The first crop grown in many states was hemp. 1850 was a peak year for Kentucky producing 40,000 tons. Hemp was the largest cash crop until the 20th Century.

o




A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
  Loading
 
 

 Anti-fungal medicines are used to treat fungal infections, which are most commonly found on the skin, hair and nails.

 
 

Top    Home

Biologically Active Cannabinoids from High-Potency Cannabis sativa

Abstract

Nine new cannabinoids (19) were isolated from a high-potency variety of Cannabis sativa. Their structures were identified as (±)-4-acetoxycannabichromene (1), (±)-3′′-hydroxy-Δ(4′′,5′′)-cannabichromene (2), (−)-7-hydroxycannabichromane (3), (−)-7R-cannabicoumarononic acid A (4), 5-acetyl-4-hydroxycannabigerol (5), 4-acetoxy-2-geranyl-5-hydroxy-3-n-pentylphenol (6), 8-hydroxycannabinol (7), 8-hydroxycannabinolic acid A (8), and 2-geranyl-5-hydroxy-3-n-pentyl-1,4-benzoquinone (9) through 1D and 2D NMR spectroscopy, GC-MS, and HRESIMS. The known sterol β-sitosterol-3-O-β-d-glucopyranosyl-6′-acetate was isolated for the first time from cannabis. Compounds 6 and 7 displayed significant antibacterial and antifungal activities, respectively, while 5 displayed strong antileishmanial activity.

(1), (+/-)-3''-hydroxy-Delta((4'',5''))-cannabichromene

(2), (-)-7-hydroxycannabichromane

(3), (-)-7R-cannabicoumarononic acid A

(4), 5-acetyl-4-hydroxycannabigerol

(5), 4-acetoxy-2-geranyl-5-hydroxy-3-n-pentylphenol

(6), 8-hydroxycannabinol

(7), 8-hydroxycannabinolic acid A

(8), and 2-geranyl-5-hydroxy-3-n-pentyl-1,4-benzoquinone

(9) through 1D and 2D NMR spectroscopy, GC-MS, and HRESIMS. The known sterol beta-sitosterol-3-O-beta-d-glucopyranosyl-6'-acetate was isolated for the first time from cannabis.

Compounds 6 and 7 displayed significant antibacterial and antifungal activities, respectively, while 5 displayed strong antileishmanial activity.

Links

  • Publisher Full Text
  • Authors

    Radwan MM, Elsohly MA, Slade D, Ahmed SA, Khan IA, Ross SA

    Institution

    Department of Pharmaceutics, National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, Mississippi 38677, USA.

    Source

    Journal of natural products 72:5 2009 May 22 pg 906-11

     

    Top    Home