Cannabis Research
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MULTIPLE SCLEROSIS and cannabis studies completed

Multiple sclerosis ( MS ) is an unpredictable, often disabling disease of the central nervous system which is composed of the brain and spinal cord.

Undated - Study ~ The use of cannabinoids in MS: is it evidence based?

1980 - Study ~ Marihuana as a therapeutic agent for muscle spasm or spasticity.

1983 - Study ~ Tetrahydrocannabinol for tremor in multiple sclerosis.

1987 - Study ~ Delta-9-THC in the treatment of spasticity associated with retinopathy.

1989 - Study ~ Effect of cannabinoids on spasticity and ataxia in multiple sclerosis.

1995 - Study ~ Nabilone in the treatment of multiple sclerosis.

1996 - Study ~ The effect of orally and rectally administered delta-9-tetrahydrocannabinol on spasticity: a pilot study with 2 patients.

1997 - Study ~ The perceived effects of smoked cannabis on patients with multiple sclerosis.

1999 - Study ~ Cannabis and cannabinoids: pharmacology and rationale for clinical use.

1999 - Study ~ Analgesic effect of the cannabinoid analogue nabilone is not mediated by opioid receptors.

2000 - Study ~ Endocannabinoids control spasticity in a multiple sclerosis model.

2000 - Study ~ Cannabinoids might reduce spasticity in multiple sclerosis.

2000 - Study ~ Cannabinoids control spasticity and tremor in a multiple sclerosis model.

2000 - News ~ Cannabinoids reduce tremor in animal model of multiple sclerosis.

2001 - Study ~ Therapeutic aspects of cannabis and cannabinoids.

2001 - Study ~ Acute and chronic effects of cannabis based medicinal extract on refractory lower urinary tract dysfunction in patients with advanced multiple sclerosis – early results.

2001 - Study ~ The cannabinoids: an overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection.

2002 - Study ~ Chronic Cannabis Use in the Compassionate Investigational New Drug Program: An Examination of Benefits and Adverse Effects of Legal Clinical Cannabis.

2002 - Study ~ Cannabinoids in the treatment of pain and spasticity in multiple sclerosis.

2002 - Study ~ Cannabinoids and multiple sclerosis.

2002 - News ~ Marijuana Helps MS Patients Alleviate Pain, Spasms.

2002 - News ~ MS SUFFERER DEFENDS DRUG; CANNABIS HELPED ME WALK.

2003 - Study ~ Cannabis Use As Described by People with Multiple Sclerosis.

2003 - Study ~ Therapeutic Action of Cannabinoids in a Murine Model of Multiple Sclerosis.

2003 - Study ~ Cannabinoids inhibit neurodegeneration in models of multiple sclerosis.

2003 - Study ~ Whether whole plant Cannabis extracts can improve intractable neurogenic symptoms?

2003 - Study ~ Immunoregulation of a viral model of multiple sclerosis using the synthetic cannabinoid R(+)WIN55,212.

2003 - Study ~ Cannabinoids inhibit neurodegeneration in models of multiple sclerosis.

2003 - Study ~ Randomised controlled trial of cannabis based medicinal extracts (CBME) in central neuropathic pain due to multiple sclerosis.

2003 - Study ~ Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): multicentre randomised placebo-controlled trial.

2003 - Study ~ Therapeutic potential of cannabinoids in CNS disease.

2003 - News/Anecdotal ~ How cannabis helped me'.

2003 - News ~ Cannabis helps symptoms of multiple sclerosis: study.

2003 - News ~ Cannabis May Help Multiple Sclerosis.

2003 - News ~ Cannabis can help MS sufferers.

2004 - Study ~ Initial experiences with medicinal extracts of cannabis for chronic pain: Results from 34 ‘N of 1’ studies.

2004 - Study ~ Does the cannabinoid dronabinol reduce central pain in multiple sclerosis? Randomised double blind placebo controlled crossover trial.

2004 - Study ~ Cannabinoids and neuroinflammation.

2004 - Study ~ Do cannabis-based medicinal extracts have general or specific effects on symptoms in multiple sclerosis? A double-blind, randomized, placebo-controlled study on 160 patients.

2004 - Study ~ Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled, crossover study.

2004 - Study ~ An open-label pilot study of cannabis-based extracts for bladder dysfunction in advanced multiple sclerosis.

2004 - Study ~ Multiple Sclerosis Following Treatment with a Cannabinoid Receptor-1 Antagonist.

2004 - Study ~ Are oral cannabinoids safe and effective in refractory neuropathic pain?

2004 - News ~ Cannabis study encouraging for MS.

2004 - News ~ Cannabis Relieves Multiple Sclerosis Pain.

2004 - News ~ Cannabis truly helps multiple sclerosis sufferers.

2005 - Study ~ Therapy Insight: Bladder Dysfunction Associated With Multiple Sclerosis.

2005 - Study ~ Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation.

2005 - Study ~ Cannabinoids in multiple sclerosis (CAMS) study: safety and efficacy data for 12 months follow up.

2005 - Study ~ Emerging properties of cannabinoid medicines in the management of multiple sclerosis.

2005 - Study ~ The synthetic cannabinoid R(+)WIN 55,212-2 inhibits the interleukin-1 signaling pathway in human astrocytes in a cannabinoid receptor-independent manner.

2005 - Study ~ Sativex: Fact Sheet.

2005 - Letter ~ Sativex: Health Care Professional letter.

2005 - Study ~ Cannabinoids in multiple sclerosis - therapeutically reasonable?

2005 - Study ~ Cannabinoid control of motor function at the basal ganglia.

2005 - Study ~ Decreased endocannabinoid levels in the brain and beneficial effects of agents activating cannabinoid and/or vanilloid receptors in a rat model of multiple sclerosis.

2005 - Study ~ Cannabis-based medicine in central pain in multiple sclerosis.

2005 - Study ~ Cannabinoids and neuroprotection in CNS inflammatory disease.

2005 - Study ~ Therapeutic action of cannabinoid on axonal injury induced by peroxynitrite.

2005 - Study ~ Cannabis-based medicinal extract (Sativex) produced significant improvements in a subjective measure of spasticity which were maintained on long-term treatment with no evidence of tolerance.

2005 - Study ~ Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis.

2005 - News ~ Marijuana derivatives may provide MS treatment.

2006 - Study ~ Medicinal marijuana use Experiences of people with multiple sclerosis.

2006 - Study ~ Experimental autoimmune encephalomyelitis disrupts endocannabinoid-mediated neuroprotection.

2006 - Study ~ Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the Management of Acute and Chronic Pain Episodes.

2006 - Study ~ Multiple sclerosis may disrupt endocannabinoid brain protection mechanism.

2006 - Study ~ Cannabinoids In Medicine: A Review Of Their Therapeutic Potential.

2006 - Patent ~ US Patent Application 20060167084 - Delta-9-THC compositions and methods for treating symptoms associated with multiple sclerosis.

2006 - Study ~ Long-term use of a cannabis-based medicine in the treatment of spasticity and other symptoms in multiple sclerosis.

2006 - Study ~ UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington's disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders.

2006 - Study ~ Sativex in patients with symptoms of spasticity due to multiple sclerosis.

2006 - Study ~ Randomised controlled study of cannabis-based medicine (Sativex®) in patients suffering from multiple sclerosis associated detrusor overactivity.

2006 - Study ~ The effect of cannabis on urge incontinence in patients with multiple sclerosis: a multicentre, randomised placebo-controlled trial (CAMS-LUTS).

2006 - Study ~ Low dose treatment with the synthetic cannabinoid Nabilone significantly reduces spasticity-related pain : A double-blind placebo-controlled cross-over trial.

2006 - News ~ Cuppa Gives A Better 'ooh'.

2007 - Study ~ The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis.

2007 - Study ~ Cannabinoid control of neuroinflammation related to multiple sclerosis.

2007 - Study ~ CB2 cannabinoid receptors as an emerging target for demyelinating diseases: from neuroimmune interactions to cell replacement strategies.

2007 - Study ~ Cannabinoid CB1 and CB2 Receptors and Fatty Acid Amide Hydrolase Are Specific Markers of Plaque Cell Subtypes in Human Multiple Sclerosis.

2007 - Study ~ The endocannabinoid system in targeting inflammatory neurodegenerative diseases.

2007 - Study ~ Control of Spasticity in a Multiple Sclerosis Model is mediated by CB1, not CB2, Cannabinoid Receptors.

2007 - Study ~ Randomized controlled trial of cannabis-based medicine in spasticity caused by multiple sclerosis.

2007 - Study ~ Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain.

2007 - Study ~ Oromucosal delta9-tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: an uncontrolled, open-label, 2-year extension trial.

2007 - Study ~ The endocannabinoid system and neurogenesis in health and disease.

2007 - Study ~ The (Endo)Cannabinoid System in Multiple Sclerosis and Amyotrophic Lateral Sclerosis.

2007 - Study ~ Cannabinoids and neuroprotection in motor-related disorders.

2007 - Study ~ Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption.

2007 - Study ~ Cannabis-based medicine in spasticity caused by multiple sclerosis.

2007 - Study ~ Excitotoxicity in a chronic model of multiple sclerosis: Neuroprotective effects of cannabinoids through CB1 and CB2 receptor activation.

2007 - Study ~ Cannabis based treatments for neuropathic and multiple sclerosis-related pain.

2007 - Study ~ Symptomatic treatment of multiple sclerosis using cannabinoids: recent advances.

2007 - News ~ Cannabis' Potential Exciting Researchers in Treatment of ALS, Parkinson's Disease.

2007 - News ~ Cannabis could hold the key to ending multiple sclerosis misery.

2008 - Study ~ Multiple sclerosis, cannabinoids, and cognition.

2008 - Study ~ Cannabinoids in the management of difficult to treat pain.

2008 - Study ~ CB2 cannabinoid receptors as an emerging target for demyelinating diseases: from neuroimmune interactions to cell replacement strategies.

2008 - Study ~ The CB2 Cannabinoid Receptor Controls Myeloid Progenitor Trafficking
INVOLVEMENT IN THE PATHOGENESIS OF AN ANIMAL MODEL OF MULTIPLE SCLEROSIS
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2008 - Study ~ Cannabinoid CB2 receptors in human brain inflammation.

2008 - Study ~ Cannabinoids in the management of spasticity associated with multiple sclerosis.

2008 - Study ~ Current Status of Cannabis Treatment of Multiple Sclerosis with an Illustrative Case Presentation of a Patient with MS, Complex Vocal Tics, Paroxysmal Dystonia, and Marijuana Dependence Treated with Dronabinol.

2008 - Study ~ The CB(2) cannabinoid receptor controls myeloid progenitor trafficking: involvement in the pathogenesis of an animal model of multiple sclerosis.

2008 - Patent ~ US Patent Application 20080181942 - Delta-9-THC compositions and methods for treating symptoms associated with multiple sclerosis.

2008 - Study ~ The endocannabinoid system and multiple sclerosis.

2008 - Study ~ Abnormalities in the cerebrospinal fluid levels of endocannabinoids in multiple sclerosis.

2008 - Study ~ Cannabinoid-mediated neuroprotection, not immunosuppression, may be more relevant to multiple sclerosis.

2008 - Study ~ Cannabis use in Spanish patients with multiple sclerosis.

2008 - News ~ Use Of Non-Psychoactive Cannabinoids In The Treatment Of Neurodegenerative Diseases.

2008 - NewsCannabis May Halt Progression Of Multiple Sclerosis.

2008 - News ~ Can Cannabis Compounds Slow The Progression Of Multiple Sclerosis?

2009 - Study ~ Emerging Role of the CB2 Cannabinoid Receptor in Immune Regulation and Therapeutic Prospects.

2009 - Study ~ Cannabinoids as Therapeutic Agents for Ablating Neuroinflammatory Disease.

2009 - Study ~ Whole plant cannabis extracts in the treatment of spasticity in multiple sclerosis: a systematic review.

2009 - Study ~ Cannabinoids as novel anti-inflammatory drugs.

2009 - Study ~ Cannabidiol: a promising drug for neurodegenerative disorders?

2009 - Study ~ The Endocannabinoid Anandamide: From Immunomodulation to Neuroprotection. Implications for Multiple Sclerosis.

2009 - Study ~ A review of complementary and alternative medicine (CAM) by people with multiple sclerosis.

2009 - Study ~ Do cannabinoids reduce multiple sclerosis-related spasticity?

2009 - Study ~ Plasma endocannabinoid levels in multiple sclerosis.

2009 - Study ~ Cannabinoids and neurodegenerative diseases.

2009 - News ~ Medical Marijuana and Multiple Sclerosis (MS).

2009 - News ~ Clinical phase III study with the cannabis extract Cannador successful in multiple sclerosis.

2009 - News ~ Marijuana Eases Spasticity in MS Patients.

2009 - News ~ Pot shows promise for reducing multiple sclerosis patients' symptoms.

2009 - News ~ Study Confirms That Cannabis Is Beneficial for Multiple Sclerosis.

2009 - News ~ Marijuana Chemicals Ease MS Symptoms, Review Confirms.

2009 - News ~ 14 of 15 MS patients show clinical improvement with cannabis consumption.

2009 - News ~ Cannabis can reduce spasticity in MS patients.

2010 - Study ~ Standardized Cannabis in Multiple Sclerosis: A Case Report.

2010 - Study ~ New approaches in the management of spasticity in multiple sclerosis patients: role of cannabinoids.

2010 - Study ~ Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression.

2010 - Study ~ Randomized controlled trial of Sativex to treat detrusor overactivity in multiple sclerosis.

2010 - Study ~ Meta-analysis of the efficacy and safety of Sativex (nabiximols), on spasticity in people with multiple sclerosis.

2010 - Study ~ The endocannabinoid system in the inflammatory and neurodegenerative processes of multiple sclerosis and of amyotrophic lateral sclerosis.

2010 - Study ~ The Multiplicity of Action of Cannabinoids: Implications for Treating Neurodegeneration.

2010 - News ~ Julie Falco brings hope to Multiple Sclerosis patients. Cannabinoids manage pain and promote repair!

2010 - News ~ Nature's (Legal) Cannabinoids.

2010 - News ~ Marijuana and MS--an unfinished story.

2010 - Anecdotal/News ~ Weed Control Part 1: MS sufferer finds relief with medical marijuana.

2011 - Study ~ Anandamide inhibits Theiler's virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB1 receptors.

2011 - Study ~ CANNABIDIOL INHIBITS PATHOGENIC T-CELLS, DECREASES SPINAL MICROGLIAL ACTIVATION AND AMELIORATES MULTIPLE SCLEROSIS-LIKE DISEASE IN C57BL/6 MICE.

2011 - Study ~ Gadolinium-HU-308-incorporated micelles.

2011 - Study ~ Emerging treatment options for spasticity in multiple sclerosis; clinical utility of cannabinoids.

2011 - Study ~ Acute and chronic cannabinoid extracts administration affects motor function in a CREAE model of multiple sclerosis.

2011- Study ~ Role of cannabinoids in multiple sclerosis.

2011 - Study ~ Inhibitory Effect of Standardized Cannabis sativa Extract and Its Ingredient Cannabidiol on Rat and Human Bladder Contractility.

2011 - Study ~ Identification of the synthetic cannabinoid R(+)WIN55,212-2 as a novel regulator of IFN regulatory factor 3 (IRF3) activation and IFN-{beta} expression: relevance to therapeutic effects in models of multiple sclerosis.

2011 - Study ~ A randomized, double-blind, placebo-controlled, parallel-group, enriched-design study of nabiximols* (Sativex(®) ), as add-on therapy, in subjects with refractory spasticity caused by multiple sclerosis.

2011- Study ~ Treating pain in multiple sclerosis.

2011 - Study ~ THC and CBD oromucosal spray (Sativex®) in the management of spasticity associated with multiple sclerosis.

2011 - News ~ New metabolic pathway for controlling brain inflammation.

2012 - Study ~ The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α.

2012 - Study ~ Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial.

2012 - Study ~ Cannabinoids ameliorate disease progression in a model of multiple sclerosis in mice, acting preferentially through CB(1) receptor-mediated anti-inflammatory effects.

2012 - Study ~ Cannabinoid receptor 2 agonists inhibit migration of activated dendritic cells via modulation of MMP-9.

2012 - Study ~ A questionnaire survey of patients and carers of patients prescribed Sativex as an unlicensed medicine.

2012 - Study ~ Potential Control of Multiple Sclerosis by Cannabis and the Endocannabinoid System.

2012 - Study ~ Evaluation of the safety and tolerability profile of Sativex: is it reassuring enough?

2012 - Study ~ Clinical efficacy and effectiveness of Sativex, a combined cannabinoid medicine, in multiple sclerosis-related spasticity.

2012 - Study ~ Multiple Sclerosis and Extract of Cannabis: results of the MUSEC trial.



Hardcover Books on Multiple Sclerosis

Managing Multiple Sclerosis Naturally: A Self-help Guide to Living with MSThe MS Recovery DietHealing Multiple Sclerosis: Diet, Detox & Nutritional Makeover for Total RecoveryThe Multiple Sclerosis Diet BookMinding My Mitochondria 2nd Edition: How I overcame secondary progressive  multiple sclerosis (MS) and got out of my  wheelchair. Multiple Sclerosis: A Guide for the Newly Diagnosed

 

 

 
 
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