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ACEA/ ARACHIDONYL-2'-CHLOROETHYLAMIDE - synthetic, CB1 agonist studies completed

Overview

Arachidonyl-2'-chloroethylamide (ACEA) is a synthetic agonist of the cannabinoid receptor 1 (CB1R). ACEA is considered to be a selective cannabinoid agonist as it binds primarily to the CB1R and has low affinity to the cannabinoid receptor 2 (CB2R) (Ki = 1.4 nM for CB1R; Ki = 3100 nM for CB2R).

Science & Research

1999 - Study ~ Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1).

2002 - Study ~ The cannabinoids R(-)-7-hydroxy-delta-6-tetra-hydrocannabinol-dimethylheptyl (HU-210), 2-O-arachidonoylglycerylether (HU-310) and arachidonyl-2-chloroethylamide (ACEA) increase isoflurane provoked sleep duration by activation of cannabinoids 1 (CB1)-receptors in mice.

2006 - Study ~ In vivo effects of CB1 receptor ligands on lipid peroxidation and antioxidant defense systems in the rat brain of healthy and ethanol-treated rats.

2006 - Study ~ Differential effect of cannabinoid agonists and endocannabinoids on histamine release from distinct regions of the rat brain.

2006 - Study ~ Arachidonyl-2'-chloroethylamide, a highly selective cannabinoid CB1 receptor agonist, enhances the anticonvulsant action of valproate in the mouse maximal electroshock-induced seizure model.

2007 - Study ~ Opposing control of cannabinoid receptor stimulation on amyloid-beta-induced reactive gliosis: in vitro and in vivo evidence.

2007 - Study ~ Ultra-low dose cannabinoid antagonist AM251 enhances cannabinoid anticonvulsant effects in the pentylenetetrazole-induced seizure in mice.

2008 - Study ~ Attenuation of Experimental Autoimmune Hepatitis by Exogenous and Endogenous Cannabinoids: Involvement of Regulatory T Cells

2008 - Study ~ Cannabinoid modulation of cutaneous Adelta nociceptors during inflammation.

2008 - Study ~ Cannabinoid-mediated antinociception is enhanced in rat osteoarthritic knees.

2008 - Study ~ Cannabinoid receptor activation induces apoptosis through tumor necrosis factor alpha-mediated ceramide de novo synthesis in colon cancer cells.

2008 - Study ~ Additive Interaction of the Cannabinoid Receptor I Agonist Arachidonyl-2-chloroethylamide with Etomidate in a Sedation Model in Mice

2009 - Study ~ Endogenous cannabinoids induce fever through the activation of CB1 receptors.

2009 - Study ~ The effects of intracerebroventricular AM-251, a CB1-receptor antagonist, and ACEA, a CB1-receptor agonist, on penicillin-induced epileptiform activity in rats.

2009 - Study ~ Involvement of nitrergic system in the anticonvulsant effect of the cannabinoid CB(1) agonist ACEA in the pentylenetetrazole-induced seizure in mice.

2009 - Study ~ Involvement of nitric oxide in the gastroprotective effect of ACEA, a selective cannabinoid CB1 receptor agonist, on aspirin-induced gastric ulceration.

2009 - Study ~ Effect of arachidonyl-2'-chloroethylamide, a selective cannabinoid CB1 receptor agonist, on the protective action of the various antiepileptic drugs in the mouse maximal electroshock-induced seizure model.

2009 - Study ~ Role of cannabinoid CB1 receptors on macronutrient selection and satiety in rats.

2010 - Study ~ Regulatory Role of Cannabinoid Receptor 1 in Stress-Induced Excitotoxicity and Neuroinflammation

2011 - Study ~ Alkamides and a neolignan from Echinacea purpurea roots and the interaction of alkamides with G-protein-coupled cannabinoid receptors.

2011 - Study ~ Inhibition of basal and ultraviolet B-induced melanogenesis by cannabinoid CB(1) receptors: a keratinocyte-dependent effect.

2011 - Study ~ L-Type Calcium Channel Mediates Anticonvulsant Effect of Cannabinoids in Acute and Chronic Murine Models of Seizure.

2011 - Study ~ Changes in the cannabinoid (CB1) receptor expression level and G-protein activation in kainic acid induced seizures.

2012 - Study ~ Contrasting effects of different cannabinoid receptor ligands on mouse ingestive behavior

2012 - Study ~ CB1 Agonist ACEA Protects Neurons and Reduces the Cognitive Impairment of AβPP/PS1 Mice.

2012 - Study ~ Protective effect of cannabinoid CB1 receptor activation against altered intrinsic repetitive firing properties induced by Aβ neurotoxicity.

2012 - Study ~ CB1 cannabinoid receptor activation rescues amyloid β-induced alterations in behaviour and intrinsic electrophysiological properties of rat hippocampal CA1 pyramidal neurones.

2012 - Study ~ Opposing Roles for Cannabinoid Receptor Type-1 (CB(1)) and Transient Receptor Potential Vanilloid Type-1 Channel (TRPV1) on the Modulation of Panic-Like Responses in Rats.

2002 - Study ~ Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro.

2012 - Study ~ Cannabinoids and muscular pain. Effectiveness of the local administration in rat.

2002 - Study ~ Revisiting CB1 Receptor as Drug Target in Human Melanoma.

2012 - Study ~ Photoperiodic Changes in Endocannabinoid Levels and Energetic Responses to Altered Signalling at CB1 Receptors in Siberian Hamsters

2012 - Study ~ Effect of ACEA-a selective cannabinoid CB1 receptor agonist on the protective action of different antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model.