HIV / AIDS & Cannabis studies completed

MEDICAL JOURNALS SHOW EVIDENCE CANNABIS BENEFICIAL FOR PERSONS LIVING WITH HIV

Overview

The Human Immunodeficiency Virus (HIV) is a lentivirus that causes the acquired immunodeficiency syndrome (AIDS), a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive.

When someone living with HIV has a weakened immune system (indicated by a low CD4 count), they are at risk of other illnesses. These are known as 'opportunistic infections' because they take the opportunity of the immune system being weak.

*Lentivirus (lente-, Latin for "slow") is a genus of viruses of the Retroviridae family.

Elvitegravir/Cobicistat & Tetrahydro-cannabinol (THC)

Drugs which inhibit CYP3A (e.g., protease inhibitors or cobicistat) may enhance THC concentrations. Monitor for dose-related effects of THC (e.g. hallucinations, delusions, paranoid thinking, altered time sense, anxiety, panic, depersonalization, loss of insight, orthostatic hypotension, heart rate).

Considering the widespread use of THC derivatives for appetite stimulation and control of nausea and vomiting, and the lack of reports documenting deleterious effects secondary to the combination of THC and protease inhibitors, a clinically significant drug interaction may not exist when THC is used in moderate amounts.

Patients who use THC and are beginning antiretrovirals should be warned about a possible accentuating of the effects of THC, and that they may need to use less THC for the same effect following treatment initiation.

Links to HIV and Cannabis Based Science & Medical Journals

2016 - Abstract ~ Identifying HIV care enrollees at-risk for cannabis use disorder.

AIDS Care: Psychological and Socio-medical Aspects of AIDS/HIV.

2016 - Study ~ Stakeholders' Views on Barriers to Research on Controversial Controlled Substances.

Journal of Clinical Ethics.

2016 - Study ~ Marijuana Use Is Not Associated With Progression to Advanced Liver Fibrosis in HIV/Hepatitis C Virus-coinfected Women.

Oxford: Clinical Infectious Diseases.

2016 - Review ~ Pharmacologic and non-pharmacologic treatments for chronic pain in individuals with HIV: a systematic review.
AIDS Care: Psychological and Socio-medical Aspects of AIDS/HIV.

2016 - Study ~ Chronic Δ9-Tetrahydrocannabinol Administration Reduces IgE+B Cells but Unlikely Enhances Pathogenic SIVmac251 Infection in Male Rhesus Macaques of Chinese Origin.

Journal of Neuroimmune Pharmacology.

2016 - Study ~ No significant effect of cannabis use on the count and percentage of circulating CD4 T-cells in HIV-HCV co-infected patients (ANRS CO13-HEPAVIH French cohort).

ASAP: Drug and Alcohol Review.

2016 - Study ~ Cannabinoids Occlude the HIV-1 Tat-Induced Decrease in GABAergic
Neurotransmission in Prefrontal Cortex Slices.

Journal of Neuroimmune Pharmacology.

2016 - Study ~ Medical use of cannabis products : Lessons to be learned from Israel and Canada.
Der Schmerz.

2016 - Study ~ Marijuana effects on changes in brain structure and cognitive function among HIV+ and HIV- adults.

Drug and Alcohol Dependence.

2016 - Study ~ Longitudinal examination of the intestinal lamina propria cellular

compartment of SIV-infected rhesus macaques provides broader and deeper insights

into the link between aberrant microRNA expression and persistent immune activation.

Journal of Virology.

2015 - Abstract ~ Behavioral, Metabolic, and Immune Consequences of Chronic Alcohol or Cannabinoids on HIV/AIDs: Studies in the Non-Human Primate SIV Model.

Journal of Neuroimmune Pharmacology.

2015 - Abstract ~ Combined effects of HIV and marijuana use on neurocognitive functioning and immune status.

AIDS Care.

2015 - Study ~ Δ9-Tetrahydrocannabinol (Δ9-THC) Promotes Neuroimmune-Modulatory MicroRNA Profile in Striatum of Simian Immunodeficiency Virus (SIV)-Infected Macaques.

Journal of Neuroimmune Pharmacology.

2015 - Study ~ Modulation of HIVGP120 Antigen-Specific Immune Responses In Vivo by Δ9-
Tetrahydrocannabinol.

Journal of Neuroimmune Pharmacology.

2015 - Study ~ Activation of Cannabinoid Type Two Receptors (CB2) Diminish Inflammatory
Responses in Macrophages and Brain Endothelium.
Journal of Neuroimmune Pharmacology.

2015 - Study ~ Neighborhood-level and individual-level correlates of cannabis use among young persons living with HIV/AIDS.

Drug and Alcohol Dependence.

2015 - Study ~ Narrative review of the safety and efficacy of marijuana for the treatment of commonly state-approved medical and psychiatric disorders.
Addiction Science & Clinical Practice.

2015 - Study ~ Alcohol and Cannabinoids Differentially Affect HIV Infection and Function of Human Monocyte-Derived Dendritic Cells (MDDC).

Frontiers in Microbiology: Virology.

2015 - Study ~ Cannabis Use and Reduced Risk of Insulin Resistance in HIV-HCV Infected Patients: A Longitudinal Analysis (ANRS CO13 HEPAVIH)

Oxford Academic: Clinical Infectious Diseases.

2015 - Study ~ Differential immune mechanism to HIV-1 Tat variants and its regulation by AEA.

Scientific Reports.

2015 - Study ~ Drugs of Abuse in HIV infection and neurotoxicity.

Frontiers in Microbiology: Virology.

2014 - Abstract ~ Attenuation of persistent pain-related behavior by fatty acid amide hydrolase (FAAH) inhibitors in a rat model of HIV sensory neuropathy.
Neuropharmacology.

2014 - Abstract ~ Cannabinoid Receptor-2 and HIV-Associated Neurocognitive Disorders.
Journal of Neuroimmune Pharmacology.

2014 - Study ~ Endocannabinoids affect innate immunity of Muller glia during HIV-1 Tat cytotoxicity.
Molecular and Cellular Neuroscience.

2014 - Study ~ Inhaled medicinal cannabis and the immunocompromised patient.

Supportive Care in Cancer.

2014 - Review ~ High-intensity cannabis use associated with lower plasma human immunodeficiency virus-1 RNA viral load among recently infected people who use injection drugs.

Drug and Alcohol Review.

2014 - Study ~ Δ(9)-Tetrahydrocannabinol treatment during human monocyte differentiation reduces macrophage susceptibility to HIV-1 infection.

Journal of Neuroimmune Pharmacology.

2014 - Study ~ Cannabinoid inhibits HIV-1 Tat-stimulated adhesion of human monocyte-like cells to extracellular matrix proteins.

Life Science.

2014 - Study ~ Patterns and correlates of cannabis use among individuals with HIV/AIDS in Maritime Canada.

Canadian Journal of Infectious Diseases and Medical Microbiology.

2014 - Study ~ Modulation of Gut-Specific Mechanisms by Chronic Δ9-THC Administration in Male Rhesus Macaques Infected with Simian Immunodeficiency Virus: A Systems Biology
Analysis.
AIDS Research and Human Retroviruses.

2014 - Study ~ Marijuana and Body Weight.

Innovations in Clinical Neuroscience.

2014 - Study ~ Nabilone for Non-chemotherapy Associated Nausea and Weight Loss due to Medical Conditions: A Review of the Clinical Effectiveness and Guidelines.

Canadian Agency for Drugs and Technologies in Health.

2013 - Study ~ Therapeutic potential of cannabinoid medicines.

Drug Testing and Analysis.

2013 - Study ~ Medicinal Cannabis and Painful Sensory Neuropathy.

AMA Journal of Ethics.

2013 - Study ~ CB2 cannabinoid agonist enhanced neurogenesis in GFAP/Gp120 transgenic mice displaying deficits in neurogenesis.

British Journal of Pharmacology.

2013 - Study ~ Epigenetics, drugs of abuse, and the retroviral promoter.

Journal of Neuroimmune Pharmacology.

2013 - Study ~ The medical use of cannabis for reducing morbidity and mortality in patients with HIV/AIDS.

Cochrane Library.

2013 - Study ~ Attenuation of HIV-1 replication in macrophages by cannabinoid receptor 2 agonists.

Journal of Leukocyte Biology.

2013 - Study ~ CB2 Receptor Agonists Protect Human Dopaminergic Neurons against Damage from HIV-1 gp120.

PLOS One.

2013 - Study ~ Cannabinoid Receptor 2: Potential Role in Immunomodulation and Neuroinflammation.

Journal of Neuroimmune Pharmacology.

2013 - Study ~ Efavirenz does not cause false-positive urine cannabis test in HIV-infected patients on Highly Active Anti-Retroviral Therapy.

International Medical University, Internal Medicine, Clinical School, Malaysia.

2013 - Study ~ Marijuana Smoking Does Not Accelerate Progression of Liver Disease in HIV-Hepatitis C Coinfection: A Longitudinal Cohort Analysis.

Oxford Academic: Clinical Infectious Diseases.

2013 - Study ~ Magnitude of stimulation dictates the cannabinoid-mediated differential T cell response to HIVgp120.

Journal of Leukocyte Biology.

2012 - Study ~ Cannabis use and HIV antiretroviral therapy adherence and HIV-related symptoms.

Journal of Behavioral Medicine.

2012 - Article ~ Cannabinoid Receptor 2-Mediated Attenuation of CXCR4-Tropic HIV Infection in Primary CD4+ T Cells.

PLOS One.

2012 - Study ~ The role of the endocannabinoid system in eating disorders: pharmacological implications.
Behavioural Pharmacology.

2012 - Abstact ~ A pilot study of the effects of cannabis on appetite hormones in HIV-infected adult men.

Brain Research.

2012 - News ~ Marijuana-Like Chemicals Inhibit Human Immunodeficiency Virus (HIV) in Late-State AIDS.

Science Daily.

2012 - News ~ Cannabinoid drugs can directly inhibit HIV in late-stage AIDS.

Medical Life Sciences.

2011 - Study ~ Activation of CB2 Cannabinoid Receptors Inhibits HIV-1 Envelope Glycoprotein gp120-Induced Synapse Loss.

Molecular Pharmacology.

2011 - Study ~ Tolerance to Chronic Delta-9-Tetrahydrocannabinol (Δ9-THC) in Rhesus Macaques Infected With Simian Immunodeficiency Virus.

Experimental and Clinical Psychopharmacology.

2011 - Study ~ Cannabinoid Neuroimmune Modulation of SIV Disease.

Journal of Neuroimmune Pharmacology.

2011 - Study ~ Immunomodulatory Properties of Kappa Opioids and Synthetic Cannabinoids in HIV-1 Neuropathogenesis.

Journal of Neuroimmune Pharmacology.

2011 - Study ~ HIV-1 infection and alcohol abuse: neurocognitive impairment, mechanisms of
neurodegeneration and therapeutic interventions.
Brain, Behavior, and Immunity.

2010 - Abstract ~ The endocannabinoid system in gp120-mediated insults and HIV-associated dementia.
Experimental Neurology.

2010 - Study ~ Efficacy and tolerability of high-dose dronabinol maintenance in HIV-positive marijuana smokers: a controlled laboratory study.

Psychopharmacology (Berl)

2010 - Study ~ Marijuana Use is Not Associated with Cervical Human Papillomavirus Natural History or Cervical Neoplasia in HIV-Seropositive or HIV-Seronegative Women.

Cancer Epidemiology Biomarkers & Prevention.

2010 - Study ~ Cannabinoid inhibition of macrophage migration to the trans-activating (Tat) protein o HIV-1 is linked to the CB(2) cannabinoid receptor.

Journal of Pharmacology and Experimental Therapeutics.

2010 - Study ~ Cannabinoid Administration Attenuates the Progression of Simian Immunodeficiency Virus.

AIDS Research and Human Retroviruses.

2010 - Study ~ Cannabinoids and Viral Infections.

Open Access Pharmaceuticals.

2010 - Study ~ Immunoregulation of a CB2 receptor agonist in a murine model of neuroAIDS.
Journal of Neuroimmune Pharmacology.

2010 - Study ~ Pharmacological Treatment of Painful HIV-Associated Sensory Neuropathy: A
Systematic Review and Meta-Analysis of Randomised Controlled Trials.

PLOS One.

2009 - Study ~ Smoked Medicinal Cannabis for Neuropathic Pain in HIV: A Randomized, Crossover Clinical Trial.
Neuropsychopharmacology.

2008 - Study ~ Recreational Drug Use and T Lymphocyte Subpopulations in HIV-uninfected and HIV-infected Men.

Drug and Alcohol Dependence.

2008 - Study ~ Cannabinoids Inhibit HIV-1 Gp120-Mediated Insults in Brain Microvascular Endothelial Cells.

Journal of Immunology.

2007 - Study ~ Marijuana as therapy for people living with HIV/AIDS: social and health aspects.

AIDS Care.

2007 - Study ~ Marijuana and AIDS: A Four-Year Study.

NCBI Book.

2007 - Study ~ The endocannabinoid system in targeting inflammatory neurodegenerative diseases.

Trends in Pharmacological Sciences.

2005 - Study ~ Cannabis use in HIV for pain and other medical symptoms.

Journal of Pain and Symptom Management.

2003 - Study ~ Short-term effects of cannabinoids in patients with HIV-1 infection: a randomized, placebo-controlled clinical trial.

Annals of Internal Medicine.

1995 - Study ~ Dronabinol as a treatment for anorexia associated with weight loss in patients with AIDS.

Journal of Pain and Symptom Management.

1993 - Study ~ Effect of dronabinol on nutritional status in HIV infection.

Annals of Pharmacotherapy.

Video
How Cannabis Is Saving A Life

FAQ's

Are there any drug Interactions with cannabis use that I should be aware of while taking other medications?

Is cannabis an anti-inflammatory?

Other HIV Related Research

APPETITE STIMULANT

CANCER (Breast)

CANCER (Cervical)

CANCER (Corolrectal)

CANCER (Glioma/Brain)

CANCER (Leukemia)

CANCER (Lung)

CANCER (Lymphoma)

CANCER (Melanoma)

CANCER (Oral)

CANCER (Ovarian)

CANCER (Pancreatic)

CANCER (Prostate)

CANCER (Risk)

CANCER (Skin)

CANCER (Testicular)

CANCER (Thyroid)

CANCER (Various)

CANNABIDIOL (CBD)