2008 - News -Pot smoking could stop Mad Cow Disease
Cannabidiol May be Effective in Preventing Bovine Spongiforme Enzephalopathy (Mad Cow Disease)
J Neurosci 2007;27(36):9537-44
Pot smoking could stop Mad Cow Disease?
A NEW Zealand pro-cannabis group believes it has scientific evidence that cannabis can stop the development of mad cow disease the New Zealand Press Association reported today. The National Organization for the Reform of Marijuana Laws (Norml) sited a French study showing cannabidiol might be effective in preventing bovine spongiform encephalopathy (BSE), also known as mad cow disease.
Scientists at the National Center for Scientific Research in France found cannabidiol – a non-psychoactive ingredient, may prevent the development of prion diseases (progressive neurodegenerative disorders), the most well known of which is BSE, Norml said.
Researchers found cannabidiol inhibited the accumulation of prion proteins in infected mice and sheep.
Norml spokesman Chris Fowlie said the discovery added to the scientific evidence supporting a bill from a New Zealand Greens MP to legalise the medicinal use of cannabis. Mr Fowlie also said:
“(It) should be supported by any MP with a clear head. Unfortunately most politicians act like mad cows whenever cannabis is mentioned.”
Cannabidiol Prevents Prion Accumulation and Protects Neurons against Prion Toxicity
- Institut de Pharmacologie Moléculaire et Cellulaire, Unité Mixte de Recherche 6097, Centre National de la Recherche Scientifique, 06560 Valbonne, France,
- , National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840, and
- Scripps Research Institute, La Jolla, California 92037
- Correspondence should be addressed to Dr. Joëlle Chabry, Institut de Pharmacologie Moléculaire et Cellulaire, Unité Mixte de Recherche 6097, Université de Nice-Sophia Antipolis, Centre National de la Recherche Scientifique, 660, route des lucioles, 06560 Valbonne, France. [email protected]
Prion diseases are transmissible neurodegenerative disorders characterized by the accumulation in the CNS of the protease-resistant prion protein (PrPres), a structurally misfolded isoform of its physiological counterpart PrPsen. Both neuropathogenesis and prion infectivity are related to PrPres formation. Here, we report that the nonpsychoactive cannabis constituent cannabidiol (CBD) inhibited PrPres accumulation in both mouse and sheep scrapie-infected cells, whereas other structurally related cannabinoid analogs were either weak inhibitors or noninhibitory.
Moreover, after intraperitoneal infection with murine scrapie, peripheral injection of CBD limited cerebral accumulation of PrPres and significantly increased the survival time of infected mice. Mechanistically, CBD did not appear to inhibit PrPres accumulation via direct interactions with PrP, destabilization of PrPres aggregates, or alteration of the expression level or subcellular localization of PrPsen. However, CBD did inhibit the neurotoxic effects of PrPres and affected PrPres-induced microglial cell migration in a concentration-dependent manner.
Our results suggest that CBD may protect neurons against the multiple molecular and cellular factors involved in the different steps of the neurodegenerative process, which takes place during prion infection. When combined with its ability to target the brain and its lack of toxic side effects, CBD may represent a promising new anti-prion drug.