Cannabis Health Science Studies Index

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MULTIPLE SCLEROSIS and cannabis studies

Overview

Multiple sclerosis ( MS ) is an unpredictable, often disabling disease of the central nervous system which is composed of the brain and spinal cord.

MS is currently classified as an autoimmune disease of the central nervous system (brain, spinal cord). The disease attacks myelin, the protective covering of the nerves, causing inflammation and often damaging the myelin. Myelin is necessary for the transmission of nerve impulses through nerve fibres. If damage to myelin is slight, nerve impulses travel with minor interruptions; however, if damage is substantial and if scar tissue replaces the myelin, nerve impulses may be completely disrupted, and the nerve fibres themselves can be damaged.

Science & Research

Undated - Study ~ The use of cannabinoids in MS: is it evidence based?

1980 - Study ~ Marihuana as a therapeutic agent for muscle spasm or spasticity.

1983 - Study ~ Tetrahydrocannabinol for tremor in multiple sclerosis.

1987 - Study ~ Delta-9-THC in the treatment of spasticity associated with retinopathy.

1989 - Study ~ Effect of cannabinoids on spasticity and ataxia in multiple sclerosis.

1995 - Study ~ Nabilone in the treatment of multiple sclerosis.

1996 - Study ~ The effect of orally and rectally administered delta-9-tetrahydrocannabinol on spasticity: a pilot study with 2 patients.

1997 - Study ~ The perceived effects of smoked cannabis on patients with multiple sclerosis.

1999 - Study ~ Cannabis and cannabinoids: pharmacology and rationale for clinical use.

1999 - Study ~ Analgesic effect of the cannabinoid analogue nabilone is not mediated by opioid receptors.

2000 - Study ~ Endocannabinoids control spasticity in a multiple sclerosis model.

2000 - Study ~ Cannabinoids might reduce spasticity in multiple sclerosis.

2000 - Study ~ Cannabinoids control spasticity and tremor in a multiple sclerosis model.

2000 - News ~ Cannabinoids reduce tremor in animal model of multiple sclerosis.

2001 - Study ~ Therapeutic aspects of cannabis and cannabinoids.

2001 - Study ~ Acute and chronic effects of cannabis based medicinal extract on refractory lower urinary tract dysfunction in patients with advanced multiple sclerosis – early results.

2001 - Study ~ The cannabinoids: an overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection.

2002 - Study ~ Chronic Cannabis Use in the Compassionate Investigational New Drug Program: An Examination of Benefits and Adverse Effects of Legal Clinical Cannabis.

2002 - Study ~ Cannabinoids in the treatment of pain and spasticity in multiple sclerosis.

2002 - Study ~ Cannabinoids and multiple sclerosis.

2002 - News ~ Marijuana Helps MS Patients Alleviate Pain, Spasms.

2002 - News ~ MS SUFFERER DEFENDS DRUG; CANNABIS HELPED ME WALK.

2003 - Study ~ Cannabis Use As Described by People with Multiple Sclerosis.

2003 - Study ~ Therapeutic Action of Cannabinoids in a Murine Model of Multiple Sclerosis.

2003 - Study ~ Cannabinoids inhibit neurodegeneration in models of multiple sclerosis.

2003 - Study ~ Whether whole plant Cannabis extracts can improve intractable neurogenic symptoms?

2003 - Study ~ Immunoregulation of a viral model of multiple sclerosis using the synthetic cannabinoid R(+)WIN55,212.

2003 - Study ~ Cannabinoids inhibit neurodegeneration in models of multiple sclerosis.

2003 - Study ~ Randomised controlled trial of cannabis based medicinal extracts (CBME) in central neuropathic pain due to multiple sclerosis.

2003 - Study ~ Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): multicentre randomised placebo-controlled trial.

2003 - Study ~ Therapeutic potential of cannabinoids in CNS disease.

2003 - News/Anecdotal ~ How cannabis helped me'.

2003 - News ~ Cannabis helps symptoms of multiple sclerosis: study.

2003 - News ~ Cannabis May Help Multiple Sclerosis.

2003 - News ~ Cannabis can help MS sufferers.

2004 - Study ~ Initial experiences with medicinal extracts of cannabis for chronic pain: Results from 34 ‘N of 1’ studies.

2004 - Study ~ Does the cannabinoid dronabinol reduce central pain in multiple sclerosis? Randomised double blind placebo controlled crossover trial.

2004 - Study ~ Cannabinoids and neuroinflammation.

2004 - Study ~ Do cannabis-based medicinal extracts have general or specific effects on symptoms in multiple sclerosis? A double-blind, randomized, placebo-controlled study on 160 patients.

2004 - Study ~ Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled, crossover study.

2004 - Study ~ An open-label pilot study of cannabis-based extracts for bladder dysfunction in advanced multiple sclerosis.

2004 - Study ~ Multiple Sclerosis Following Treatment with a Cannabinoid Receptor-1 Antagonist.

2004 - Study ~ Are oral cannabinoids safe and effective in refractory neuropathic pain?

2004 - News ~ Cannabis study encouraging for MS.

2004 - News ~ Cannabis Relieves Multiple Sclerosis Pain.

2004 - News ~ Cannabis truly helps multiple sclerosis sufferers.

2005 - Study ~ Therapy Insight: Bladder Dysfunction Associated With Multiple Sclerosis.

2005 - Study ~ Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation.

2005 - Study ~ Cannabinoids in multiple sclerosis (CAMS) study: safety and efficacy data for 12 months follow up.

2005 - Study ~ Emerging properties of cannabinoid medicines in the management of multiple sclerosis.

2005 - Study ~ The synthetic cannabinoid R(+)WIN 55,212-2 inhibits the interleukin-1 signaling pathway in human astrocytes in a cannabinoid receptor-independent manner.

2005 - Study ~ Sativex: Fact Sheet.

2005 - Letter ~ Sativex: Health Care Professional letter.

2005 - Study ~ Cannabinoids in multiple sclerosis - therapeutically reasonable?

2005 - Study ~ Cannabinoid control of motor function at the basal ganglia.

2005 - Study ~ Decreased endocannabinoid levels in the brain and beneficial effects of agents activating cannabinoid and/or vanilloid receptors in a rat model of multiple sclerosis.

2005 - Study ~ Cannabis-based medicine in central pain in multiple sclerosis.

2005 - Study ~ Cannabinoids and neuroprotection in CNS inflammatory disease.

2005 - Study ~ Therapeutic action of cannabinoid on axonal injury induced by peroxynitrite.

2005 - Study ~ Cannabis-based medicinal extract (Sativex) produced significant improvements in a subjective measure of spasticity which were maintained on long-term treatment with no evidence of tolerance.

2005 - Study ~ Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis.

2005 - News ~ Marijuana derivatives may provide MS treatment.

2006 - Study ~ Medicinal marijuana use Experiences of people with multiple sclerosis.

2006 - Study ~ Experimental autoimmune encephalomyelitis disrupts endocannabinoid-mediated neuroprotection.

2006 - Study ~ Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the Management of Acute and Chronic Pain Episodes.

2006 - Study ~ Multiple sclerosis may disrupt endocannabinoid brain protection mechanism.

2006 - Study ~ Cannabinoids In Medicine: A Review Of Their Therapeutic Potential.

2006 - Patent ~ US Patent Application 20060167084 - Delta-9-THC compositions and methods for treating symptoms associated with multiple sclerosis.

2006 - Study ~ Long-term use of a cannabis-based medicine in the treatment of spasticity and other symptoms in multiple sclerosis.

2006 - Study ~ UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington's disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders.

2006 - Study ~ Sativex in patients with symptoms of spasticity due to multiple sclerosis.

2006 - Study ~ Randomised controlled study of cannabis-based medicine (Sativex®) in patients suffering from multiple sclerosis associated detrusor overactivity.

2006 - Study ~ The effect of cannabis on urge incontinence in patients with multiple sclerosis: a multicentre, randomised placebo-controlled trial (CAMS-LUTS).

2006 - Study ~ Low dose treatment with the synthetic cannabinoid Nabilone significantly reduces spasticity-related pain : A double-blind placebo-controlled cross-over trial.

2006 - News ~ Cuppa Gives A Better 'ooh'.

2007 - Study ~ The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis.

2007 - Study ~ Cannabinoid control of neuroinflammation related to multiple sclerosis.

2007 - Study ~ CB2 cannabinoid receptors as an emerging target for demyelinating diseases: from neuroimmune interactions to cell replacement strategies.

2007 - Study ~ Cannabinoid CB1 and CB2 Receptors and Fatty Acid Amide Hydrolase Are Specific Markers of Plaque Cell Subtypes in Human Multiple Sclerosis.

2007 - Study ~ The endocannabinoid system in targeting inflammatory neurodegenerative diseases.

2007 - Study ~ Control of Spasticity in a Multiple Sclerosis Model is mediated by CB1, not CB2, Cannabinoid Receptors.

2007 - Study ~ Randomized controlled trial of cannabis-based medicine in spasticity caused by multiple sclerosis.

2007 - Study ~ Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain.

2007 - Study ~ Oromucosal delta9-tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: an uncontrolled, open-label, 2-year extension trial.

2007 - Study ~ The endocannabinoid system and neurogenesis in health and disease.

2007 - Study ~ The (Endo)Cannabinoid System in Multiple Sclerosis and Amyotrophic Lateral Sclerosis.

2007 - Study ~ Cannabinoids and neuroprotection in motor-related disorders.

2007 - Study ~ Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption.

2007 - Study ~ Cannabis-based medicine in spasticity caused by multiple sclerosis.

2007 - Study ~ Excitotoxicity in a chronic model of multiple sclerosis: Neuroprotective effects of cannabinoids through CB1 and CB2 receptor activation.

2007 - Study ~ Cannabis based treatments for neuropathic and multiple sclerosis-related pain.

2007 - Study ~ Symptomatic treatment of multiple sclerosis using cannabinoids: recent advances.

2007 - News ~ Cannabis' Potential Exciting Researchers in Treatment of ALS, Parkinson's Disease.

2007 - News ~ Cannabis could hold the key to ending multiple sclerosis misery.

2008 - Study ~ Multiple sclerosis, cannabinoids, and cognition.

2008 - Study ~ Cannabinoids in the management of difficult to treat pain.

2008 - Study ~ CB2 cannabinoid receptors as an emerging target for demyelinating diseases: from neuroimmune interactions to cell replacement strategies.

2008 - Study ~ The CB2 Cannabinoid Receptor Controls Myeloid Progenitor Trafficking
INVOLVEMENT IN THE PATHOGENESIS OF AN ANIMAL MODEL OF MULTIPLE SCLEROSIS
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2008 - Study ~ Cannabinoid CB2 receptors in human brain inflammation.

2008 - Study ~ Cannabinoids in the management of spasticity associated with multiple sclerosis.

2008 - Study ~ Current Status of Cannabis Treatment of Multiple Sclerosis with an Illustrative Case Presentation of a Patient with MS, Complex Vocal Tics, Paroxysmal Dystonia, and Marijuana Dependence Treated with Dronabinol.

2008 - Study ~ The CB(2) cannabinoid receptor controls myeloid progenitor trafficking: involvement in the pathogenesis of an animal model of multiple sclerosis.

2008 - Patent ~ US Patent Application 20080181942 - Delta-9-THC compositions and methods for treating symptoms associated with multiple sclerosis.

2008 - Study ~ The endocannabinoid system and multiple sclerosis.

2008 - Study ~ Abnormalities in the cerebrospinal fluid levels of endocannabinoids in multiple sclerosis.

2008 - Study ~ Cannabinoid-mediated neuroprotection, not immunosuppression, may be more relevant to multiple sclerosis.

2008 - Study ~ Cannabis use in Spanish patients with multiple sclerosis.

2008 - News ~ Use Of Non-Psychoactive Cannabinoids In The Treatment Of Neurodegenerative Diseases.

2008 - NewsCannabis May Halt Progression Of Multiple Sclerosis.

2008 - News ~ Can Cannabis Compounds Slow The Progression Of Multiple Sclerosis?

2009 - Study ~ Emerging Role of the CB2 Cannabinoid Receptor in Immune Regulation and Therapeutic Prospects.

2009 - Study ~ Cannabinoids as Therapeutic Agents for Ablating Neuroinflammatory Disease.

2009 - Study ~ Whole plant cannabis extracts in the treatment of spasticity in multiple sclerosis: a systematic review.

2009 - Study ~ Cannabinoids as novel anti-inflammatory drugs.

2009 - Study ~ Cannabidiol: a promising drug for neurodegenerative disorders?

2009 - Study ~ The Endocannabinoid Anandamide: From Immunomodulation to Neuroprotection. Implications for Multiple Sclerosis.

2009 - Study ~ A review of complementary and alternative medicine (CAM) by people with multiple sclerosis.

2009 - Study ~ Do cannabinoids reduce multiple sclerosis-related spasticity?

2009 - Study ~ Plasma endocannabinoid levels in multiple sclerosis.

2009 - Study ~ Cannabinoids and neurodegenerative diseases.

2009 - News ~ Medical Marijuana and Multiple Sclerosis (MS).

2009 - News ~ Clinical phase III study with the cannabis extract Cannador successful in multiple sclerosis.

2009 - News ~ Marijuana Eases Spasticity in MS Patients.

2009 - News ~ Pot shows promise for reducing multiple sclerosis patients' symptoms.

2009 - News ~ Study Confirms That Cannabis Is Beneficial for Multiple Sclerosis.

2009 - News ~ Marijuana Chemicals Ease MS Symptoms, Review Confirms.

2009 - News ~ 14 of 15 MS patients show clinical improvement with cannabis consumption.

2009 - News ~ Cannabis can reduce spasticity in MS patients.

2010 - Study ~ Standardized Cannabis in Multiple Sclerosis: A Case Report.

2010 - Study ~ New approaches in the management of spasticity in multiple sclerosis patients: role of cannabinoids.

2010 - Study ~ Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression.

2010 - Study ~ Randomized controlled trial of Sativex to treat detrusor overactivity in multiple sclerosis.

2010 - Study ~ Meta-analysis of the efficacy and safety of Sativex (nabiximols), on spasticity in people with multiple sclerosis.

2010 - Study ~ The endocannabinoid system in the inflammatory and neurodegenerative processes of multiple sclerosis and of amyotrophic lateral sclerosis.

2010 - Study ~ The Multiplicity of Action of Cannabinoids: Implications for Treating Neurodegeneration.

2010 - News ~ Julie Falco brings hope to Multiple Sclerosis patients. Cannabinoids manage pain and promote repair!

2010 - News ~ Nature's (Legal) Cannabinoids.

2010 - News ~ Marijuana and MS--an unfinished story.

2010 - Anecdotal/News ~ Weed Control Part 1: MS sufferer finds relief with medical marijuana.

2011 - Study ~ Anandamide inhibits Theiler's virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB1 receptors.

2011 - Study ~ CANNABIDIOL INHIBITS PATHOGENIC T-CELLS, DECREASES SPINAL MICROGLIAL ACTIVATION AND AMELIORATES MULTIPLE SCLEROSIS-LIKE DISEASE IN C57BL/6 MICE.

2011 - Study ~ Gadolinium-HU-308-incorporated micelles.

2011 - Study ~ Emerging treatment options for spasticity in multiple sclerosis; clinical utility of cannabinoids.

2011 - Study ~ Acute and chronic cannabinoid extracts administration affects motor function in a CREAE model of multiple sclerosis.

2011- Study ~ Role of cannabinoids in multiple sclerosis.

2011 - Study ~ Inhibitory Effect of Standardized Cannabis sativa Extract and Its Ingredient Cannabidiol on Rat and Human Bladder Contractility.

2011 - Study ~ Identification of the synthetic cannabinoid R(+)WIN55,212-2 as a novel regulator of IFN regulatory factor 3 (IRF3) activation and IFN-{beta} expression: relevance to therapeutic effects in models of multiple sclerosis.

2011 - Study ~ A randomized, double-blind, placebo-controlled, parallel-group, enriched-design study of nabiximols* (Sativex(®) ), as add-on therapy, in subjects with refractory spasticity caused by multiple sclerosis.

2011- Study ~ Treating pain in multiple sclerosis.

2011 - Study ~ THC and CBD oromucosal spray (Sativex®) in the management of spasticity associated with multiple sclerosis.

2011 - News ~ New metabolic pathway for controlling brain inflammation.

2012 - Study ~ The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α.

2012 - Study ~ Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial.

2012 - Study ~ Cannabinoids ameliorate disease progression in a model of multiple sclerosis in mice, acting preferentially through CB(1) receptor-mediated anti-inflammatory effects.

2012 - Study ~ Cannabinoid receptor 2 agonists inhibit migration of activated dendritic cells via modulation of MMP-9.

2012 - Study ~ A questionnaire survey of patients and carers of patients prescribed Sativex as an unlicensed medicine.

2012 - Study ~ Potential Control of Multiple Sclerosis by Cannabis and the Endocannabinoid System.

2012 - Study ~ Evaluation of the safety and tolerability profile of Sativex: is it reassuring enough?

2012 - Study ~ Clinical efficacy and effectiveness of Sativex, a combined cannabinoid medicine, in multiple sclerosis-related spasticity.

2012 - Study ~ Multiple Sclerosis and Extract of Cannabis: results of the MUSEC trial.