Medical Marijuana: Thyroid cancer is a disease that you get when abnormal cells begin to grow in your thyroid gland. The thyroid gland is shaped like a butterfly and is located in the front of your neck. It makes hormones that regulate the way your body uses energy.
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CANCER - THYROID & cannabis studies completed
There are different types of thyroid cancer but the most common, occurring in 80% of cases, is known as Differentiated Thyroid Cancer (papillary, follicular or mixed papillary and follicular forms). Provided a careful history is obtained, 5-10% of patients with Differentiated Thyroid Cancer will have a positive family history.
Anaplastic Thyroid Cancer is a rare type of cancer with a poor prognosis. Occasionally individuals develop lymphoma of the thyroid gland or with metastasis from other cancer types.
Medullary Thyroid Cancer is a rare tumor, arising not from the follicular cells that produce the thyroid hormone but from C-cells which are also present in the thyroid.
also see Cannabis Research on Other Forms of CancerControl by the endogenous cannabinoid system of ras oncogene-dependent tumor growth
Inhibitory effects of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading: actions on signals involved in angiogenesis and metastasis1
A new strategy to block tumor growth by inhibiting endocannabinoid inactivation.
Endocannabinoids in endocrine and related tumours
Cannabinoid 2 receptor induction by IL-12 and its potential as a therapeutic target for the treatment of anaplastic thyroid carcinoma.
A metabolically stable analogue of anandamide, Met-F-AEA, inhibits human thyroid carcinoma cell lines by activation of apoptosis
Cozzolino R, Calì G, Bifulco M, Laccetti P
A metabolically stable analogue of anandamide, Met-F-AEA, inhibits human thyroid carcinoma cell lines by activation of apoptosis. [JOURNAL ARTICLE]
Invest New Drugs 2009 Feb 3.
The active components of Cannabis sativa and their derivatives produce a wide spectrum of effects, some of which may have clinical application. The discovery of specific cannabinoid receptors and a family of endogenous ligands of those receptors has attracted much attention to cannabinoids as agents capable of controlling the decision of cells to survive or die. We analysed the effects exerted by 2-methyl-2'-F-anandamide (Met-F-AEA), a metabolically stable analogue of anandamide, and observed a growth inhibition in cell lines derived from thyroid carcinomas. Growth inhibition was associated with a high level of CB1 receptor expression, suggesting that the cytotoxic effect is due to interaction with the CB1 receptor. This phenomenon was associated with activation of the protein, p53, an increased apoptotic rate, and expression of p21(CIP1/WAF1). This study provides new insights into the mechanism of Met-F-AEA action, and could have significance in providing a basis for the management of thyroid carcinoma.