Cannabis Health Science Studies Index

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CANCER - THYROID & cannabis studies completed

Overview

There are different types of thyroid cancer but the most common, occurring in 80% of cases, is known as:

Differentiated Thyroid Cancer (papillary, follicular or mixed papillary and follicular forms). Provided a careful history is obtained, 5-10% of patients with Differentiated Thyroid Cancer will have a positive family history.

Anaplastic Thyroid Cancer is a rare type of cancer with a poor prognosis. Occasionally individuals develop lymphoma of the thyroid gland or with metastasis from other cancer types.

Medullary Thyroid Cancer is a rare tumor, arising not from the follicular cells that produce the thyroid hormone but from C-cells which are also present in the thyroid.

 

also see Cannabis Research on Other Forms of Cancer

image of thyroid cancer

Science & Research

1968 - Study - Byssinosis, Chronic Bronchitis, and Ventilatory Capacities in Workers Exposed to Soft Hemp Dust.

1997 - News - Heavy Long-Term Marijuana Use Does Not Impair Lung Function.

1997 - Study - Heavy Habitual Marijuana Smoking Does Not Cause an Accelerated Decline in FEV with Age.

2005 - Study ~ The cannabinoid receptor agonist WIN 55212-2 inhibits neurogenic inflammations in airway tissues.

2005 - Lecture - THC effective in appetite and weight loss in severe lung disease (COPD).

2005 - News - Researchers to test if cannabis ingredient can help COPD patients.

2005 - News ~ THC effective in appetite and weight loss in severe lung disease (COPD).

2007 - Study ~ Effects of Marijuana Smoking on Pulmonary Function and Respiratory Complications: A Systematic Review.

2007 - Study ~ No Decrease in Pulmonary Function Associated with Long-Term Cannabis Smoking, Study Says.

2009 - Study ~ Marijuana. Respiratory tract effects.

2009 - Study ~ Marijuana and chronic obstructive lung disease: a population-based study.

2009 - Patent ~ US Patent Application 20090197941 - Pharmaceutical Compositons for the Treatment of Chronic Obstructive Pulmonary Disease.

2009 - News - Smoking Pot, Cigarettes Ups COPD Risk.

2009 - News - Does smoking marijuana increase the risk of chronic obstructive pulmonary disease?

2009 - Study - Marijuana and chronic obstructive lung disease: a population-based study.

2010 - Study - Effects of cannabis on lung function: a population-based cohort study.

2011 - Study ~ Effects of smoking cannabis on lung function.

2011 - Study ~ Cannabinoid effects on ventilation and breathlessness: A pilot study of efficacy and safety.

2011 - Study ~ Beneficial effects of cannabinoids (CB) in a murine model of allergen-induced airway inflammation: role of CB1/CB2 receptors.

2012 - News ~ Marijuana Smoke Not as Damaging as Tobacco, Says Study.

A metabolically stable analogue of anandamide, Met-F-AEA, inhibits human thyroid carcinoma cell lines by activation of apoptosis

 

Cozzolino R, Calì G, Bifulco M, Laccetti P 
A metabolically stable analogue of anandamide, Met-F-AEA, inhibits human thyroid carcinoma cell lines by activation of apoptosis. [JOURNAL ARTICLE]
Invest New Drugs 2009 Feb 3.

The active components of Cannabis sativa and their derivatives produce a wide spectrum of effects, some of which may have clinical application. The discovery of specific cannabinoid receptors and a family of endogenous ligands of those receptors has attracted much attention to cannabinoids as agents capable of controlling the decision of cells to survive or die. We analysed the effects exerted by 2-methyl-2'-F-anandamide (Met-F-AEA), a metabolically stable analogue of anandamide, and observed a growth inhibition in cell lines derived from thyroid carcinomas. Growth inhibition was associated with a high level of CB1 receptor expression, suggesting that the cytotoxic effect is due to interaction with the CB1 receptor. This phenomenon was associated with activation of the protein, p53, an increased apoptotic rate, and expression of p21(CIP1/WAF1). This study provides new insights into the mechanism of Met-F-AEA action, and could have significance in providing a basis for the management of thyroid carcinoma.

 

 

 

 

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