ENCEPHALOMYELITIS/ EAE & Cannabis studies completed
Encephalomyelitis is a general term for inflammation of the brain and spinal cord, describing a number of disorders:
- Acute disseminated encephalomyelitis or postinfectious encephalomyelitis, a demyelinating disease of the brain and spinal cord, possibly triggered by viral infection;
- Encephalomyelitis disseminata, a synonym for multiple sclerosis;
- Equine encephalomyelitis, a potentially fatal mosquito-borne viral disease that infects horses and humans;
- Myalgic encephalomyelitis, a syndrome involving inflammation of the central nervous system with symptoms of muscle pain and fatigue; the term has sometimes been used interchangeably with chronic fatigue syndrome, though there is still controversy over the distinction.
- Experimental autoimmune encephalomyelitis (EAE), an animal model of brain inflammation.
The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis
- cerebrospinal fluid
- experimental autoimmune encephalomyelitis
- endocannabinoid system
- excitatory postsynaptic current
- fatty acid amide hydrolase
- holding potential
- inhibitory postsynaptic current
- multiple sclerosis
- N-acyl-phosphatidylethanolamines (NAPE)-hydrolysing phospholipase D
- paired pulse ratio
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Articles citing this article
CB2 cannabinoid receptors as an emerging target for demyelinating diseases: from neuroimmune interactions to cell replacement strategies
Br J Pharmacol. 2008 January; 153(2): 216–225.
Published online 2007 September 24. doi: 10.1038/sj.bjp.0707466.
Since the late 1970s, it was clear that the psychoactive compounds of Cannabis sativa, such as delta-9-tetrahydrocannabinol (Δ9-THC), modulate the inflammatory response (Zimmerman et al., 1977; Smith et al., 1978). In the following years, numerous studies...read entire study