study ~ Endocannabinoids and the processing of value-related signals.

2012 - Study ~ Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α.

2012- Study ~ Mitochondrial CB(1) receptors regulate neuronal energy metabolism.

2012 - Study ~ Effects of cannabinoids Δ(9)-tetrahydrocannabinol, Δ(9)-tetrahydrocannabinolic acid and cannabidiol in MPP(+) affected murine mesencephalic cultures.

2012 - Study ~ Cannabinoid modulation of midbrain urocortin 1 neurones during acute and chronic stress.

2012 - Study ~ Long-lasting potentiation of hippocampal synaptic transmission by direct cortical input is mediated via endocannabinoids

2012 - Study ~ Excitability of prefrontal cortical pyramidal neurons is modulated by activation of 98 intracellular type-2 cannabinoid receptors.

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NEUROPATHIC PAIN

1997- Study ~ The perceived effects of smoked cannabis on patients with multiple sclerosis

1997 - Study ~ Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain.

1999 - Study ~ Analgesic effect of the cannabinoid analogue nabilone is not mediated by opioid receptors.

2000 - Study ~ Cannabinoid Receptor Messenger Rna Levels Decrease in a Subset of Neurons of the Lateral Striatum, Cortex and Hippocampus of Transgenic Huntington's Disease Mice.

2001 - Study ~ The synthetic cannabinoid WIN55,212-2 attenuates hyperalgesia and allodynia in a rat model of neuropathic pain.

2002 - Study ~ The potent emetogenic effects of the endocannabinoid, 2-AG (2-arachidonoylglycerol) are blocked by delta(9)-tetrahydrocannabinol and other cannnabinoids.

2003 - Study ~ Whether whole plant Cannabis extracts can improve intractable neurogenic symptoms?

2003- Study ~ Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: Pain inhibition by receptors not present in the CNS

2003 - Study ~ Analgesic effect of the synthetic cannabinoid CT-3 on chronic neuropathic pain: a randomized controlled trial.

2003 - Study ~ Randomised controlled trial of cannabis based medicinal extracts (CBME) in central neuropathic pain due to multiple sclerosis.

2003- Study ~ The effects of smoked cannabis in painful peripheral neuropathy and cancer pain refractory to opiods.

2003 - News ~ New Compound That Acts On Peripheral Receptors May Be Promising Treatment For Some Nerve Pain

2004 - Study ~ Initial experiences with medicinal extracts of cannabis for chronic pain: Results from 34 ‘N of 1’ studies

2004- Study ~ Efficacy of two cannabis based medicinal extracts for relief of central neuropathic pain from brachial plexus avulsion: results of a randomised controlled trial

2004 - Study ~ Are oral cannabinoids safe and effective in refractory neuropathic pain?

2003 - News ~ Marijuana-like compounds may aid array of debiliating conditions ranging from Parkinson's to pain

2005- Study ~ Ajulemic acid (IP-751): Synthesis, proof of principle, toxicity studies, and clinical trials

2003 - Study ~ Smoked cannabis therapy for HIV-related painful peripheral neuropathy: results of a randomized, placebo-controlled clinical trial.

2005 - Study ~ Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis

2006- Study ~ Effects of a Cannabinoid Agonist on Spinal Nociceptive Neurons in a Rodent Model of Neuropathic Pain

2006 - Study ~ Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models

2006 - Study ~ Cannabinoids In Medicine: A Review Of Their Therapeutic Potential

2006- Study ~ CB1 receptor selective activation inhibits beta-amyloid-induced iNOS protein expression in C6 cells and subsequently blunts tau protein hyperphosphorylation in co-cultured neurons.

2006 - News ~ In MedPanel Summit, Leading Pain Experts Name Cannabinoids Among Most Promising Approaches to Treating Neuropathic Pain, Assert That Sociopolitical Climate Will Hamper Drug Approvals

2007 - Study ~ Endocannabinoid metabolism and uptake: novel targets for neuropathic and inflammatory pain

2007- Study ~ The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice.

2007 - Study ~ Cannabinoid CB2 receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain

2007 - Study ~ Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain.

2007- Study ~ Sativex successfully treats neuropathic pain characterised by allodynia: A randomised, double-blind, placebo-controlled clinical trial

2007 - Study ~ Oromucosal delta9-tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: an uncontrolled, open-label, 2-year extension trial.

2007 - Study ~ The synthetic cannabinoids attenuate allodynia and hyperalgesia in a rat model of trigeminal neuropathic pain.

2007 - Study ~ Cannabis in painful HIV-associated sensory neuropathy: A randomized placebo-controlled trial.

2007 - News ~  Study Supports Medical Marijuana Use

2007 - News ~ Smoked Cannabis Reduces Foot Pain Associated With HIV In Placebo Trial

2007 - News ~ Marijuana gives relief from chronic pain for AIDS sufferers

2007 - News ~ Cannabis may be safe and effective for HIV-related neuropathic pain

2007 - News ~ Marijuana, Very Efficient in Cutting Off HIV Related Nerve Pain

2007 - Study ~ Smoked Cannabis Proven Effective In Treating Neuropathic Pain

2008 - Study ~ Selective Activation of Cannabinoid CB2 Receptors Suppresses Neuropathic Nociception Induced by Treatment with the Chemotherapeutic Agent Paclitaxel in Rats

2008 - Study ~ Crucial Role of CB2 Cannabinoid Receptor in the Regulation of Central Immune Responses during Neuropathic Pain

2008 - Study ~ Double Blind, Placebo Controlled Trial of Smoked Marijuana on Neuropathic Pain

2008 - Study ~ Comparison of analgesic effects and patient tolerability of nabilone and dihydrocodeine for chronic neuropathic pain: randomised, crossover, double blind study.

2008 - Study ~ Design and synthesis of a novel series of N-alkyl isatin acylhydrazone derivatives that act as selective cannabinoid receptor 2 agonists for the treatment of neuropathic pain.

2008 - Study ~ Differential effects of repeated low dose treatment with the cannabinoid agonist WIN 55,212-2 in experimental models of bone cancer pain and neuropathic pain.

2008- Study ~ Antihyperalgesic effect of a Cannabis sativa extract in a rat model of neuropathic pain: mechanisms involved.

2008 - News ~ Medicinal Marijuana Effective For Neuropathic Pain In HIV, Study Finds

2008 - News ~ Marijuana May Be Effective For Neuropathic Pain

2009 - Study ~ Tetrahydrocannabinol (Delta 9-THC) Treatment in Chronic Central Neuropathic Pain and Fibromyalgia Patients: Results of a Multicenter Survey

2009 - Study ~ Sustained antinociceptive effect of cannabinoid receptor agonist WIN 55,212-2 over time in rat model of neuropathic spinal cord injury pain

2009 - Study ~ Neuropathic Pain and Endocannabinoid-Degradation Blockade

2009 - Study ~ Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain.

2009 - Study ~  Cannabinoids as pharmacotherapies for neuropathic pain: from the bench to the bedside.

2009- Study ~ Beneficial effects of a Cannabis sativa extract treatment on diabetes-induced neuropathy and oxidative stress.

2009 - News ~ Medical Marijuana and Peripheral Neuropathy

2010 - Study ~ Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain

2010 Study ~ R-Flurbiprofen Reduces Neuropathic Pain in Rodents by Restoring Endogenous Cannabinoids

2010 - Study ~ Pharmacological Treatment of Painful HIV-Associated Sensory Neuropathy: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

2010 - Study ~ Smoked cannabis for chronic neuropathic pain: a randomized controlled trial

2010 - Study ~ Pharmacological characterization of a novel cannabinoid ligand, MDA19, for treatment of neuropathic pain.

2010 - Study ~ Misdiagnosed chronic pelvic pain: pudendal neuralgia responding to a novel use of palmitoylethanolamide.

2010- Study ~ An Open-Label Comparison of Nabilone and Gabapentin as Adjuvant Therapy or Monotherapy in the Management of Neuropathic Pain in Patients with Peripheral Neuropathy.

2010 - Study ~ Effect of dronabinol on central neuropathic pain after spinal cord injury: a pilot study.

2010- Study ~ Cannabinoid subtype-2 receptors modulate the antihyperalgesic effect of WIN 55,212-2 in rats with neuropathic spinal cord injury pain.

2010 - News ~ Study Claims Cannabis Reduces Chronic Pain

2010 - News ~ Cannabinoids inhibit and may prevent neuropathic pain in diabetes.

2010 - News ~ Study: Smoking pot may ease chronic pain

2011 - Study ~ Cannabinoid Agonists Inhibit Neuropathic Pain Induced by Brachial Plexus Avulsion in Mice by Affecting Glial Cells and MAP Kinases.

2011 - Study ~ Mutations in ABHD12 cause the neurodegenerative disease PHARC: An inborn error of endocannabinoid metabolism.

2011 - Study ~ Spinal cannabinoid CB2 receptors as a target for neuropathic pain: an investigation using chronic constriction injury.

2011 - Study ~ Cannabinoids for Treatment of Chronic Non-Cancer Pain; a Systematic Review of Randomized Trials.

2011 - Study ~ Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress.

2011 - Study ~ Self-medication of a cannabinoid CB(2) agonist in an animal model of neuropathic pain.

2011 - Study ~ Activation of spinal and supraspinal cannabinoid-1 receptors leads to antinociception in a rat model of neuropathic spinal cord injury pain.

2011 - News ~ Cannabinoid 'Completely' Prevents Chemotherapy-Induced Neuropathy, Study Says

2011 - News ~ Marijuana component may ease pain from chemo therapy drugs

2012 - Study ~ Prescribing Cannabis for Harm Reduction.

2012 - Study ~ The atypical cannabinoid O-1602 increases hind paw sensitisation in the chronic constriction injury model of neuropathic pain.

2012 - Study ~ Cannabinoid agonist WIN 55,212-2 prevents the development of paclitaxel-induced peripheral neuropathy in rats. Possible involvement of spinal glial cells.

2012 - Study ~ Low brain penetrant CB1 receptor agonists for the treatment of neuropathic pain.

2012 - Study ~ Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors.

2012 - Study ~ Characterization of cannabinoid-induced relief of neuropathic pain in rat models of type 1 and type 2 diabetes.

2012 - Study ~ Prevention of Paclitaxel-Induced Neuropathy Through Activation of the Central Cannabinoid Type 2 Receptor System

2012 - Study ~ A Randomized, Double-Blind, Placebo Controlled, Parallel Assignment, Flexible Dose, Efficacy Study of Nabilone as Adjuvant in the Treatment of Diabetic Peripheral Neuropathic Pain Using an Enriched Enrollment Randomized Withdrawal Design

2012 - Study ~ The Novel Reversible Fatty Acid Amide Hydrolase Inhibitor ST4070 Increases Endocannabinoid Brain Levels and Counteracts Neuropathic Pain in Different Animal Models


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NEUROPROTECTANT

Marijuana Protects Your Brain
http://www.roninpub....rt-mjbrain.html

The neuroprotective effect of cannabinoids in a rat model of Parkinson's disease
(may need free registration)
http://www.medscape....stract/17196181

Neuroprotective and Intraocular Pressure-Lowering Effects of (-)Delta-THC
http://www.unboundme...del_of_Glaucoma

Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol
http://www.unboundme...f_peroxynitrite

Neuroprotection induced by Delta(9)-tetrahydrocannabinol in AF5 cells
http://www.unboundme...ol_in_AF5_cells

Cannabidiol has a cerebroprotective action
http://www.unboundme...iting_mechanism

Cannabidiol but not Delta(9)-THC has a neuroprotective effect without the development of tolerance..
http://www.unboundme...nt_of_tolerance

Delta(9)-THC) prevents cerebral infarction
http://www.unboundme...ent_hypothermia

Delta(9)-Tetrahydrocannabinol protects hippocampal neurons from excitotoxicity
http://www.unboundme..._excitotoxicity

Cannabis and Neuroprotection
http://www.pacifier....oprotection.htm

Neuroprotection by Delta 9-THC against Ouabain-Induced In Vivo Excitotoxicity
http://www.jneurosci...ourcetype=HWCIT

Cannabinoids and Neuroprotection in Global and Focal Cerebral Ischemia and in Neuronal Cultures
http://www.jneurosci...ourcetype=HWCIT

Cannabinoid activation of PPARalpha; a novel neuroprotective mechanism
http://www.nature.co...s/0707478a.html

The use of cannabinoids in MS: is it evidence based?
http://www.ukcia.org...idenceBased.pdf

Neurons on Cannabinoids: Dead or Alive?
http://www.ukcia.org...DeadOrAlive.pdf

Cannabinoids and Brain Injury: Therapeutic Inplications
http://www.ukcia.org...BrainInjury.pdf

Cannabidiol and delta 9THC are neuroprotective antioxidants
http://www.ukcia.org...ntioxidants.pdf

Cannabidiol and (−)Δ9-tetrahydrocannabinol are neuroprotective antioxidants
http://www.pubmedcen...&tool=pmcentrez

Endocannabinoids in the retina: From marijuana to neuroprotection.
http://www.unboundme...europrotection_

Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders.
http://www.unboundme..._CNS_disorders_

Cannabidiol: a promising drug for neurodegenerative disorders?
http://www.unboundme...ative_disorders

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NUTRITION

Undated - Article ~ Hemp Protein = King of the Plant Kingdom.

Undated - Article ~ Hemp Powder Vs. Hemp Oil.

Undated - Article ~ Hemp Foods & Oils Primer.

Undated - Article ~ Hemp Packs in Powerful Source of Preconception Nutrition.

Undated - Article ~ Hemp: Nature's Forgotten Superfood.

1955 - Study (forum) ~ HEMP AS A MEDICAMENT : Importance of hemp seeds in the tuberculosis therapy.

1992 - Study - PART 1 ~ HEMP SEED: THE MOST NUTRITIONALLY COMPLETE FOOD SOURCE IN THE WORLD.

1992 - Study - Part 2 ~ HEMP SEED: THE MOST NUTRITIONALLY COMPLETE FOOD SOURCE IN THE WORLD.

1992 - News ~ Hempseed: Nature's Perfect Food?

1994 - Study ~ The trypanocidal effect of Cannabis sativa constituents in experimental animal trypanosomiasis.

1997 - Study ~ Marijuana-positive urine test results from consumption of hemp seeds in food products.

1998- Study ~ Isolation and primary structure of a methionine- and cystine-rich seed protein of Cannabis sativa.

1999 - Study - Part 1 ~ Hemp Foods and THC Levels: A Scientific Assessment.

1999 - Study - Part 2 ~ Hemp Foods and THC Levels: A Scientific Assessment.

1999 - Book Excerpt ~ Hemp and Health.

1999 - News ~ A history of the Royal Grain.

2001 - Study ~ Evaluating the impact of hemp food consumption on workplace drug tests.

2003 - Study ~ Nutritional Profile and Benefits of Hemp Seed, Nut, and Oil.

2004 - News ~ Cannabis butter to spread across Europe.

2005 - Study ~ The effect of feeding hemp seed meal to laying hens.

2006 - Study ~ Alpha-linolenic acid content of commonly available nuts in Hangzhou.

2006 - News ~ Oily fish makes 'babies brainier'.

2007 - Study ~  Effect of dietary hempseed intake on cardiac ischemia-reperfusion injury.

2008 - Study ~ Δ9-Tetrahydrocannabinol Content of Commercially Available Hemp Products.

2008 - Study ~ Characterization, amino acid composition and in vitro digestibility of hemp (Cannabis) proteins.

2008 - Study ~ Initial study of Hemp seeds protein on antifatigue and the immunomodulation effects in mice.

2008 - Study ~ Cholesterol-induced stimulation of platelet aggregation is prevented by a hempseed-enriched diet.

2008 - Study ~ Initial study of Hemp seeds protein on antifatigue and the immunomodulation effects in mice.

2009 - News ~ Hemp: A replacement for common food allergens?

2009 - News ~ Curb Cravings With Hemp Seeds.

2010 - Article ~ Information on Chia, Hemp & Flax.

2010 - Study ~ The cardiac and haemostatic effects of dietary hempseed.

2010 - Study ~ Influence of Feed Supplementation with Cannabis Sativa on Quality of Broilers Carcass.

2010 - Study ~ Dietary intakes in a group of marihuana smoking patients.

2010 - Study ~ Evaluating the Quality of Protein from Hemp Seed (Cannabis sativa L.) Products Through the use of the Protein Digestibility-Corrected Amino Acid Score Method.

2010 - News ~ The Calories in Hemp Seeds.

2010 - News ~ Hemp Seeds are Full of Health.

2010 - News ~ Unhulled Hemp Seed Uses.

2010 - News ~ What Is Hemp Protein?

2011 - Study ~ Efficacy of a Chinese herbal proprietary medicine (Hemp Seed Pill) for functional constipation.

2011 - Study ~ The effect of dietary hempseed on atherogenesis and contractile function in aortae from hypercholesterolemic rabbits.

2011 - Study ~ The effects of hempseed meal intake and linoleic acid on Drosophila models of neurodegenerative diseases and hypercholesterolemia.

2011 - Study ~ Distinctive effects of plant protein sources on renal disease progression and associated cardiac hypertrophy in experimental kidney disease.

2011 - News ~ Hemp Fiber Cereal.

2011 - News ~ What Are the Benefits of Hemp Seeds for Toddlers?

2012 - Study ~ Searching for health beneficial n-3 and n-6 fatty acids in plant seeds.

2012 - Study ~ Proteomic profiling of hempseed proteins from Cheungsam.

2012 - Study ~ Effect of feeding hemp seed and hemp seed oil on laying hen performance and egg yolk fatty acid content: Evidence of their safety and efficacy for laying hen diets.

2012 - Study ~ Fatty Acid Profile and Sensory Characteristics of Table Eggs from Laying Hens Fed Hempseed and Hempseed Oil.

 

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