CANNABICHROMENE / CBC & Cannabis studies completed


Cannabichromene (abbreviated as CBC) is a cannabinoid found in the cannabis plant. It bears structural similarity to the other natural cannabinoids.

Science and Research

Undated - News ~ Phytocannabinoids.
2012 - Study ~ Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice

2011 - Study ~ The endocannabinoid system and cancer: therapeutic implication.

2011 - Study ~ Phytocannabinoids for use in the treatment of cancer - Patent GB2478595 (A) ― 2011-09-14.

2011 - Study ~ Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes.

2011 - Study ~ The intersection between cannabis and cancer in the United States.

2011 - Study ~ Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action.

2011 - Study ~ Cannabinoids in children.

2011 - News ~ Cannabis Science Reports: National Cancer Institute Updates Confirm Successful Cancer Treatments with Medical Cannabis.

2010 - Study ~ Antidepressant-like effect of Delta(9)-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L.

2010 - Study ~ Disposition of Cannabichromene, Cannabidiol, and Δ9-Tetrahydrocannabinol and its Metabolites in Mouse Brain following Marijuana Inhalation Determined by High-Performance Liquid Chromatography-Tandem Mass Spectrometry.

2010 - Study ~ Pharmacological evaluation of the natural constituent of Cannabis sativa, cannabichromene and its modulation by Δ9-tetrahydrocannabinol.

2009 - Study ~ Evaluation of Prevalent Phytocannabinoids in the Acetic Acid Model of Visceral Nociception.

2009 - Study ~ TRB3 links ER stress to autophagy in cannabinoid anti-tumoral action.

2008 - Study ~ Antibacterial cannabinoids from Cannabis sativa: a structure-activity study.
1990 - Study ~ In vitro metabolism of cannabichromene in seven common laboratory animals
1989 - Study ~ Antiinflammatory and antimicrobial compounds and compositions
United States Patent 4837228

1989 - Study ~ Antiinflammatory and antimicrobial compounds and compositions
United States Patent 4837228

1984 - Study ~ Intraocular pressure, ocular toxicity and neurotoxicity after administration of delta 9-tetrahydrocannabinol or cannabichromene

1983 - Study ~ Neurobehavioral actions of cannabichromene and interactions with delta 9-tetrahydrocannabinol.

1983 - Study - Allergenic properties of naturally occurring cannabinoids.

1983 - Study ~ Neurobehavioral actions of cannabichromene and interactions with delta 9-tetrahydrocannabinol
1982 - Study ~ Process for preparing cannabichromene.

1981 - Study - Biological activity of cannabichromene, its homologs and isomers.

1975 - Study ~ Constituents of Cannabis sativa L. VIII: Possible biological application of a new method to separate cannabidiol and cannabichromene.

Similar Research


Allergenic properties of naturally occurring cannabinoids.

J Pharm Sci. 1983 Aug;72(8):954-5.


The guinea pig maximization test was used to determine the potential of seven cannabinoids to produce allergic contact dermatitis. delta 9-Tetrahydrocannabinol and cannabinol were found to be extreme (Grade V) sensitizers. Cannabidiol, delta 8-tetrahydrocannabinol, and cannabichromene were moderate (Grade III) sensitizers. Cannabigerol and cannabinol methyl ether were not sensitizers.

Most of the cannabinoids were found to be allergenically cross-reactive. Additionally, it was shown that the presence of a free 1'-hydroxyl group was required for sensitization, but not to elicit a response in sensitive animals.

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Biological activity of cannabichromene, its homologs and isomers

J Clin Pharmacol. 1981 Aug-Sep;2

Turner CE, Elsohly MA


Cannabichromene (CBC) is one of four major cannabinoids in Cannabis sativa L. and is the second most abundant cannabinoid in drug-type cannabis.

Cannabichromene and some of its homologs, analogs, and isomers were evaluated for antiinflammatory, antibacterial, and antifungal activity. Antiinflammatory activity was evaluated by the carrageenan-induced rat paw edema and the erythrocyte membrane stabilization method.

In both tests, CBC was superior to phenylbutazone. Antibacterial activity of CBC and its isomers and homologs was evaluated using gram-positive, gram-negative, and acid-fast bacteria.

Antifungal activity was evaluated using yeast-like and filamentous fungi and a dermatophyte. Antibacterial activity was strong, and the antifungal activity was mild to moderate.



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