Cannabis Health Science Studies Index


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DEPRESSION & Cannabis studies completed


Depression is a tough thing. There are more than 350 million people worldwide that suffer from depression. One of the saddest things to me about depression is the lack of effective medications that a person can take. Doctors almost always prescribe pharmaceuticals for depression, many of which have harmful side effects. Whenever you see a commercial on TV for a depression medication, the list of potential side effects is usually longer than the segment of the commercial dedicated to how well it works. I have seen many pharmaceutical commercials list ‘thoughts of suicide’ as one of the main potential side effects.

A study was recently released which found that cannabis can be an effective treatment for depression. Cannabis of course doesn’t cause the side effects that pharmaceuticals do. Per the Huffington Post:

Recommended Cannabis Strain for Treating Depression

Choose an uplifting sativa strain such as
Jack Herer
Pineapple Express

Science & Research

2000 - Study ~ Anxiety with Depression Research Review.

2001 - Study ~ Therapeutic Aspects of Cannabis and Cannabinoids.

2004 - Study ~ Association between cannabis use and depression may not be causal, study says.

2005 - Study ~ Cannabinoids promote hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects.

2005 - Study ~ Antidepressant-like activity by blockade of anandamide hydrolysis.

2005 - Study ~ Depression in Parkinson's disease is related to a genetic polymorphism of the cannabinoid receptor gene (CNR1).

2005 - Study ~ Antidepressant-like Activity and Modulation of Brain Monoaminergic Transmission by Blockade of Anandamide Hydrolysis.

2005 - Study ~ Decreased Depression in Marijuana Users.

2005 - News ~ Depression: URB597 increases endocannabinoids in brain.

2005 - News ~ New Antidepressant Drug Increases 'Brain's Own Cannabis'.

2005 - News ~ Cannabis' Acts as Antidepressant.

2005 - News ~ Cannabis And Depression Research.

2005 - News ~ High-dose cannabis stimulates growth of brain cells in rats.

2005 - News ~ Good News For The Medical Marijuana Movement: Pot Proliferates Brain Cells And Boosts Mood.

2005 - News ~ Marijuana might cause new cell growth in the brain.

2005 - News ~ Surprising Brain Effects From Pot-Like Drug.

2006 - Study ~ Decreased depression in marijuana users.

2006 - Study ~ The synthetic cannabinoid nabilone improves pain and symptom management in cancer patients.

2006 - Study ~ Marijuana use and depression among adults: Testing for causal associations.

2006 - Study ~ Do patients use marijuana as an antidepressant?

2006 - Study ~ A possible role for the endocannabinoid system in the neurobiology of depression.

2007 - Study ~ Chronologically overlapping occurrences of nicotine-induced anxiety- and depression-related behavioral symptoms: effects of anxiolytic and cannabinoid drugs.

2007 - Study ~ Cannabinoids elicit antidepressant-like behavior and activate serotonergic neurons through the medial prefrontal cortex.

2007 - Study ~ Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress.

2007 - Study ~ Dronabinol and marijuana in HIV-positive marijuana smokers: caloric intake, mood, and sleep.

2007 - News ~ Marijuana-Like Brain Chemicals Work As Antidepressant.

2007 - News ~ Marijuana chemical may treat depression.

2007 - News ~ Cannabis: Potent Anti-Depressant In Low Doses, Worsens Depression At High Doses.

2007 - News ~ Synthetic form of THC is an effective anti-depressant at low doses.

2007 - News ~ Rimonabant: safety issues.

2008 - Study ~ Treating depression with cannabinoids.

2008 - Study ~ Nicotine (NC)-induced "depressive" behavioral symptoms and effects of antidepressants including cannabinoids (CBs).

2008 - Study ~ Animal research highlights a therapeutic potential of cannabinoids for the treatment of depression.

2009 - Study ~ Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress.

2009 - Study ~ Impairments in Endocannabinoid Signaling and Depressive Illness.

2009 - Study ~ Protracted cannabinoid administration elicits antidepressant behavioral responses in rats: role of gender and noradrenergic transmission.

2009 - Study ~ Cannabis and suicide: longitudinal study.

2009 - News ~ Medical Marijuana and Major Depression.

2010 - Study ~ Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L.

2010 - Study ~ Brain CB2 Receptors: Implications for Neuropsychiatric Disorders.

2010 - Study ~ Uni-Morbid and Co-Occurring Marijuana and Tobacco Use: Examination of Concurrent Associations with Negative Mood States.

2010 - Study ~ Genes differentially expressed in CB1 knockout mice: involvement in the depressive-like phenotype.

2010 - Study ~ Deficiency in Endocannabinoid Signaling in the Nucleus Accumbens Induced by Chronic Unpredictable Stress.

2010 - Study ~ Pharmacological exploitation of the endocannabinoid system: new perspectives for the treatment of depression and anxiety disorders?

2011 - Study ~ Gadolinium-HU-308-incorporated micelles.

2011 - Study ~ Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions.

2011 - Study ~ Endocannabinoid system dysfunction in mood and related disorders.

2011 - Study ~ Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress.

2011 - Study ~ Cannabinoids and emotionality: a neuroanatomical perspective.

2011 - Study ~ Testing bidirectional effects between cannabis use and depressive symptoms: moderation by the serotonin transporter gene.

2011 - News ~ Deficiency of Dietary Omega-3 May Explain Depressive Behaviors.

2011 - News ~ A Brain Wrought Without Omega-3.

2011 - News ~ Omega-3 deficiency disrupts cannibinoid receptor function in brain.

2011 - News ~ Natural Herbs That Increase Serotonin.

2011 - News ~ Research provides new clues to understand link between deficits of AGPO-3, depression.

2012 - Study ~ High on Life? Medical Marijuana Laws and Suicide.

2012 - Study ~ Serum contents of endocannabinoids are correlated with blood pressure in depressed women.

2012 - Study ~ Cannabinoid Receptor Genotype Moderation of the Effects of Childhood Physical Abuse on Anhedonia and Depression.

2012 - Study ~ Effect of delta-9-tetrahydrocannabinol on behavioral despair and on presynaptic and postsynaptic serotonergic transmission.

2012 - Study ~ Nature Against Depression.

2012 - Study ~ Lower levels of cannabinoid 1 receptor mRNA in female eating disorder patients: Association with wrist cutting as impulsive self-injurious behavior.

2012 - Study ~ Expression pattern of the cannabinoid receptor genes in the frontal cortex of mood disorder patients and mice selectively bred for high and low fear.

2012 - Study ~ The combined effects of parental divorce and parental history of depression on cannabis use in young adults in France.

2012 - Study ~ Genetic variability in the endocannabinoid system and 12-week clinical response to citalopram treatment: the role of the CNR1, CNR2 and FAAH genes

2012 - Study ~ Opposing local effects of endocannabinoids on the activity of noradrenergic neurons and release of noradrenaline: relevance for their role in depression and in the actions of CB(1) receptor antagonists.

2012 - Study ~ Essential fatty acids and lipid mediators. Endocannabinoids

2012 - Study ~ Endocannabinoid system and mood disorders: Priming a target for new therapies.

2012 - News ~ Smoking Cannabis Increases Risk of Depression in the Case of Genetic Vulnerability, 

2013 - Study ~ Effect of dietary fat type on anxiety-like and depression-like behavior in mice

2013 - Study ~ Translational evidence for the involvement of the endocannabinoid system in stress-related psychiatric illnesses

2013 - Study ~ Screening genetic variability at the CNR1 gene in both major depression etiology and clinical response to citalopram treatment.

2013 - Study ~ Additive effect of rimonabant and citalopram on extracellular serotonin levels monitored with in vivo microdialysis in rat brain.

2013 - Study ~ Entopeduncular nucleus endocannabinoid system modulates sleep-waking cycle and mood in rats.

2013 - Study ~ Can Marijuana Reduce Social Pain?

2013 - Study ~ Sleep Quality Moderates the Relation between Depression Symptoms and Problematic Cannabis Use among Medical Cannabis Users

2013 - Study ~ The effects of anandamide signaling enhanced by the FAAH inhibitor URB597 on coping styles in rats.

2013 - Study ~ Cannabinoids, Neurogenesis and Antidepressant Drugs: Is there a Link?

2013 - Study ~ The endocannabinoid system and emotional processing: A pharmacological fMRI study with ∆9-tetrahydrocannabino

2013 - Study ~ Cannabinoid Receptor Activation Prevents the Effects of Chronic Mild Stress on
Emotional Learning and LTP in a Rat Model of Depression.

2013 - Study ~ Endocannabinoid Signaling in the Etiology and Treatment of Major Depressive Illness.

2013 - Study ~ The endocannabinoid system and its possible role in neurobiology of psychiatric

2013 - Study ~ Low frequency stimulation evokes serotonin release in the nucleus accumbens and induces long-term depression via production of endocannabinoid.

2013 - Study ~ Testing bidirectional effects between cannabis use and depressive symptoms: moderation by the serotonin transporter gene

2013 - News ~ THC Increases Brain Activity In Response To Positive Stimuli

2013 - News ~ This bud’s for you: Marijuana identified as a buffer against loneliness, study suggests

2013 - News ~ 5 Health Benefits Of Cannabichromene (CBC)

2014 - Study ~ Monoacylglycerol Lipase Inhibition Blocks Chronic Stress-Induced Depressive-Like Behaviors via Activation of mTOR Signaling

2014 - Study ~ Anti-depressive mechanism of repetitive transcranial magnetic stimulation in rat: The role of the endocannabinoid system.