Fever and Cannabis Research dating from 1973-2017


Fever (also known as pyrexia) is one of the most common medical signs and is characterized by an elevation of body temperature above the normal range of 36.5-37.5 C (98-100 F) due to an increase in the temperature regulatory set-point.

Video - Fever: Definition

Fever & Cannabis Health Sciences & Medical Journals

2017 - Study ~ Thermolytic degradation of synthetic cannabinoids: chemical exposures and pharmacological consequences. Journal of Pharmacology and Experimental Therapeutics.

2016 - Study ~ Short-term effects of cannabidiol after global hypoxia-ischemia in newborn piglets. Pediatric Research.
2016 - Study ~ Pharmacological hypothermia: a potential for future stroke therapy? Journal of Progress in Neurosurgery, Neurology and Neurosciences.

2016 - Study ~ Endocannabinoids, through opioids and prostaglandins, contribute to fever induced by key pyrogenic mediators. Brain, Behavior, and Immunity.

2016 - Study ~ Effect of JWH-250, JWH-073 and their interaction on "tetrad", sensorimotor, neurological and neurochemical responses in mice. Progress in Neuro-Psychopharmacology and Biological Psychiatry.

2016 - Study ~ Behavioral Characterization of Kappa Opioid Receptor Agonist Spiradoline and Cannabinoid Receptor Agonist CP55940 Mixtures in Rats. Journal of Pharmacology and Experimental Therapeutics.

2016 - Study ~ α/β-Hydrolase Domain 6 in the Ventromedial Hypothalamus Controls Energy Metabolism Flexibility. Open Access - Cell Reports.

2016 - Study ~ Acetaminophen Use for Fever in Children Associated with Autism Spectrum Disorder. Department of Physiology, School of Medicine, University of Texas.

2016 - Study ~ Turning Up the Heat on Endocannabinoid Signaling. American Epilepsy Society.
2016 - Study ~ Effects of Cannabidiol and Hypothermia on Short-Term Brain Damage in New-Born Piglets after  Acute Hypoxia-Ischemia. Frontiers in Neuroscience.

2016 - Study ~ Hypothermic activity of acetaminophen; involvement of GABAA receptor, theoretical and experimental studies. Iranian Journal of Basic Medical Sciences.

2016 - Study ~ A Curious Case of Inhalation Fever Caused by Synthetic Cannabinoid. American Journal of Case Reports.
2016 - Study ~ Prostaglandin E2 that triggers fever is synthesized through an endocannabinoid dependent pathway. Taylor & Francis.
2016 - Study ~ Case Series of Synthetic Cannabinoid Intoxication from One Toxicology Center. Department of Emergency Medicine, Allentown, Pennsylvania.

2016 - Study ~ Transient increase of interleukin-1β after prolonged febrile seizures promotes adult epileptogenesis through long-lasting upregulating endocannabinoid signaling. Scientific Reports.
2015 - Study ~ "Spice" Can Really Heat Things Up. American Journal of Respiratory and Critical Care Medicine.
2015 - Study ~ ENP11, a potential CB1R antagonist, induces anorexia in rats. Pharmacology Biochemistry and Behavior.
2015 - Study ~ Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition. National Academy of Sciences of the United States of America.
2015 - Study ~ Hyperthermia and severe rhabdomyolysis from synthetic cannabinoids. American Journal of Emergency Medicine.
2014 - Study ~ Cannabidiol fails to reverse hypothermia or locomotor suppression induced by Δ9 tetrahydrocannabinol in Sprague-Dawley rats. British Journal of Pharmacology.
2014 - Study ~ Effect of intermittent cold exposure on brown fat activation, obesity, and energyhomeostasis in mice. National Institute of Diabetes and Digestive and Kidney Diseases.

2013 - Study ~ Dissociation of the pharmacological effects of THC by mTOR blockade. Neuropsychopharmacology.

2013 - Study ~ Behavioral responses to acute and sub-chronic administration of the synthetic cannabinoid JWH-018 in adult mice prenatally exposed to corticosterone. Neurotoxicity Research.

2013 - Study ~ Tolerance and cross-tolerance among high-efficacy synthetic cannabinoids JWH-018 and JWH-073 and low-efficacy phytocannabinoid Δ9-THC. Journal of the Federation of American Societies for Experimental Biology. (FASEB)

2013 - Study ~ Cannabinoid 1 receptors are critical for the innate immune response to TLR4 stimulation. American Physiological Society.

2013 - Study ~ Improved cardiac and neurologic outcomes with postresuscitation infusion of cannabinoid receptor agonist WIN55, 212-2 depend on hypothermia in a rat model of cardiac arrest. Critical Care Medicine.

2012 - Study ~ Contribution of hypothermia and CB1 receptor activation to protective effects of TAK-937, a cannabinoid receptor agonist, in rat transient MCAO model. PLOS One.

2012 - Study ~ Cannabinoid 1 (CB1) receptor mediates WIN55, 212-2 induced hypothermia and improved survival in a rat post-cardiac arrest model. Journal of the European Resuscitation Council.

2012 - Study ~ Δ(9)-Tetrahydrocannabinol acts as a partial agonist/antagonist in mice. Behavioral Pharmacology.

2012 - Study ~ Determination of naphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-018) in mouse blood and tissue after inhalation exposure to ‘buzz’ smoke by HPLC/MS/MS. National Institute of Health, Biomed Chromatogr.

2010 - Study ~ Pharmacologically induced hypothermia with cannabinoid receptor agonist WIN55, 212-2 after cardiopulmonary resuscitation. Critical Care Medicine.

2009 - Study ~ Endogenous cannabinoids induce fever through the activation of CB1 receptors. British Journal of Pharmacology.

2008 - Study ~ Behavioral and temperature effects of delta 9-tetrahydrocannabinol in human-relevant doses in rats. National Institute of Health, Brain Research.

2007 - Study ~ Effects of a Selective Cannabinoid Agonist and Antagonist on Body Temperature in Rats. Journal of the Federation of American Societies for Experimental Biology. (FASEB)

2007 - Study ~ A Novel Role of Cannabinoids: Implication in the Fever Induced by Bacterial Lipopolysaccharide. Journal of Pharmacology and Experimental Therapeutics.

2003 - Study ~ Drug-Induced Hypothermia Reduces Ischemic Damage. American Stroke Association.

2002 - Study ~ CB1 Receptors in the Preoptic Anterior Hypothalamus Regulate WIN 55212-2 [(4,5-Dihydro-2-methyl-4(4-morpholinylmethyl)-1-(1-naphthalenyl-carbonyl)-6H-pyrrolo[3,2,1ij]quinolin-6-one]-Induced Hypothermia. Journal of Pharmacology and Experimental Therapeutics.

1996 - Study ~ Marijuana and hyperthermia. Journal of Toxicology. Clinical Toxicology.

1982- Study ~ Changes in body temperature and oxygen consumption rate of conscious mice produced by intrahypothalamic and intracerebroventricular injections of delta 9-tetrahydrocannabinol. Department of Pharmacology, University of Aberdeen.

1978 - Study ~ The effects of cannabinoids on body temperature and brain catecholamine synthesis. Research Communications in Chemical Pathology and Pharmacology.

1977 - Study ~ Effects of delta9-tetrahydrocannabinol on the rates of oxygen consumption of mice. Department of Pharmacology, University Medical Buildings, Foresterhill, Aberdeen.

1976 - Study ~ Marijuana Smoking and Cold Tolerance in Man. Aviation, Space, and Enviromental Medicine.

1975 - Study ~ Absence of interaction between delta9-tetrahydrocannabinol (delta-THC) and cannabidiol (CBD) in aggression, muscle control and body temperature experiments in mice. Psychopharmacologia.

1973 - Study ~ The effects of (-)-Δ9-tetrahydrocannabinol on reserpine-induced hypothermia in rats. British Journal of Pharmacology.

1973 - Study ~ Evaluation valuation of the hypothermic action of tetrahydrocannabinoids in a squiiel monkeys. Journal of Pharmacology and Experimental Therapeutics.

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